Test Program Research Articles

Cost-effectiveness of expanded latent TB infection testing and treatment: Lynn City, Massachusetts, USA.

BACKGROUND: Between October 2016 and March 2019, Lynn Community Health Center in Massachusetts implemented a targeted latent TB infection testing and treatment (TTT) program, increasing testing from a baseline of 1,200 patients tested to an average of 3,531 patients tested, or 9% of the population per year.METHODS: We compared pre-implementation TTT, represented by the first two quarters of implementation data, to TTT, represented by 12 quarters of data. Time, diagnostic, and laboratory resources were estimated using micro-costing. Other cost and testing data were obtained from the electronic health record, pharmaceutical claims, and published reimbursement rates. A Markov cohort model estimated future health outcomes and cost-effectiveness from a societal perspective in 2020 US dollars. Monte Carlo simulation generated 95% uncertainty intervals.RESULTS: The TTT program exhibited extended dominance over baseline pre-intervention testing and had an incremental cost-effectiveness ratio (ICER) of US$52,603 (US$22,008â-"US$95,360). When compared to baseline pre-TTT testing, the TTT program averted an estimated additional 7.12 TB cases, 3.49 hospitalizations, and 0.16 deaths per lifetime cohort each year.CONCLUSIONS: TTT was more cost-effective than baseline pre-implementation testing. Lynn Community Health Centerâ-™s experience can help inform other clinics considering expanding latent TB infection testing.

Nonclinical Safety Testing of RNA Vaccines.

In this chapter, we will first consider the overall goal of nonclinical safety testing during drug development and have a brief overview of its regulatory background. We will then discuss some basic requirements of safety/toxicity testing before concentrating on the safety testing of RNA vaccines and developing a sample RNA vaccine safety testing program.

Shear rate induced viscosity change of human blood samples and blood mimicking fluids.

Purpose: The aim of this study was to measure blood and blood mimicking fluids viscosity at different shear rates (on the interval of 0.1-5000 1/s and 0.1-10000 1/s) while taking into consideration the measuring device's capability and blood's characteristics. We also provided the measurement results of the most accurate measuring program. Methods: We measured blood samples from five donors, and four different blood mimicking fluid compositions. The measurements were done on an Anton Paar Physica MCR301 rotational rheometer with two measuring programs varying in the shear rate intervals, the number of measuring points and the measuring point durations. Results: The results confirmed the significant shear thinning and thixotropic effects of blood. Blood mimicking fluids also had these characteristics. The measured blood viscosity values are in agreement with those of the literature. Conclusions: It can be concluded that the step test program was able to give more stable results as the measured torque was over the nominal limit of 0.05 ìNm over 0.1 1/s and over the selected torque limit of 0.5 ìNm over 31.6 1/s. Blood mimicking fluid measurement results were different from that of the literature due to different measuring conditions. The sample consisting of water, glycerol and starch mimicked well blood's behaviour and viscosity values at 37 degrees Celsius.

Experimental evidences of bio-chemo-mechanical processes in contaminated sediments

The research shows the results of a micro to macro testing programme carried out on contaminated marine sediments from a natural deposit to assess the effects of bio-chemo-mechanical coupled processes which may act in complex natural environments and affect the geotechnical properties of the clays. The research has been triggered by the emblematic case of the contaminated Mar Piccolo (MP) basin in Taranto (Southern Italy), where the high degree of pollution recorded in the clayey sediments at the sea bottom, has been found to worsen water quality and promote bioaccumulation of pollutants in several species. Several samples of sediments collected in the basin from the top layer exhibited peculiar geotechnical properties, in terms of plasticity and activity indexes, compressibility and hydraulic permeability. The results of the geotechnical testing were interpreted taking into account the XRD mineralogical results and the chemical composition of the soil matrix. Furthermore, thermogravimetry tests results were examined to explore the nature of the sediment skeleton and of its organic matter content, based on the main thermal reactions occurring within different temperature ranges. Lastly, scanning electron microscopy and mercury intrusion porosimetry were performed to assess the sediment pore size distribution as well as their content in microfossils and diatoms. The original multiscale analysis carried out on some selected sediment samples showed that the biogeochemical degradation of organic matter and the presence of microfossils and diatoms significantly affect the micro to macro behaviour of marine sediments.

Impact of Self-Monitoring Blood Glucose on Glycaemic Control Among Insulin-Treated Patients With Diabetes Mellitus in Northeastern Tanzania: A Randomised Controlled Trial.

