Theoretical Foundation For Research Research Articles

Transcriptome and genome-wide analysis of the mango glycosyltransferase family involved in mangiferin biosynthesis.

Mangiferin, a C-glucosyl xanthone, is a biologically active glycoside naturally synthesized in mango. Glycosyltransferase can catalyze the biosynthesis of mangiferin. In this study, we identified 221 members of the UGT glycosyltransferase family in mango. The 221 MiUGT genes were grouped into 13 subfamilies through phylogenetic tree analysis with Arabidopsis, Chinese bayberry, and mango. All UGT family members in mango were unevenly distributed on 17 chromosomes and found that tandem duplication dominated the expansion of UGT family members in mango. Purification selection primarily influenced the evolution of the mango UGT family members. In addition, cis-element analysis of the mango UGT gene family revealed the presence of MYB binding sites, which are involved in flavonoid biosynthesis; which further supports the role of UGT family members in the synthesis of flavonoids. To verify these results, we analyzed the expression of UGT family members in mango leaves, stems, and different developmental stages of fruit peel. The RNA-seq and qRT-PCR results showed significant differences in the expression patterns of MiUGT genes in various tissues and developmental stages of mango. We identified MiUGT gene-specific expression at different stages of fruit development. These results lay a theoretical foundation for research on the relationship between members of the mango UGT family and the synthesis of flavonoids, mangiferin.

Construction of a Digital Twin System and Dynamic Scheduling Simulation Analysis of a Flexible Assembly Workshops with Island Layout

Assembly Workshops with Island Layout (AWIL) possess flexible production capabilities that realize product diversification. To cope with the complex scheduling challenges in flexible workshops, improve resource utilization, reduce waste, and enhance production efficiency, this paper proposes a production scheduling method for flexible assembly workshops with an island layout based on digital twin technology. A digital twin model of the workshop is established according to production demands to simulate scheduling operations and deal with complex scheduling issues. A workshop monitoring system is developed to quickly identify abnormal events. By employing an event-driven rolling-window rescheduling technique, a dynamic scheduling service system is constructed. The rolling window decomposes scheduling problems into consecutive static scheduling intervals based on abnormal events, and a genetic algorithm is used to optimize each interval in real time. This approach provides accurate, real-time scheduling decisions to manage disturbances in workshop production, which can enhance flexibility in the production process, and allows rapid adjustments to production plans. Therefore, the digital twin system improves the sustainability of the production system, which will provide a theoretical research foundation for the real-time and unmanned production scheduling process, thereby achieving sustainable development of production.

Exploration of the Technologies Application Experience of Landscape-Scale Green Infrastructure by the Conservation Fund

As the earliest discussed concept of Green Infrastructure (GI), Landscape-scale GI, in the form of an ecological network capable of balancing development and conservation, has received widespread attention. Its multifunctionality is one of the important features. However, the lack of information and funding, weakness of management authority and technical support make the practice of Landscape-scale GI challenging. Compared to GI adapted in stormwater management, which has comprehensive guidance from theory to practical technologies by officials during its introduction and promotion in other countries, Landscape-scale GI, despite a rich theoretical research foundation, is often overlooked due to insufficient summary research on practical techniques. To address this gap, this study uses mixed methods research to comprehensively analyze 27 Landscape-scale GI practical projects led by the Conservation Fund over the past 20 years to explore patterns in their technical applications. Through qualitative analysis, we standardized and classified descriptive information for these 27 projects and, combined with statistical analysis, clarified the practice development trends committed to balancing development and conservation. The quantitative analysis concentrated on the corresponding relationships between technical applications and project objectives, and GI functions. Based on this, the study categorized the technologies used, summarizing core technologies applicable to most Landscape-scale GI practices, providing some support for the promotion of Landscape-scale GI.

Design and analysis of a novel rotary inertance hydraulic converter with the continuous controlling turntable

The inertance hydraulic converter is an energy-efficient hydraulic component, its output efficiency and dynamic performance are seriously affected by the switched valve. This paper proposed an innovative a rotary inertance hydraulic converter (RIHC), which uses a continuous controlling turntable to determine the ratio of the high pressure oil and the low pressure oil to change the output energy, instead of the discrete controlling of the switched valve. The working principle and mechanical design of the RIHC are described, and mathematical models are established. The effects of the key variables on energy efficiency are evaluated using numerical analysis. The operating performance is analyzed based on simulation, and a control strategy to achieve stable system output is proposed. The results provide a foundation for theoretical research and practical application of the novel RIHC.

