Text Of Article Research Articles

Sars-Cov-2 and Chronic Myeloid Leukemia: A Systematic Review

Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus causing the coronavirus disease of 2019. Numerous mutations had developed in SARS-CoV-2 virus that resulted in strains (Alfa Beta Delta Omicron) with varying degrees of virulence disease severity. In coronavirus disease of 2019 (COVID-19) patients with chronic myeloid leukemia (CML), there is a controversy regarding the effect of tyrosine kinase inhibitors (TKI) on SARS-CoV-2 infection and patients' outcomes. Some studies showed that CML patients with COVID-19 had better outcomes; other reports showed no significant difference. Method Following the PRISMA (preferred reporting items for systematic reviews and meta-analyses) guidelines, PubMed, Scopus, and Google Scholar databases were searched for published articles through 20 April 2023 for qualified studies. The search included retrospective, prospective studies, reviews, case series, and case reports. The inclusion criteria were English literature with CML patients above 18 years who had SARS-CoV-2 infection. Articles in languages other than English and articles with non-sufficient information were excluded, and patients with bone marrow transplants were excluded. Search terms were (chronic myeloid leukemia) OR (chronic myelogenous leukemia) AND (SARS-CoV-2) OR (COVID-19). Two eligibility checks were done on the included studies. Title and abstract screening was completed first, and the full text of articles that met the requirements for inclusion was subsequently obtained. The search included all articles published up to 20 April 2023. The review is registered in PROSPERO (registration number is: CRD42022326674). Results We reviewed 36 articles of published literature up to April 2023 and collected data for a total of 686 CML patients with COVID-19. The vast majority of patients were in the chronic phase; seven patients were in the accelerated phase, and eight patients were in the blast phase. Disease severity was classified according to WHO criteria. Twenty-seven patients were managed at home, and 21 patients were in ICU (intensive care unit) during the hospital course. Twenty-six patients required oxygen therapy; among them, seven patients required intubation and mechanical ventilation, and six patients required non-invasive ventilation. Mortality was seen in 47 patients, and there were no reports of thrombotic events, but some patients developed AKI, autoimmune hemolytic anemia, rhabdomyolysis, and DKA during COVID-19. Limitations The major limitation is the lack of details about the use or hold of TKIs during SARS-CoV-2 infection in the majority of the reports. Also, the specific or predominant strain of SARS-CoV-2 was not mentioned. Few studies mentioned the variant of the virus, which make it difficult to compare the outcome of the different variant of the SARS-CoV-2 virus in patients with CML. Discussion/Conclusions Hematological cancers are associated with an increased risk of thrombosis. Thrombosis risk is expected to increase in patients with COVID-19; interestingly, patients with CML have not been reported to have a significant increase in the risk of thrombosis during COVID-19. The crucial point is, does TKI continuation during COVID-19 beneficial or harmful? Few patients continued TKIs during Covid-19 without serious adverse events. For patients who had the TKI continued, there were no mortality or serious adverse events. In vitro, TKIs were found to have a significant effect on inhibiting viral replication, which might be the reason behind the better outcome in CML patients infected with SARS-CoV-2 virus. On the other hand, there is a theoretical risk of increased severe infection in CML patients taking TKI due to targeted inhibition of kinases involved in immune cell function. This might result in suppressed cellular immune response that facilitates viral replication. Despite that, CML patients with COVID-19 have no significant increase in mortality or ICU admission compared to other hematological malignancies. in fact, our review showed that the mortality of CML patients with COVID-19 has significantly improved from 0.12% in the pre-vaccination period to 0.04% in the post-vaccination era. The available data indicates that, COVID-19's effect on patients with chronic myeloid leukemia (CML) still needs to be better understood due to the limited data.

Should Obesity Be an Exclusion Criterion for Extracorporeal Membrane Oxygenation Support? A Scoping Review.