Introduction: Tracking of blood glucose levels by patients and care providers remains an integral component in the management of diabetes mellitus (DM). Evidence, primarily from high-income countries, has illustrated the effectiveness of self-monitoring of blood glucose (SMBG) in controlling DM. However, there is limited data on the feasibility and impact of SMBG among patients in the rural regions of sub-Saharan Africa. This study is aimed at assessing SMBG, its adherence, and associated factors on the effect of glycaemic control among insulin-treated patients with DM in northeastern Tanzania. Materials and Methods: This was a single-blinded, randomised clinical trial conducted from December 2022 to May 2023. The study included patients with DM who had already been on insulin treatment for at least 3 months. A total of 85 participants were recruited into the study and categorised into the intervention and control groups by a simple randomization method using numbered envelopes. The intervention group received glucose metres, test strips, logbooks, and extensive SMBG training. The control group received the usual care at the outpatient clinic. Each participant was followed for a period of 12 weeks, with glycated haemoglobin (HbA1c) and fasting blood glucose (FBG) being checked both at the beginning and at the end of the study follow-up. The primary and secondary outcomes were adherence to the SMBG schedule, barriers associated with the use of SMBG, and the ability to self-manage DM, logbook data recording, and change in HbA1c. The analysis included descriptive statistics, paired t-tests, and logistic regression. Results: Eighty participants were analysed: 39 in the intervention group and 41 in the control group. In the intervention group, 24 (61.5%) of patients displayed favourable adherence to SMBG, as evidenced by tests documented in the logbooks and glucometer readings. Education on SMBG was significantly associated with adherence. Structured SMBG improved glycaemic control with a HbA1c reduction of -1.01 (95% confidence interval (CI) -1.39, -0.63) in the intervention group within 3 months from baseline compared to controls of 0.18 (95% CI -0.07, 0.44) (p < 0.001). Conclusion: Structured SMBG positively impacted glycaemic control among insulin-treated patients with DM in the outpatient clinic. The results suggest that implementing a structured testing programme can lead to significant reductions in HbA1c and FBG levels. Trial Registration: Pan African Clinical Trials Registry identifier: PACTR202402642155729.

The Manhattan Project and the Development of Nuclear Astrophysics

This paper will provide a historical analysis of the impact of the US Manhattan Project from 1942 to 1945 and the subsequent nuclear test program 1945-1970 towards the development of the field of Nuclear Astrophysics and the interpretation of nuclear reaction processes in stars and explosive stellar environments.

Physical and mechanical characteristics of pyroclastic soil for the construction of embankments

In the framework of wider research activity on the physical and mechanical behaviour of volcanic soils, this paper reports the results of some laboratory tests on this type of geomaterial. The background of this research is the need for a construction company to possibly use pyroclastic material excavated along a tunnel profile to build railway embankments included in the design of a new High-Speed Train Line near the city of Naples, Italy. However, according to the standards of the National Italian Railways Company, pyroclastic soils cannot be employed as construction materials unless they are supported by a specific testing program demonstrating their good performance. The pyroclastic soil, which is widespread in the project area, is the product of Mt. Vesuvius volcanic activity. It is a coarse-graded soil that includes a significant percentage of non-plastic fines. They should be placed under compact conditions. The experimental campaign was aimed at identifying some physical characteristics that can synthesize the homogeneity of the pyroclastic deposit in terms of shearing resistance. The preliminary results obtained in terms of grading curves, modified Proctor compaction curves, and stress-strain curves from conventional drained triaxial tests are presented and discussed in this paper. The latter were executed on fully saturated specimens after compacting the soil at the optimum water content and on the dry and wet sides of the Proctor curve. The overall initial outcomes of the experimental campaign indicated that this material has acceptable characteristics and is suitable for the construction of railway embankments.

Push-out tests on steel composite sections with engineered cementitious composite

This paper investigates the shear strength and failure modes of steel-concrete-steel (SCS) sandwich composite member with Engineered Cementitious Concrete (ECC) and explores the influences of various shear connectors such as headed stud and bolt on shear behavior of SCS sandwich composite member by carrying out push-out testing program. Based on the test results in this study, the failure modes and the load-slip behavior of the specimens are investigated. In addition, the experimental results on the shear resistance of the headed stud connector with various connector spacing and numbers of connector is compared and explored.

