This study presents a new analytical procedure developed for the optimum cross-section design of the thin-walled box sections subject to oblique bending. The box sections designed in this study have been assumed to be achieved by hollowing out the rectangular solid sections at different subtraction ratios including arbitrary, optimum, and maximum. The optimum subtraction ratio has been determined based on the adequate-strength condition while the maximum subtraction ratio has been determined taking into account both adequate-strength and local buckling conditions. The optimal design of the box sections for the arbitrary subtraction ratio has been attained by minimizing the maximum normal stress, taking into account the adequate-strength condition. Conversely, the cross-sections of the box profiles for the optimum and maximum subtraction ratios have been optimized by minimizing their cross-section area, accounting for the defined combined strength condition involving adequate- strength and local stability requirements. An equivalent box section design model that allows checking the local stability of the box sections possessing dissimilar wall segment thicknesses has been developed to perform the local buckling control on the designed optimum box sections with unequal wall thicknesses. The new local stability conditions have been defined relying on this developed equivalent box section design model. The analytical results, validated through numerical predictions obtained from linear elastic local buckling and post-buckling analyses performed using Abaqus software, have shown that the optimally designed box section achieves substantial material savings per unit length compared to its corresponding equivalent box section.