Skin Temperature Research Articles

Identifying and Assessing Physiological Biomarkers for Food and Energy Intake: A Systematic Review with Meta-Analysis Protocol

Background Traditional dietary assessments are often inaccurate and prone to self-reporting biases. Tracking the physiological responses associated with eating and digestion events via wearable technologies may provide an effective approach for continuously monitoring food intake and estimating energy consumption. Eating and digestion are accompanied by a series of changes in the heart rate, skin temperature, blood oxygen saturation, and blood pressure. These changes can be tracked by wearable devices, such as smartwatches, which have been widely accepted in the market. This systematic review is the first to evaluate the effectiveness of tracking such physiological biomarkers in differentiating between high- and low-calorie meals, potentially paving the way for more accurate dietary monitoring. Methods Following the PRISMA-P guidelines, we will conduct a systematic literature search through MEDLINE, EMBASE, and PubMed for clinical trials that investigated physiological responses following meal intake in healthy subjects. Two independent reviewers will screen and select articles based on pre-defined eligibility criteria, with a third review to resolve any discrepancies. This will be followed by data extraction and quality assessment of the included studies. Statistical analyses, including meta-analyses, will be performed using R Studio software. Our primary outcome will be the comparison of physiological biomarkers before and after meal intake, while secondary outcomes will include comparisons of physiological biomarkers between high- and low-calorie meal consumption and the correlation between the caloric content of consumed meals and postprandial physiological changes. Discussion This systematic review and meta-analysis will identify physiological indicators for eating events and inform the design of wearable sensors that estimate food intake in healthy subjects. Systematic Review Registration PROSPERO Registration ID: CRD42024544353

Local and systemic photobiomodulation using a 650 nm LED on skin temperature and hyperalgesia in cellulite: a randomized, placebo-controlled and double-blinded clinical trial

Local and systemic photobiomodulation using a 650 nm LED on skin temperature and hyperalgesia in cellulite: a randomized, placebo-controlled and double-blinded clinical trial

The novel estrogen receptor beta agonist EGX358 and APOE genotype influence memory, vasomotor, and anxiety outcomes in an Alzheimer’s mouse model

IntroductionAlzheimer’s disease (AD) prevalence and severity are associated with increased age, female sex, and apolipoprotein E4 (APOE4) genotype. Although estrogen therapy (ET) effectively reduces symptoms of menopause including hot flashes and anxiety, and can reduce dementia risk, it is associated with increased risks of breast and uterine cancer due to estrogen receptor alpha (ERβ)-mediated increases in cancer cell proliferation. Because ERβ activation reduces this cell proliferation, selective targeting of ERβ may provide a safer method of improving memory and reducing hot flashes in menopausal women, including those with AD. APOE genotype influences the response to ET, although it is unknown whether effects of ERβ activation vary by genotype.MethodsHere, we tested the ability of long-term oral treatment with a novel highly selective ERβ agonist, EGX358, to enhance object recognition and spatial recognition memory, reduce drug-induced hot flashes, and influence anxiety-like behaviors in female mice expressing 5 familial AD mutations (5xFAD-Tg) and human APOE3 (E3FAD) or APOE3 and APOE4 (E3/4FAD). Mice were ovariectomized at 5 months of age and were then treated orally with vehicle (DMSO) or EGX358 (10 mg/kg/day) via hydrogel for 8 weeks. Spatial and object recognition memory were tested in object placement (OP) and object recognition (OR) tasks, respectively, and anxiety-like behaviors were tested in the open field (OF) and elevated plus maze (EPM). Hot flash-like symptoms (change in tail skin temperature) were measured following injection of the neurokinin receptor agonist senktide (0.5 mg/kg).ResultsEGX358 enhanced object recognition memory in E3FAD and E3/4FAD mice but did not affect spatial recognition memory. EGX358 also reduced senktide-induced tail temperature elevations in E3FAD, but not E3/4FAD, females. EGX358 did not influence anxiety-like behaviors or body weight.DiscussionThese data indicate that highly selective ERβ agonism can facilitate object recognition memory in both APOE3 homozygotes and APOE3/4 heterozygotes, but only reduce the magnitude of a drug-induced hot flash in APOE3 homozygotes, suggesting that APOE4 genotype may blunt the beneficial effects of ET on hot flashes. Collectively, these data suggest a potentially beneficial effect of selective ERβ agonism for memory and hot flashes in females with AD-like pathology, but that APOE genotype plays an important role in responsiveness.

