Electrochemical Impedance Spectroscopy Techniques Research Articles

Development of ultrasensitive new sensors based on thio-functionalized heterogeneous layers of gold/graphene/copper for glucose detection

In this work, we report for the first time a new electro-chemical sensors based on (4-Nitrothiophenol) 4-NTP functionalized heterogeneous layers of gold/graphene/Cu for highly sensitive detection of glucose. 4-NTP molecules were immobilized into the surface of gold nanostructures. Surface enhanced Raman scattering was performed in order to assure of the 4-NTP bonding and the optical enhancement of gold nanostructures. SERS intensities generated by the new sensors confirm the presence of active catalytic sites rich with charges. The electrochemical measurement performed for glucose using cyclic voltammetry showed an increasing of sensitivity 3 times faster in the case of functionalized sensors than the standard ones. Nyquist plot proved a decrease in the impedance for glucose with the presence of 4-NTP into the surface. Due to the 4-NTP molecules attached to their surface, the new sensors were proved to be higher sensitive for the detection of glucose. The sensitivity obtained by cyclic voltametric techniques was 179.6 μA/mM.cm2 and 420.8 μA/mM.cm2 for electrode 1 and 2 respectively. The dynamic range is 2.0–19.6 mM (36.0––353.2 mg/dL) of glucose for electrode 1 while it is 2.0–29.1 mM (36.0–524.9 mg/dL) of glucose for electrode 2. The lower detection limit is thus 0.5 mM (9.0 mg/dL) the same for both electrodes. The electrode was also tested as glucose sensor using electrochemical impedance spectroscopy (EIS) techniques.

On the electrochemical properties of lithium‑sulfur batteries

We report in this work the electrochemical analysis of lithium‑sulfur batteries (LSB) composed of sulfur and activated carbon (AC) as the positive electrode and lithium metallic as the negative electrode. Cyclic voltammetry, galvanostatic charge-discharge, and electrochemical impedance spectroscopy (EIS) techniques were employed for the in-situ characterization of the coin cell battery device. Electrochemical studies were performed at different state-of-charge (SoC) in 5 %-steps, covering the 0 to 100 % range. Our major findings include a high specific capacity of 1044 mAh gsulfur−1, which decreased to 200 mAh g−1 after 150 cycles. At the same time, the coulombic efficiency increased during the discharge from 78 % to 99 % due to a progressive activation of the narrow pores present in AC structures. Galvanostatic EIS findings as a function of SoC helped us in predicting the SoC and state-of-health (SoH). A 1500-h self-discharge result was presented and analyzed, indicating the presence of a small leakage current of ca. 600 nA. All electrochemical findings were corroborated by a comprehensive ex-situ materials characterization using Raman, scanning electron microscopy, X-ray photoelectron spectroscopy, and energy-dispersive X-ray spectrometry techniques. The electrochemical (in-situ) and ex-situ characterization of electrodes and coin cell devices allowed us to provide a critical discussion regarding the overall characteristic exhibited by LSBs.

Development of Poly(2-Methyl Thioaniline)/Vanadium Pentoxide Hybrid Electrode Material for High Performance Supercapacitor Applications

To satisfy the constantly growing demand for energy, it is crucial to design electrode materials that have high specific capacitance and excellent reversibility to be used in applications such as portable electronics, backup power supplies, smart grids, hybrid vehicles, transportation and wearable electronics fields. This report presents a novel approach to creating such materials through the electrochemical deposition of a poly(2-methyl thioaniline)/vanadium pentoxide (PMTA/V2O5) hybrid material. The hybrid material was tested as a supercapacitor electrode material by means of cyclic voltammetry, galvanostatic charge/discharge and electrochemical impedance spectroscopy techniques. The PMTA/V2O5 hybrid demonstrated excellent charge-storage capabilities within a large potential window (–1.0 to 1.0 V), with a specific capacitance of 698 F/g at a current density of 1 A/g for samples that had a 1 mm thickness. This value is higher than the specific capacitance of V2O5 and resulted from the organic-inorganic synergistic effect between PMTA and V2O5. Facilitated charge-transfer between the two components owing to the presence of a strong electron-donating group (-SCH3) in PMTA led to a superior electrochemical performance of the PMTA/V2O5 hybrid. This strategy can be applied to produce thin films based on PMTA/V2O5, which have the potential to serve as active electrode material in supercapacitor devices.