Study on the Efficacy of Recessed Green Space in Rainwater Harvesting and Utilization in Urban Roads

Abstract In order to confirm the performance of recessed green space in rainwater collection and utilization of urban roads, this paper proposes a corresponding experimental test program, which mainly covers the evaluation of rainwater infiltration, the evaluation of rainwater purification, and the simulation of rainfall-runoff reduction. Using the above test methods, the effectiveness of recessed green space in collecting and utilizing rainwater was analyzed. The results showed that in the one-way analysis of the compositional structure of the undercroft green space, the gravel layer, the media layer, and the vegetation layer had no significant difference in the infiltration rate sig&lt;0.05, and all three had no significant difference with the infiltration rate. The order of rainwater infiltration effect of the four reactors was 3/7 mixed media reactor (23.08 ml/min) &gt; red loam reactor (23.04 ml/min) &gt; 2/8 mixed media reactor (23 ml/min) &gt; black loam reactor (23.08 ml/min), while the order of purification effect was 3/7 mixed media &gt; 2/8 mixed media &gt; red loam &gt; black loam. In addition, the combined high infiltration hypolimnetic green space had a better retention effect (flow yield range from 0 to 10 L) in rainfall-runoff with a reproduction period of 3 and 4 years. Based on the analysis results, the application effect of undercroft green space in urban road rainwater collection and utilization is comprehensively verified, and it is hoped that the investigation of this paper can bring certain references and references to the relevant personnel.

Results and learnings from Europe's largest cargo bike testing program for companies and public institutions

To enhance the empirical knowledge of commercial cargo bike utilization, 755 companies and public institutions throughout Germany tested cargo bikes in operational use for a duration of three months. This article provides a characterization of the users, their experiences and evaluation of the vehicle type and addresses its use and environmental impact. Three waves of online surveys were conducted over three years, and around 30,000 vehicle trips were recorded. The organizations showed considerable heterogeneity in terms of size, economic sector, and location. The study identified environmental protection and taking a pioneering role as the main motivations for participation. Cargo bikes were used more frequently for services than for deliveries, with an average of 2.8 days per week and 12 km per day of use. The general suitability of cargo bikes was positively assessed, but potential product improvement was seen, e.g., with regard to the handling of the cargo box. About one third of the participants decided to buy their own cargo bike after the test phase. The study suggests that policy measures such as purchase incentives during the market ramp-up period and improvements to bicycle infrastructure, should be taken, while the industry should improve the reliability of vehicle components and offer better maintenance services to customers.

Magnetic Alignment of Micro Steel Fibers Embedded in Self-Compacting Concrete

Steel fiber reinforced cementitious composites (SFRCC) have emerged as one of the most efficient techniques to improve the flexural capacity and ductility performance of concrete. However, one of the most significant shortcomings is the randomness of steel fibers direction in the concrete matrix, which influences the extent of mechanical enhancement for a limited fiber content. An experimental approach to control the direction of steel fibers embedded in self-compacting concrete is presented in this study, which is based on generating a driving rotating force to overcome the viscous impeding forces acting onto the embedded fiber. The mechanical performance of micro steel fiber reinforced self-compacting concrete members was investigated. A uniform magnetic field of 9.8×10-3 Tesla generated by a cylindrical powered coil was capable of aligning micro steel fibers embedded in fresh self-compacting concrete along the desired direction. The testing program included seven beam specimens of size of 100 ×100 x 500 mm3. The micro steel fiber contents considered were 0.35%, 0.70%, and 1.05% by volume. Fiber volume fraction of 0.35% was the optimum dosage for magnetic alignment as it achieved the highest extents of mechanical enhancement. The concrete specimens reinforced with 0.35% of steel fiber content have exhibited enhancement rates of 5%, 28%, and 30% in four-point failure load, maximum mid-span deflection, and compressive strength, respectively. Based on the visual analysis of cross-sectional images, the highest orientation factor achieved was 0.91 when steel fiber dosage was 0.35%, whereas the random non-magnetized steel fiber reinforced beams achieved an orientation factor ranging from 0.30 to 0.50.

