Heat transfer processes in geothermal wellbores are an essential component to overall system performance, but can be overlooked in subsurface modelling studies that tend to focus on reservoir response. This study addresses heat transfer in the wellbore through a comprehensive modelling study of 10 different parameters on OpenGeoSys software designed to evaluate heat losses during open-loop production conditions for typical low-temperature (<100 °C) single phase geothermal systems. Models were set-up to focus on wellbore effects only, using a single production well with constant fluid inlet temperature boundary condition. Results indicate that under base case conditions for a 2-km deep well surrounded by rock formations with a thermal conductivity of 2.5 W/(m.K) and bottom-hole temperature of 60 °C, the difference in inlet (reservoir) and production (wellhead) temperature at the end of a 40-year production period is 2.06 °C. This corresponds to minimum heat losses into the surrounding formations of −63.3 W/m, which is ∼ 7 % of the thermal power recorded at the wellhead (assuming a rejection temperature of 30 °C) and a 3.4 % difference to bottom-hole temperature. These losses in heat can be significant, particularly when in combination with surface losses through the heat exchanger or in the reservoir through thermal breakthrough. Wellbore insulation can reduce losses, but it would appear this only impacts the short-term. Wellbore performance can also be improved, with heat losses minimized, when developing wells above the reservoir interval in low thermal conductivity rock with high geothermal gradients.