A Study on the Progress of Astragalus-Coptis Chinensis Medicinal Pair in the Treatment of Diabetes Mellitus

According to the relevant studies in recent years, it was found that astragalus - Coptis Chinensis drug pair and its analogous formula have a broad prospect for the treatment of type 2 diabetes mellitus (T2DM). Pharmacological studies have shown that Coptis Chinensis possesses the pharmacological activities of antimicrobial, anti-inflammatory, anti-tumor, lipid regulating, hypoglycemic, anti-arrhythmic, and antioxidant activities[1], and Astragalus possesses the effects of enhancing the function of the immune system, antimyocardial ischemia, bi-directional regulation of blood pressure, anti-tumor, anti-aging, hypoglycemia, and protection of metabolic tissues (liver and kidneys, etc.) [2] [3], the use of Astragalus and Coptis Chinensis pairs has demonstrated significant multiple effects. Specifically, this combination not only effectively reduces blood glucose levels, but also significantly enhances the body's sensitivity to insulin, thus helping to improve the phenomenon of insulin resistance and further enhance the overall health status of patients [1][2][3]. This paper analyzes and researches the research progress of astragalus-Coptis Chinensis medicinal pair and its analogous formulae in the treatment of type 2 diabetes mellitus and the improvement of its complications through the collation and summarization of the literature, in order to lay a certain theoretical research foundation for the clinical diagnosis and treatment of type 2 diabetes mellitus by astragalus-Coptis Chinensis medicinal pair and its related formulae, prevention of diabetes mellitus complications, and rational use of medicines in diabetes mellitus clinical treatment.

A Literature Review of Teachers' Preparedness to Teach and its Influencing Factors

Pre-service teachers' self-assessment of their preparedness to teach is closely related to their sense of teaching efficacy. A clear definition of the concept of preparedness to teach, an understanding of its structure, and the corresponding measurement tools based on national and regional professional standards for teachers are essential scientific and theoretical foundations for research on preparedness to teach. This study collects the latest research findings and policies on teaching readiness in different countries and regions based on national contexts. It then complements and organizes them to form a literature review.

Проблема типологизации игры в игротехнической деятельности: социально-философский анализ

The article addresses the game typologization issue in modern society, particularly the lack thereof despite the significant interest in the phenomenon itself, which manifests in a plethora of diverse forms. Based on the typological analysis, a review of philosophical and scientific literature is provided. Two primary philosophical approaches to understanding game are delineated: as a distinct reality (R.R. Ilyasov) and as a complement to existing ones (L.T. Retyunskikh). Specific scientific definitions in the realms of psychology, sociology, and economics are provided. The analysis reveals that definitions of game given by various scientists are largely congruent, yet the typology of the phenomenon itself remains underdeveloped by representatives of the scientific community. However, this is essential for the theoretical foundation of research on the application of gaming in social activities. Thus, existing scientific approaches and theories do not provide exhaustive systemic disclosure of the game specificity, indicating the need for developing a typology of this phenomenon in the context of its application for the needs of modern society. In conclusion, the absence of a developed typology of gaming poses a significant challenge for understanding its multifaceted nature within modern society. Despite the alignment of definitions across various disciplines, the lack of a comprehensive typology impedes theoretical advancements and practical applications in utilizing games for social activities. Addressing this issue is crucial for harnessing the potential of game to address the needs of modern society effectively.