МЕТОДИКА ОПРЕДЕЛЕНИЯ НЕСУЩЕЙ СПОСОБНОСТИ КОРРОЗИОННО- ПОВРЕЖДЕННЫХ КОЛОНН ПРИ СЕЙСМИЧЕСКИХ ВОЗДЕЙСТВИЯХ

During building and construction maintenance, corrosion of reinforced concrete bearing structures may occur due to various factors (errors at the design stage, exposure to external aggressive media, insufficient construction control, etc.). Thus, there is a need to develop certain methods of calculation of structures which take into account the effect of damage on load-bearing capacity and stability. To date, there are engineering methods for calculating corrosion-damaged reinforced concrete elements under the action of static and dynamic loads. However, there is a need to assess the bearing capacity of corrosion-damaged structures under seismic effects, both in verification calculations of existing buildings and at the design stage of buildings subject to corrosion of reinforcement due to increased aggressiveness of the environment or other negatively influencing factors. The paper discusses the developed methodology and test program for evaluating the seismic resistance of reinforced concrete columns at various levels of reinforcement damage. This test methodology is developed with the recommendations of GOST 27751. To ensure the reliability and mechanical safety of buildings and constructions, it is necessary to perform calculations using data from experimental studies of real building structures or models of construction sites and connection nodes.

Facilitating the access to HIV testing at lower costs: "To the laboratory without prescription" (ALSO), a pilot intervention to expand HIV testing through medical laboratories in France.

A pilot HIV testing programme, Au Labo sans Ordo (ALSO; "to the laboratory without prescription") was implemented in two French Fast-Track Cities Initiative areas from 07/2019 to 12/2020. ALSO aimed to remove barriers to HIV testing by providing free testing with widespread access through all laboratories, extended opening hours, and no prescription requirements. Assessing the ALSO programme in terms of testing activity, user characteristics, and costs, compared to other HIV testing offers. Laboratories and STI clinics reported the monthly numbers of tests performed and positive tests. Two short surveys were carried out 12 months apart in people who sought HIV testing. In each offer, the mean costs of HIV testing have been estimated according to negative or positive results using a microcosting approach. During the study period, 214/264 laboratories reported performing 38,941 ALSO tests that accounted for 7.2% of laboratory HIV testing activity. Positivity rates of ALSO and prescribed tests were similar (2.2/1000) but lower than that in STI clinics (6.0/1000). Heterosexual men, and individuals with multiple sexual partners, poor health insurance and few visits to GPs were more likely to use the ALSO offer than tests upon prescription. Compared to ALSO, STI clinic users were younger, more exposed to HIV and with a less favourable socio-economic situation. ALSO had low costs: €13 for a negative test, €163 for a positive test and €5,388 to identify an HIV-positive person (versus €9,068 in STI clinics and €20,126 with prescribed tests). ALSO has attracted users less likely to visit STI clinics or to seek a prescribed test, particularly heterosexual men. Activities, user profiles and costs suggested the complementarity of the HIV testing offers and the relevance of making them coexist. French health authorities have decided to maintain and expand this programme to complement existing HIV testing offers.

Utility of data from the Danish National School Test Program for health research purposes: Content and associations with sociodemographic factors and higher education.

The Danish National School Test Program is a set of nationwide tests performed annually since 2010 in all public schools in Denmark. To assess the utility of this data resource for health research purposes, we examined the association of school test performance with demographic and socioeconomic characteristics as well as correlations with ninth-grade exams and higher educational attainment. This nationwide descriptive register-based study includes children born between 1994 and 2010 who lived in Denmark at the age of six years. Norm-based test scores (range 1-100, higher scores indicate better performance) in reading (Danish) and mathematics from the Danish National School Test Program were obtained for children aged 6-16 attending public schools in Denmark from 2010 to 2019. Population registers were used to identify relevant demographic and socioeconomic variables. Mean test scores by demographic and socioeconomic variables were estimated using linear regression models. Among the full Danish population of 1,137,290 children (51.3% male), 960,450 (84.5%) children attended public schools. There were 885,360 children who completed one or more tests in reading or mathematics (test participation was 77.8% for the entire population, and 92.1% for children in public schools). Mean test scores varied by demographic and socioeconomic characteristics, most notably with education and labour market affiliation of parents. For every 1-point decrease in the test scores, there was a 0.95% (95% CI: 0.93%; 0.97%) lower probability of scoring B or higher in the ninth-grade exam and a 1.03% (95% CI: 1.00%; 1.05%) lower probability of completing high school within five years after graduating from lower secondary school. In this study of schoolchildren in Denmark, demographic and socioeconomic characteristics were associated with test scores from the Danish National School Test Program. Performance in school tests correlated closely with later educational attainment, suggesting that these early measures of school performance are good markers of subsequent academic potential.

