Technical Transfer Research Articles

Optimising Paediatric HIV Treatment: Recent Developments and Future Directions.

Treatment options for children living with HIV have historically been less effective, less practical and more difficult to implement compared with those for adults, as the research and development of new drugs for children has lagged behind. Significant progress has been achieved in response to the paediatric HIV epidemic over the last decade. Several optimised paediatric antiretroviral formulations are currently available or in development, including fixed-dose combination tablets containing a complete World Health Organization-recommended regimen. Despite these advancements, virological suppression rates in children are generally lower than in adults. Even when oral fixed-dose combinations with the optimal target profiles are developed, for some children virological suppression is not achievable for reasons such as adherence challenges, intolerance, toxicity and genotypic resistance. New safe, effective, well-tolerated antiretroviral agents from existing and novel classes, as well as innovative administration strategies are essential. To achieve the UNAIDS target of virological suppression in 95% of children receiving antiretroviral therapy, concerted efforts are required. This includes identifying priority drugs in line with latest developments, focusing drug development studies on these priorities, ensuring a timely technical knowledge transfer between originator and generic companies, accelerating regulatory approvals and facilitating procurement and implementation in countries. Success in these efforts depends on collaboration among all stakeholders, including communities, researchers, pharmaceutical companies, guideline and policymakers, governments, funders, regulators and healthcare providers. This review outlines which paediatric antiretroviral therapies are currently available, those which are under development and the future directions of paediatric HIV treatment.

Effect of sequencing platforms on the sensitivity of chemical mutation detection using Hawk-Seq™

BackgroundError-corrected next-generation sequencing (ecNGS) technologies have enabled the direct evaluation of genome-wide mutations after exposure to mutagens. Previously, we reported an ecNGS methodology, Hawk-Seq™, and demonstrated its utility in evaluating mutagenicity. The evaluation of technical transferability is essential to further evaluate the reliability of ecNGS-based assays. However, cutting-edge sequencing platforms are continually evolving, which can affect the sensitivity of ecNGS. Therefore, the effect of differences in sequencing instruments on mutation data quality should be evaluated.ResultsWe assessed the performance of four sequencing platforms (HiSeq2500, NovaSeq6000, NextSeq2000, and DNBSEQ-G400) with the Hawk-Seq™ protocol for mutagenicity evaluation using DNA samples from mouse bone marrow exposed to benzo[a]pyrene (BP). The overall mutation (OM) frequencies per 106 bp in vehicle-treated samples were 0.22, 0.36, 0.46, and 0.26 for HiSeq2500, NovaSeq6000, NextSeq2000, and DNBSEQ-G400, respectively. The OM frequency of NextSeq2000 was significantly higher than that of HiSeq2500, suggesting the difference to be based on the platform. The relatively higher value in NextSeq2000 was a consequence of the G:C to C:G mutations in NextSeq2000 data (0.67 per 106 G:C bp), which was higher than the mean of the four platforms by a ca. of 0.25 per 106 G:C bp. A clear dose-dependent increase in G:C to T:A mutation frequencies was observed in all four sequencing platforms after BP exposure. The cosine similarity values of the 96-dimensional trinucleotide mutation patterns between HiSeq and the three other platforms were 0.93, 0.95, and 0.92 for NovaSeq, NextSeq, and DNBSeq, respectively. These results suggest that all platforms can provide equivalent data that reflect the characteristics of the mutagens.ConclusionsAll platforms sensitively detected mutagen-induced mutations using the Hawk-Seq™ analysis. The substitution types and frequencies of the background errors differed depending on the platform. The effects of sequencing platforms on mutagenicity evaluation should be assessed before experimentation.

Implementation of a Web-Based Outpatient Asynchronous Consultation Service: Mixed Methods Study.