Obesity is often considered a contraindication to extracorporeal membrane oxygenation (ECMO) candidacy due to technical challenges with vascular access, higher cardiac output requirements, and known associations between obesity and overall increased morbidity and mortality due to chronic health conditions. However, a growing body of literature suggests that ECMO may be as safe and efficacious in both obese and nonobese patients. This scoping review provides a synthesis of the available literature on the outcomes of obese patients supported with (1) venovenous (VV)-ECMO in acute respiratory distress syndrome (ARDS) not due to coronavirus disease 2019 (COVID-19), (2) VV-ECMO in ARDS due to COVID-19, (3) venoarterial (VA)-ECMO for all indications, and (4) studies combining data of patients supported with VA- and VV-ECMO. A librarian-assisted search was performed using 4 primary electronic medical databases (PubMed, Web of Science, Excerpta Medica database [Embase], and Cochrane Library) from January 2003 to March 2023. Articles that reported outcomes of obese patients requiring ECMO support were included. Two reviewers independently screened titles, abstracts, and full text of articles to determine eligibility. Data extraction was performed using customized fields established a priori within a systematic review software system. A total of 354 publications were imported for screening on titles and abstracts, and 30 studies were selected for full-text review. A total of 26 publications met the inclusion criteria: 7 on VV-ECMO support in non-COVID-19 ARDS patients, 6 on ECMO in COVID-19 ARDS patients, 8 in patients supported with VA-ECMO, and 5 combining both VA- and VV-ECMO data. Although the included studies are limited to retrospective analyses and display a heterogeneity in definitions of obesity and comparison groups, the currently available literature suggests that outcomes and complications of ECMO therapy are equivalent in obese patients as compared to nonobese patients. Hence, obesity as measured by body mass index alone should not be considered an exclusion criterion in the decision to initiate ECMO.

Neuroendocrine features of the pathogenesis of polycystic ovary syndrome (literature review)

Polycystic ovary syndrome (PCOS) is one of the most pressing problems in endocrine gynecology. The main signs of the disease are hyperandrogenism, menstrual and/or ovulatory dysfunction, and polycystic ovarian structure according to ultrasound. Women with PCOS are at risk for developing metabolic syndrome, type 2 diabetes, cardiovascular disease, and endometrial cancer. In this connection, the pathogenetic mechanisms of the occurrence of this syndrome are continuously studied and new methods of treatment are being sought. PCOS is characterized by a wide range of various disorders of the neuroendocrine regulation of the reproductive system. The main focus of the review is aimed at summarizing information about the etiological role of neuropeptides and neurotransmitters, such as phoenixin, galanins, orexins, GABA, in the pathophysiology of PCOS and about the possibility of their use for diagnostic and therapeutic purposes. In recent decades, the interest of scientists has been focused on the study of KNDy neurons, because it is the kisspeptin synthesized by them that is one of the main regulators of the hypothalamic-pituitary-ovarian axis. This article discusses data on the significance of KNDy neurons in the pathogenesis of the syndrome. Information is provided on the effect of elevated levels of androgens and anti-Müllerian hormone on GnRH neurons. Also analyzed are studies on functional and structural disorders in the hypothalamus in PCOS. Literature search was carried out in national (eLibrary, CyberLeninka.ru) and international (PubMed, Cochrane Library) databases in Russian and English. The priority was free access to the full text of articles. The choice of sources was prioritized for the period from 2018 to 2023.However, taking into account the insufficient knowledge of the chosen topic, the choice of sources dates back to 1998.

