Text Of Article Research Articles

What is the most dangerous sexual position that caused the penile fracture? A systematic review and meta-analysis.

Penile fracture (PF) affects 1,14 to 10,48 men in every 100.000 men in East Asia, and the primary aetiology is sexual intercourse, but the knowledge regarding the most dangerous sexual position is not well explained. This study compares three sexual positions: man on top position (MTP), woman on top position (WTP), and doggy style position (DSP), leading to PF potential. A search of sexual position-related PF in Google Scholar, PubMed, Cochrane, and PMC Europe was performed. Criteria inclusion was the full text of relevant articles which describ the number of sexual positions. It was analyzed by odds ratio, random model effect, and the OR and 95%CI were calculated. 12 relevant papers involving 490 patients comprised 169 MTP, 120 WTP, 158 DSP, and 43 no intercourse cases. Meta-analysis of all sexual positions was a MTP P= 0,04, WTP P=0,49, and DSP P=0,0005. The man-dominant positions (MTP and DSP) were significantly potential for PF, which speculated that when a man is dominant and very excited, intercourse may become highly vigorous and impact trauma. This study found that man's dominant position consists of DSP and the MTP significantly lead to PF.

A research map analysis of methods to improve the happiness of Japanese older adults based on the context of big data

All articles must contain an abstract. The abstract text should be formatted using 10 point Times or Times New Roman and indented 25 mm from the left margin. Leave 10 mm space after the abstract before you begin the main text of your article, starting on the same page as the abstract. The abstract should give readers concise information about the content of the article and indicate the main results obtained and conclusions drawn. The abstract is not part of the text and should be complete in itself; no table numbers, figure numbers, references or displayed mathematical expressions should be included. It should be suitable for direct inclusion in abstracting services and should not normally exceed 200 words in a single paragraph. Since contemporary information-retrieval systems rely heavily on the content of titles and abstracts to identify relevant articles in literature searches, great care should be taken in constructing both.

Hunting for Creativity

Science communicators, including journalists and experts in the field of public relations in science, are often seen as an external and optional addition to the scientific community. Their influence on scientific practices and public perception of science is often underestimated, and their role is understood as a technical one: as a simple retelling of scientific research in a language understandable to the public. In this paper, using the example of such a criterion as “creativity”, we propose to reconsider the role of science communicators more broadly. The paper shows that it is science communicators, rather than representatives of the scientific community, who should be the primary subjects of evaluating articles according to the criterion of creativity. The authors argue that the creativity of scientific research is an essential element in the development of science as a social phenomenon, rather than just a component of its internal operation. Science communicators are not considered as “external” actors in relation to science – their work has a significant impact on the fundamental criteria for scientific success, such as the establishment of scientific reputation, and influences the perception of science among the general public. They do not just describe research, they form ideas about the value aspects of science in society and influence the image of science, which is broadcast into the public space, selecting articles according to certain criteria that are not always the most significant in science, endowing scientific results with a special, socially relevant significance that is not explicitly presented in the texts of scientific articles. The activities of science communicators can influence the funding and development of a scientific field, its public and government support, its popularity among applicants, students and young scientists – and, consequently, the quality of scientific personnel involved in this field. In fact, science communicators turn out to be key architects of public, and often intrascientific, ideas about science and various scientific fields.

Treatment with Rapamycin in Animal Models of Traumatic Brain Injuries; a Systematic Review and Meta-Analysis.