A new ITO-based Aβ42 biosensor for early detection of Alzheimer's disease

In this study, a novel label-free impedimetric immunosensor was fabricated for rapid, selective, and sensitive quantitative analysis of Aβ42 protein for use in the diagnosis of Alzheimer's disease. The immunosensor was fabricated using inexpensive and disposable indium tin oxide polyethylene terephthalate (ITO-PET) electrodes. After the electrodes were modified with 3-glycidoxypropyldimethoxymethylsilane (GPDMMS), the antibody specific to the Aβ42 protein (anti-Aβ42) was immobilized. The affinity interaction between anti-Aβ42 and Aβ42 in the immobilization steps in immunosensor fabrication and in the quantitation of Aβ42 were analyzed using Electrochemical Impedance Spectroscopy (EIS) and Cyclic Voltammetry (CV) techniques. Additionally, the morphological changes occurring on the electrode surface during each immobilization step were imaged using scanning electron microscopy (SEM). The linear detection range of the immunosensor was determined as 1–100 pg/mL with the limit of detection value of 0.37 pg/mL. Analytical properties of the biosensor, including reproducibility, repeatability, storage stability, selectivity, and regeneration were investigated. The kinetic behavior of antibody-antigen complex formation was determined for the first time using single frequency impedance (SFI) analysis on an Aβ42 biosensor. The potential for use of the immunosensor in clinical studies was demonstrated by analysis of Aβ42 in commercially purchased human serum.

Anti-corrosive and anti-microbial activity of MTMI on CRCA metal

The present study was intended to demonstrate the synthesis, and characterization of 1-(3-methoxyphenyl)-N-(4H-1,2,4-triazol-4-yl)methan-imine(MTMI) as an inhibitor for the corrosion on CRCA in 1 M HCl. In addition to this, molecular docking, and biological activity was carried out. MTMI formation was confirmed by FTIR and NMR spectroscopic studies. The corrosion inhibition effect was studied by weight loss, potentiodynamic polarization (PDP) measurements, and electrochemical impedance spectroscopy (EIS) techniques. The conditions for optimum inhibition efficiency were established by varying the concentration of the inhibitor and temperature by weight loss method. Kinetic and thermodynamic parameters were calculated and discussed. Results were fitted into various adsorption isotherm models. The adsorption of MTMI on CRCA was confirmed by scanning electron microscopy (SEM). Adsorption obeyed the Langmuir isotherm model and followed physical adsorption. Increasing inhibitor concentration led to a significant reduction in the corrosion rate of mild steel, with an inhibitor efficiency value above 93%. A molecular docking study showed the binding capacity of the protein endo-polygalacturonase (1HG8) and the activity of polygalacturonase enzyme on MTMI was measured.

Investigation of the Effect Chloride Ions on Carbon Steel in Closed Environments at Different Temperatures

This paper investigated carbon steel corrosion in an enclosed environment, where one set of steel was immersed in 3.5 wt.% NaCl solution and another exposed to humid (condensation) conditions. The study employed electrochemical noise and electrochemical impedance spectroscopy techniques to monitor real time corrosion behaviour. The samples were evaluated with surface characterisation techniques including optical light microscope, scanning electron microscope with energy dispersive X-ray spectroscopy, and Raman spectroscopy. The results showed that carbon steel immersed in the liquid phase at a constant temperature exhibited the highest weight loss. However, the carbon steel exposed to water condensation (gas phase) at 80 °C manifested extensive localised corrosion. EN results agreed with the microscopy findings.

Halloysite@Polyaniline Nanoparticles Loaded with the Praseodymium (III) Cation for Improving Active Corrosion Protection of Waterborne Epoxy Coating.

