Introduction: Adolescent drug abuse is a global concern, affecting young people's freedom and development. In Indonesia, illicit drug abuse has increased, causing severe social, political, and economic problems. Methods: A quasi-experimental design was used in this study to test the effects of life skills-based drug education on knowledge about drug use, self-esteem, and assertiveness skills. Teen participants were divided into experimental and control groups. Results: Language and Social Education (LSE) significantly influences students’ understanding of drug use and assertiveness training while also somewhat raising their self-esteem. On the other hand, it had no appreciable impact on Indonesia’s at-risk students in Semarang, Central Java Province. The report stressed that the first stages in an LSE program intended to stop teenage drug use are for students to gain knowledge and skills. To attain the best results in drug use prevention, more routes must be created. Conclusions: gaining information and skills improves attitudes and values, which in turn encourages drug use in a good way. Consequently, to support Indonesian students who are at risk of drug use in staying drug-free and developing into healthy, contributing members of society, these programs require further study and improvement.