In light of the potential of enhanced functional and neurological recovery in traumatic brain injury (TBI) with the administration of rapamycin, this systematic review and meta-analysis aimed to investigate the efficacy of rapamycin treatment in animal models of TBI. An extensive search was conducted in the electronic databases of Medline, Embase, Scopus, and Web of Science by July 1st, 2023. Two independent researchers performed the screening process by reviewing the titles and abstracts and the full texts of the relevant articles, including those meeting the inclusion criteria. Apoptosis rate, inflammation, locomotion, and neurological status were assessed as outcomes. A standardized mean difference (SMD) with a 95% confidence interval (95%CI) was calculated for each experiment, and a pooled effect size was reported. Statistical analyses were performed using STATA 17.0 software. Twelve articles were deemed eligible for inclusion in this meta-analysis. Pooled data analysis indicated notable reductions in the number of apoptotic cells (SMD for Tunnel-positive cells = -1.60; 95%CI: -2.21, -0.99, p<0.001), p-mTOR (SMD=-1.41; 95%CI: -2.03, -0.80, p<0.001), and p-S6 (SMD=-2.27; 95%CI: -3.03, -1.50, p<0.001) in TBI post-treatment. Our analysis also indicated substantial IL-1β reductions after rapamycin administration (SMD= -1.91; 95%CI: -2.61, -1.21, p<0.001). Moreover, pooled data analysis found significant neurological severity score (NSS) improvements at 24 hours (SMD= -1.16; 95%CI: -1.69, -0.62, p<0.001; I²=0.00%), 72 hours (SMD= -1.44; 95%CI: -2.00, -0.88, p<0.001; I²=0.00%), and 168 hours post-TBI (SMD= -1.56; 95%CI: -2.44, -0.68, p<0.001; I²=63.37%). No such improvement was observed in the grip test. Low to moderate-level evidence demonstrated a significant decrease in apoptotic and inflammatory markers and improved neurological status in rodents with TBI. However, no such improvements were observed in locomotion recovery.

Consequences of Natural and Man-made Disasters on Pregnancy Outcomes and Complications: A Systematic Review.

Due to their unique circumstances, pregnant women face a heightened risk of experiencing pregnancy complications during and after catastrophic events. This study aims to investigate the consequences of both natural and man-made disasters on pregnancy outcomes. This study is a systematic review. Searches were performed until May 31, 2024, in the electronic databases including Medline, Web of Science, Embase, and Scopus. Outcomes such as preterm birth, low birth weight (LBW), small for gestational age (SGA), stillbirth, spontaneous abortion, and pregnancy-related blood pressure complications were studied. The search conducted in the databases yielded 3307 non-duplicate records. After reading the abstracts, 3204 articles were excluded based on inclusion and exclusion criteria. Full texts of 103 article were obtained. However, upon reading the full texts of articles, 13 of them did not meet the inclusion criteria for the study. Consequently, 90 articles were ultimately included. Natural and man-made disasters exert significant influence on adverse pregnancy outcomes. While it is impossible to prevent the incidence of natural disasters and often man-made disasters occur abruptly, the negative consequences of disasters, particularly natural ones, can be mitigated by enhancing prenatal care and avoiding detrimental elements such as smoking and alcohol.

Grounds and purposes of the investigative inspection in criminal proceedings

An analysis of the text of Article 176 of the Criminal Procedure Code of the Russian Federation "Grounds for Inspection" indicates a discrepancy between its title and content. The concept of "grounds for inspection" is not contained or disclosed in this article, and the objectives of the inspection are formulated incorrectly and do not express the specifics of the investigative action in question. In practice, this leads to a misunderstanding of the purpose of the inspection and, as a result, to the ineffectiveness of its application in specific situations. In some cases, the lack of a clear and understandable definition of the grounds and purposes of the inspection leads to the inadmissible substitution of other investigative actions (for example, a search) by the inspection and, thus, to the violation of the rights of citizens whose interests are affected by the conduct of such an action. As a result of the analysis of legislation, the practice of its application and scientific literature, the authors come to the conclusion that it is necessary to distinguish between general and special legal grounds (permits) for inspection. A general legal permission is a written decision (resolution) to initiate criminal proceedings (in exceptional cases, a report of a crime). A special legal permission is an oral decision (expressed outside the will of the investigator) to conduct an inspection. At the same time, the objects of inspection are various kinds of material traces that are important for establishing the presence or absence of the circumstances of the criminal case (single real objects or groups of objects, their attributes, properties and states, location environment). Sufficient evidence obtained from a legally recognized non-procedural or procedural source to indicate the existence of such traces constitutes the factual basis for the inspection that will be carried out for the purpose of their detection, recording and seizure.

The influence of vitamin and mineral consumption on the course of coronavirus disease (COVID-19).