Asynchronous outpatient patient-to-provider communication is expanding in UK health care, requiring evaluation. During the pandemic, Aberdeen Royal Infirmary in Scotland expanded its outpatient asynchronous consultation service from dermatology (deployed in May 2020) to gastroenterology and pain management clinics. We conducted a mixed methods study using staff, patient, and public perspectives and National Health Service (NHS) numerical data to obtain a rounded picture of innovation as it happened. Focus groups (3 web-based and 1 face-to-face; n=22) assessed public readiness for this service, and 14 interviews with staff focused on service design and delivery. The service's effects were examined using NHS Grampian service use data, a patient satisfaction survey (n=66), and 6 follow-up patient interviews. Survey responses were descriptively analyzed. Demographics, acceptability, nonattendance rates, and appointment outcomes of users were compared across levels of area deprivation in which they live and medical specialties. Interviews and focus groups underwent theory-informed thematic analysis. Staff anticipated a simple technical system transfer from dermatology to other receptive medical specialties, but despite a favorable setting and organizational assistance, it was complicated. Key implementation difficulties included pandemic-induced technical integration delays, misalignment with existing administrative processes, and discontinuity in project management. The pain management clinic began asynchronous consultations (digital appointments) in December 2021, followed by the gastroenterology clinic in February 2022. Staff quickly learned how to explain and use this service. It was thought to function better for pain management as it fitted preexisting practices. From May to September 2022, the dermatology (adult and pediatric), gastroenterology, and pain management clinics offered 1709 appointments to a range of patients (n=1417). Digital appointments reduced travel by an estimated 44,712 miles (~71,956.81 km) compared to the face-to-face mode. The deprivation profile of people who chose to use this service closely mirrored that of NHS Grampian's population overall. There was no evidence that deprivation impacted whether digital appointment users subsequently received treatment. Only 18% (12/66) of survey respondents were unhappy or very unhappy with being offered a digital appointment. The benefits mentioned included better access, convenience, decreased travel and waiting time, information sharing, and clinical flexibility. Overall, patients, the public, and staff recognized its potential as an NHS service but highlighted informed choice and flexibility. Better communication-including the use of the term assessment instead of appointment-may increase patient acceptance. Asynchronous pain management and gastroenterology consultations are viable and acceptable. Implementing this service is easiest when existing administrative processes face minimal disruption, although continuous support is needed. This study can inform practical strategies for supporting staff in adopting asynchronous consultations (eg, preparing for nonlinearity and addressing task issues). Patients need clear explanations and access to technical support, along with varied consultation options, to ensure digital inclusion.

Optimising parameters for pilot scale steam explosion and continuous pressurised disc refining of Miscanthus and sugarcane bagasse for xylose and xylo-oligosaccharide release

The first comparative pre-treatment study of Miscanthus (Mxg) and sugarcane bagasse (SCB) using steam explosion (SE) and pressurised disc refining (PDR) pretreatment to optimise xylose and xylo-oligosaccharide release is described. The current investigation aimed to 1) Develop optimised batch-wise steam explosion parameters for Mxg and SCB, 2) Scale from static batch steam explosion to dynamic continuous pressurised disc refining, 3) Identify, understand, and circumvent scale-up production hurdles.Optimised SE parameters released 82% (Mxg) and 100% (SCB) of the available xylan. Scaling to PDR, Miscanthus yielded 85% xylan, highlighting how robust scouting assessments for boundary process parameters can result in successful technical transfer. In contrast, SCB technical transfer was not straightforward, with significant differences observed between the two processes, 100% (SE) and 58% (PDR).This report underlines the importance of feedstock-specific pretreatment strategies to underpin process development, scale-up, and optimisation of carbohydrate release from biomass.

Инструменты финансового сопровождения научно-технологического трансфера

The issues of using financial support tools for technological entrepreneurship, both on the part of the university implementing acceleration programs to support scientific and technical projects, and on the part of the project team developing a startup from the idea stage are considered. The purpose of the study is to identify the specifics of financing scientific and technological transfer and identify areas of application of financial instruments in the field of technological entrepreneurship based on the analysis of sources of scientific literature and foreign practice. The objectives of the study are a review of scientific sources on the problems of financing scientific and technological transfer; assessment of the state of the regulatory framework for ensuring scientific and technological transfer; setting the problem of finding financial support for technological entrepreneurship from the university, using financial instruments to attract private capital, as well as determining the solution to it. The research methods were the bibliographic method for performing a literature review, statistical analysis based on the use of data from Rosstat of the Russian Federation, analysis, and synthesis of the subject area – financial support for scientific and technical transfer and visualization of the data obtained by graphical methods. The option for modifying the financial model of the university, structuring the levels of readiness of the investment project for technological entrepreneurship, selection of financial instruments for promoting the project at different stages of readiness are proposed.

Transferability of Technical Skills Across Robotic Surgery Platforms: A Scoping Review.

