Three-dimensional Analysis Research Articles

BiliQML: a supervised machine-learning model to quantify biliary forms from digitized whole slide liver histopathological images.

The progress of research focused on cholangiocytes and the biliary tree during development and following injury is hindered by limited available quantitative methodologies. Current techniques include two-dimensional standard histological cell-counting approaches, which are rapidly performed, error prone, and lack architectural context or three-dimensional analysis of the biliary tree in opacified livers, which introduce technical issues along with minimal quantitation. The present study aims to fill these quantitative gaps with a supervised machine-learning model (BiliQML) able to quantify biliary forms in the liver of anti-keratin 19 antibody-stained whole slide images. Training utilized 5,019 researcher-labeled biliary forms, which following feature selection, and algorithm optimization, generated an F score of 0.87. Application of BiliQML on seven separate cholangiopathy models [genetic (Afp-CRE;Pkd1l1null/Fl, Alb-CRE;Rbp-jkfl/fl, and Albumin-CRE;ROSANICD), surgical (bile duct ligation), toxicological (3,5-diethoxycarbonyl-1,4-dihydrocollidine), and therapeutic (Cyp2c70-/- with ileal bile acid transporter inhibition)] allowed for a means to validate the capabilities and utility of this platform. The results from BiliQML quantification revealed biological and pathological differences across these seven diverse models, indicating a highly sensitive, robust, and scalable methodology for the quantification of distinct biliary forms. BiliQML is the first comprehensive machine-learning platform for biliary form analysis, adding much-needed morphologic context to standard immunofluorescence-based histology, and provides clinical and basic science researchers with a novel tool for the characterization of cholangiopathies.NEW & NOTEWORTHY BiliQML is the first comprehensive machine-learning platform for biliary form analysis in whole slide histopathological images. This platform provides clinical and basic science researchers with a novel tool for the improved quantification and characterization of biliary tract disorders.

The Efficacy of Anterior Cruciate Ligament Reconstruction with Peroneus Longus Tendon and its Impact on Ankle Joint Function.

Peroneus Longus Tendon (PLT), a viable anterior cruciate ligament (ACL) graft, shares similar biomechanics, making it suitable for reconstruction. Controversy exists over whether PLT transplants affects the donor ankle joint. The purpose of this study was to examine the recovery of knee joint function following arthroscopic ACL restoration using autologous PLT and its influence on the donor ankle joint. A retrospective analysis was conducted on 65 patients with ACL rupture who underwent PLT graft reconstruction in our hospital from January 2016 to December 2021. A three-dimensional gait analysis of the bilateral knee and ankle joints was performed postoperatively using an Opti_Knee three-dimensional motion measurement and analysis system-Yidong Medical Infrared Motion Gait Analyzer. Knee function scores and changes in the range of motion of the bilateral knee and ankle joints were collected. The analysis of preoperative and postoperative joint function scores, bilateral knee and ankle mobility was performed by t-tests. One year after surgery, the patients' International Knee Documentation Committee (IKDC) scores, Knee Injury and Osteoarthritis Outcome Scores (KOOSs), and Lysholm scores were significantly improved compared to preoperative scores, with statistically significant differences (p < 0.05). There was no statistical difference in the American Orthopedic Foot and Ankle Society (AOFAS) score of the donor ankle joint before and after surgery (p > 0.05). During different gait cycles, there was no statistical difference in knee joint mobility between the affected and healthy sides (p > 0.05), but there was a statistical difference in the inversion and eversion angle of the donor ankle joint during the support phase (p < 0.05). ACL reconstruction using the PLT can yield satisfactory knee joint function. However, it does affect inversion and eversion in the donor ankle joint, necessitating postoperative exercises. Similar subjective function ratings for both operated and non-operated feet, despite increased inversion-eversion motion in the operated foot, may be influenced by the subjective nature and margin of error in the AOFAS Ankle-hindfoot score, along with the relatively small variation in ankle inversion-eversion angles.