Study of anti-inflammatory activity and acute toxicity indicators of new silver salt of pyrazole-3-carboxamide

Objective. To study the anti-inflammatory activity and some toxicological indicators of the new derivative of pyrazole-3-carboxamide SSP. Materials and methods. To assess the biological activity of the compound, its anti-inflammatory effect was studied in the model of acute inflammatory edema caused by sub-plantar injection of carrageenan solution into a rat`s hind leg. The duration effect was assessed by the intensity of suppression of the inflammatory response in relation to the control level. In order to study the safety of the substance, the local irritant effect was determined when applied cutaneously in the experiments on rats. The severity of the irritant effect was assessed by the erythema degree, the amount of edema and the increase in local skin temperature. In addition, acute toxicity of the substance under study was determined. The test compound and reference drugs were applied to the skin. Results. The study of acute toxicity of the compound SSP and the reference drug nystatin when applied cutaneously to rats showed that LD50 of both substances was more than 2500,0 mg/kg. Indicators of the degree of local irritating effect of the drugs demonstrate its absence. At the same time, the studied SSP compound has no anti-inflammatory effect administered either orally or cutaneously. Conclusions. The data obtained allow us to classify the new silver salt of pyrazol-3-carboxamide SSP as a class 5 non-toxic substance. The studied SSP compound has no local irritant effect and does not demonstrate anti-inflammatory activity in the carrageenan inflammation model.

Effects of cryo-facial mask on running performance in amateur middle-distance runners

The excess heat accumulated during exercise can lead to stress-induced fatigue, possibly impairing athletic performance. Various precooling techniques have been applied to enhance thermal comfort, reduce perception of effort, and improve endurance. In this randomized crossover study, twelve male amateur middle-distance runners (age: 33.69 ± 5.9 years; body mass: 71.9 ± 4.4 kg; height: 178.4 ± 5.6 cm; V˙O2 peak: 63.3 ± 5.6 mL min−1·kg−1) wore a facial cooling mask before a time-to-exhaustion (TTE) test on a treadmill, under cryostimulation or control conditions. The running performance comprised also two constant load trials, one conducted before and another after wearing the mask, both performed at the velocity of the first ventilatory threshold. Under cryostimulation condition, the TTE was 13 % higher than the control condition (p = 0.0049; d = −0.19) with a significant main effect of time for both ratings of perceived exertion (F1, 22 = 50.10; p < 0.0001; η2p = 0.69) and heart rate (F1, 22 = 31.53; p < 0.0001; η2p = 0.59). A significant interaction “condition × time” was found for facial skin temperature (F2, 44 = 36.93; p < 0.0001; η2p = 0.63) and for heart rate during the constant load trial after wearing the mask (F1, 22 = 5.90; p = 0.0238; η2p = 0.21). The localized cryostimulation provided by the mask lowered the skin temperature on the face, potentially mitigating the negative effects of heat stress during running. Incorporating the cryo-facial mask as part of a pre-exercise routine for runners may offer a practical and convenient method to optimize performance and enhance overall training outcomes.