The corrosion resistance of the waterborne epoxy coating is poor during long-term service, which greatly limits its widespread application. In this paper, the halloysite nanotubes (HNTs) were modified by polyaniline (PANI) and then used as nanocontainers to encapsulate the green corrosion inhibitor praseodymium (III) cations (Pr3+), obtaining HNTs@PANI@Pr3+ nanoparticles. A scanning electron microscope, transmission electron microscopy, energy dispersive spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and thermogravimetric analysis were applied to characterize the formation of PANI and the absorption of Pr3+ cations. The corrosion-inhibiting ability of the HNTs@PANI@Pr3+ nanoparticles for iron sheets and the anticorrosion properties of the nanocomposite coatings were evaluated by the electrochemical impedance spectroscopy technique. The results indicated that the coating containing HNTs@PANI@Pr3+ nanoparticles exhibited excellent anticorrosion performance. After immersion in 3.5 wt % NaCl solution for 50 days, its Zf=0.01Hz value was still as high as 9.4 × 108 Ω cm2. The icorr value was 3 orders of magnitude lower than that of the pure WEP coating. The excellent anticorrosion property of the HNTs@PANI@Pr3+ coating could be attributed to the synergy of three beneficial factors, including evenly distributed nanoparticles, PANI, and Pr3+ cations. This research will provide theoretical and technical support for the development of waterborne coatings with high corrosion resistance.

A Facile Preparation Method for Corrosion-Resistant Copper Superhydrophobic Surfaces with Ordered Microstructures by Etching

Superhydrophobic surfaces wit ordered hierarchical microstructures were prepared on copper substrates by combining thermal transfer and etching. The surface morphology, wettability, chemical composition and corrosion resistance were, respectively, characterized via scanning electron microscopy, a three-dimensional confocal microscope, contact angle measurement, X-ray diffraction, X-ray photoelectron spectroscopy, electrokinetic polarization and electrochemical impedance spectroscopy techniques. The contact angle of the obtained superhydrophobic surface is up to 153.3° with a reduction in the corrosion current density from 3.9105 × 10−5 A/cm2 to 3.5421 × 10−6 A/cm2 via the electrokinetic polarization curve test, and the maximum capacitive arc radius of the superhydrophobic surface is about 2.5 × 104 Ω cm2 via the electrochemical impedance spectroscopy test, which is two orders of magnitude higher than that of bare copper substrate, and the maximum modulus value |Z| is also two orders of magnitude higher than that of bare copper substrate, indicating that the superhydrophobic surface has better corrosion resistance. This method provides an effective etching approach toward preparing superhydrophobic surfaces with ordered microstructures.

Titanium carbide MXene and V2O5 composite-based electrochemical sensor for detection of bisphenol A

In recent years, 2D layered titanium carbide (Ti3C2Tx) MXene has been widely used in the electrochemical sensing of various analytes. This paper focuses on fabricating a glassy carbon electrode modified with Ti3C2Tx MXene and V2O5. The electrochemical studies for the detection of bisphenol A (BPA) have been carried out using the modified glassy carbon electrode (GCE) electrode and also the electrochemical oxidation of BPA has been described through cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS) techniques. The voltammetric behavior of the material by detecting BPA in different concentrations has been studied. The materials have been synthesized and characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and Energy-Dispersive X-ray spectroscopy (EDX). The differential pulse voltammetry exhibits a linear range from 414 nM − 31.2 µM with a detection limit of 87 nM for BPA. This novel BPA sensor showed satisfactory results and also it has the potential to create a great platform in the environmental monitoring system.

Employment of relaxation times distribution with improved elastic net regularization for advanced impedance data analysis of a lithium-ion battery

Electrochemical impedance spectroscopy (EIS) is a familiar conventional approach that has been widely applied to analyze electrochemical systems, such as batteries and fuel cells, to determine the polarization resistances of their electrodes. An improved method that can effectively interpret EIS spectra with high resolution and provide close knowledge of the time features of the electrochemical system being considered is the distribution of relaxation times (DRT). However, estimating and attaining DRT is a challenging issue that involves solutions being obtained by employing regularization techniques. This study proposed an improved elastic net (IEN) regularization with an adaptive elastic net penalty, wherein adaptive weight matrices were incorporated into the elastic net penalty. The proposed technique was first validated on standard artificial experimental elements: RC circuit, fractal-RC (FRC) circuit, ZARC element, and Gerischer element, each with a known analytical DRT. The results showed that the proposed method exhibited better estimation accuracy in obtaining the exact known DRTs and resistances, and lower mean square errors (MSEs) when compared with the conventional elastic net (EN) regularization method. Furthermore, the proposed method was applied to the EIS data of real lithium-ion batteries with different state-of-charge (SOC) and temperatures, where the obtained DRTs provided an intuitive analysis of the processes within the battery. The proposed model can accurately estimate various time characterizations and identify their processes. Besides the DRTtool results are correspondingly similar to this study's results showing the effectiveness of the proposed approach when compared. However, the limitations and weaknesses of the proposed approach were recognized and reported in this study. Moreover, the proposed approach can be further extended, improved, and employed for advanced EIS techniques and multidimensional EIS data analyses.