Spatial Analysis of the Distribution of COVID-19 Vulnerable Groups to COVID-19 Cases in Brebes Regency

The number of COVID-19 cases in Brebes Regency within a year is still quite high. The elderly, Hypertension and Diabetes Mellitus are the most important COVID-19 vulnerable groups and have the highest risk of death. The purpose of this study is to determine the distribution of COVID-19 vulnerable groups and their spatial relationship to COVID-19 cases in Brebes Regency. This study used a correlation or ecology study design. The data used is secondary data obtained from the Brebes Regency Health Office, namely the number of COVID-19 cases, the number of elderly, people with hypertension and diabetes mellitus in 2021. The data then analyzed using univariate, bivariate analysis and spatial analysis with the help of QuantumGIS software (QGIS). The results showed that the proportion of the elderly age group correlated with the number of COVID-19 cases (p value is 0.005), while the prevalence of hypertension and diabetes mellitus had no correlation with the number of COVID-19 cases (p value more than 0.05). The high-risk areas are Brebes, Wanasari, Banjarharjo and Bumiayu Districts. The existence of this study, the local government is expected to be able to optimize the Testing, Tracing and Treatment program (3T), posyandu for the elderly and achieve vaccination targets, especially in high elderly population areas, in order to detect and predict the spread of COVID-19 and the selection of appropriate treatment.

Diagonal Compression Tests on Unfired and Fired Masonry Wallettes Retrofitted with Textile-Reinforced Alkali-Activated Mortar

This paper discusses the integration of an alkali-activated mortar (AAM), based on industrial waste, into a novel composite material fit for structural upgrading purposes and rendered with high temperature endurance and a low CO2 footprint. The AAM combined with carbon fiber textiles form a new generation of sustainable inorganic matrix composites—that of textile-reinforced alkali-activated mortars (TRAAM). A test program was designed to assess the effectiveness of carbon TRAAM overlays in increasing the shear capacity of masonry wall specimens comprising solid clay bricks bonded with lime-based mortar and furnished with TRAAM jackets on both sides. The initial and the residual capacity of the reinforced walls were evaluated, the latter by performing diagonal compression tests after exposure to 300 °C and 550 °C. It was shown that TRAAM jacketing can increase the shear capacity of unfired masonry walls by 260% and 335% when a single or a double layer of textile is used, respectively. Rapid heating to temperatures up to 550 °C, one-hour-long steady-state heating, and natural cooling bore no visible thermal cracks on the specimens and had little effect on their residual capacity. Based on these results, the prospect of using TRAAM for retrofitting applications for fire-resilient structures seems very auspicious.

The Patient Satisfaction Level Analysis on the Application of Compliance with Islamic Law Elements in Sultan Agung Islamic Oral and Dental Hospital

Background: The existence of hospitals that apply sharia hospital standards can be a solution to muslim communities in Indonesia. Many hospitals currently go by the label of being Islamic hospitals, but their applications have yet to comply with sharia standards. The success of hospital services can be seen in service quality, one can be seen from element of compliance with Islamic law.Method: This study applied analytical observational research (cross-sectional) using an accidental sampling technique of 133 patients. The variables in this study included the independent variable, the application of the element of compliance with Islamic law, while the level of patients' satisfaction served as its dependent variable. Distribution of a questionnaire was used for the instrument. Analysis of the data that has been obtained is then processed using the SPSS Spearman correlation test program. Result: This study used a program using the Spearman correlation test. The study showed a relationship between applying the element of compliance with Islamic law and the level of patients' satisfaction at Rumah Sakit Islam Gigi dan Mulut Pendidikan (RSIGMP) Sultan Agung Semarang (P=0,000). Applying the element of compliance with Islamic law revealed that results averaged 79,9 fell into the range 61-90 being very good and patients' satisfaction yielded an average of 22,5 fell into the range 16,7-25 being very satisfied.Conclusion: The level of patients' satisfaction is related to applying the element of compliance with Islamic law. The better the application of the element of compliance with Islamic law, the better the patients' satisfaction. Applying the compliance with Islamic law and patients’ satisfaction have been performed properly.