EXTH-74. COOLING GLIOBLASTOMA WITH A NEURAL IMPLANT

Abstract Survival rates for glioblastoma (GBM) patients are low due to the difficulty in eradicating all tumor cells, leading to frequent recurrence. This recurrence is frequently within 2-cm from the original site. Studies indicate that supra-total resection improves survival, and non-destructive local therapies show promise in preventing GBM recurrence. Our research demonstrates that non-freezing, ‘cytostatic’ hypothermia is effective against GBM in rats and can be scaled to pig models. This method, unlike ablative cryogenic hypothermia, safely inhibits GBM growth without damaging healthy tissue. Using in vitro culture models and in vivo rat models via a Peltier device, we tested cytostatic hypothermia. This was followed by finite-element modeling (FEM) to simulate bioheat transfer in human and pig brains. The system consists of a neural implant with a multiprobe array, a Peltier chip, a water block, and an artificial internal circulation system with a piezoelectric pump. In vitro tests identified a cytostatic window of 20–25°C. Miniature Peltier devices were fabricated to achieve this in rats to inhibit GBM growth and extend survival. Rats whose tumors received cytostatic levels of hypothermia survived their full study period. FEM simulations confirmed that multiprobe arrays could cool brain tissue to 25°C without significantly raising skin temperature. Portable systems were successfully fabricated and tested in pigs, achieving safe target temperatures with minimal EEG and OCTA changes. Our findings suggest that cytostatic hypothermia can be scaled to larger animals and made implantable and portable, offering a promising non-destructive approach to halting GBM growth and prolonging survival, moving closer to becoming a viable treatment option for patients with GBM.

Thermopixelgraphy: a new method for analyzing the skin temperature of the lower limbs through infrared thermography

Thermopixelgraphy: a new method for analyzing the skin temperature of the lower limbs through infrared thermography

Machine learning-based assessment of thermal comfort for the elderly in warm environments: Combining the XGBoost algorithm and human body exergy analysis

Many elderly people rarely own or use air conditioners because of low income and economising habits, causing them to live in warm thermal environments when heat waves and hot weather occur. Living in warm conditions worsens thermal discomfort and poses health risks this group. To investigate the thermal comfort and adaptation of the elderly, a total of 38 participants were recruited for two parts of experiments in a climate chamber: Part A collected thermal sensation vote (TSV) and physiological parameters for 30 min at 28, 30, and 32 °C, and Part B presented a 20-min cooling with fans (air velocities of 0.6 and 1.4 m/s) at the same temperature. Furthermore, we constructed a thermal comfort model for the elderly based on human body exergy analysis and the GBDT, AdaBoost, and XGBoost machine-learning algorithms. The results showed that the predicted mean vote considerably overestimated the actual TSV. The TSV and mean skin temperature were decreased by 0.1–0.5 scores and 0.4–0.5 °C by the behavioural adaptation of fan cooling. The predictive results showed that the XGBoost model performed better, with R2 score, mean absolute error (MAE), and mean squared error (MSE) of 81 %, 0.10, and 0.01. Exergy transfer from evaporation (Ex-Esk), mean skin temperature (mtsk), air velocity (va), and convective exergy transfer (Ex-C) contributed more to the feature importance in the SHAP value analysis. The current study has implications for investigating physiological comfort and age-friendly environmental designs for the elderly, providing new perspectives for thermal comfort evaluations.

Preliminary Examination of the Effects of Focused Ultrasound on Living Skin and Temperature at the Skin–Transducer Interface

Transcranial Focused Ultrasound Stimulation (tFUS) is a new, rapidly growing field related to the study and treatment of brain circuits. Establishing safety cutoffs for focused ultrasound is crucial for non-ablative neurological ultrasound experiments. In addition to potential focal heating, there is concern about temperature elevation at the skin surface. Much work has been performed at or near the FDA guideline of ISPTA.3 = 720 mW/cm2, which technically only applies to diagnostic, not therapeutic, ultrasound. Furthermore, evidence of brain tissue damage on histology in the focal region has been shown not to occur until ISPTA.3 &gt; 14 W/cm2. Therefore, this study was conducted across a range of intensities between these two values, evaluating both subjective and objective side effects. Subjective side effects encompassed any discomfort experienced during and after focused ultrasound stimulation, while objective side effects included clinical findings of skin irritation, such as erythema, edema, or burns. This study also examined how the skin temperature at the skin–transducer interface would change in order to assess whether there would be significant heating. The subjects did not experience any unpleasant sensation at the point of stimulation, including heat or pain, and no objective findings of skin irritation were observed following stimulation and the removal of the transducer. In addition, there was no intensity-dependent effect on temperature, and the maximal rise in temperature was 1.45 °C, suggesting that these parameters do not result in the heating of the skin at the interface in such a way that poses a risk to subjects when operating at or below the intensities tested in this experiment.