Electrochemical evaluation of Daphne gnidium extract's antioxidant capacity and its potential for mild steel corrosion protection in NaCl medium

AbstractIn this study, the leaf extract of the plant Daphne gnidium L. (Thymemeacea) was used as a corrosion inhibitor for mild steel in 0.1 M NaCl. The content of total polyphenols was evaluated by UV visible spectrophotometry and with cyclic voltammetry. The results show that the extract contains a high content of total phenols estimated at 90.26 (mg GAE/g). Besides this, the plant extract was characterized via Fourier transform infrared spectroscopy. Electrochemical impedance spectroscopy and polarization techniques were used to investigate the extract's anticorrosive performance. The results indicated that the addition of 3% of the extract increased the inhibition efficiency to 90.8% after 4 h of immersion. In addition, the results of the polarization tests showed that the extract acted as a mixed‐type inhibitor, mainly affecting the anodic reaction. Scanning electron microscopy was used to study the morphology of the metal surface. The results revealed a less corrosion impact on mild steel in an inhibited solution.

Fabrication of metal–organic framework based electrochemical Leishmania immunosensor

Leishmaniasis is a disease with a high impact on public health in many countries. In this study, an electrochemical immunosensor for Leishmania major surface protease (Gp63) antibody detection was developed using copper metal organic framework (Cu-(NH2-BDC)-MOF) modified gold screen printed electrode (AuSPE). For this purpose, after modification step of AuSPE with Cu-(NH2-BDC)-MOF, recombinant L.donovani antigen was immobilized on to electrode surface via crosslinker where change in electrochemical signal was monitored with electrochemical impedance spectroscopy technique. After conducting comprehensive optimization studies on experimental parameters of developed Leishmania immunosensor, analytical characteristics were searched. As a result, it was observed that anti-gp63 solution diluted up to the ratio of 1:1500 could be detected with the developed sensor. Meanwhile, relative standard deviation value was found as 4.67% for anti-gp63 diluted in the ratio of 1:80 (n = 3). Accordingly, real sample analysis was also performed by using Leishmania parasite crude antigen and rabbit serum which were positive and negative control samples, respectively. According to the results obtained, it can be concluded that a practical immunosensor that can allow the early diagnosis of leishmaniasis was developed.

Synthesis, Corrosion Inhibition Efficiency and Adsorption Behavior of Dibenzo [a,c] Quinoxalino(2,3-I)Phenazine on Mild Steel in Acidic Medium

Designing new inhibitors and understanding the mechanisms responsible for the inhibition are required in developing techniques to prevent corrosion. A new azaacene organic corrosion inhibitor, DQP (dibenzo[a,c]quinoxalino (2,3-i)phenazine), for mild steel in an acidic medium was successfully synthesized, characterized and reported for the first time using electrochemical impedance spectroscopy (EIS) and Potentiodynamic polarization measurement techniques (PDP). Surface morphologies and average percentage by weight of elements existing in mild steel were determined by SEM-EDX. The alterations in the impedance characteristics showed that DQP inhibitor adsorbed to the surface of mild steel, resulting in the creation of a protective coating. At the maximal concentration of 2.618 x 10-5 M, the inhibition efficiency reached 98.02% demonstrating DQP effectiveness in reducing corrosion process that may occur in mild steel in HCl. However, this efficiency is weakened by increase in temperature. The PDP curve revealed that DQP functions as a mixed inhibitor but is mostly cathodic. The adsorption behavior of DQP was best supported by the Langmuir adsorption isotherm (R2 = 0.9837) while the adsorption-free energy (G0ads) ranging from -41.749 to -43.183 kJmol-1 indicate chemical adsorption on metal surface. This study demonstrates that the synthesized DQP functions admirably well as a corrosion inhibitor in HCl solution.