Aim: The study of the role of micronutrients in the prevention of the severe course of the coronavirus disease. Materials and Methods: In order to fulfill the task, there was conducted an analytical review of medical and biological publications in English in the electronic databases PubMed Medline of the US National Library of Medicine (NLM), Embase, Cochrane Database of Systematic Reviews for the period from 2015 to November 2023, where included 50 published articles, 28 preprints and 109 trials. In the course of the study, the bibliographic-semantic research method was used according to the "Preferred Reporting Elements for Systematic Reviews and Meta-Analyses" (PRISMA) protocol. According to this protocol, identified literary sources were sequentially analyzed by title, keywords, abstract and full text of articles. Based on the results of 16 searches, 2650 articles from PubMed, Cochrane Database of Systematic Reviews and Embase, 3162 articles from preprint servers and 237 trials were rejected. In the final article synthesis, we included 50 published articles, 28 preprints, and 109 trials. Conclusions: The most effective in preventing complications of the coronavirus disease are vitamins A, D, E, K, C, B3, B6, B9, B12 and such mineral substances as Mg, Se and Zn. The consumption of appropriate bioactive complexes and source products can be considered a clinically and economically effective strategy for the prevention of a severe course of the coronavirus disease.

Presentation of a Poststructuralist Educational System Model Based on Rhizomatic Philosophy: A Synthesis Research Approach

Purpose: The present study aimed to provide a model of a poststructuralist educational system based on rhizomatic philosophy. Methodology: This study is of a fundamental research type, and the research method was qualitative, specifically utilizing a synthesis research approach. The research environment included all published domestic articles (from 2010 to 2022) and international articles (from 2007 to 2023). Purposeful sampling was used in this study until data saturation was achieved, thus sampling continued until the necessary data for analysis were obtained (23 articles). Following the review of the selected article texts, data were obtained through a combined synthesis method based on interpretive and analytical approaches. Subsequently, concepts were categorized based on their similarities into central categories, and ultimately, core categories were identified by combining the central categories. Findings: The findings revealed that a poststructuralist educational system based on rhizomatic philosophy includes three dimensions: reengineering planning, technological teaching, and curriculum reading. Conclusion: Given that in rhizomatic thinking, hierarchy or other concepts that impose a structure are not possible, democratic structures should be established in determining the strategies and programs of the educational system to ensure the participation of all stakeholders and the utilization of all capabilities and resources.

Effects of posterior intrusion using skeletal anchorage on treating anterior open bite: A systematic review and meta-analysis.

Posterior intrusion with skeletal anchorage is one of the effective methods in the treatment of anterior open bite. Knowing the effects of posterior intrusion, the amount of possible molar intrusion using skeletal anchorage, and its impact on clinical and cephalometric indicators can help the clinician choose the optimal treatment method, especially in borderline surgical cases. In this systematic review, a series of articles were collected through a systematic search in databases, and the titles and summaries of all these articles were reviewed. After removing the irrelevant articles, the full texts of the related articles were read carefully, and their validity was evaluated. Only RCTs and observational studies that complied with PICO questions were included. The Cochrane Risk of Bias 2.0 (RoB 2), ROBINS-I, and GRADE were used to assess the risk of bias in the included studies. The relevant information on selected articles was extracted, and a meta-analysis was performed with Review Manager 5.4 software. The meta-analysis revealed a significant average molar intrusion of 2.89 mm using temporary anchorage devices (TADs). A subgroup analysis showed that miniplates achieved greater intrusion (3.29 mm) compared to miniscrews (2.25 mm) (P=0.03). The level of applied force did not significantly affect the degree of intrusion. Dental parameters such as overbite and overjet were notably altered, with overbite increasing by 4.81 mm and overjet decreasing by 2.06 mm on average. As for the skeletal cephalometric characteristics, SNB, ANB, and SN-Pog increased while mandibular plane angle and lower anterior facial height (LAFH) decreased, and these changes were significant. Meanwhile, SNA and palatal angle changes were not significant. TADs have proved effective in achieving significant intrusion of maxillary molars, leading to marked improvements in dental and skeletal characteristics in patients with open bite malocclusion. Miniplates proved more effective in achieving greater intrusion.

Kajian manajemen mutu terpadu pendidikan di perguruan tinggi

This research aims to analyze the concept and implementation of Integrated Quality Management (IQM) within the realm of higher education institutions. The research method employed here is a systematic literature review to construct a comprehensive overview of IQM within the context of higher education. The analysis technique involves article retrieval, text review, data categorization, and synthesis of relevant information. The research findings indicate that IQM in higher education involves the integration of various management components to enhance the quality of education, teaching, research, and institutional governance. In conclusion, the implementation of IQM can strengthen the overall quality of higher education institutions, but it requires a well-integrated approach among various elements to achieve these objectives.