Utilizing Pho’s Move in Composing Scientific Paper within AIMRD

Objective: Composing and publishing a scientific article needs compound responsibilities, mainly when Indonesian students write it since English is their foreign language. Swales pioneered CARS with three moves, followed by Pho, who mentions moves and steps in a research article using AIMRD, which can be worthy of consideration in composing a scientific article. Method: The moves and steps of undergraduate students’ research articles were analyzed qualitatively, using Pho’s moves and steps as parameters. The data analyzed consists of nine articles on English Education, seven on Applied Linguistics, and six on Applied Literature. Tables of move-analysis were prepared as the research instrument with different codes for classifying and analyzing the articles. Results: Undergraduate students place and develop moves along with steps effectively, which was inflicted by the thought patterns and the tendency of undergraduate students. Thus, writing research articles developed by undergraduate students could be considered in revising institution guides for composing research articles and reflection in composing research articles for other disciplines. Novelty: Most research on sections of research articles applying a move-based approach have worked with first language studies published in journals and focused on a particular section of the research article, while this study using Pho's moves and steps works with EFL learners, which compose an unpublished complete text of the scientific article. The findings of current research mediate both students' critical thinking and unfathomable argumentation skills by the availability manifestation of the rhetorical move. The main contribution of this research result is meant to alleviate writers, mainly undergraduate students, in generating research articles successfully.

HOW TO START AN UNBIASED CONVERSATION ABOUT EXHAUSTION

AbstractThe author, a self‐employed occupational health psychologist, presents her research on various nuanced aspects of exhaustion, stress, and burnout, as they related to leadership and organizations. She also notes her TEDx talk “Let’s talk about the bright side of exhaustion,” and writes that “using study results based on data of more than 26,000 participants and illustrative anecdotes, I will explain why exhaustion is more complicated than most realize, that there is not only a dark but also a bright side, and how leaders can make sure that people in their environment experience the bright side of exhaustion by improving person‐job matches.” She describes her own personal background within these issues, and Figure 1 depicts a Conversation Starter for Exhaustion Model. The Venn diagram has “Joyfully Exhausted” in the middle, surrounded by the keywords Meaning, Support, Autonomy, and Appreciation. In the article text, regarding meaning, she writes “As a leader you need to know what kind of work is meaningful for each person around you and ideally create work environments where people can mainly focus on performing these tasks. This makes it easier for individuals in your work environment to better perform and make the effort feel worthwhile.”

LEADERSHIP LESSONS FROM FORMULA 1 MOTOR RACING

AbstractThe author has advised and taught business leaders worldwide for the past 25 years, and was previously Director at the European Bank for Reconstruction and Development. His article examines the business, organizational, and leadership aspects of the highly popular Formula 1 (F1) motor racing. He provides a quick primer on how F1 operates, noting that “Formula 1 racing is a competitive, global industry at the pinnacle of motor sport in terms of technology and innovation.” He notes his own background within F1, including co‐authoring a book that inspired a BBC 8‐part television series, Formula for Success. He outlines the PATL (Performance at the Limit) Framework, in both the article text and a table. It describes the role of individuals, teams, organizations, and partners. He writes: “Surrounding these elements are three dynamic processes influencing performance: Innovating, Transforming, and Integrating.” Another table presents the F1 Performance Pyramid, with leadership and teamwork around Focus, Continual Learning, and Creating a Winning Culture. The final table presents the Plan‐Do‐Review Model. F1 teams “have formal reviews after each of the on‐track sessions. All key decision‐makers and decision‐influencers attend in person or virtually. A template is used to keep the discussion on point and time efficient.”

Childhood Trauma and Exposure to Violence Interventions: The Need for Effective and Feasible Evidence-Based Interventions.

Several crimes in South Africa cause physical, economic, and mental problems. Xenophobic attacks, mob justice, and other violent conduct directly traumatise children. Service delivery riots and physical and sexual abuse are examples. This evaluation evaluates childhood trauma and exposure to violence interventions. The review describes the therapeutic methods for traumatised children exposed to violence, the healthcare professionals administering them, and the strategies used to tailor the interventions. The researcher systematically searched PsycINFO, Google Scholar, PubMed, Science Direct, and EBSCOhost. Literature from 2011 to 31 July 2023 was searched, and 19 papers were chosen for further review after the systematic search. The authors conducted an eligibility evaluation according to PRISMA guidelines. A thorough review of article texts identified 19 papers that met eligibility standards. Only nineteen studies have validated trauma and violence therapies for children. An effective multi-phased intervention that is feasible and adaptable to varied socioeconomic backgrounds is needed. Further studies on the mental health benefits of brief trauma intervention treatment are needed.

