Robotic manipulators can reduce the cost of production and improve productivity; however, controlling a manipulator to follow a desired trajectory is a thorny problem. In this study, we introduced various forms of interference to facilitate the modeling of a dual-axis manipulator. The interference associated with the payload is handled by an adaptive radial basis neural network (ARBNN) controller, while other interference is estimated by a time delay estimator (TDE). The control signal is output by a non-singular fast terminal sliding mode controller (NFTSMC) to minimize further interference. Since the proposed controller can deal with the payload, system uncertainties, external disturbances, friction, and backlash, compared with conventional control methods, it has better tracking accuracy and stability.