Analyzing Clarity and Readability of Text Used In Critical Reading Comprehension Classroom at English Education Department of Unismuh Makassar

Annisa Asamarqandi . 2023. Analyzing the Clarity and Readability of texts used in critical Reading Comprehension Classroom in the English Education Department. Faculty of Teaching and Education, University of Muhammadiyah Makassar (supervised by Ratna Dewi and Herlina).&#x0D; This research aims to determine clarity and readability in analyzing journal articles used in critical reading comprehension classroom in the English Education Department by using a calculator website. Critical reading in the Department of English Education. This study focuses on analyzing the clarity and readability of journal article texts in critical reading comprehension classroom at the Department of English Education, Unismuh Makassar. research sample, by communicating with an English lecturer in a critical reading comprehension classroom at Muhammadiyah University Makassar. The data analysis technique used is using a simple web calculator, to measure concrete sentences, examples per page, word frequency, and active sentences of a journal article that can be found using a calculator. And using the website readability calculator calculates the number of sentences, words, syllables, and characters in your sample. This study uses the Flashch equation convenience formula to measure the readability of journal article texts.

ANALIS TERHADAP PASAL 409 UNDANG -UNDANG KESEHATAN TERKINI YANG MENIMBULKAN KONTROVERSI PERKEMBANGAN HUKUM PIDANA

This journal aims to provide an in-depth analysis of the impact and controversy arising from the introduction and amendments to Article 409 of the recent Health Law. The primary focus of this research is on how this article influences and shapes the development of criminal law, particularly in the context of public health. This study employs a normative legal analysis method by thoroughly examining the text and substance of Article 409. Additionally, it incorporates a case study approach to understand its implementation in real-world situations. Controversies surrounding this article are discussed by considering diverse perspectives from legal experts, healthcare practitioners, and relevant community groups. By exploring these viewpoints, this research presents a comprehensive picture of both the positive and negative impacts of Article 409, as well as broader consequences on the criminal legal system. The research findings contribute to our understanding of legal changes related to health and lay the groundwork for more in-depth policy discussions. The conclusions and recommendations resulting from this research are expected to assist policymakers and legal practitioners in formulating more effective and equitable policies in the field of public health.

Impact of Self-medications and Medications Misuse on Health Outcomes

Introduction: The availability of prescription drugs as OTC medications is also becoming more common. However, self-medication carries risks such as misdiagnosis, use of excessive drug doses, prolonged use, and drug interactions. This review aimed to collect evidence about the impact of self-medications on health outcomes. Methods: The systematic review in this study involved several steps to identify and assess relevant research. The search phase involved finding potentially relevant studies in various databases such as PubMed, PsychInfo, EBSCO Medline, BioMed central, and Science Direct. The screening phase involved applying predetermined inclusion and exclusion criteria to determine which studies were appropriate for the review. To conclude the selection process, the full text of the articles was reviewed to determine whether they met the inclusion criteria. Additionally, the full text of review articles was reviewed to identify any additional articles that might be relevant and included in the review. Results: A total of 17 studies were found that met the inclusion criteria. The majority (11/17) of these studies were cross-sectional and relied on self-report. The combined sample size of the 17 studies was 28,628 (ranging from 5 to 5,426), and the average response rate was 66%. In 76% of the studies, reported self-treatment was 50% (ranging from 12% to 99%). Overall, only one or two respondents were registered with a general practitioner (GP) or primary care physician (mean of 56%, ranging from 21% to 96%). In the 13 studies that provided information on self-prescription, the mean percentage of physicians reporting self-prescription was 61% with a standard deviation of 25% and a range of 9% to 99%. Conclusions: Although many patients view over-the-counter (OTC) medications as completely safe, their use always carries some degree of risk for the consumer. This is especially true for patients who do not follow the instructions on the label or package insert.

