Temporary Removal Research Articles

TEMPORARY REMOVAL: VP.47 Interleukin 31 (IL-31) inhibition as a trigger for an immune-mediated myopathy?

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.

Hybrid Manufacturing Process Planning for Arbitrary Part and Tool Shapes

Hybrid manufacturing (HM) technologies combine additive and subtractive manufacturing (AM/SM) capabilities in multi-modal process plans that leverage the strengths of each. Despite the growing interest in HM technologies, software tools for process planning have not caught up with advances in hardware and typically impose restrictions that limit the design and manufacturing engineers’ ability to systematically explore the full design and process planning spaces. We present a general framework for identifying AM/SM actions that make up an HM process plan based on accessibility and support requirements, using morphological operations that allow for arbitrary part and tool geometries to be considered. To take advantage of multi-modality, we define the actions to allow for temporary excessive material deposition or removal, with an understanding that subsequent actions can correct for them, unlike the case in unimodal (AM-only or SM-only) process plans that are monotonic. We use this framework to generate a combinatorial space of valid, potentially non-monotonic, process plans for a given part of arbitrary shape, a collection of AM/SM tools of arbitrary shapes, and a set of relative rotations (fixed for each action) between them, representing build/fixturing directions on 3-axis machines. Finally, we define a simple objective function quantifying the cost of materials and operating time in terms of deposition/removal volumes and use a search algorithm to explore the exponentially large space of valid process plans to find “cost-optimal” solutions. We demonstrate the effectiveness of our method on 3D examples.

Gene Therapy for Human Diseases: Recent Achievements and Near-Term Development Prospects

The article briefly summarizes recent advances in genetic medicine that paved the way for the further development of gene therapy and set the stage for the development of next generation technology. Issues related to the main obstacle for wider application of gene therapy methods, in particular, with the immune response to gene delivery vectors and transgene products are considered. In this context, the role of new technology allowing to bypass the immune obstacle, such as development of modified capsids of adeno-associated viruses (AAV) and methods for temporary removal of antibodies from the bloodstream, as well as gene transfer into tissues using nanoparticles, is discussed. Along with the technology of the first generation gene therapy focused on the delivery of transgenes into target tissues, latest advances in the development of a completely new approach to gene therapy which is based on precise modification of the human genome sequence, gene editing technology, are summarized. Finally, promising next-generation gene editing technology is outlined, such as RNA-targeted editing technology and epigenome editing technology, which are more specific, precise, efficient and applicable to different groups of diseases. The article concludes that gene therapy and, in particular, human genome editing is perhaps the most exciting and revolutionary biotechnology of our time, due to both recent developments and opportunities it might provide in the nearest future.

TEMPORARY REMOVAL: Direct oral anticoagulants in antithrombin deficiency: initial experience in a single center.

The publisher announces that this article has been temporarily removed. An edited version will be published under the same DOI as soon as possible. We thank you for your understanding. If you have any questions, please contact am-query@thieme.com.

Effects of methylmercury and food stress on migratory activity in song sparrows, Melospiza melodia

Avian migration is a challenging life stage susceptible to the adverse effects of stressors, including contaminants like methylmercury (MeHg). Although birds often experience stressors and contaminants concurrently in the wild, no study to date has investigated how simultaneous exposure to MeHg and food stress affects migratory behavior. Our objectives were to determine if MeHg or food stress exposure during summer, alone or combined, has carry-over effects on autumn migratory activity, and if hormone levels (corticosterone, thyroxine) and body condition were related to these effects. We tested how exposure to dietary MeHg and/or food stress (unpredictable temporary food removal) affected migratory behavior in captive song sparrows, Melospiza melodia. Nocturnal activity was influenced by a 3-way interaction between MeHg × stress × nights of the study, indicating that activity changed over time in different ways depending on prior treatments. Thyroxine was not affected by treatment or sampling date. During the migratory season, fecal corticosterone metabolite concentrations increased in birds co-exposed to MeHg and food stress compared to controls, suggesting an additive carry-over effect. As well, during the period of behavioral recording, body condition increased with time in unstressed birds, but not in stressed birds. Fecal corticosterone metabolite concentrations were positively correlated to duration of nocturnal activity, but thyroxine levels and body condition were not. The differences in nocturnal activity between groups suggest that food stress and MeHg exposure on breeding grounds could have direct and indirect carry-over effects that have the potential to affect the fall migration journey.

History, creativity, and value: The modern making of Gold Jun Mei tea

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal .

Feasibility of EXIME® temporary prosthesis placement and removal in men with acute or chronic urinary retention after failure or inability to selfcatheterize

Urological emergencies represent 7% of admissions, 29% of which are acute urine retention. We report the first results of a protocol evaluating a new device in case of failure of self-catheterization, replacing a permanent catheter: the urethral device EXIME®.Intention-to-treat study on the feasibility of inserting the EXIME® prosthesis in a day hospital after simple urethral gel instillation in men with urine retention. EXIME® was proposed to all patients after failure of Foley catheter removal and refusal or inability to learn self-catheterization. The protocol was referenced (NCT04218942) after obtaining the agreement of the committee for the protection of individuals.Among 278 patients admitted for a trial of Foley catheter removal, 15 patients with failed voiding resumption and refusal or failure of self-catheterization were offered the prosthesis. The median age was 73 years with a median retention volume of 700mL. The median prostatic volume was 60g. Fourteen patients had their prosthesis inserted in good conditions of comfort for the practitioner and the patient. One failed placement was noted. The difficulty of insertion was estimated by the practitioner at 0 on median (VAS from 0 to 10), and for its removal at 0. The pain during the insertion of the device was evaluated by the patients at 2.00 and for the removal at 0 (VAS from 0 to 10). 6 patients had satisfactory voiding recovery at D0.We proposed the placement of EXIME to patients who had failed the trial of Foley removal and were unable and/or unwilling to self-catheterize. These were patients with poor bladder contractility and a high risk of retention recurrence. Despite this mixed result, the simplicity of the device and the comfortable expectation of an endoscopic procedure seem promising.Insertion and retrieval of EXIME®prostatic prosthesis were easy and well tolerated in our population. Insertion failed in one patient. A comparative prospective study with self catheterization is necessary to determine its effectiveness.

TEMPORARY REMOVAL: Adverse pregnancy outcomes after in vitro fertilization due to undiagnosed urogenital tuberculosis and proposed screening algorithm for patients from tuberculosis-endemic countries

ObjectiveTo report 2 cases of adverse pregnancy outcomes due to delayed diagnosis of urogenital tuberculosis and propose a screening algorithm for patients from tuberculosis-endemic countries.DesignCase report.SettingAcademic medical center.Patient(s)Two patients with delayed diagnosis of urogenital tuberculosis leading to a fetal loss and a preterm delivery of an infant with congenital tuberculosis.Intervention(s)Endometrial biopsy, acid-fast bacilli culture of urine, and endometrium.Main outcome measure(s)Pregnancy outcomes.Result(s)Fetal loss at 19 weeks and preterm delivery of an infant with congenital tuberculosis before urogenital tuberculosis treatment.Conclusion(s)Patients who are at risk of urogenital tuberculosis should be screened in advance of infertility treatment to potentially prevent adverse pregnancy outcomes.

TEMPORARY REMOVAL: Impact of critical parameters influencing enzymatic production of structured lipids using response surface methodology with water activity control

Structured lipids with desired properties can be produced by enzymatic transesterification. This is a multistep reaction with many factors influencing both the product yield and quality. In this study, the single and combined effects of water activity, temperature and substrate ratio were studied on the reaction between high oleic sunflower oil and ethyl stearate producing 1,2-stearin-3-olein (SOS) using immobilized lipase from Rhizopus oryzae (Lipase DF “Amano” IM). Product quality was assessed as the ratio between SOS and the unwanted isomer SSO. Response surface methodology was used to create models at several time points, for increased understanding and showing the importance of the factors studied, for efficient production of structured lipids. To set the water activity, a control system based on dry/humid nitrogen gas sparging was developed. The models were found to adequately describe the effect of the factors on product yield and quality as well as being robust. For the yield, it was found that the factors influencing the enzymatic activity were highly important initially whereas factors affecting the thermodynamic equilibrium were dominating later. Increased temperature and water activity had initial positive influence that shifted to substrate ratio and a negative influence of water activity as equilibrium was approached. Product quality was mostly affected by temperature negatively, as an increased temperature promoted acyl migration. • System for water activity control in non-aqueous media in a SpinChem® RBR. • Factors affect enzyme kinetics or thermodynamic equilibrium in different stages of the reaction. • Higher water activity increases yield of structured lipids initially but is negative at equilibrium. • Combined effect of water activity and temperature affects lipase stability. • Higher reaction temperatures reduce product quality by promoting acyl migration.