An Investigation of Indoor Environment Quality on Occupants’ Thermal Responses, Health, and Productivity: A Study Based on Physiological Data in Occupied Office Space

This study explores the impact of Indoor Environment Quality (IEQ) on the health and productivity of office workers in an office building in Fujisawa, Kanagawa, Japan. Previous studies have shown that IEQ can affect the physiological responses of occupants, such as of skin temperature, heart rate, and metabolic rate, which are indicators of health and productivity. However, most studies took place in controlled laboratory environments, which may not accurately represent real-life experiences. The study collected subjective and objective data from actual occupied office space, including on perceptions of IEQ, health, and productivity, and measurements of IEQ parameters such as on the thermal environment, light environment, indoor air quality, and acoustics. The study used correlation and linear regression methods to examine the relationship between IEQ, physiological data, and subjective responses to health and productivity. The stable thermal environment and low physical intensity of office work may contribute to the weak correlation between physiological data, thermal responses, and health–productivity variables. The results of this study can provide insights into how IEQ affects the psychological responses, well-being, and performance of office workers in real-world settings.

Hyperbranched Thermosensitive Polymer-AuNP Composite Probe for Temperature Colorimetric Detection

Temperature detection is particularly important in the medical and scientific fields. Although there are various temperature detection methods, most of them focus on broad temperature detection, and basic research in specific fields, especially the detection of subtle temperature changes (32–34 °C) during wound infection, is still insufficient. For this purpose, a novel colorimetric temperature sensing probe is designed in this paper, which can quickly and intuitively respond to small temperature changes within a specific range through color changes. In this paper, hyperbranched polyethyleneimine (HPEI) was modified by isobutyrylation to prepare hyperbranched temperature-sensitive polymer (HPEI-IBAm). And it was combined with gold nanoparticles (AuNPs) prepared by a sodium citrate reduction method to construct an HPEI-IBAm-AuNP colorimetric probe. The probe exhibits excellent stability, even at salt concentrations of up to 12 g/L, thanks to the abundant amino functional groups and the large steric hindrance effect unique to HPEI-IBAm. In particular, the temperature detection range of the probe is precisely locked within 32–34 °C, enabling it to respond quickly and accurately to small temperature changes of only 2 °C. This feature is perfectly suited to the practical needs of temperature detection in infected wounds. The linear fitting coefficient of the temperature response is as high as 0.9929, ensuring the accuracy of the test results. The detection performance of the probe remained highly consistent over 10 cycles, fully proving its excellent reusability and durability. In addition, a flexible colorimetric sensor was prepared by combining the probe with polydimethylsiloxane (PDMS) film. This sensor is capable of rapidly detecting human skin temperature in real time, achieving an accuracy of 99.07% to 100.61%. It can provide a possible solution to the challenges of delayed and difficult temperature detection caused by different body parts and uneven surfaces, among others. This demonstrates its extensive practical value and potential, and it is expected to be further applied in the monitoring of wound infections.

Genetic variation in surface temperature measured using infra-red thermography and genetic associations with production traits in grazing dairy cattle

ABSTRACT Increasing global temperatures and the incidence of extreme weather conditions will result in heat stress becoming a greater issue in production animals. Genetic selection and breeding for heat-tolerant animals have been promoted as a possible mitigation strategy in dairy cattle. The objectives of this study were to obtain in-field skin temperature measurements of the eye, muzzle and udder using infra-red thermography to examine the genetic variation in skin temperature within cows of a dairy herd and to estimate the genetic correlations between skin temperature and production traits. Thermal images and herd test records were obtained for the dairy herd at Massey University’s dairy farm 1. Estimates of (co)variances were obtained using the JWAS program with univariate and bivariate animal models. The heritability estimates for the eye, muzzle and udder temperature were low to moderate at 0.20, 0.24 and 0.39, respectively. All genetic correlations between production and temperature traits were positive except for eye temperature with milk yield and protein yield which was negative and weak. These results indicate that it may be possible to select for a greater skin temperature, however, these results need to be validated using a larger sample size.