Performance of Pile–Wall System Adjacent to Footings

The performance of a retaining wall is dependent on multiple factors including lateral earth pressure, which results from backfill soils and adjacent footings located behind a retaining wall. The prediction of a retaining wall’s performance in a footing–soil–wall system (FSPS) must incorporate the influences caused by the movement of a retaining wall. This study examines the performance of a retaining wall formed by driven, precast, concrete piles located adjacent to a concrete footing using two- and three-dimensional finite element analysis (2D and 3D FEA) by ANSYS 13.0 software. Both soil and concrete are assumed to behave as non-linear, elastic-perfectly plastic and rate-independent materials in compliance with the upper-bound model of Drucker–Prager yield criterion. Three backfill and foundation soils are considered: kaolin, silty clay, and kaolin–sand. Various conditions of soil type, footing shape ratio, pile width, and footing–pile distance through 180 FEA runs are investigated. The effects of 2D and 3D FEA on the behavior of the pile–wall system are compared. The lateral deflection and pressure distribution profiles along the pile–wall are studied and presented. Two empirical equations predicting lateral deflections at the pile toe and pile head and useful for pile structural design are developed under the ultimate pressure of the adjacent footing.

Body composition and motor function in children born large for gestational age at term.

This cross-sectional study compared body composition and motor function between children who were born large for gestational age (LGA) and those born appropriate for gestational age (AGA) and to investigate the association between gait quality and other variables. Body composition was determined using a bioelectrical impedance analyzer. Motor functions were assessed using one-leg standing time, timed up-and-go test, five times sit-to-stand test, and three-dimensional gait analysis. We compared the results between two groups. We performed multiple regression analysis to evaluate the association between gait deviation index and variables of LGA, fat mass index, and motor functions (adjusted for age and sex). Children aged 6-12 years who were born LGA at term (n = 23) and those who were born AGA at term (n = 147) were enrolled. The LGA group had a higher fat mass index (2.9 vs. 2.2, p = 0.006) and lower gait deviation index (91.4 vs. 95.4, p = 0.011) than the AGA group. On multiple regression analysis, gait deviation index was associated with being LGA and fat mass index. In school-aged children who were born LGA, monitoring increased fat mass index and decreased gait deviation index could lessen the risk of metabolic syndrome and reduced gait function. Children aged 6-12 years who were born large for gestational age (LGA) at term showed a higher fat mass index and lower gait deviation index than those who were born appropriate for gestational age at term. No significant differences in balance function or muscle strength were observed between groups. On multiple regression analysis, gait deviation index was associated with being LGA at birth and fat mass index. In school-aged children who were born LGA, monitoring increased fat mass index and decreased gait deviation index could lessen the risk of metabolic syndrome and reduced gait function.

Effect of cross wall on the strut forces for braced excavations in clays

This study evaluates and estimates the effect of cross walls on the strut force for braced excavation in clays by using three-dimensional finite element analysis. A well-documented case history of a braced excavation with cross walls was utilized to validate the numerical analysis. Furthermore, a series of parametric studies were conducted to evaluate the distribution of strut force by considering different schematics of cross walls. The results revealed that implementing cross walls inside the excavation could significantly reduce the wall deformation and strut force along the wall section, particularly for the location near cross walls. In addition, a new empirical method was proposed to estimate the maximum strut force based on the apparent earth pressure for braced excavation with cross walls, which was verified through case histories. Finally, this study concluded that the existence of cross walls in braced excavations could ensure a safer bracing system and excavation design.

The controversial case of a coastal Mesolithic tool: A geometric approach to the analysis of the Asturian pick

The Mesolithic period along the coast of the Cantabrian Region (Spain), known as the “Asturian,” is distinguished by the presence of shell middens and a particular lithic tool, the Asturian pick. Despite the tool’s archaeological significance, its technological and functional aspects have not been fully understood, resulting in ambiguous interpretations of its morphological relationships and utilitarian purposes. Our research aims to quantify and analyse the technological processes that have influenced the Asturian pick's form and investigate the selection criteria governing its morphology and choice of raw materials. A novel aspect of our approach is the use of digital methods, including photogrammetry and three-dimensional geometric morphometric analysis. We analysed a sample of Asturian picks, compared against a control group of different elements and raw material specimens. The findings corroborate the homogeneity and standardisation of the Asturian pick's design and unveil regional shape variations that correspond with the distinct raw materials available in each locality.