Discursive realization of the verb «would» as a marker of epistemic modality in English publicistic text

The article presents the results of the empirical study aimed at revealing epistemic modality realization in utterances with the verb would in English publicistic texts of analytical political articles. The relevance of the research is determined by the fact that discursive characteristics of modal syntagms with epistemic meaning in speech act are one of the least studied aspects of text modality. The basis of the research is the idea of epistemic modality being different from «root» modality expressed by the «material» meaning of the verb. Epistemic modality is expressed in lexico-syntactic mode which implies its study in terms of speech act syntagmatics. The results of the analysis demonstrate low frequency of the verb would as a lexical means. At the same time instances of its functioning in syntagms as a lexico-syntactic means of expressing modality are numerous. Discursive realization of the verb would is characterized by the category of polarity which is reflected in the opposition of the expected and the real. Illocutionary markers of the opposition are syntagms which contain lexical units with epistemic meaning or modal verbs with functions contrastive to those of the verb would. The main rhetorical model of speech acts organization is symmetry backed up by syntactically, lexically and phonologically similar text units. This principle of text organization is most clearly manifested in parallel word-combinations with the verbs would, «could», «should», and paronymic attraction.

Realization of cognitive models of situations through phraseological units in English-language articles on culture

Currently, in the media discourse, the authors of articles actively realize their pragmatic intentions through the pragmatic potential of phraseological units. The relevance of the study can be proved due to the fact that at the moment there is no information about the components of cognitive models of situations which can be most effectively used by the authors of articles to realize their pragmatic intentions through the pragmatic potential of phraseological units in articles of certain thematic groups. The purpose of the article is to determine the components of cognitive models of situations that are actualized and brought to the fore through the pragmatics of phraseological units in the texts of the English-language media discourse on the topic «culture», the reasons for the actualization of these components of cognitive models of situations by phraseological units, as well as to establish what pragmatic goals of the authors this is due. The study was conducted on the material of media texts – the texts of articles posted on the website of The Guardian newspaper. The research used methods of discourse analysis, semiotic analysis, observation and description techniques. As a result of the analysis of the articles on the topic «culture», it was identified that in the most of the examples the components «situation» and «circumstances» of cognitive models were brought to the fore through the pragmatics of phraseological units, also there was determined the cause of this phenomenon.

Association between intrapartum fetal pulse oximetry and adverse perinatal and long-term outcomes: a systematic review and meta-analysis protocol

Background: Current methods of intrapartum fetal monitoring based on heart rate, increase the rates of operative delivery but do not prevent or accurately detect fetal hypoxic brain injury. There is a need for more accurate methods of intrapartum fetal surveillance that will decrease the incidence of adverse perinatal and long-term neurodevelopmental outcomes while maintaining the lowest possible rate of obstetric intervention. Fetal pulse oximetry (FPO) is a technology that may contribute to improved intrapartum fetal wellbeing evaluation by providing a non-invasive measurement of fetal oxygenation status. Objective: This systematic review and meta-analysis aims to synthesise the evidence examining the association between intrapartum fetal oxygen saturation levels and adverse perinatal and long-term outcomes in the offspring. Methods: We will include randomised control trials (RCTs), cohort, cross-sectional and case-control studies which examine the use of FPO during labour as a means of measuring intrapartum fetal oxygen saturation and assess its effectiveness at detecting adverse perinatal and long-term outcomes compared to existing intrapartum surveillance methods. A detailed systematic search of PubMed, EMBASE, CINAHL, The Cochrane Library and Web of Science will be conducted following a detailed search strategy until August 2023. Three authors will independently review titles, abstracts and full text of articles. Two reviewers will independently extract data using pre-defined data extraction and assess the quality using the Risk of Bias tool for RCTs and Newcastle-Ottawa Scale for observational studies. We will use random-effects meta-analysis for each exposure-outcome association to calculate pooled estimates using the generic variance method. This systematic review will follow the Preferred Reporting Items for Systematic reviews and Meta-analyses guidelines. PROSPERO registration: CRD42023457368 (04/09/2023)