Atmospheric warming during rapid sea ice loss over the Barents–Kara seas in winter

AbstractThe atmospheric temperature change associated with rapid sea ice loss events over the Barents–Kara Seas (BKS) is explored. Rapid sea ice loss events are defined as periods with a tendency for sea ice concentration averaged over BKS to be below the fifth percentile of the probability density function distribution during the winters of 1979–2020 for at least three consecutive days. Composite analysis shows that there is a significantly positive bottom‐amplified temperature anomaly ahead of the rapid sea ice loss, which is closely associated with a wave train composed of a Ural blocking and an upstream positive phase of the North Atlantic Oscillation. This structure is favorable for the transport of warm and moist air into the BKS, and therefore, the tropospheric temperature, including the surface air temperature, increases through horizontal warm‐temperature advection, specifically through warm advection of the climatological temperature by the anomalous wind. The cooling over the BKS due to the adiabatic effect and vertical mixing opposes the horizontal warm‐temperature advection above and below about 900 hPa, respectively. However, an increase in skin temperature prominently results from enhanced downward long‐wave radiation, which is also the main contributor to the rapid sea ice loss.

Characteristics of R2019 Processing of MODIS Sea Surface Temperature at High Latitudes

Satellite remote sensing is the best way to derive sea surface skin temperature (SSTskin) in the Arctic. However, as surface temperature retrieval algorithms in the infrared (IR) part of the electromagnetic spectrum are designed to compensate for atmospheric effects mainly due to water vapor, MODIS SSTskin retrievals have larger uncertainties at high latitudes where the atmosphere is very dry and cold, which is an extreme in the distribution of global conditions. MODIS R2019 SSTskin fields are currently derived using latitudinally and monthly dependent algorithm coefficients, including an additional band above 60°N to better represent the effects of Arctic atmospheres. However, the R2019 processing of MODIS SSTskin still has some unrevealed error characteristics. This study uses 21 years (2002–2022) of collocated, simultaneous satellite brightness temperature (BT) data from Aqua MODIS and in situ buoy-measured subsurface temperature data from iQuam for validation. Unlike elsewhere over the oceans, the 11 μm and 12 μm BT differences are poorly related to the column water vapor at high latitudes, resulting in poor atmospheric water vapor correction. Anomalous BT difference signals are identified, caused by the temperature and humidity inversions in the lower troposphere, which are especially significant during the summer. Although the existence of negative BT differences is physically reasonable, this makes the retrieval algorithm lose its effectiveness. Moreover, the statistics of the MODIS SSTskin data when compared with the iQuam buoy temperature data show large differences (in terms of mean and standard deviation) for the matchups at the Northern Atlantic and Pacific sides of the Arctic due to the disparity of in situ measurements and distinct surface and vertical atmospheric conditions. Therefore, it is necessary to further improve the retrieval algorithms to obtain more accurate MODIS SSTskin data to study surface ocean processes and climate change in the Arctic.

Dynamic thermal comfort skin temperatures of young adults during sleep and the effects of gender and sleep stage

This study aims to investigate the local skin temperatures of young adults during sleep in a thermally comfortable indoor environment (thermal sensation vote of -1 to +1). Differences in the thermal comfort skin temperatures (Tsk,tc) caused by changes in gender and sleep stage (i.e., wake, REM, light, deep) are discussed. 8-hour sleep tests were conducted involving 40 subjects (20/20 males/females). Their local skin temperatures at nine sites were recorded every minute, forming a physiological database of thermal comfort. Analysis on the collected data demonstrated significant (p<0.05) variations in local Tsk,tc both between genders and between distinct stages of sleep. Throughout the 8-hour sleep, females had higher Tsk,tc than males. Notably, this difference is most pronounced at the abdomen region, where the Tsk,tc was 0.43°C higher for females. Additionally, females had a wide range of mean Tsk,tc from 34.08°C to 34.75°C, while males had a narrow range from 33.80°C to 34.25°C. Furthermore, the Tsk,tc during the wake stage is significantly lower compared to that in the other three stages, implying skin temperature could be used as an indicator to distinguish sleep stages. Also, the variation in Tsk,tc across sleep stages is more pronounced among females than males. This research reveals gender-specific and sleep stage-related disparities in local Tsk,tc. These findings provide a scientific basis for set-point skin temperatures in thermal regulation models for sleeping. Besides, the development of personalized sleep comfort systems and indoor environment would benefit from current findings, which improves human sleep thermal comfort and quality.