Development of dynamic centrifuge models for measurement and visualization of deformation mechanisms in liquefiable soils

Recent advancements in geotechnical physical modeling have enabled visualization and analysis of deformation mechanisms in soil sections through the integration of Particle Image Velocimetry (PIV) in dynamic centrifuge modeling. PIV requires a rigid wall container. In this paper, we summarize the design considerations that enable reliable measurement and visualization of soil deformation mechanisms at the University of Colorado (CU) Boulder’s 400 g-ton, 5.5 m radius centrifuge facility. The primary objective of this system is to investigate the response of complex and stratigraphically variable, saturated granular soil deposits beneath shallow-founded structures, though it can also be used for other configurations that benefit from advanced visualization in the centrifuge. The setup aims to enable quantification and visualization of different deformation mechanisms, including shear, volumetric, and soil ejecta formation, near and away from structures. The paper provides detailed design considerations for the system components, including a rigid container with a transparent Perspex wall and duct seal inclusions, a linear-elastic single-degree of freedom (SDOF) structure, soil texture, a potential ground improvement technique, and a high-speed camera system. Through fully-coupled, three-dimensional (3D) nonlinear finite element analyses, we investigate the influence of container type, domain size, and duct seal geometry on boundary effects, with consideration of nonlinearities within various soil profile configurations with and without the presence of a building model. The findings highlight the critical impact of proximity to lateral boundaries of the container on accelerations, excess pore pressures, foundation settlement, tilt, and shear strains, as well as the benefits of duct seal in reducing those boundary effects. The results also show that the extent of boundary effects on key performance measures depends on the properties of the container, soil layers, and ground motion. The simulations also show that surface ejecta potential within stratigraphic soil profiles is highly sensitive to the depth of the groundwater table and variations in soil permeability, which must be considered in designing experimental programs that investigate the development of soil ejecta.

Characteristics of Midface Asymmetry in Skeletal Class III Malocclusion Using Three-Dimensional Analysis

Characteristics of Midface Asymmetry in Skeletal Class III Malocclusion Using Three-Dimensional Analysis

Effect of padeye offset ratio on keying behaviours and capacity of square plate anchors in clay

This paper reports the effect of padeye offset ratio on the keying behaviours and capacity of square plate anchors in clay. The investigation is conducted through three-dimensional large deformation finite element analyses using the Remeshing and Interpolation Technique with Small Strain in ABAQUS. Strain rate dependency of the undrained shear strength and soil remoulding are accounted for adopting an extended Tresca model. The results from LDFE analyses are compared with existing analytical solutions, centrifuge test data, and numerical results; with reasonable agreement obtained. Parametric analyses are then carried out varying several critical factors including initial embedment depth, load eccentricity, padeye offset ratio, soil sensitivity, and soil strength heterogeneity. It is seen that the padeye offset has significant influence on the ultimate loss of embedment and capacity under vertical loading. To assess the keying behaviour of square plate anchors in clay, an equivalent soil strength incorporating strain rate dependency and remoulding is adopted. A combined factor defined as a function of the initial embedment depth and equivalent soil strength is used to estimate the ultimate loss of embedment. An equivalent ultimate bearing capacity factor is shown to be a function of the initial embedment depth, padeye offset ratio, and load eccentricity.

Three-dimensional analysis of the positional relationship between the dentition and basal bone region in patients with skeletal Class I and Class II malocclusion with mandibular retrusion.

