A micro-cantilever with thermally stable strain gauge of a NiCr thin film and a self-assembled monolayer was fabricated by surface micromachining. Liposomes, as biosensing molecules, were immobilized on its surface. To prevent evaporation of the water solvent, a reservoir made of polydimethylsiloxane around the micro-cantilever was fabricated and covered with a glass plate. The resistance of the strain gauge increases with time in the amyloid beta ( $\text{A}\beta $ ) solution, because the cantilever is bent downward caused by interaction between $\text{A}\beta $ and liposomes immobilized on the micro-cantilever surface. Moreover, resistance change depends on the interaction ability of $\text{A}\beta $ proteins with liposomes. It is therefore indicated that the fabricated static mode micro-cantilever sensor with immobilized liposomes can be used to detect $\text{A}\beta $ proteins.