As the application of robotic approaches to surgery continues to broaden, new consoles have been introduced to the market. Due to the global utilization of a single platform, previously validated curricula have not been assessed on new robotic systems. Surgery by its nature occurs in a high-stakes environment, potentially exacerbated by non-standardized robotic systems. The aim of this review is to critique the evidence available regarding the transferability of technical skills across robotic platforms. A scoping review utilizing the Medline (Pubmed) and Cochrane Databases was conducted. Full texts were reviewed and appraised. Selected articles were eligible for inclusion if they investigated the ability or implications of the transfer of skill across robotic platforms. Data was extracted, coded inductively, and themes synthesized. NVIVO software was used as an adjunct for this qualitative analysis. Following the removal of duplicates a total of 278 papers were screened according to the eligibility criteria. Fifty full-text articles were reviewed and four met the criterion for inclusion. Novices' performance across platforms was comparable. Increasing levels of prior robotic experience revealed an improvement in technical performance on a novel robotic platform. Safety metrics appear comparable across systems. Quantifying learning curves across robotic platforms and their implications for the robotic surgeon in training remains to be determined. Future research needs to address the gaps in the literature by clearly defining the extent of technical skills transfer between robotic platforms. These factors will guide the next iteration of surgical training curriculums and regulations for robotic surgery.

Quality by Design Framework Applied to GMMA Purification

In recent years, Generalized Modules for Membrane Antigens (GMMA) have received increased attention as an innovative vaccine platform against bacterial pathogens, particularly attractive for low- and middle-income countries because of manufacturing simplicity. The assessment of critical quality attributes (CQAs), product-process interactions, identification of appropriate in process analytical methods, and process modeling is part of a robust quality by design (QbD) framework to support further development and control of manufacturing processes. QbD implementation in the context of the GMMA platform will ensure robust manufacturing of batches with desired characteristics, facilitating technical transfer to local manufacturers, regulatory approval, and commercialization of vaccines based on this technology. Here, we summarize the methodology suggested, applied to a first step of GMMA manufacturing process.Graphical

Supporting and Inhibiting Factors of Agricultural Extension Interpersonal Communication Competence in Enrekang Regency

Agricultural extension workers play an essential role in increasing shallot yields. They provide technical counseling, transfer knowledge and skills, and are involved in post-harvest monitoring, mentoring, and counseling. In addition, they also provide information about business development and marketing. Agricultural extension interpersonal communication competence plays a crucial role in efforts to increase shallot yields in Enrekang. With these competencies, agricultural extension agents can establish good relationships with farmers, understand their needs, and communicate effectively to transfer relevant knowledge and skills. Through effective interpersonal communication, agricultural extension workers can assist farmers in implementing proper cultivation practices, overcoming obstacles, providing motivation, and building collaboration between farmers and related parties. This article uses a qualitative descriptive methodology. The result showed that the agricultural extension interpersonal communication competence is outstanding and has a positive value for farmers in Enrekang Regency. Some farmers are still reluctant and indifferent to following directions from extension agents because they consider themselves quite experienced in farming.
 Keywords: agricultural extension, interpersonal communication, Enrekang

Qualification of the Microsatellite Instability Analysis (MSA) for Bladder Cancer Detection: The Technical Challenges of Concordance Analysis.

Bladder cancer (here we refer to transitional carcinoma of bladder) is a major cause of morbidity and mortality in the Western world, and recent understanding of its etiology, the molecular characteristics associated with its progression, renders bladder cancer an ideal candidate for screening. Cystoscopy is invasive and sometimes carries unwanted complications, but it is the gold standard for the detection of bladder cancer. Urine cytology, while the most commonly used test as an initial screening tool, is of limited value due to its low sensitivity, particularly for low-grade tumors. Several new "molecular assays" for the diagnosis of urothelial cancer have been developed over the last two decades. Here, we have established our new bladder cancer test based on an assay established for the Early Detection Research Network (EDRN) study. As a part of the study, a quality control CLIA/College of American Pathology (CAP) accredited laboratory, (QA Lab), University of Maryland Baltimore Biomarker Reference Laboratory (UMB-BRL), performed quality assurance analysis. Quality assurance measures included a concordance study between the testing laboratory (AIBioTech), also CLIA/CAP accredited, and the QA lab to ensure that the assay was performed and the results were analyzed in a consistent manner. Therefore, following the technical transfer and training of the microsatellite analysis assay to the UMB-BRL and prior to the initiation of analysis of the clinical samples by the testing lab, a series of qualification studies were performed. This report details the steps taken to ensure qualification of the assay and illustrates the technical challenges facing biomarker validation of this kind.

Laparoscopic but not open surgical skills can be transferred to robot-assisted surgery: A systematic review and meta-analysis.