Electrochemical evaluation of Trasar trac 102 as a corrosion inhibitor on API 5L X65 steel and theoretical study

Electrochemical evaluations of the commercially available inhibitor Trasar Trac102 were carried out under static and hydrodynamic conditions on API 5L X65 steel immersed in NaCl 3% wt. By Electrochemical Impedance Spectroscopy (EIS) techniques, obtaining the best efficiency of 95.4% under static conditions at 20 ppm. It was detected by rotating cylinder electrode that as the revolutions per minute of 100, 500 and 1000 rpm were increased, the inhibition efficiency tended to decrease as a result of the adsorption–desorption process of the organic molecules by the rotation rate. The results showed that the adsorption type of Trasar Trac102 on API 5L X65 steel in NaCl 3% wt was to form a monolayer on the metal surface according to the model fit with Langmuir isotherm. Scanning Electron Microscopy (SEM) was used for surface characterization, which shows a great difference in the target systems with corrosion products as a result of the deterioration caused by the corrosive medium and in the presence of the inhibitor. The results of the chemical analysis (EDX) show a significant decrease of oxygen in the presence of the inhibitor, suggesting that Trasar Trac102 is adsorbed directly on the steel. Dispersion-Corrected Density Functional Theory (DFT) calculations were used to characterize the interactions between the inhibitor components and the steel surface by a cluster approach. Mostly, chemisorption was explained by bonds established between oxygen atoms of inhibitor components and iron ones of the steel surface. Due to their free binding energies computed, metasilicate and mercaptobenzothiazol are expected to interact strongly and to adsorb spontaneously on the steel surface. Also, metasilicate is the component that obtained the largest charge transference to iron cluster.

N,N-Dimethylaniline as corrosion inhibitor for zinc in sulphuric acid medium

The inhibitive effect of N, N-Dimethylaniline (DMA) as corrosion inhibitor for zinc in 0.1, 0.3 and 0.5 M H2SO4 solutions has been investigated by using weight loss, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) techniques. The results obtained reveal that inhibition efficiency (I.E.) increases with increase in concentration of inhibitors but decreases with increase in temperature. As inhibitor concentration increases corrosion rate decreases. The rate constant ‘k’ decreases while half-life ‘t½’ increases with the increase in concentration of inhibitor. DMA showed maximum I. E. of 93.51 % at 60 mM in 0.5 M H2SO4 acid at 301 K. The inhibition effect is discussed in view of DMA molecules adsorbed on the metal surface and it obeys Langmuir adsorption isotherm. Polarization curve indicates that inhibitor act as mixed type for zinc corrosion in sulphuric acid solutions.

Achieving in-system modification of Zn anode on stainless steel mesh for seawater-based energy storage with advanced dendrite-free self-regulation mechanism

In this work, Zn anode with a high compatibility to seawater system is fabricated on stainless steel mesh using an ultra-simple in-system synthesis technique. Physical characterizations reveal that the film electrode is composed by cross-linked Zn nanoflakes structure with outstanding adhesion and mechanical deformation tolerance. Being adopted as seawater-compatible anode, the as-synthesized Zn electrode exhibits a high reversible capacity of 30 mAh cm−2 with obvious advantages such as outstanding rate capability, strong tolerance to real-time varied current, low capacity decay, and good long-term cycling stability. The assembled Zn-air battery performs a maximum energy density of 285 Wh m−2 and successfully lights up various electronic devices. Furthermore, the self-regulation working mechanism and the growth kinetic of Zn electrode are further investigated using in-situ optical microscopy observations and in-situ electrochemical impedance spectroscopy (EIS) techniques. This work demonstrates a promising feasibility for fabricating highly reversible and low-cost Zn electrode in seawater system aiming to large-scale energy storage.

Electrochemical behavior of zinc anode in acidic zinc electrolyte -influence of lead as an impurity in zinc anodic dissolution

Zinc is common metal used for steel protection. In this work, an alloy Zn-1 % wt. Pb was prepared by fusion at 500°C. The analysis of the corrosion behavior was studied with pure Zn anode as control in aerated solution of 0.9 M ZnSO4.7H2O + 1.63 M H2SO4 at 38°C.The effect of lead impurity on corrosion resistance of zinc anode in zinc electrorefining process was investigated using open circuit potential (OCP), Tafel plots, chronoamperometry at imposed constant anodic potential and electrochemical impedance spectroscopy (EIS) techniques. Samples were characterized by chemical analysis, optic microscope (OM) and X-ray diffraction (XRD). The results show that the lead impurity leads to degradation of the behavior of the alloy due to negative effect on the microstructure. Lead increases the corrosion rate and decreases the corrosion resistance of Zn-1 % wt. Pb alloy.