Doubt about the Common Will of Contracting Parties as a Path to Judicial Jurisprudence in Iraqi and Tunisian Legislation: A Comparative Study

The contract is a tool for exchanging interests between the parties, and when it is concluded between them, each party is obligated to implement the obligations contained in it without increase or decrease in accordance with the principle of the contract, the law of the contracting parties, which is considered one of the results of the principle of the authority of the will, and that this will is the source of the binding force of the contract, so the basis in The issue of contract formation is that the contracting parties have complete freedom to determine the subject of the rights and obligations between them as long as it does not violate public order, public morals, and peremptory rules in the law, in addition to not affecting the interest of one of the contracting parties at the expense of the other contracting party. It is not fair for the content of the contract to be determined based on The will of one party over another, as the idea of contracting must express the common will of the contracting parties, which must be free from any defect of will, which in turn leads to no disparity in the rights and privileges of one party at the expense of another, and then the contract has been taken into account. A manifestation of contractual balance through contractual balance through balance and equality between the contracting parties in terms of the rights and obligations that the contract assigned to its parties. Under the title of interpretation of the contract and the semantic disclosure of the contractual content, it was mentioned under the title of Chapter (513) of the Tunisian Journal of Obligations and Contracts, in which it was stated: “If the words of the books are clear, then the meaning does not matter.” Chapter (515) of the magazine also stated that: “The lesson is in Expression through purposes, not apparent words and structures.” Likewise, what is stated with the same meaning in the text of Article (155) of the Iraqi Civil Code, which states: “1- What matters in contracts is the purposes and meanings, not the words and buildings. 2- The principle in speech is the truth, but if the truth is not possible, it becomes metaphorical.” However, ambiguity may occur in the contract when the phrases used do not express the common will of the contracting parties. This is in the event that the phrases of the contract are unclear and surrounded by ambiguity and contradiction. This case shows the need to interpret the contract with the aim of arriving at the common will of the contracting parties. If this is not possible, the general rule is It indicates that doubt is interpreted in the interest of the debtor, and we will discuss this rule with all its terms and conditions in this research.

Antioxidant and Anti-Inflammatory Properties of Bee Products Potentially Reduce Oxidative Stress and Inflammation After Physical Activity/Exercise: A Systematic Review

Study purpose. This research aims to analyze and highlight the potential of bee products in reducing oxidative stress and inflammation after physical activity/exercise. Materials and methods. This research uses a systematic review method by searching various journal databases such as Scopus, Web of Science, PubMed and Embase. The inclusion criteria in this study were articles published in the last 5 years and articles discussing bee products, honey, oxidative stress, inflammation, physical activity, and exercise. The exclusion criteria in this study were articles published in disreputable journals. Titles, abstracts, and full texts of articles were screened then verified and stored in Mendeley software. A total of 7,124 articles from the Scopus, Web of Science, PubMed and Embase databases were identified. A total of 8 articles that met the inclusion criteria were selected and analyzed for this systematic review. Results. Bee products that have anti-oxidant properties can reduce oxidative stress and the anti-inflammatory properties of bee products can reduce uncontrolled inflammation due to exercise. Conclusions. Bee products contain flavonoids which have anti-oxidant properties which can reduce oxidative stress. In addition, the anti-inflammatory properties of bee products can reduce uncontrolled inflammation due to physical activity/exercise. In this case, honey works by inhibiting inflammation through NF-κB signals and reducing inflammation by suppressing the secretion of pro-inflammatory cytokines such as TNF-α and inflammatory markers such as CRP. Reducing inflammation can reduce the intensity of muscle pain. It is recommended that bee products be used in individuals to reduce oxidative stress and inflammation after physical activity/exercise.

Interpreting the Concept of Ngalap Berkah as Pesantren Tradition in the Perspective of Santri

Discussion on the tradition of Pesantren is critical and needs to be studied in more depth. This is because the study never ceases to be debated both from the historical side and its characteristics. This goal aims to understand three things: First, the existence of students viewed from the point of historicity through the study of the sociology of religion in Indonesia. Second, the paradigm of the concept of barakah is rooted in the world of Pesantren. Third, understanding the concept of barakah that internalizes students to take action in tabarruk or ngalap berkah social practices. The method used is through a literature study approach, examining the texts of articles with similar themes based on the theory of symbolic interactionism. Data collection is carried out by selection, classification, and categorization. The results found three things: First, in the study of the sociology of religion, Santri is an essential element in the Indonesian subculture called Pesantren. The existence of Santri is the typical determinant of a Pesantren. Second, the concept of barakah that students understand is very diverse; some call it ziyādatul khoīr, the Grace of God, miracles, benefits, and an amulet. In this case, the variety of meanings is adjusted to each insight and experience of Santri in Pesantren. Third, the concept of ngalap berkah becomes a tradition in Pesantren as a form of social practice of Santri which starts from the understanding of each Santri. The term tabarrukan is divided into two parts, namely in the form of ta’zīm and sam’an wa thā’atan. The conclusion of this paper shows that these three aspects (santri, barakah, and ngalap berkah) are a unity that cannot be validated in forming a pesantren.