Study on shear behavior and acoustic emission characteristics of precast concrete segmental cover beams with large key teeth

AbstractThe mechanical characteristics of segmental joints are pivotal in defining the comprehensive stress behavior of prefabricated assembled cover beams. In this research, direct shear tests were conducted on dry key‐tooth joints, and acoustic emission technology was employed for monitoring purposes. The shear failure mechanism was explored under a range of influential parameters. Building upon these observations, the study delved into the mechanical response of joints within segmental cover girders subjected to concurrent bending and shear forces. Specimen K‐3‐3 exhibited a higher shear carrying capacity compared to other specimens, indicating that the shear resistance of dry joints proportionally increases with the height of the specimen and the strength of the concrete. The carrying capacity of Specimen K‐4 was marginally lower than that of Specimens K‐3‐1 and K‐3‐2, suggesting that increasing the number of keys does not significantly impact the shear resistance of dry joints. Notably, Specimen K‐3 demonstrated exceptional shear carrying capacity, exhibiting minimal relative slip during failure, and streamlined the casting process. Consequently, these dry joints featuring large key teeth are deemed more appropriate for use as shear connectors in precast concrete segmental cover beams. Crack patterns in large key tooth precast concrete segmental cover beams propagate along the joints. A damage evolution model for the specimens, based on spatial b‐values and T‐values, visually depicts the damage extent in large key tooth precast concrete segmental cover beams. This model demonstrates excellent agreement with experimental results and provides a solid foundation for theoretical research and practical applications of large key tooth precast concrete segmental cover beams.

Adsorption behavior of CuO doped GeS monolayer on the thermal runaway gas evolution in lithium battery energy storage systems

Considering that the thermal runaway failure of lithium battery energy storage system will cause serious safety accidents, and lithium battery thermal runaway will precipitate various detectable gases through the safety gas valve. Effective monitoring of the precipitated gas can ensure the safe operation of the energy storage system. In this study, the adsorption behavior of CuO-GeS towards the main precipitated gases CO, CO2, CH4, and C2H4 in Lithium battery before thermal runaway is systematically studied based on DFT. The adsorption structure, DOS, DCD, and ELF are analyzed to explore the interactions between CuO-GeS monolayer and the gases. The results show that CuO-GeS monolayer achieves strong adsorption of CO and C2H4 and highly sensitive monitoring of CO2 and CH4. Furthermore, the relative molecular mass ratios of CxHy and CxHy-1F (x = 1, 2 y=2, 4, 6) gases to doped CuO can satisfy Smoothing Spline with adsorption energy and charge transfer, which can be used to estimate the adsorption properties of the homologous gases. The potential application of CuO-GeS monolayer in lithium battery energy storage systems lays a theoretical research foundation for the adsorption and detection of thermal runaway gas in lithium battery energy storage systems.

Advances in the application of logic gates in nanozymes.

Nanozymes are a class of nanomaterials with biocatalytic function and enzyme-like activity, whose advantages include high stability, low cost, and mass production. They can catalyze the substrates of natural enzymes based on specific nanostructures and serve as substitutes for natural enzymes. Their applied research involves a wide range of fields such as biomedicine, environmental governance, agriculture, and food. Molecular logic gates are a new cross-disciplinary discipline, which can simulate the function of silicon circuits on a molecular scale, perform single or multiple input logic operations, and generate logic outputs. A molecular logic gate is a binary operation that converts an input signal into an output signal according to the rules of Boolean logic, generating two signals, a high level, and a low level. The high and low levels represent the "true" and "false" values of the logic gates, and their outputs correspond to "l" and "0" of the molecular logic gates, respectively. The combination of nanozymes and logic gates is a novel and attractive research direction, and the cross-application of the two brings new opportunities and ideas for various fields, such as the construction of efficient biocomputers, intelligent drug delivery systems, and the precise diagnosis of diseases. This review describes the application of logic gates based on nanozymes, which is expected to provide a certain theoretical foundation for researchers' subsequent studies.

Virtual Skin Outfit in PUBG Mobile Games: Value and Enjoyment with Virtual Appearance

Ningxia Yanchi handmade carpets have a history of more than 300 years. They are one of the important handicrafts intangible cultural heritages (ICH) in China, similar to other handicrafts, facing the challenge of disconnecting from daily life. Cultural and creative development, as an important non-inheritable approach, has played a significant role in the modernisation and branding of various arts and crafts. The purpose of this study is to analyse the technological process and creation mode of Ningxia Yanchi handmade carpets on the basis of the theory of design affairology, and to propose a new optimal design framework. Based on the theory of design transactions, establish the "thing" logic in the creation of Yanchi handmade carpets and extract "elements". By transitioning from "thing" to "elements" in terms of graphical structure and colours, the individual pattern elements with modern aesthetics are organised. Based on the theoretical research foundation of Design Doctrine, cultural and creative design has the characteristics of clear thematic expression and coherent structure, which not only satisfies people's daily needs through traditional forms but also promotes the revival of traditional Chinese craftsmanship. It can serve as a new path for the innovation and development of traditional techniques. From a practical perspective, design affairology combines traditional skills of Intangible Cultural Heritage (ICH) with cultural creative design, creating new avenues for research and development of ICH-related designs. At the same time, the modernisation of ICH products through cultural and creative design is just one approach to heritage preservation and protection, expanding the scope of theoretical research.

