ObjectivesThis study aimed to evaluate the adhesive properties of a MDP-containing resin cement to a colored zirconia ceramic, using an experimental zirconia–silica coating technique with different priming conditions. Methods18 zirconia ceramic discs (Cercon base colored) were divided into two groups: the control group and the experimental zirconia–silica coating group. Specimens in each group were further divided into 3 subgroups (n=3) according to the priming conditions: no primer, a MDP-containing primer (ED Primer II) or a silane coupling primer (RelyX™ Ceramic Primer). Then resin-composite discs (Filtek™ Z250) were bonded to the treated surface using a MDP-containing resin cement (Panavia F 2.0). The bi-layered specimens were cut into microbars and 20 microbars were randomly selected from each specimen, half of which were stored in 37°C water bath for 24h, and the other half were stored for 30days. After water storage, the samples were exposed to a micro tensile bond strength test (MTBS). The results were analyzed by ANOVA, while the fracture surfaces were examined by SEM. ResultsAfter 24h water storage, zirconia–silica coating followed by silanization showed a significantly (P<0.001) higher MTBS value 45.0 (10.9)MPa. Water storage affected (P<0.05) MTBS in the control group (24.1–30.3MPa to 2.8–3.1MPa), but only partially in the zirconia–silica coating group (20.0–45.1MPa to 17.4–25.9MPa). SEM analysis revealed a failure mode change after water storage. SignificanceThe combination of zirconia–silica coating with silane coupling can improve the bonding of resin cement to this colored zirconia.