Optimal duration of whole-body cryostimulation exposure to achieve target skin temperature: influence of body mass index—a randomized cross-over controlled trial

BackgroundThe efficacy of whole-body cryostimulation (WBC) may be influenced by individual characteristics. The aim of this study is to determine the optimal exposure time required to reach the analgesic threshold of 13.6 °C, which has been proposed to be a target temperature to be reached at skin level. Our objective is also to follow the skin temperature changes during and after WBC considering the participants body mass index (BMI).MethodsThirty healthy men were assigned into 2 groups based on their BMI [normal weight (n = 15; BMI = 21.53 ± 1.63 kg·m−2) and overweight (n = 15; BMI = 27.98 ± 1.16 kg·m−2)]. In a random order, each participant experienced a 4-min WBC exposure, as well as a control session with no cold exposure. Skin temperature was measured using a thermal imaging camera during and after cold exposure.ResultsNormal weight participants reached the threshold in 4 min, whereas overweight participants reached it in 3 min 30 s. Following WBC, a rapid mean skin temperature (MsT°) increase was observed for both groups, immediately after exposure. However, after 30 min, MsT° remained significantly lower than at baseline.ConclusionOur findings suggest that appropriate WBC dosage may differ according to BMI. Understanding the impact of such variable on cold exposure outcomes can help to optimize WBC treatments and maximize potential benefits.

The Effect of a Synthetic-Grass Sport Surface on Physiology and Perception During Intermittent Exercise in Hot Conditions.

The current study aimed to determine the effect of a synthetic-grass sport surface on core body temperature, skin temperature, heart rate, thermal sensation, thermal comfort, and rating of perceived exertion (RPE)during intermittent exercise in hot conditions. Using a randomized crossover design, 13 trained/developmental team-sport athletes completed two 50-minute standardized intermittent running protocols on a synthetic and anatural-grass surface, on separate days (control-condition air temperature 32.6 °C [1.3 °C], relative humidity 43.2% [5.3%]). Final skin temperature was significantly higher on synthetic compared with natural grass at the calf (40.1 °C [2.5 °C] vs 33.4 °C [0.6 °C]; P < .001), shoulder (36.6 °C [1.7 °C] vs 33.7 °C [0.7 °C]; P < .001), and chest (33.2 °C [1.1 °C] vs 31.8 °C [1.2 °C]; P = .02). Thermal sensation (median: 2.3; interquartile range [0.5] vs 2.2 [0.5], P = .03) and sweat rate (1.5 [0.4]L·h-1 vs 1.2 [0.3]L·h-1; P = .02) were also significantly higher on synthetic grass. While final core body temperature was significantly higher on the natural than synthetic grass (38.4 °C [0.3 °C] vs 38.2 °C [0.4 °C]),there were no significant differences in delta core temperature, as well as heart rate, thermal comfort, or RPE. Higher skin temperatures, thermal sensation, and sweat rates suggest that exercising on synthetic grass in hot conditions may increase some markers of heat strain during exercise. However, delta core body temperature, heart rate, thermal comfort, and RPE remained unaffected.

Clinical efficacy evaluation and safety study of Qishen Tongmai Yin I combined with moxibustion therapy on ASO: A retrospective study.