Trans-Disciplinary Communication: Context and Semantics

Science is split into subject-oriented disciplines that are grounded on varying shades of the scientific method. Being a social activity, communication lays at the creative core of the sciencebuilding process of facts and explanations. To communicate means, in its most seminal sense, to bring something in common between distinct parts or to transfer something from one part to another. This 'commonality,' or what lays in common to the parts, can occur not just among persons but also among persons and nature or persons and non-human things. This article starts discussing communication at the human scale from the very beginning, widening the scope from its inner kernel in individuals towards social interactions in the scientific community. The perspectives, concepts, and guidelines unveiled by this exercise are applied in the article's text itself.

Linguistic means of forming the image of the head of a foreign state in the American media (based on the material of The New York Times)

This article is devoted to the study of linguistic means of forming the image of the former president of the Federative Republic of Brazil – Jair Bolsonaro. The purpose of this study is to study the linguistic means of forming the image of the head of a foreign state, who receives representation on the pages of The New York Times. The subject of the study is the lexical and semantic field (LSF) of Personal Names as a model of representation of knowledge about the leader of a foreign state, as well as the contexts of the linguistic implementation of the core of the studied LSF. The main objectives of the study included the study of the structure and composition of the lexico-semantic field of Personal Names, as well as concordance analysis of the contexts of the linguistic implementation of the Personal Names LSF core. The research material is presented by The New York Times newspaper's 2019 issues of articles about Brazil. Using the method of corpus analysis of the texts of articles using the Wmatrix computer program made it possible to identify the lexical and semantic field of Personal Names in the structure of the cognitive matrix Brazil. Concordance analysis of the contexts of the linguistic implementation of the Bolsonaro lexical unit allowed us to identify 3 leading typical arguments that are formed by the newspaper around the name of the politician. The novelty of the study lies in the choice of the material and the subject of the study: the image of President Jair Bolsonaro in the American media has not been studied by linguists to date. The results of the study showed that the image of a politician is formed, among other things, by building contextual connections between the core of the lexico-semantic field under study and the units that make up the structure of this field, while the majority of lexical units relate to figures of political figures in Brazil and foreign countries who do not support the policy of J. Bolsonaro. The nature of the typical arguments identified by examining the concordance of the core of the studied LSF allows us to confirm that the image of this politician, formed by The New York Times newspaper, tends to be negatively biased. Readers are being shown the image of Jair Bolsonaro as a politician advocating the disappearance of the Amazon forests, being an ultra-right populist and not supporting the rights of the indigenous peoples of Brazil.