EXPERIMENTAL STUDIES ON THE STRENGTHENING OF A BEAM DAMAGED IN THE TENSILE ZONE

The paper presents the results of a study of the bearing capacity of a beam damaged during hostilities, which was reinforced with steel-reinforced concrete. Consider a beam with 40% damage in the stretched zone. Before concreting, a foam insert was installed in the zone of planned damage, the shape and dimensions of which corresponded to the planned damage. After the concrete set to 70% strength, the liner was removed, and the formed cavity was filled with a 2% fiber concrete mixture. This is one of the options for beam strengthening in a complex program of testing damaged beams, which involves the study of a series of beams with different types of damage, the damage zone (tension and compression) and its dimensions, geometry and method of strengthening. For testing, the authors developed a special stand. The plane-transverse load bending of the beam under study is created with the help of a hydraulic jack and a metal I-beam with a traverse, which transmits two equally concentrated forces to the beam. The generated load is controlled by a model dynamometer of the Tokar system and a ring dynamometer, which acts as a support. Experimental studies have established that a beam whose cross-section is 40% damaged in the middle stretched zone, and the shape of the damage is close to rectangular, has a bearing capacity of 91.0 kN, which is 92.38% of the bearing capacity of an intact beam (98.5 kN ). Cracking started at the 5th loading stage, when the load value was 32.5kN, i.e. 35.7% of the bearing capacity of the damaged beam. At the same time, 4 cracks were formed. At the sixth stage, three more cracks appeared. At stages 9-12 of loading, 9 more cracks formed. The maximum final crack opening width was 1.1 mm. At the same time, 6 cracks formed in the zone of clean bending. During the entire testing process, the fiber concrete liner worked with the beam as a single unit. It can be argued that the strengthening of a beam with 40% damage in the stretched zone in the manner considered in the paper allows to achieve its bearing capacity, which is 92.38% of the bearing capacity of an undamaged beam.

EXPERIMENTAL STUDIES OF A DAMAGED BEAM REINFORCED WITH FIBER CONCRETE

The paper presents the results of a study of the load-bearing capacity of a beam damaged during hostilities, which was reinforced with steel fiber concrete. A beam with 20% damage in the compressed zone is considered. Before concreting, a foam liner was installed in the area of the planned damage, the shape and dimensions of which corresponded to the planned damage. After the concrete gained 70% of the brand strength, the liner was removed, and the resulting cavity was filled with a 2% mixture of fiber-reinforced concrete. This is one of the options for strengthening a beam in a comprehensive testing program for damaged beams, which involves studying a series of beams with different types of damage, damage zone (tension and compression) and its size, geometry and method of strengthening. The authors have developed a special stand for testing. Plane transverse bending of the loading of the beam under test is created using a hydraulic jack and a metal I-beam with a traverse that transmits two equal concentrated forces to the beam. The created load is controlled by an exemplary dynamometer of the Tokar system and a ring dynamometer, which acts as a support. Experimental studies have shown that a beam, the cross-section of which is 20% damaged in the middle compressed zone, and the shape of the damage is close to rectangular, has a load-bearing capacity of 93.6 kN, which is 95.0% of the load-bearing capacity of an undamaged beam (98.5 kN). Crack formation began on the 5th stage of loading, when the load value was 32.5 kN, that is, 34.7% of the load-bearing capacity of the damaged beam. In this case, 4 cracks formed in the pure bending zone. At the sixth stage, three more cracks appeared. At stages 9, 10 and 14 of loading, 7 more cracks formed. The maximum final crack opening width was 0.8 mm. throughout the testing process, the fiber-reinforced concrete liner worked with the beam as a single unit. It can be argued that strengthening a beam with 20% damage in the compressed zone using the method considered in the work makes it possible to achieve its load-bearing capacity, which is 95% of the load-bearing capacity of an undamaged beam.

An Approach to Flavor Chemical Thermal Degradation Analysis.

Toxicological evaluations of flavor chemicals for use in inhalation products that utilize heat for aerosol generation are complicated because of the potential effect heat may have on the flavor chemical. The objective was to develop a thermal degradation technique to screen flavor chemicals as part of a toxicological testing program for their potential use in ENDS formulations. Based upon published data for acetaldehyde, acrolein, and glycidol from ENDS products (common thermal degradants of propylene glycol and glycerin), the pyrolizer temperature was adjusted until a similar ratio of acetaldehyde, acrolein, and glycidol was obtained from a 60/40 ratio (v/v) of glycerin/propylene glycol via GC/MS analysis. For each of 90 flavor chemicals, quantitative measurements of acetaldehyde, acrolein, and glycidol, in addition to semiquantitative non-targeted analysis tentatively identifying chemicals from thermal degradation, were obtained. Twenty flavor chemicals transferred at greater than 99% intact, another 26 transferred at greater than 95% intact, and another 15 flavor chemicals transferred at greater than 90% intact. Most flavor chemicals resulted in fewer than 10-12 tentatively identified thermal degradants. The practical approach to the thermal degradation of flavor chemicals provided useful information as part of the toxicological evaluation of flavor chemicals for potential use in ENDS formulations.