This study aimed to assess the therapeutic efficacy of moxibustion assisted therapy in combination with Qishen Tongmai Yin No. 1 on arteriosclerosis obliterans (ASO) patients. The impact on clinical symptoms, sign scores, foot dorsum temperature, foot dorsum artery blood flow, and overall clinical efficacy were analyzed. Sixty-three ASO patients from Beijing Xiaotangshan Hospital and Beijing Shijitan Hospital (January 2020-December 2021) were divided into 3 groups: a Qi Shen Tong Mai Yin I-only group, a moxibustion-only group, and a combined treatment group receiving both moxibustion and Qi Shen Tong Mai Yin No. 1. The treatment group took Qi Shen Tong Mai Yin No. 1 orally 3 times daily for 1 month. Moxibustion, employing a mild method, was applied once daily for 35 minutes over a month. Key acupoints included bilateral kidney Shu, Guan Yuan, Ming Men, Zu San Li, Wei Zhong, San Yin Jiao, and Yao Yang Guan. Posttreatment, clinical symptom scores, and dorsum foot parameters were measured, including foot temperature and dorsum foot artery blood flow. Total effective and cure rates were calculated. Pretreatment, no significant differences existed among the 3 groups (P > .05). Posttreatment, the clinical efficacy, dorsalis pedis temperature, dorsalis pedis artery blood flow, and symptom scores significantly improved in all groups (P < .05). Differences in these indicators were also significant among the 3 groups (P < .05). Moxibustion assisted therapy combined with Qishen Tongmai Yin No. 1 enhances total effective and cure rates in ASO patients, improving foot temperature, blood flow, microcirculation, and overall clinical efficacy. Additionally, this combination reduces scores for intermittent claudication, pain, skin temperature, soreness, skin color, and numbness, mitigating disease progression. Safety evaluation indicated no adverse events during treatment, demonstrating the safety of the combined therapy.

Effects of window view and local airflow on human thermal comfort in a sudden change environment

Transitioning from outdoors to indoors involves a sudden environmental change. However, current thermal comfort standards and design guidelines focus on steady-state environments, which do not fully address the urgent need for comfort during dynamic recovery periods. This study uses a climate chamber experiment to investigate the effects of window view and local airflow on thermal recovery under sudden environmental changes. Twenty participants, after exercising in a 34°C environment for 10 minutes, sat for 60 minutes in a 28°C room (with a microenvironment featuring window view/local airflow). Physiological parameters and subjective responses were measured during this period. The results indicate that under sudden environmental changes, window view significantly positively affects thermal recovery through psychological effects, while local airflow mainly accelerates convective heat exchange. The influence on thermal sensation recovery and recovery speed is as follows: window view and local airflow coupling > local airflow > window view. In terms of physiological parameters, both of them only had a significant effect on skin temperature but not on heart rate and blood pressure. The results of the study not only reveal the key role of indoor microenvironment on the effect and speed of thermal sensation recovery under the sudden change environments, which enriches the theory of dynamic thermal comfort, but also provides a scientific basis for the control strategy of indoor environments under sudden change environments.

Exploring the effect of clothing moisture content on heat and moisture transfer from the human body using a sweating thermal manikin

Evaporative heat loss is an important component of the human body's energy balance and several developed thermal comfort models are available to assess heat and mass transfer during human sweating. However, the impact of sweat-soaked clothing due to human perspiration on heat and moisture transfer from the body remains understudied. In this study, the thermal and moisture properties of typical summer clothing were evaluated and moisture adsorption and desorption curves were obtained. The heat losses of the human body in different sweating states were compared using a sweating thermal manikin. It was found that the clothing moisture content and the clothing coverage ratio had a significant effect on the human body heat loss. As the sweating rate increases, additional resistances of the sweat moisture transfer will be added in the sweat-soaked clothing, which would adversely affect the skin temperature. The results show that the total thermal resistance of fully wetted clothing decreased by an average of almost 30% compared to dry clothing ensembles. To account for such differences, the clothing thermal and evaporative resistance, along with the temperature and vapor pressure at varying moisture contents were evaluated and predicted with empirical equations. This enables integrating a dynamic heat and moisture transfer model for the sweat-soaked clothing into a prevailing thermo-physiological model. Accounting for real clothing physical parameters is vital when evaluating thermal comfort in hot and humid weather conditions.