The standard preparation routine of a calcium phosphate cement includes mixing a solid and a liquid component (reactive cement powder and mixing liquid) in an open bowl at the operating theatre. This poses the risk of preparation-related deviations of the resulting properties when the cements are mixed by different persons. Hence, facilitating this mixing procedure is highly desirable. It can be achieved by application of premixed cement pastes: The mixing liquid and a stable suspension of the cement powder are assembled and mixed in a special syringe, minimizing the impact of these preparation-related effects.In this study, a suspension of reactive α-tricalcium phosphate powder in water was stabilized by sodium pyrophosphate decahydrate (PP). Controlled activation of these premixed pastes was then accomplished by adding a concentrated Na2HPO4/NaH2PO4 (Na2/Na) solution. Systematic assessment of the activation mechanism, including the effect of the PP concentration and the amount of Na2/Na added, was performed by isothermal calorimetry, quantitative in-situ X-ray diffraction, rheological characterization and automated Gillmore needle measurements at 37 °C.Premixed pastes with addition of at least 0.05 wt% PP were successfully stabilized for up to 2 weeks at 25 °C, and even 4 weeks at 4 °C. This pre-storage had no significant impact on the setting performance of the pastes. Increasing the PP concentration at constant Na2/Na amount systematically retarded the setting reaction, while an elevated quantity of Na2/Na addition at constant PP concentration resulted in an acceleration.Based on these results, a composition stabilized with 0.05 wt% PP and activated with 20.8 vol% Na2/Na related to the amount of liquid in the premixed pastes appears ideal with respect to the desired setting performance.