체계기능언어학의 주기어 위계 연구

Objectives The purpose of this study is to explicitly show how the hierarchy of periodicity in Korean texts is ana-lyzed based on Systemic Functional Linguistics.
 Methods The hierarchy of periodicity is viewed as having an expanding structure, like the flow of water, which expands into small waves, large waves, and tidal waves. It is explained that when the flow of text expands from clause to paragraph (→ chapter → text), it does not continue in a straight line, but expands like a wave in a circle. Assuming that this hierarchy of periodicity has genre differences, this paper analyzed the text of political news-paper articles related to the ‘Itaewon tragedy’ in written language and the text of parliamentary meeting related to the ‘Itaewon tragedy’ in spoken language.
 Results In terms of the hierarchical structure of the periodical, the newspaper article and the meeting showed different characteristics. The newspaper article (Text-I) was relatively well organized and followed the typical hi-erarchical structure of a periodical. In particular, it showed that it faithfully followed the structure of HyperTheme - (Elaboration) - HyperNew, which is necessary to organize paragraphs (paragraphs). It also followed the structure of MacroTheme - (Paragraph) - MacroNew when organizing units larger than paragraphs. The meeting text, on the other hand, shows a weak hierarchy, as the MacroTheme is sometimes omitted, and when organizing para-graphs, the HyperNew following the HyperTheme is omitted before moving on to the next topic, the MacroTheme.
 Conclusions This paper introduced the concepts of hierarchy of periodic words and serial word expansion of dis-course as two double-headed wagons for studying discourse meaning. I hope this article to be useful for future research on periodicity in Korean texts of various genres, as it demonstrates how to analyze discourse at the para-graph and text level beyond the analysis of ‘clause’ units, and examines the genre differences between them.

Semantics of the word tutor in modern Russian

In the late 20th – the early 21st century, new names of professions that can be called the key words of the epoch entered the terminological vocabulary of the sphere of education. One of these lexemes is the borrowed word tutor, which is currently characterised by a high frequency of use in connection with the active introduction of the tutor profession into the educational system of Russia. This article examines the features of the semantics of the word tutor based on lexicographic sources, the National Corpus of the Russian language, texts of scientific articles on pedagogic topics. During the study, it was found that in modern Russian the lexeme tutor is used to name a wide range of people in the Russian educational system. At the same time, there is no description of the above-mentioned word in lexicographic sources with the definition of its meaning at different stages and forms of the educational system, in connection with which there is a vague understanding of its content. The paper defines the meanings of this name of a person, taking into account the peculiarities of its functioning in different speech spheres. The conclusion is made about the transformation of the semantics of the word tutor, which is associated with the introduction, and later with the expansion of tutor activity in the system of education and upbringing in Russia. As a result of the analysis of examples of the combination of the noun tutor, the spheres of its functioning are determined.

Does flapless immediate implant placement lead to significant preservation of buccal bone compared to flap surgical protocol?

