Effluent reuse is a rapidly growing field of research where assessing the quality of effluent is one of the focus areas. This research examines the viability of using wastewater in agriculture by testing an integrated Upflow Anaerobic Sludge Blanket (UASB) reactor with a trickling filter (TF) system during the dry season. Compliance monitoring was conducted for 30 days from May 11 to June 9 of 2021. Samples were collected, handled, and analyzed following standard wastewater analysis procedures for biological oxygen demand (BOD), chemical oxygen demand (COD), total suspended solids (TSS), volatile suspended solids (VSS), cations, anions, heavy metals, E. coli, and helminth egg. The UASB-TF system in Kality wastewater treatment performed well in removing COD, BOD5, and TSS with average removal rates of 80.5%, 82.9%, and 80.9%, respectively, compared well with similar treatment configurations. The effluent quality satisfied the national inland discharge limit with a residual concentration of 125.1 mg/L for COD, 61.7 mg/L for BOD5 and 85.8 mg/L for TSS. On the other hand, high concentrations of chromium, nitrate-nitrogen, and helminth egg count restricted effluent reuse for agricultural purposes due to high health risks and environmental contamination. We found out that discharging industrial sewage into the domestic sewer network could inhibit microbial growth and affect the biological treatment processes. Furthermore, adopting integrated treatment systems in developing countries might face operational challenges and monitoring nitrate, helminth egg, and heavy metals would help provide timely operational feedback. An appropriate tertiary treatment unit—constructed wetlands or polishing ponds—is therefore needed to be introduced to ensure effluent reuse for agricultural purposes.