AbstractThis study presents geomorphological, paleoenvironmental, and archaeological data from the upland upper Susitna River basin in the central Alaska Range. The goal of this study is to establish the landscape history and record of human use of the study area and test regional land‐use models. The results indicate that the upper Susitna was first occupied in the early Holocene at least 2,000 years after the end of full‐glacial conditions and 1,000 years after evidence of landscape recovery. Early Holocene land‐use consisted of short‐term task‐specific camps occupied by highly mobile groups on logistical forays. Upland land use intensified in the middle and late Holocene after modern vegetation patterns were established; during this time hunter‐gatherers occupied both residential and task‐specific camps in the study area in a logistical land‐use system. These results support a shift in land use in the early Holocene to include upland landscapes and intensification of upland landscape use in the late–middle Holocene. A shift in residential base camp location in the late Holocene may be tied to changing subsistence activities. There is evidence for a hiatus in human occupation following Holocene tephra fall, but it is unclear whether this was related to tephra deposition or broader climate instability.