With an increase in robot-assisted surgery across all specialties, adequate training and credentialing strategies need to be identified to ensure patients safety. The meta-analysis assesses the transferability of technical surgical skills between laparoscopic surgery, open surgery, and robot-assisted surgery. A systematic search was conducted in Medline, Cochrane Central Register of Controlled Trials, and Web of Science. Outcomes were categorized into time, process, product, and composite outcome measures and pooled separately using Hedges'g (standardized mean difference [SMD]). Subgroup analyses were performed to assess the effect of study design, virtual reality platforms and task difficulty. Out of 14,120 screened studies, 30 were included in the qualitative synthesis and 26 in the quantitative synthesis. Technical surgical skill transfer was demonstrated from laparoscopic to robot-assisted surgery (composite: SMD 0.40, 95%-confidence interval [CI] [0.19; 0.62], time: SMD 0.62, CI [0.33; 0.91]) and vice versa (composite: SMD 0.66, CI [0.33; 0.99], time [basic skills]: SMD 0.36, CI [0.01; 0.72]). No skill transfer was seen from open to robot-assisted surgery with limited available data. Technical surgical skills can be transferred from laparoscopic to robot-assisted surgery and vice versa. Robot-assisted and laparoscopic surgical skills training and credentialing should not be regarded separately, but a reasonable combination could shorten overall training times and increase efficiency. Previous experience in open surgery should not be considered as an imperative prerequisite for training in robot-assisted surgery. Recommendations for studies assessing skill transfer are proposed to increase comparability and significance of future studies. PROSPERO CRD42018104507.

Enhancing Blockchain Technology Platforms: Leveraging Artificial Intelligence for Optimal Support and Efficiency

Recently, the landscape of e-commerce has undergone a remarkable transformation, propelled by a sudden surge in blockchain technology. The traditional era of bank transactions was plagued by technical difficulties, transfer limitations, security breaches, and high transfer fees. However, blockchain technology, which utilizes a decentralized public database for storing and transferring funds via cryptocurrencies, has emerged as a promising solution. This literature review delves into the multifaceted challenges associated with blockchain technology and explores various works addressing these concerns. Additionally, this study investigates the potential of integrating artificial intelligence to tackle the obstacles faced by blockchain technology, paving the way for an even more efficient and secure e-commerce ecosystem.

Early safety and mid-term clinical outcomes of technology transfer of transcatheter aortic valve implantation in patients with severe aortic valve stenosis in Vietnam: a single-center experience of 90 patients

This study investigated the early safety and mid-term outcomes of stepwise implementation of transcatheter aortic valve implantation (TAVI) in Vietnamese patients with severe aortic stenosis (AS) at a single center, following the process of technical transfer. From 2017 to 2022, 90 patients with symptomatic severe AS underwent TAVI at a tertiary hospital in Vietnam. The first 30 cases received support for technology transfer from international proctors. One-year outcomes were evaluated using the Valve Academic Research Consortium-2 (VARC-2) criteria. Forty patients (45.5%) had bicuspid aortic valve (BAV). The Medtronic Evolut R/Pro self-expanding valve system was used in 98.9% of all cases, with a 29-mm valve being the most common. Device success was achieved in 95.6% of cases, whereas one procedural death occurred. At one year, four deaths (5.3%) occurred and all were in the BAV group. Other complications included stroke (2.8%), hospital readmission due to the valve or worsening heart failure (2.8%), permanent pacemaker implantation (9.9%), and moderate paravalvular leak (3.0%). The left ventricular ejection fraction and mean transvalvular gradient significantly improved after TAVI. There were no significant differences in procedural success and mortality when the proctor support period and the subsequent solo operator period were compared. TAVI procedure is safe for treating severe AS in Vietnamese patients, despite the high prevalence of BAV. The procedural complication rate was low, with promising outcomes at one year. These results also highlight the effectiveness of the TAVI technical transfer model in Vietnam. No funding was provided for this study.

Difference Between Corporate Logistics Management and Defense Logistics Management

Logistics Management basically starts from logistics management for war. To go to war, you must have good logistics management in order to win the war. Along with the times, logistics management has evolved to be used for a company. Against this background, the title of this study is the difference between corporate logistics management and defense logistics management. The research methodology used in this study is a literature review. The conclusion of this study is that Logistics management in companies with logistics management in defense has the same outline. Basically, logistics management focuses on maintenance planning, workforce and personnel, supply support, equipment support and testing, equipment training and education, technical documentation, computer facilities, contracts, negotiation and Transfer of Storage, Space, Stability and Maintenance. Meanwhile, logistics management in defense focuses on the main areas of logistics and supply chain management in the context of sustainability, inventory management, resilience, procurement, information systems and crisis response.

