The article is devoted to the application of digital twin technologies in the activities of innovative enterprises. The relevance of applying high technologies in all areas is justified. Features of the application of 4.0 industrial platform elements in the activity of innovative enterprises are explained. The issues of effective management of the activities of innovative enterprises where high technologies are produced have been investigated. The directions for improving the ICT infrastructure for the innovative digitization of the economy were studied. In the realization of innovation potential, the features of science and technology-intensive product production were given, and the global market of high-tech products was analyzed. The issues of innovative digital development of industrial-economic systems were investigated. Emphasis was placed on the fundamentals of the development model of industrial-economic systems based on innovative digitization processes. The stages of the formation of technical and technological paradigms for the development of industrial-economic systems are given. The application features of digital twin technologies in digital transformation processes have been explained. Attention is paid to the importance of the application of digital twin technology in increasing the efficiency of innovation activity. The process of managing innovative industrial-economic systems based on digital twin technology has been investigated. The analysis of the process of using digital twins in the management of innovative industrial-economic systems was carried out. The concept of creating a digital twin, its development, and the content of continuous innovation processes have been investigated. The importance of development of the expanded architectural system of the digital twin of the innovative production enterprise, as well as the conceptual model of the digital plant, was noted. Recommendations were given on the application of digital twin technologies in the activities of innovative enterprises.