A systematic review and meta-analysis of randomized clinical trials. The electronic search included Pubmed, Web of Science, Embase, and Cochrane databases up to June 2022. Cross-referencing, searching for gray literature at ( www. gov ), and hand searching of seven relevant journals were also performed. Inclusion criteria consisted of: randomized clinical trials (RCTs) published in English comparing flapless to flap surgery for IIP using single titanium implants in the esthetic zone of healthy ≥18 years old patients. Prospective and retrospective case series, cross-sectional studies, letters to editors and reviews were excluded. The key study factor was to assess the impact of the surgical approach (flap versus flapless surgery) on buccal hard and soft tissue changes after single immediate implants for the anterior teeth in healthy adult patients. The primary outcome was horizontal buccal bone change (HBBC), measured by CBCT. Secondary outcomes were implant survival, vertical buccal bone change, postoperative pain, and clinical and esthetic parameters. Two independent reviewers conducted both electronic and manual searches for eligible clinical studies. The evaluation was carried out at the title level followed by the abstract level, and the full texts of the qualified articles were then examined. Any disagreements were resolved by discussion with a third reviewer. Quality assessment of the included RCTs was conducted by two additional reviewers who were not part in the search process using the revised Cochrane risk-of-bias tool for randomized trials (RoB 2). A meta-analysis was conducted on outcome variables that were documented in three or more articles. Five RCTs fully met the selection criteria for the final qualitative analysis comprising data of 140 patients who received 140 single immediate implants (flapless: 68; flap:72) with a mean age ranging from 30 to 67 years. Follow-up extended for 6-12 months. Two RCTs showed an overall low risk of bias, whereas the other three RCTs had an overall high risk, basically due to using inappropriate methods of outcome measurements. Meta-analysis included three RCTs and revealed a mean difference of 0.48 mm (95% CI [0.13,0.84], p = 0.007) in HBBC between surgical approaches, favoring flapless surgery. Heterogeneity among the studies was low (I2 = 29%; p = 0.250). For implant survival, however, meta-analysis failed to find a significant difference among the groups (RR 1.00, 95% CI [0.93, 1.07], p = 0.920). Due to limited data, meta-analyses could not be conducted for other secondary outcomes. Available studies consistently showed a favorable effect of flapless surgery in terms of vertical buccal bone change and pain, while only one study assessed the vertical midfacial soft tissue change, and no data were reported on esthetic outcomes. According to CBCT data, flapless IIP resulted in greater preservation of buccal bone as compared to flap IIP. However, the clinical significance of this finding remains uncertain since clinical and esthetic outcomes were insufficiently reported.

Association of metformin use with age-related macular degeneration

Background: The association between metformin use and age-related macular degeneration (AMD) risk has been explored. Studies have shown a positive association, no association, or ambiguous results. The aim of this narrative review is to compile these divergent findings, and thereby, better assess the potential of metformin use in reducing the AMD risk.
 Methods: Studies were extracted in two ways. First, a standard Google Scholar™ search was performed using the keywords “metformin” AND “macular degeneration” without language or time restrictions. The full texts of relevant articles identified in this search were retrieved and assessed, and articles of peer-reviewed original studies and meta-analyses were included. Second, the reference lists of the included articles were used to identify additional articles that satisfied the search algorithm and included in this review.
 Results: Of the 12 studies included in this review, eight showed a positive correlation between metformin use and a reduced AMD risk, while one showed no association. Of the eight positive studies, seven were retrospective. Apart from the design, the studies were also diverse. The number of participants in each study ranged from over 300 to 30 million person-years. The study populations included those with type 2 diabetes mellitus, those with AMD, and those without either. The study locations were the United States, Europe, and Asia. The ambiguous or negative results from four studies could largely be rationalized based on the confounding factor of study design.
 Conclusions: Most studies examined in this review demonstrated a positive association between metformin use and a reduced AMD risk. Studies not reporting such an association did not definitively demonstrate its absence. Overall, the studies reviewed herein support further clinical investigation of metformin as a prophylactic and potential treatment modality for AMD. Further randomized clinical trials with reasonably longer follow-up periods are necessary to determine the generalizability of the findings of studies reporting positive results.

