Thioester Enolate Research Articles

ChemInform Abstract: A Convenient Method for Generation of Tin(II) Thioester Enolate and Its Reaction with Aldehyde.

AbstractDie durch Addition der Zinnthiolate (II) an die Ketene (I) erhaltenen Thioesterenolate (III) reagieren mit den Carbonylverbindungen (IV) chemo‐ und diastereoselektiv überwiegend zu den Hydroxythioestern (V).

A NOVEL METHOD FOR THE STEREOSELECTIVE SYNTHESIS OF β-AMINOACID DERIVATIVES VIA TIN(II) CARBOXYLIC THIOESTER ENOLATES

Abstract Tin(II) carboxylic thioester enolates, formed in situ from stannous 2-methyl-2-propanethiolate and ketenes, react with imines in the presence of stannous triflate to give the corresponding β-aminocarboxylic thioesters in an anti-selective manner. This method is successfully applied to a diastereoselective synthesis of a carbapenem antibiotic PS-5 intermediate.