Experimental study on mechanical properties and damage mechanism of self-stress grouted crushed coal of different grain sizes

The reinforcement mechanism of self-stress grouted crushed coal of different grain sizes is not clear. In this study, crushed coal of 5∼10, 10–20 and 20∼30 mm grain was selected. It obtained that the grain size was proportional to the width of sedimentary fissure among coal blocks and inversely proportional to its distribution range. As coal grain size increases, the uniaxial compression strength (UCS) of grouted specimens decrease and the AE parameters increase, respectively. The slurry forms a mesh skeleton structure in the 5∼10 mm specimen, significantly increasing its bearing capacity. However, in the 20∼30 mm specimen, the porous coal block is the main carrier, reducing the bearing capacity. Swelling needle-like Aft crystals produced closely occludes the coal, increasing the binding ability and overall compactness; almost none of the coal-slurry intersections are damaged during uniaxial compression. The main damage areas of 10∼20 mm and 20∼30 mm grouted specimens are inside coal by SEM, and the cracks increase with the rise of coal grain size. The trends of damage variable and cumulative energy counts curves are approximately the same, further confirming the reliability of the analysis of the AE experimental results. This paper can lay the foundation for theoretical research and field practice of self-stress grouting reinforcement.

Strategies to Promote the Export Competitiveness of the Laver Industry in South Korea: Focusing on the SWOT-AHP Method

Purpose - Currently, South Korean laver is called the semiconductor of the food industry, and it has become a representative K-Food. However, these positive achievements are counterbalanced with challenges such as the deterioration of water laver productivity due to climate change and the increase in global competition for laver. In particular, the recent issue of discharge of contaminated water from Fukushima could pose a threat to the growth of the South Korean laver industry. Accordingly, this study attempted to present a development direction that could help the South Korean laver industry maintain sustainable growth and create market opportunities. Design/Methodology - This study sought to provide insights and implications that could contribute to enhancing the export competitiveness and sustainable growth of the South Korean laver industry. To conduct this study, the SWOT factors of the South Korean laver industry were derived through literature research using the latest research data. Based on this, an AHP analysis was conducted on laver industry experts to derive a SWOT matrix and present business strategies and policies. Findings - The development strategies based on the results of this study are as follows. The SO strategy was identified as the first priority. This strategy requires maximizing cost-effectiveness and quality, which are the strengths of South Korean laver, and actively seeking overseas market opportunities triggered by the high interest in Hallyu. The WO strategy was identified as the second priority. This strategy requires fostering and industrializing new varieties of laver with significant resistance and high quality, and expanding the demand for South Korean laver by actively capitalizing on the opportunities created by the popularity of Hallyu. Originality/value - Given the lack of studies on the promotion of the export competitiveness of the South Korean laver industry, this study is expected to provide the theoretical foundation for research on the development of the South Korean laver industry and contribute to the expansion of research to secure K-Food’s global competitive advantages. Additionally, the SWOT matrix proposed in this study is expected to enhance the competitiveness of South Korean laver in overseas markets.

Extending the job demands-resources model to understand the effect of the interactions between home and work domains on work engagement.

Scholars have extensively used the job demands-resources model to explain the dynamics underlying work engagement and proposed several versions of the model. However, in theoretical terms, nonwork elements have not been incorporated into the model. This study investigated the roles of home demands and resources in the model by testing the boost/buffer hypotheses for work engagement from the perspective of the work-home interface. We demonstrated that (1) the demands of a domain boost the positive impact of resources drawn from another domain on work engagement, (2) the resources of a domain buffer the negative impact of demands derived from another domain on work engagement; and (3) the buffering and boosting effects of home demands and resources impact work engagement. We conducted a diary study on a group of coffee shop employees in Ireland. The results partially supported the proposed hypotheses but nevertheless indicated support for the cross-domain boost/buffer hypotheses with regard to work engagement. The proposed model may serve as a theoretical foundation for research on issues related to the impact of work and nonwork domains on work engagement.

