Objective To explore the effects of transitional care based on network cooperation in patients with gastrointestinal tumors surgery treated with nursing care according to fast track surgery (FTS) . Methods A total of 120 patients with gastrointestinal tumors surgery were recruited as the study subjects from January 2012 to March 2015. They all received nursing care according to FTS in duration of hospital stay. They were divided into experimental group (transitional care based on network cooperation) and control group (traditionally transitional care by telephone of the general hospital + traditional community follow-up of the community hospital) in accordance with the random number table according to 1∶1 proportions. The visit times, readmission rates, symptoms, anxiety, depression and satisfaction at the thirtieth day after surgery were compared between two groups. Results At the thirtieth day after surgery, the visit times of experimental group was less than that of control group with a significant difference (Z=-2.730, P=0.006) . There was no significant difference in readmission rates between two groups (χ2=0.158, P=0.691) . There was no significant differences in the incidence rates of pain, nausea and vomiting, the degree of abdominal distension between two groups (Z=-0.655, -0.356, -0.785; P=0.513, 0.722, 0.433) . The scores of anxiety and depression of patients in experimental group were significantly lower than those in control group (t=-2.580, -2.380; P=0.011, 0.019) . The satisfaction with the general hospital and community hospital of experimental group was higher than those of control group with significant differences (Z=-2.133, -2.331; P=0.033, 0.020) . Conclusions The application of transitional care based on network cooperation after FTS on the stomach and intestine can nicely make patients to avoid unnecessary return visit in outpatient and emergency department, can meet the requirements of patients for social and mental support so as to make the general hospital and community hospital be recognised by patients. Key words: Gastrointestinal neoplasms; Transitional care; Fast track surgery; Network cooperation