Synthesis, characterization, and electrochemical performance of reduced graphene oxide decorated with Ag, ZnO, and AgZnO nanoparticles

Graphene oxide (GO) derived from the oxidization of graphite exhibits high specific surface area with potential in electrochemical applications. Furthermore, silver and zinc oxide nanoparticles, further denoted as AgNPs and ZnONPs, respectively, display superior physicochemical and electronic properties, that would significantly improve the electrocatalytic properties by being applied in electrochemical sensing. Consequently, in the present work, three different hybrid nanomaterials consisting of reduced graphene oxide (rGO) modified with either AgNPs, ZnONPs, or combined AgZnONPs were synthesized and characterized. The synthesis of GO was performed by a modified Hummer's method, while the decoration of GO with the nanoparticles was carried out by self-assembly solvothermal processes. The Ag-rGO, ZnO-rGO, and AgZnO-rGO nanocomposite hybrid materials were characterized by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), Raman spectroscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM) combined with energy-dispersive X-ray spectroscopy (EDX). Furthermore, the electrochemical responses of the fabricated nanocomposites towards the standard ferrocyanide/ferricyanide [Fe(CN)6]3-/4- redox system were investigated using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) techniques. The results have been explained in terms of structural differences between the nanoparticles formed on the surface of the fabricated nanocomposite materials. Namely, the improved electrochemical performance of ZnO-rGO can be attributed to the high surface to volume ratio of ZnO, which provides greater area of electrode/electrolyte junction and consequently, large number of sites at the electrolyte-ZnO interface. The aim of the present work is the fabrication of novel high-performance rGO-based nanomaterials for applications in electrochemical sensing.

Corrosion mitigation characteristics of some novel organoselenium thiourea derivatives for acid pickling of C1018 steel via experimental and theoretical study

Two organoselenium thiourea derivatives, 1-(4-(methylselanyl)phenyl)-3-phenylthiourea (DS036) and 1-(4-(benzylselanyl)phenyl)-3-phenylthiourea (DS038) were produced and categorized using FTIR and NMR (1H and 13C). The effectiveness of the above two compounds as C-steel corrosion inhibitors in molar HCl was evaluated using the potentiodynamic polarization (PD) and electrochemical impedance spectroscopy (EIS) techniques. PD findings indicate that DS036 and DS038 have mixed-type features. EIS results show that growing their dose not only changes the polarization resistance of C-steel from 18.53 to 363.64 and 463.15 Ω cm2 but also alters the double layer capacitance from 710.9 to 49.7 and 20.5 μF cm−2 in the occurrence of 1.0 mM of DS036 and DS038, respectively. At a 1.0 mM dose, the organoselenium thiourea derivatives displayed the highest inhibition efficiency of 96.65% and 98.54%. The inhibitory molecule adsorption proceeded along the Langmuir isotherm on the steel substrate. The adsorption-free energy of the adsorption process was also intended and indicated a combined chemical and physical adsorption on the C-steel interface. FE-SEM studies support the adsorption and protective abilities of the OSe-based molecule inhibitor systems. In Silico calculations (DFT and MC simulations) explored the attraction between the studied organoselenium thiourea derivatives and corrosive solution anions on a Fe (110) surface. The obtained results show that these compounds can make a suitable preventing surface and control the corrosion rate.

Corrosion inhibition properties of schiff base derivative against mild steel in HCl environment complemented with DFT investigations

There is growing interest in using corrosion inhibitors and protective treatments to limit the degradation of mild steel, leading to the development of numerous Schiff bases as cutting-edge inhibitors. In this study, the effectiveness of a Schiff base, 3-((5-mercapto-1,3,4-thiadiazol-2-yl)imino)indolin-2-one (MTIO), to prevent mild steel corrosion in HCl was investigated using weight loss measurements, potentiodynamic polarization measurements, electrochemical impedance spectroscopy techniques, and surface characterization. The experimental results showed that 0.5 mM MTIO exhibited a satisfactory inhibitor efficiency of 96.9% at 303 K. The MTIO molecules physically and chemically adsorbed onto the mild steel surface following the Langmuir model, forming a compact protective film attributed to the presence of a thiazole ring in the MTIO structure. Theoretical calculations were combined with experimental techniques to investigate the anticorrosion performance and mechanism of inhibition.