This study aimed to determine the maxillary and mandibular basal bone regions and explore the three-dimensional positional relationship between the dentition and basal bone regions in patients with skeletal Class I and Class II malocclusions with mandibular retrusion. Eighty patients (40 each with Class I and Class II malocclusion) were enrolled. Maxillary and mandibular basal bone regions were determined using cone-beam computed tomography images. To measure the relationship between the dentition and basal bone region, the root position and root inclination were calculated using the coordinates of specific fixed points by a computer program written in Python. In the Class II group, the mandibular anterior teeth inclined more labially (P < 0.05), with their apices positioned closer to the external boundary. The apex of the maxillary anterior root was positioned closer to the external boundary in both groups. Considering the molar region, the maxillary first molars tended to be more lingually inclined in females (P = 0.037), whereas the mandibular first molars were significantly more labially inclined in the Class II group (P < 0.05). Mandibular anterior teeth in Class II malocclusion exhibit a compensatory labial inclination trend with the crown and apex relative to the basal bone region when mandibular retrusion occurs. Moreover, as the root apices of the maxillary anterior teeth are much closer to the labial side in Class I and Class II malocclusion, the range of movement at the root apex should be limited to avoid extensive labial movement.

Three-Dimensional Analysis for the Documentation of the Restoration of an Earthquake-Damaged Triptych

Three-Dimensional Analysis for the Documentation of the Restoration of an Earthquake-Damaged Triptych

Three-dimensional elastoplastic post-buckling analysis of porous FG plates resting on Winkler/Pasternak foundation using meshless RRKPM

This paper presents a three-dimensional (3D) analysis of the elastoplastic post-buckling behavior of porous functionally graded (FG) plates resting on Winkler/Pasternak foundations under uniaxial and biaxial in-plane loadings using an enhanced meshless approach. The principle of virtual work is used to derive the governing equations, and 3D nonlinear Green–Lagrange strains are considered. Plastic deformation is modeled employing the Prandtl–Reuss flow law and the isotropic hardening von Mises criterion. A novel meshless radial basis reproducing kernel particle approach is used to obtain the discretized system of equations. The Newton–Raphson method, coupled with the arc-length technique, is used to compute post-buckling paths of porous FG plates. Numerical assessments show that post-buckling paths are significantly influenced by porosity parameter, porosity distribution, foundation parameters, material gradient, plate thickness, loading ratio, and boundary conditions (BCs).

Thermo-fluid characteristics and lock-on range efficiency of infrared suppression (IRS) devices with diathermic funnels in the presence of surface radiation: A comparative study

This investigation examines the influence of surface radiation on the thermo-fluid characteristics of three distinct infrared suppression (IRS) mechanisms employing diathermic funnels. Managing the flow and heat transfer attributes within an IRS apparatus becomes increasingly intricate owing to the convergence of frigid ambient mass entering via inter-funnel apertures and the high-temperature flue gas generated by the turbine on naval or cargo vessels. Conducting a three-dimensional analysis involving conical, louvered conical, and louvered cylindrical funnels, computational simulations based on the Navier-Stokes equation, encompassing the energy and radiative transfer equations, are conducted. This study offers a comprehensive elucidation of how the Reynolds number (ranging from 6.1 × 105 to 3.18 × 106), FOL (negative, zero, and positive), and NOL collectively influence the temperature variations at the system’s exit. Louvered cylinder-shaped funnels, specifically in zero-overlap scenarios, emerge as the optimal configuration for the IRS system. The computations undertaken aim to gauge the ship’s lock-on range, accounting for the presence or absence of the IRS system.

Time-dependent performance of large piled raft in clayey soil

In this study, three-dimensional numerical analysis has been performed to comprehend the time-dependent behavior of large piled rafts founded in saturated clayey soil, explicitly for the time of superstructure construction and post-construction up to the end of soil consolidation. The performance under different construction times for the corresponding unpiled raft and the piled raft with uniform pile length configuration of varying pile number, spacing, and length have been examined and then compared with that of non-uniform length configuration for the same total pile length. The dissipation of excess pore water pressure, average settlement, and differential settlement are presented and discussed in detail. A quicker dissipation rate of excess pore pressure is noted with either fewer piles, wider pile spacing, or shorter-length piles. An increase in construction time results in a lesser total average settlement at the end of consolidation. The piled raft with uniform pile length configuration shows a higher differential settlement than the unpiled raft. However, by adopting a suitable non-uniform length configuration, negligible differential settlement, higher load-carrying capacity, and a significant reduction in pile material volume can be achieved. Predictive expressions have been proposed to estimate the average and differential settlements of piled raft with uniform length configuration.