ТРАНСФОРМАЦІЯ ЕКОНОМІКИ ТА СУСПІЛЬСТВА: РЕТРОСПЕКТИВА І СУЧАСНІ ПРІОРИТЕТИ ДОСЛІДЖЕНЬ

The article is devoted to the deepening of the theoretical foundations of research on the transformation of the economy and society, which are based on a retrospective analysis of the factors (contexts) of transformational changes and the determination of modern priorities in the conditions of global instability and security challenges of the development of Ukraine. The relevance of transformation research for Ukraine during the difficult period of the Russian-Ukrainian war is due to the need to define targeted changes and ways to ensure them, which will strengthen the stability and possibilities of economic and social recovery. Theoretical methods of analysis and generalization are used to review economic studies on transformation issues with a high citation index. This makes it possible to reveal the chronology of research on transformation issues – from the formation of a market economy to the strengthening of the influence of globalization, digitalization and sustainable development policy. Particular attention is paid to the social dimension of research, which reveals the influence of human labor and its efficiency, population migration on transformational changes. The meaning of transformation is determined as a regular, targeted and regulated process that modifies existing and creates new systems that exert lasting effects on other phenomena and processes in the unity of changes. The key features of transformation are singled out, namely changes and development of systems, process nature, target regulation and self-regulation, institutional support, time measurement, duration, stability and consistency of changes. The difference between transformation and related systemic processes, in particular modernization, revolution, reform and development, is substantiated. Taking into account the types of transformation that are studied in world and domestic science, classification criteria for its analysis are proposed – by object, space, nature, spheres, consequences and scales. The criterion of the sphere makes it possible to distinguish economic, social, scientific-technical, cultural and administrative transformations and to determine the perspective of scientific research on transformation in the social context in the projection of Ukraine’s recovery.

Символическая политика (в) Российской империи: состояние теоретического и историографического поля

The article discusses the study of the symbolic politics in the Russian Empire in national historiography over the past two decades. The author examines the theoretical foundations of research, terminology, and charac-teristics of various political science approaches, arguing that these tools can be applied to historical studies of the long 19th century. These approaches help reframe the issues of cultural memory and commemorations, signifi-cantly expanding the source base for research and deepening our understanding of political and cultural process-es within the Empire. An analysis of Russian historiography over the last two decades reveals a shift in research strategies for this issue, driven by the integration of foreign approaches to cultural memory into Russian academ-ia. Through the use of various reference works as examples, the author describes the process of heuristic transi-tion from a narrow understanding of symbolic politics as a minor component of the political process, to the idea of its versatility, multi-actor nature, and interconnectedness with cultural, national, and social issues. The final part of the article analyzes a monograph by Russian historian Ekaterina Boltunova relevant to this topic. By pre-senting an example of using political science and the “mixed” approach of R. Wortman, the book clearly demon-strates the prospects for studying the symbolic aspects of autocratic power’s activities in connection with a wide range of issues of the national and cultural policies of the Empire.

Improving the Professional Competencies of Students of the Specialty 029 IBAS (ILAS) in the Process of Practice Performing