Representations of Obesity and COVID-19 in Leading Stock Photography Websites

Emerging research on the news representation of obesity and Covid-19 has found that obese individuals are overwhelmingly presented in stigmatizing ways in news article texts, but the visual representation of obesity and Covid-19 has been understudied, even in the increasingly ubiquitous news stock photographs. This study analyzed the representation of obesity and Covid-19 in 111 editorial stock photographs from Adobe Stock, Getty Images, and Shutterstock using visual content analysis and semantic field analysis. In contrast to past research, which has found well over 65% of the analyzed photographs to be stigmatizing, only slightly over half of the analyzed editorial stock photographs were stigmatizing. Potentially destigmatizing associations of obesity with attractive appearance and positive emotions were also present.

Effectiveness of nutritional support to improve treatment adherence in patients with tuberculosis: a systematic review.

Nutritional interventions substantially improve tuberculosis (TB) treatment outcomes and prevent complications. However, there is limited evidence about the connections between having nutritional support and TB treatment adherence. The aim of this study was to determine the effectiveness of nutritional support in improving treatment adherence among patients with TB. Databases, including PubMed, Embase (Ovid), Web of Science, and Scopus, were comprehensively reviewed to identify relevant studies reporting the impacts of nutritional support on TB treatment adherence. Two authors independently screened the title, abstracts, and full article texts to identify eligible studies and assess the risk of bias. Observational and interventional studies were included. A narrative synthesis approach was used to summarize the findings qualitatively. From the search, 3059 publications were identified; of these, 8 studies were included in this systematic review. Three types of nutritional interventions were identified: food baskets (eg, energy, micronutrient- or macronutrient-enriched food support), nutritional advice and guidance, and incentives for buying foods. Although 5 studies reported that nutritional support significantly improved treatment adherence in patients with TB, 3 studies showed that nutritional support had no effect on TB treatment adherence. Providing nutritional support may improve adherence to TB treatment. However, more well-powered, high-quality trials are warranted to demonstrate the effect of nutrition support on cost-effectively improving adherence to TB treatment. PROSPERO registration no. CRD42023392162.

Range of Clinical Manifestations Caused by Invasive Meningococcal Disease Due to Serogroup W: A Systematic Review.

Invasive meningococcal disease (IMD) due to serogroup W meningococci (MenW) is consistently reported with atypical clinical manifestations, including gastrointestinal symptoms, bacteremic pneumonia, and septic arthritis. We undertook a systematic review of the literature for a comprehensive assessment of the clinical presentation of IMD caused by MenW. PubMed and Embase databases were searched from inception to June 2022 using a combination of MeSH terms and free text for articles that reported symptoms and signs of MenW IMD, and associated manifestations. The most commonly reported symptoms identified included: fever (range 36-100% of cases), nausea and/or vomiting (range 38-47%), vomiting (range 14-68%), cough (range 7-57%), sore throat (range 13-34%), headache (range 7-50%), diarrhea (range 8-47%), altered consciousness/mental status (range 7-38%), stiff neck (range 7-54%), and nausea (range 7-20%). Sepsis (range 15-83% of cases) was the most commonly reported manifestation followed by meningitis (range 5-72%), sepsis and meningitis (range 6-74%), bacteremic pneumonia (range 4-24%), arthritis (range 1-15%), and other manifestations (e.g., pharyngitis/epiglottitis/supraglottitis/tonsillitis/conjunctivitis; range 1-24%). The case fatality rates ranged from 8-40%, and among the survivors 4-14% had long-term sequelae. Clinicians need to be aware of the nonspecific symptoms and signs of IMD, as well as of the atypical manifestations in regions where MenW is known to circulate to ensure timely diagnoses and treatment.

The diagnosis performance of convolutional neural network in the detection of pulmonary nodules: a systematic review and meta-analysis.