Correction of Plane Strain Analyses for Corrugated Metal Culverts Subjected to Patch Loads

Today, culverts are often analyzed and designed using plane strain finite element analyses in which a transverse slice of the structure is simulated and assumed equal to any other slice. Although this works well for soil loads, in reality live loads are discrete pressure loads from tires, and the out-of-plane effects can be significant, especially when cover depths are relatively low. While current design specifications define minimum cover that precludes significant localized pressure effects on culverts, many culverts are currently in service that were constructed under very shallow cover depths. In this study, analyses of corrugated metal culverts under truck load were carried out using two-dimensional (2D) (plane strain) and three-dimensional (3D) finite element analyses to assess the difference between structural responses predicted by these two approaches. Thirty-six culvert models with different shapes, spans, and cover depths were created using both 2D and 3D meshes. A significant difference was found between the results of these two analysis methods. Specifically, the thrust from the 3D models under shallow cover can be as much as three times the thrust results from the 2D model, which is unconservative from a safety standpoint. An innovative explanation was provided to explicate the differences. Finally, to address the issue, a reduction ratio method was developed to correct the 2D results to match the corresponding 3D results so that the relatively simple plane strain approach can be used.

Three-dimensional nonlinear stress analysis of functionally graded shells subjected to displacement-dependent loads

The nonlinear geometrically exact (GeX) hybrid-mixed four-node solid-shell element under non-conservative loading, developed in the companion paper, is here extended to the stress analysis of functionally graded material (FGM) shells. The term GeX means that the middle surface is described by analytical functions, including spline functions, and, therefore, the coefficients of the first and second fundamental forms can be taken exactly at element nodes. The FGM solid-shell element formulation is based on the choice of N sampling surfaces (SaS) parallel to the middle surface and located at Chebyshev polynomial nodes within the shell as well as on the outer surfaces, to introduce the displacements of these surfaces as basic unknowns. The use of Lagrange polynomials of degree N–1 in the distributions of displacements, strains, stresses, and elastic coefficients through the thickness of the shell leads to an efficient 3N-parameter shell formulation. To develop the FGM four-node solid-shell element based on the hybrid-mixed method, in which strains and stresses are utilized as primary variables, the Hu-Washizu variational principle is applied. Due to the analytical integration used to evaluate the tangent stiffness matrix, the developed FGM solid-shell element subjected to displacement-dependent loads shows superior performance in the case of coarse meshes and allows the use of only one load step in most of the considered benchmark problems. It has been established that the difference between the second Piola-Kirchhoff and Cauchy stress tensors in non-conservative problems for FGM shells undergoing moderately large strains can be significant.

Investigating the Effects of Adhesive on the Shear Capacity of Bolted Steel Connections

Recently, there has been a particular emphasis on the use of structural adhesives in steel connection systems. Applying adhesives that possess both high strength and flexibility would be highly advantageous for structural purposes. In this study, experimental tests are conducted on two main different types of steel-plate connections; namely, bolted connections and bolted connections with glue. The number of bolts ranged from one to eight for each connection type, such that a total of seven specimens of each type are tested. Additionally, one specimen with only glue is also tested for comparison. The findings indicated that the inclusion of up to four bolts with glue along the connection does not significantly increase the ultimate stress. This can be attributed to the non-uniform distribution of normal stresses, induced by the tightening of the small number of bolts that are not arranged across the entire connection region, on the capacity of the connection in the perpendicular direction. Thus, the connection could have been adequately established the same capacity through the use of adhesive alone. In contrast, the capacity is increased up to 60% and 100% when six or eight bolts are added, respectively, compared to the use of the connection with glue only. A three-dimensional finite-element analysis is developed based on the tested connections using ABAQUS/Explicit software. The glued interface between two steel plates is modelled using cohesive and damage criteria. The results are demonstrated to be consistent with the experimental findings. Keywords: ABAQUS, Adhesive, Bolts, Finite-element analysis, Shear, Steel connections

Differences in lower-limb biomechanics during single-leg landing considering two peripheral fatigue tasks.

