Objective To observe the changes of electroencephalogram (EEG) and its clinical significance in patients with acute cerebral infarction. Methods From January 2017 to January 2019, 96 patients with acute cerebral infarction treated in Zhejiang Xiaoshan Hospital were randomly selected as observation group, and 96 healthy persons of the same age from the same period in our hospital were selected as control group.All the participants were given EEG examination.The values of alpha, beta, delta, theta and DTABR were compared between the two groups.The focal cerebral infarction and large area cerebral infarction in observation group were compared.The values of alpha, beta, delta, theta and DTABR of the dead patients were observed, and the factors affecting the prognosis of the patients with good prognosis and poor prognosis were observed.Logistic multivariate regression analysis was carried out with the prognosis of the patients as a strain to analyze the factors affecting the prognosis of the patients. Results The values of delta, theta and DTABR of patients in the observation group were (43.26±10.51)Hz, (29.30±9.88)Hz, (1.14±0.40), respectively, which were higher than those in the control group[(22.49±5.37)Hz, (26.42±5.73)Hz, (0.92±0.37)](t=17.243, P=0.000; t=2.471, P=0.014, P=0.014; t=3.956, P=0.000). The alpha and theta of patients with focal cerebral infarction were (15.94±5.33)Hz and (30.76±10.02)Hz, respectively, which were higher than those of patients with large cerebral infarction[(11.37±4.06)Hz and (27.55±7.75)Hz](t=6.683, P=0.000; t=2.483, P=0.014). Delta and DTABR in patients with focal cerebral infarction were (37.42±5.33)Hz and (1.03±0.52)Hz, which were lower than those of patients with massive cerebral infarction[(52.36±5.21)Hz and (1.48±0.45)Hz](t=19.640, P=0.000; t=6.412, P=0.000). There was no significant difference in beta between the two groups (P>0.05). The patients with good prognosis had higher levels of alpha and beta on the affected side[(27.18 ±9.65)Hz and (14.83±5.06)Hz] than those with poor prognosis[(14.06 ±3.94)Hz and 9.03±4.33)Hz](t=8.034, P=0.000; t=5.841, P=0.000). The delta, theta, DTABR of affected side, affected side DTABR/contralateral DTABR were (31.42±9.83)Hz, (32.19 ±8.57)Hz, (0.916±0.371)Hz, (1.051±0.246), respectively, which were lower than those of patients with poor prognosis[(40.13±14.37)Hz, (37.44±10.11)Hz, (1.331±0.712)Hz, (1.376±0.352)](t=3.529, P=0.001; t=2.739, P=0.007; t=3.728, P=0.000; t=5.329, P=0.000). Logistic multivariate regression analysis was used to analyze the prognosis of patients with acute cerebral infarction.DTABR on the affected/healthy side was the factor influencing the prognosis of patients with acute cerebral infarction. Conclusion EEG in patients with acute cerebral infarction may increase the value of delta, theta and DTABR, and decrease the value of alpha and beta.DTABR in the affected side and the contralateral side is the prognostic factor. Key words: Brain infarction; Electroencephalography; Prognosis; Risk factors; logistic models