Abstract

Abstract Tin(II) carboxylic thioester enolates, formed in situ from stannous 2-methyl-2-propanethiolate and ketenes, react with imines in the presence of stannous triflate to give the corresponding β-aminocarboxylic thioesters in an anti-selective manner. This method is successfully applied to a diastereoselective synthesis of a carbapenem antibiotic PS-5 intermediate.

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