Opening the Door: Alosa pseudoharengus (Alewife) Passage through Tide Gates in Two Adjacent Rivers on the Chignecto Isthmus, Bay of Fundy, Canada

We assessed Alosa pseudoharengus (Alewife) upstream passage during 2016–2019 spawning runs using radio frequency identification (RFID) tracking through a periodically submerged and a constantly submerged top-hinged tide gate in the LaPlanche and Missaquash rivers, respectively, on the Chignecto Isthmus, Canada. First detection of individuals tagged in previous years (i.e., returnees) revealed synchronous upstream run timing in both rivers during 2015 and 2018. Greater delays of migrants attempting passage through the periodically submerged tide gate prompted temporary removal of 1 flapper door during 2016–2019 runs. During a 7-day period following door removal, the number of individuals passing per day increased 4- to 6-fold during 2016–2017 and less than 2-fold during 2018–2019. More than 80% of returnees passed the periodically submerged gate following door removal, decreasing mean delay to less than that of migrants attempting passage of the constantly submerged gate. Most individuals passed the periodically submerged gate during mid-flood daily tide phases and none passed during low-tide outflow due to high water velocities. Passage of the constantly submerged gate occurred during all tide phases, with 77% passing during ebb and low tides. The constantly submerged tide gate provided greater windows of opportunity, resulting in relatively shorter delays compared to the periodically submerged tide gate. Long-term monitoring in this study highlighted the effectiveness of temporary and/or adaptive mitigation when addressing issues in river connectivity and fish passage.

Firearms, Physicians, Families, and Kids: Finding Words that Work

Firearms, Physicians, Families, and Kids: Finding Words that Work

PO-34: Antiplatelet and cytostatic properties of nilotinib synthetic analogues

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

Author index

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

PO-48: Coagulopathy in multiple myeloma

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

PO-58: Cancer-associated venous thromboembolism: the Onco-VTE START2 - Registry

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

PO-08: Characterisation of plasma extracellular vesicles in myeloproliferative neoplasms

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

Bionomic aspects of dengue vectors Aedes aegypti and Aedes albopictus at domestic settings in urban, suburban and rural areas in Gampaha District, Western Province of Sri Lanka

BackgroundThe lack of information on behavioural patterns of Aedes aegypti and Aedes albopictus has become a significant limitation in vector control and disease management programmes. Therefore, the current study was focused on determining some bionomics aspects: breeding, resting, host-seeking and feeding preferences of Ae. aegypti and Ae. albopictus in Sri Lanka.MethodsLarval and adult surveys were conducted from April 2017 to April 2019 monthly in six selected Medical Officer of Health (MOH) areas in Gampaha Distinct, Western province, Sri Lanka, representing urban, suburban and rural settings. Resting preferences of adult mosquitoes were observed from indoor and outdoor places using a Prockopack aspirator. The information on resting height, surface, material and locality was recorded. Human-baited double-net traps were used to determine the host-seeking time of Aedes mosquitoes. Statistical differences in the spatial distribution of mosquitoes in selected MOH areas and prevalence of vectors were analysed using general linear model (GLM). A chi-square test was used to analyse the resting behaviour.ResultsTotal of 19,835 potential breeding sites were examined at 13,563 premises, and 18.5% (n = 1856) were positive for Aedes larvae. Distribution of Ae. aegypti and Ae. albopictus was statistically significant at species level (df = 1; F = 137.134; P < 0.05 GLM) and study setting (df = 2; F = 8.125; P < 0.05). Aedes aegypti breeding was found mainly in temporary removals (18.8%; n = 34), discarded non-degradables (12.15%; n = 22) and tyres (9.95%; n = 18). Natural (14.7%; n = 246) and temporary removals (13.6%; n = 227) and discarded non-reusable items were the key ovipositing sites for Ae. albopictus. In the adult mosquito survey, the majority was comprised of Ae. albopictus (54.5%; n = 999), which denoted exophilic nature (90.8%; n = 758), and 45.5% (n = 835) represented by Ae. aegypti mosquitoes who were mainly endophilic (84.3%; n = 842). Aedes aegypti rested on cloth hangings and curtains, followed by the furniture, while Aedes albopictus was predominant in outdoor vegetation. In both vectors, biting patterns denoted a typical diurnal pattern with two peaks of host-seeking and biting activity in the morning and afternoon.ConclusionsThe majority (80%) of the larval habitats were artificial containers. The use of larvicides for vector control as the prominent measure is questionable since applying these chemicals may target only 20% of the total breeding grounds, which are permanent. The resting places of adult mosquitoes are mainly indoors. Therefore, using thermal space spraying of insecticide may not be appropriate, and indoor residual spraying is recommended as a suitable intervention to target adult mosquitoes. This study warrants a holistic vector control approach for all medically important mosquitoes and insects, ensuring the rational use of finance and resources.Graphical

TEMPORARY REMOVAL: Exploring synergies between lean construction theory and industry 4.0 technologies in the architectural, engineering and construction industry: A people, process, technology perspective

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.

WITHDRAWN: A method to isolate forces and moments applied to teeth: An in vitro experiment

The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.

TEMPORARY REMOVAL: Autoría responsable

TEMPORARY REMOVAL: Autoría responsable