The creep behavior of the CuCrZr alloy, used in the combustion chamber wall of reusable launch vehicles, was investigated at 600-700 K and 150–250 MPa. Results demonstrate significant differences in the creep behavior, microstructure evolution including texture component, dislocation configurations and cavities at 600 K and 700 K, particularly at 250 MPa. At 600 K, the creep life exceeds 400 h, while at 700 K it drops below 0.5 h. The texture components evolved at 600 K-250 MPa are more balanced between hard texture (Brass texture) and soft texture (Goss texture and R-Goss texture). The texture components at 700 K-250 MPa are integrally biased toward the soft texture, implying that it is favorable to accelerate creep strain. The introduced high-density dislocations before creep act as an effective barrier to impede the motion of dislocations at 600 K, inducing long-time dynamic balance of work hardening and recovery softening, while the pre-creep dense dislocations act as an energy supplement at 700 K, promoting that recovery softening dominates the creep process. The dense dislocations can provide energetic support for cavity nucleation.