Dynamic knee valgus (DKV) occurs during landing after a fatigue task involving the lower extremity. However, the manner in which different peripheral fatigue tasks affect DKV remains unknown. In this study, we investigated the DKV via electromyography during single-leg landing considering the hip-joint fatigue task (HFT) and knee-joint fatigue task (KFT) performed by healthy men. We recruited 16 healthy male participants who performed a single-leg jump-landing motion from a height of 20 cm before and after an isokinetic hip abduction/adduction task (HFT) and knee extension/flexion task (KFT). Three-dimensional motion analysis systems were attached to the left gluteus medius and quadriceps, and surface electromyography was used to analyze the lower limb kinematics, kinetics, and muscle activity. The primary effects and interactions of the task and fatigue were identified based on the two-way repeated-measures analysis of variance. The results of the average angle during landing indicated that DKV occurs in KFT, whereas HFT applies external forces that adduct and internally rotate the knee at peak vertical ground reaction force (vGRF). Furthermore, both KFT and HFT exhibited an increase in muscle activity in the quadriceps. The analysis revealed that the occurrence of DKV varies depending on the peripheral fatigue task, and the effects on average DKV during landing and DKV at peak vGRF vary depending on the peripheral fatigue task.

Assembly accuracy prediction method of planetary gear train considering bolt-bearing-shaft-gear coupling effects

Planetary gear train (PGT) is a complex transmission system composed of gears, shafts, bearings and bolted joints, of which the assembly accuracy affects the transmission accuracy and dynamic behavior. In this paper, a new assembly accuracy prediction method is proposed for PGT considering gear-shaft-bearing-bolt coupling effects. The new method is formulated by establishing three models for bolt assembly, shaft error motion and assembly accuracy (transmission error) of PGT. The model for bolt assembly is an original FE-analytical model to analyze the bolt assembly effect on elastic deformation of bearing cap, which is developed by finite element (FE) method and analytical method for addressing the elastic effect of bearing cap and elastic interaction between bolts. The models for shaft error motion and assembly accuracy are performed by the three-dimensional contact analysis with errors and preload of bearing cap based on analytical method and kinematic geometry relationship. Combining the three models, the assembly accuracy can be predicted by simulations. The simulations indicate that the proper bolt assembly parameters can alleviate the influence of manufacturing errors on assembly accuracy. The assembly accuracy tests of PGT are conducted. The results well agree with the simulations’, and the assembly accuracy is improved by the proper bolt assembly parameters.

Numerical assessment of using FRP rebars as an alternative passive reinforcement in RC beams

AbstractRecent sustainable building strategies make the right decisions to be environmentally friendly and reduce carbon emissions. In some reinforced concrete (RC) elements, fiber-reinforced polymer (FRP) bars have been proposed as an alternative to conventional steel bars. The demand for using noncorrosive and/or nonmetallic reinforcing bars in various reinforced concrete projects has increased. Although these concrete elements are lightweight, have a long lifespan, and need little maintenance, their non-ductile nature and bond with the surrounding concrete create significant challenges. Several experimental investigations have been conducted to evaluate the behavior of RC elements, even with their high cost. This study aims to assess numerically the viability of using FRP bars instead of traditional steel ones in simply supported reinforced concrete beams (RCBs) as longitudinal reinforcement (passive reinforcement). Utilizing the three-dimensional (3D) nonlinear finite element analysis (FEA) software (ABAQUS), a total of eighteen models were carried out to validate the results available in reference case studies with FRP bars. The verification of the numerical results has been verified by comparing them with the reference experimental data. Next, in order to assess the rigidity of such RCBs with FRP bars, parametric research was carried out. The numerical results proved that RCBs with FRP bars have a positive impact on enhancing load-carrying capacities. But on the other hand, the strain energy of such RCBs with CFRP bars is reduced to about 75% of the strain energy of RCBs with steel bars, which leads to low beam ductility.