PM10 is widely identified as an important atmospheric pollutant posing a serious threat to human health and environment as well as it influences the climate system. To unearth the mechanism involved in its sources and circulation behavior in environment, this study focuses on the role of large-scale atmospheric circulation on the long-term variability of PM10 over Turkey by applying rotated empirical orthogonal functions (REOF) analysis. As a result of the implementation of REOF to the daily PM10 data for 80 air quality stations throughout the period 2010-2020, first REOF mode (REOF1 44.9% in winter, 43.2% in spring, 39.5% in summer and 31.6% in fall) for all the four seasons indicated the role of local emission sources on the variations of PM10, which show high PM10 values in different geographical regions. The results of the second mode (REOF2, 17.9% in winter, 14.0% in spring, 14.0% in summer and 16.3% in fall) indicate the role of large-scale atmospheric circulations on the values of PM10. From the REOF2 analysis and extracted synoptic composite maps, the strength of southerly winds and the presence of southwesterly winds at low levels are very important in transporting of dust pollutants from the Arabian Peninsula and Northern Africa, respectively, to the eastern (EAR) and southeastern (SEAR) regions of Turkey during winter. In spring, sand particles in the interior terrestrial part of the country are carried to the northern regions by the effect of large-scale southerly winds, which cause above-normal PM10 concentrations in the Black Sea region of Turkey. In summer, dust particles together with warm dry air intrusion to the eastern region of Turkey by strong easterly winds are sourced by Caspian Sea and result in high PM10 values. Our findings emphasize that the long-term variations in air quality over Turkey are affected secondary by the variations in the large-scale atmospheric circulations with primary contributions from the changes in local emission sources.