Background: Breast cancer screening helps in early intervention and treatment. Post COVID, there is a huge backlog of women who missed their regular screening resulting in increased workload for radiologists, delayed reporting and intervention for malignant women. Thermalytix is an AI-based tool over thermal images that generates a 5 point score called B-Score where 5 is highest suspected risk for breast cancer and 1 is the lowest risk. In this study, we propose and evaluate a multimodal imaging modality called MaThAI that combines mammography and Thermalytix for prioritization of Mammography scans using B-Score. Materials and Methods: Data from two clinical studies were pooled together and a total of 583 women who took both mammography and thermal scans were included in the study. Among them, 72 women were diagnosed to be malignant using mammography, ultrasound, and/or biopsy. Sensitivity and specificity of (i) Mammography alone (as reported by experienced radiologists), (ii) Thermalytix alone (using B-Score ≥3 as positive) and (iii) MaThAI (considering a scan as positive if either Mammogram interpretation or Thermalytix interpretation or both were positive) were computed. As a second experiment, we assessed the benefit of MathAI prioritized mammography scans by estimating the reporting times for detecting 95% malignant patients. Results: The sensitivity and specificity of mammography were 81.9% and 98.8%, respectively, assuming BIRAD 0 as negative. Assuming BIRAD 0 as positive the sensitivity and specificity were 90.3% and 86.9%, respectively. Six malignancies were found in the 67 women with inconclusive reports (BIRADS 0). When Thermalytix B-Score was considered, the sensitivity and specificity were 94.4% and 81.0%, respectively. MaThAI showed an overall sensitivity and specificity of 98.6% (CI: 95.9%–100%) and 80.6% (CI: 77.2%–84.1%), respectively. The combo modality increased sensitivity over mammography alone by 16.7%, and Thermalytix alone by 4.2%, while decreasing the specificity of mammography by 6.3%. In the second experiment, we evaluated the benefit of MaThAI in prioritizing mammography scans using Thermalytix B-Score. Assuming mammography interpretation time is 20 minutes per exam and considering the order of the interpretation to be scan date + time, a single radiologist would have released the reports of 95% of the women with malignancy in 6720 minutes. Whereas using B-Score to reorder the scans for interpreting, the same radiologist would release the reports of 95% of the women with malignancy in 3080 minutes. Conclusion: MaThAI is a promising multimodal tool for breast screening that enables effective and efficient adjunct usage of thermal image along with mammography. It was effective in increasing the sensitivity of mammography by 16.7% and is estimated to reduce the reporting time for malignant patients by 54%. Conflict of interest: Ownership: Yes Board of Directors: Yes Corporate-sponsored Research: Yes