The rapid development of aerospace, automobile, national defense and other manufacturing industries has continuously improved the performance requirements of high speed and high positioning accuracy of the CNC machine tool feed system. As the thermal deformation error increases, the system structural rigidity decreases, the vibration increases, and accuracy of machine tool reduces. Existing research mainly focuses on the properties of mechanical and single thermal feed system, and less considers the dynamic performance under the action of thermal-mechanical coupling. For the improvement of feed system performance, it is very beneficiary. This paper takes the high-speed tool of CNC feed system as objective, combined with the actual working conditions to analyze the thermal characteristics, dynamic characteristics and vibration characteristics of the system under the effect of thermal-mechanical coupling. The thermal resistance and convective heat transfer of the key joint surface, the application of moving thermal loads, and the establishment of a simulation model to complete the steady-state temperature field, transient temperature field and thermal-structure coupling analysis. The results show that the maximum temperature rise of the feed system is 21.08 °C, The maximum thermal deformation is 17.264 um. The study found that the parameters such as flow rate and airflow temperature have a significant impact on the cooling effect, so the cooling device was further optimized. This paper proposes a control method for cutting chatter of CNC machine tools based on coupling of characteristics of thermal and mechanical. The thermal characteristic of the feed system and the thermal-mechanical coupling vibration characteristic test provides the maximum temperature error of 3.2 %, verifying the correctness of the theoretical method and analysis model. The highest temperature obtained by the test is 39.7 °C, indicating that the high-speed feed system has a large thermal effect. The relative error of the vibration amplitude of the test and simulation is 12.5 %, which verifies coupling in terms of thermal-mechanical. The accuracy of the vibration analysis method; the experiment depicts that the vibration amplitude increases by 19.7 % under the coupling effect of thermal and mechanical, indicating the effectiveness of dynamic characteristics of the high-speed feed system considering the thermal-mechanical coupling effect.