Case. Since the mid-20th century, innovations and new technologies in developed countries have become a powerful driver for sustainable economic growth. According to experts, the GDP growth in these countries is by nearly 90 % ensured through the development of technological entrepreneurship. In Russia, technological (innovative) entrepreneurship is not the basis of economic growth for a number of reasons, which include lacking infrastructure for research and development in order to introduce innovations and implement innovative projects. In this regard, strengthening the interaction of the state, science and business is necessary, a vital role in it to be assigned to flagship regional universities. The article mainly aims at analyzing the potential of a flagship university for the development of technological entrepreneurship (on the example of Volgograd State Technical University) and at developing practical recommendations for innovative activities acceleration in the region. The systematic methodology of the research implies using general scientific methods of analyzing and synthesizing information, content analysis of normative legal acts of Volgograd region in the sphere of innovation regulation and documents on the university’s strategic development, comparative analysis and theoretical generalization, as well as the method of included observation. In addition, within this study, in Volgograd State Technical University there was conducted a survey among students of technical and economic profiles. The total sample of respondents was 135 people. The article analyzes the concept of technological entrepreneurship, reveals the potential of Volgograd State Technical University as a flagship university in the context of technological entrepreneurship development, and outlines the limitations hindering the development of technological entrepreneurship at the regional level. For the successful implementation of research and innovation, human and institutional capacity for the development of technological entrepreneurship in Volgograd region, it is proposed to introduce a set of activities aimed at implementing training programmes on technological entrepreneurship and organizing networking between professional, scientific, and business communities of the region. The conclusions may be of interest to regional universities and to public authorities when creating favorable conditions for the development of technological entrepreneurship.