Sars-Cov-2 and Chronic Myeloid Leukemia: A Systematic Review

Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus causing the coronavirus disease of 2019. Numerous mutations had developed in SARS-CoV-2 virus that resulted in strains (Alfa Beta Delta Omicron) with varying degrees of virulence disease severity. In coronavirus disease of 2019 (COVID-19) patients with chronic myeloid leukemia (CML), there is a controversy regarding the effect of tyrosine kinase inhibitors (TKI) on SARS-CoV-2 infection and patients' outcomes. Some studies showed that CML patients with COVID-19 had better outcomes; other reports showed no significant difference. Method Following the PRISMA (preferred reporting items for systematic reviews and meta-analyses) guidelines, PubMed, Scopus, and Google Scholar databases were searched for published articles through 20 April 2023 for qualified studies. The search included retrospective, prospective studies, reviews, case series, and case reports. The inclusion criteria were English literature with CML patients above 18 years who had SARS-CoV-2 infection. Articles in languages other than English and articles with non-sufficient information were excluded, and patients with bone marrow transplants were excluded. Search terms were (chronic myeloid leukemia) OR (chronic myelogenous leukemia) AND (SARS-CoV-2) OR (COVID-19). Two eligibility checks were done on the included studies. Title and abstract screening was completed first, and the full text of articles that met the requirements for inclusion was subsequently obtained. The search included all articles published up to 20 April 2023. The review is registered in PROSPERO (registration number is: CRD42022326674). Results We reviewed 36 articles of published literature up to April 2023 and collected data for a total of 686 CML patients with COVID-19. The vast majority of patients were in the chronic phase; seven patients were in the accelerated phase, and eight patients were in the blast phase. Disease severity was classified according to WHO criteria. Twenty-seven patients were managed at home, and 21 patients were in ICU (intensive care unit) during the hospital course. Twenty-six patients required oxygen therapy; among them, seven patients required intubation and mechanical ventilation, and six patients required non-invasive ventilation. Mortality was seen in 47 patients, and there were no reports of thrombotic events, but some patients developed AKI, autoimmune hemolytic anemia, rhabdomyolysis, and DKA during COVID-19. Limitations The major limitation is the lack of details about the use or hold of TKIs during SARS-CoV-2 infection in the majority of the reports. Also, the specific or predominant strain of SARS-CoV-2 was not mentioned. Few studies mentioned the variant of the virus, which make it difficult to compare the outcome of the different variant of the SARS-CoV-2 virus in patients with CML. Discussion/Conclusions Hematological cancers are associated with an increased risk of thrombosis. Thrombosis risk is expected to increase in patients with COVID-19; interestingly, patients with CML have not been reported to have a significant increase in the risk of thrombosis during COVID-19. The crucial point is, does TKI continuation during COVID-19 beneficial or harmful? Few patients continued TKIs during Covid-19 without serious adverse events. For patients who had the TKI continued, there were no mortality or serious adverse events. In vitro, TKIs were found to have a significant effect on inhibiting viral replication, which might be the reason behind the better outcome in CML patients infected with SARS-CoV-2 virus. On the other hand, there is a theoretical risk of increased severe infection in CML patients taking TKI due to targeted inhibition of kinases involved in immune cell function. This might result in suppressed cellular immune response that facilitates viral replication. Despite that, CML patients with COVID-19 have no significant increase in mortality or ICU admission compared to other hematological malignancies. in fact, our review showed that the mortality of CML patients with COVID-19 has significantly improved from 0.12% in the pre-vaccination period to 0.04% in the post-vaccination era. The available data indicates that, COVID-19's effect on patients with chronic myeloid leukemia (CML) still needs to be better understood due to the limited data.

Should Obesity Be an Exclusion Criterion for Extracorporeal Membrane Oxygenation Support? A Scoping Review.

Obesity is often considered a contraindication to extracorporeal membrane oxygenation (ECMO) candidacy due to technical challenges with vascular access, higher cardiac output requirements, and known associations between obesity and overall increased morbidity and mortality due to chronic health conditions. However, a growing body of literature suggests that ECMO may be as safe and efficacious in both obese and nonobese patients. This scoping review provides a synthesis of the available literature on the outcomes of obese patients supported with (1) venovenous (VV)-ECMO in acute respiratory distress syndrome (ARDS) not due to coronavirus disease 2019 (COVID-19), (2) VV-ECMO in ARDS due to COVID-19, (3) venoarterial (VA)-ECMO for all indications, and (4) studies combining data of patients supported with VA- and VV-ECMO. A librarian-assisted search was performed using 4 primary electronic medical databases (PubMed, Web of Science, Excerpta Medica database [Embase], and Cochrane Library) from January 2003 to March 2023. Articles that reported outcomes of obese patients requiring ECMO support were included. Two reviewers independently screened titles, abstracts, and full text of articles to determine eligibility. Data extraction was performed using customized fields established a priori within a systematic review software system. A total of 354 publications were imported for screening on titles and abstracts, and 30 studies were selected for full-text review. A total of 26 publications met the inclusion criteria: 7 on VV-ECMO support in non-COVID-19 ARDS patients, 6 on ECMO in COVID-19 ARDS patients, 8 in patients supported with VA-ECMO, and 5 combining both VA- and VV-ECMO data. Although the included studies are limited to retrospective analyses and display a heterogeneity in definitions of obesity and comparison groups, the currently available literature suggests that outcomes and complications of ECMO therapy are equivalent in obese patients as compared to nonobese patients. Hence, obesity as measured by body mass index alone should not be considered an exclusion criterion in the decision to initiate ECMO.