The aim of the article is to determine step-by-step improving the professional competences of the first education level students in specialty 029 “Information, Library and Archival Studies” in conditions of the practice process, and in accordance with the standard, educational and professional programs elaborated by the Department of Information Technologies at Kyiv National University of Culture and Arts (KNUKiM/KNUCA).
 Research methods are based on both general scientific methods and special ones. The use of analysis and synthesis makes it possible to analyze the theoretical research foundation. Systemic and structural-functional methods make it possible to comprehensively study the peculiarities of the practice organization at different educational levels. Argumentation of conclusions and scientific ideas is carried out using the method of generalization and content analysis.
 The scientific novelty consists in substantiating the step-by-step competences formation in practice conditions by students of the first education level, in accordance with the Standard of Higher Education of Ukraine: the first level (a Bachelor’s degree), a field of study 02 Culture and Art, specialty 029 “Information, Library and Archival Studies”, as well as educational and professional programs developed at the Department of Information Technologies, namely, “Manager of Library and Information Systems and Technologies”, “Documentation Science Specialist, Manager of State and Local Authorities”.
 Main conclusions. The first Bachelor’s degree of higher education requires students to master an educational and professional program. A mandatory component of this program is introductory, educational, productional and pre-diploma practice. The process of practice performing is aimed at improving, deepening and developing professional competencies that are formed during the assimilation of theoretical material and practical classes.
 The organization of practice in appropriate bases, particularly, in libraries, archives, information and analytical institutions, and other documentary and communication establishments has a number of advantages, contributes to the development of integral, general and professional competences.
 The effectiveness of the students’ acquisition of professional competencies depends on a variety of factors, which include these ones: the quality of practice, the training program and the tutors’ support, the students’ activity, the relevance of practice to educational goals, feedback and self-evaluation, which, in turn, help future specialists to prepare for a successful career, expand their opportunities, and increase confidence in their own abilities.

Alexa, may I adopt you? The role of voice assistant empathy and user-perceived risk in customer service delivery

PurposePowered by artificial intelligence, voice assistants (VAs), such as Alexa, Siri and Cortona, are at early-stage adoption rates in service contexts. Customers express hesitance in using the technology. Furthermore, the effect of a relevant variable (VA empathy) as a determinant of VAs is not widely researched. This study aims to extend the unified theory of acceptance and use of technology (UTAUT) and social response theory (SRT) to propose and test a conceptual model of the role of customer perceptions of VA empathy and risk on VA adoption and usage intensity.Design/methodology/approachIn this study, data were collected from 387 VA users in the USA using a survey administered through Amazon MTurk. Data cleaning retained a final n = 318 for structural equation modeling analysis.FindingsFindings show that perceived VA empathy enhances customers’ attitude toward VA and drives adoption, thereby increasing VA usage intensity. Perceived risk is a moderator; users with high perceptions of VA empathy have greater VA adoption rates when they have high (vs low) risk perceptions of using VA.Originality/valueThis research is one of the first known studies to provide empirical evidence of the role of customer perceptions of VA empathy and risk on VA adoption in service delivery. It goes beyond VA adoption research to provide empirical evidence of the impact of VA adoption on actual usage intensity. By extending the UTAUT and SRT, this research adds to the theoretical foundation for research on VA adoption, offering practical insights for firms regarding empathetic VA design to enhance customer service delivery.

Mechanism of action of Huangbaichen Sanwei formulation in treating T2DM based on network pharmacology and molecular docking.

Huangbaichen Sanwei formulation (HBCS) has been reported to have a good hypoglycemic effect, but its pharmacological mechanism of action remains unclear. We used network pharmacology and molecular docking to explore the potential mechanism of action of HBCS against type-2 diabetes mellitus (T2DM). Fifty-five active components from HBCS interfered with T2DM. Twenty-five core targets, such as AKT1, INS, INSR, MAPK1 were identified. Enrichment analyses showed that HBCS was involved mainly including insulin receptor signaling pathway, extracellular region, and insulin-like growth factor receptor binding and other biological processes; common targets had roles in treating T2DM by regulating diabetic cardiomyopathy and insulin resistance. Molecular docking verified that components combined with core targets. HBCS play a part in treating T2DM through multiple components and targets at the molecular level, which lays a theoretical foundation for research using HBCS to treat T2DM. The components, predicted targets, and T2DM targets of HBCS were searched through databases, and common targets were determined. Further screening of the core targets was conducted through the establishment of a protein -protein interaction network. The core targets were analyzed by Gene Ontology (GO) annotation utilizing the DAVID platform. And the enrichment of signaling pathways was explored by employing the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Cytoscape 3.9.1 was employed to construct a "TCM-components-core target-pathway" network. Autodock Vina was used to dock molecules to compare the binding activity of active molecules with targets.

Elemene Antitumor Drugs Development Based on "Molecular Compatibility Theory" and Clinical Application: A Retrospective and Prospective Outlook.

Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE Tian, introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles, specifically the "monarch, minister, assistant, and envoy" theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the "molecular compatibility theory", further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".