Pulmonary nodules are an early imaging indication of lung cancer, and early detection of pulmonary nodules can improve the prognosis of lung cancer. As one of the applications of machine learning, the convolutional neural network (CNN) applied to computed tomography (CT) imaging data improves the accuracy of diagnosis, but the results could be more consistent. To evaluate the diagnostic performance of CNN in assisting in detecting pulmonary nodules in CT images. PubMed, Cochrane Library, Web of Science, Elsevier, CNKI and Wanfang databases were systematically retrieved before 30 April 2023. Two reviewers searched and checked the full text of articles that might meet the criteria. The reference criteria are joint diagnoses by experienced physicians. The pooled sensitivity, specificity and the area under the summary receiver operating characteristic curve (AUC) were calculated by a random-effects model. Meta-regression analysis was performed to explore potential sources of heterogeneity. Twenty-six studies were included in this meta-analysis, involving 2,391,702 regions of interest, comprising segmented images with a few wide pixels. The combined sensitivity and specificity values of the CNN model in detecting pulmonary nodules were 0.93 and 0.95, respectively. The pooled diagnostic odds ratio was 291. The AUC was 0.98. There was heterogeneity in sensitivity and specificity among the studies. The results suggested that data sources, pretreatment methods, reconstruction slice thickness, population source and locality might contribute to the heterogeneity of these eligible studies. The CNN model can be a valuable diagnostic tool with high accuracy in detecting pulmonary nodules.

Professional identity formation among undergraduate pre-medical students: a scoping review protocol

BackgroundProfessional Identity formation is the process by which learners internalize a profession’s values, behaviors, and perceptions. With respect to physicians, this occurs at multiple levels of medical education, including the undergraduate, graduate, and continuing medical education stages. Professional identity formation likely starts even earlier, during the undergraduate pre-medical years but, to date, no known scoping or systematic review has been conducted on this topic. The objective of this scoping review is to systematically map the literature on professional identity formation among undergraduate pre-medical students.MethodsThis review protocol has been designed following the Arksey and O’Malley framework. We will search MEDLINE, CINAHL, Embase, and Scopus, as well as relevant grey literature, conference proceedings, and citations of selected articles. Inclusion criteria are articles (1) written in the English language, (2) involving undergraduate pre-medical students in the USA and Canada, and (3) containing original data about professional identity formation. Two independent reviewers will evaluate the titles, abstracts, and full articles for eligibility. A third reviewer will help resolve any disputes. Once the full text of articles are obtained, data will be abstracted using a standardized form. A narrative summary of findings will then be conducted, as well as a consultation exercise with university pre-medical students, pre-med advisors, and first-year medical students.DiscussionBy conducting this scoping review, we expect to gain a better understanding of how the experiences of undergraduate pre-medical students impact their professional identity formation. These findings will help to identify gaps in the literature, to better characterize professional identity formation in the specific context of the undergraduate pre-medical track, and to outline potential approaches to facilitate professional identity formation among undergraduate pre-medical students.Systematic review registrationThe protocol is registered with the Open Science Framework (htps://osf.io/nfzxc).

Exploring the Use of Lung Ultrasonography to Assess Cardiac Surgery Patients: A Scoping Review

Objective: Lung ultrasonography (LUS) is a safe, quick, and portable diagnostic tool, which can accurately detect postoperative pulmonary complications, postsurgically, without ionizing radiation. The aim of this scoping review was to map the evidence base regarding the use of LUS to assess cardiac surgery patients. Materials and Methods: The JBI methodology was used to conduct this particular scoping review. Results: In total, 90 publications were identified and of those, 73 were research studies, six were narrative reviews, and 11 were narrative, opinion, and text articles. The studies that were included were predominantly observational cohorts and aimed to determine or compare LUS diagnostic ability, prognostic ability, or both. The LUS methods used with patients were heterogeneous and variably reported. Conclusion: Despite an increasing number of studies since 2014, standardized protocols for the use of LUS are yet to be widely adopted and remain an important area for further work. Future research should consider exploring perceptions and experiences of LUS, the use of LUS in treatment outcome measurement, and use by nonphysician health care professionals.