Does Mentoring Directly Improve Students’ Research Skills? Examining the Role of Information Literacy and Competency Development

This work proposes a structural model highlighting the research skills of undergraduate students. Due to the stages in their research project implementation, mentoring students becomes a crucial initiative in higher education institutions. Despite substantial progress in the literature linking mentoring and skills development, there is a lack of greater emphasis on research skills, especially for undergraduate students facing research work for the first time. Consequently, the direct relation between mentoring and research skills may not be straightforward. Thus, driven by social learning theory, the proposed model highlights the mediating effects of information literacy constructs and competency development on the relationship between mentoring and research skills. An empirical study of 539 participants via Partial Least Squares–Structural Equation Modeling supports six of the seven hypothesized paths. Three major theoretical contributions arise from the findings. Firstly, mentoring improves information-seeking skills and information-sharing behaviors and facilitates students’ competency development due to the technical knowledge transfer from the faculty mentor to student mentees. Secondly, information literacy constructs and competency development promote research skills, emphasizing that students with those behaviors and capacities will achieve enhanced research skills. Finally, our findings suggest that mentoring does not directly translate to improved research skills; instead, information-seeking and sharing behaviors and competency development fully mediate such a link. Thus, mentors must shape these behaviors for mentoring to develop students’ research skills. Theoretical and practical insights are outlined from these findings for university leadership to inform the design of mentoring initiatives for undergraduate students.

Fairness and feasibility in deep mitigation pathways with novel carbon dioxide removal considering institutional capacity to mitigate

Questions around the technical and political feasibility of deep mitigation scenarios assessed by the Intergovernmental Panel on Climate Change have increasingly been raised as have calls for more directly analyzing and incorporating aspects of justice and fairness. Simultaneously, models are increasing the technical representation of novel carbon-dioxide removal (CDR) approaches to provide policy-relevant analyses of mitigation portfolios in the context of the rising number of net-zero CO2 and GHG targets made by parties to the Paris Agreement. Still, in most cost-effective mitigation scenarios developed by integrated assessment models, a significant portion of mitigation is assumed to take place in developing regions. We address these intersecting questions through analyzing scenarios that include direct air capture of CO2 with storage (DACCS), a novel CDR technology that is not dependent on land potential and can be deployed widely, as well as regional variations in institutional capacity for mitigation based on country-level governance indicators. We find that including novel CDR and representations of institutional capacity can enhance both the feasibility and fairness of 2 °C and 1.5 °C high-overshoot scenarios, especially in the near term, with institutional capacity playing a stronger role than the presence of additional carbon removal methods. However, our results indicate that new CDR methods being studied by models are not likely to change regional mitigation outcomes of scenarios which achieve the 1.5 °C goal of the Paris Agreement. Thus, while engineered carbon removals like DACCS may play a significant role by midcentury, gross emissions reductions in mitigation pathways arriving at net-zero CO2 emissions in line with 1.5 °C do not substantially change. Our results highlight that further investment and development of novel CDR is critical for post-net-zero CO2 mitigation, but that equitable achievement of this milestone will need to arrive through technical and financial transfers, rather than by substantial carbon removals in developed countries before mid-century.

Role of capacity building, extension and services in tasar sector

Aim: To train manpower for disseminating the technologies to the grassroots level stakeholders and facilitate to replicate the successful model of sericulture practice developed in tasar sector. Methodology: Central Tasar Research and Training Institute (CTRTI), Ranchi organizes different training programmes for the benefit of various stakeholders of the industry. These programmes are tailor-made to meet the specific needs of each sector and of immense help in updating the knowledge and skills of the extension personnel and sericulturists, through Field Day, Farmers Day, Technology Demonstration, Awareness Programme, Group Discussion and Farmers Meet / Krishi Mela, etc., which are the major platforms of ECPs providing technical support and transfer of technologies developed by CTRTI. Results: For the purpose, different training programmes were organized in last five years (2017-2022) from time to time by CTRTI and approximately 6753 persons were trained in different subsectors of sericulture through training programmes like: Structured Training Course (PGDS-Vanya Silk), Farmers Skill Training, Exposure visit for Technology Awareness, Technology Orientation Programme for the frontline officers / officials of DOS/NGO/ Lead farmers /student / project work on microbiology/biotechnology, etc., Seri Resource Centre (SRC),Competency Enhancement Training Programme (CETP), Training under Post Cocoon Sector, Lab-to-land demonstration, Establishment of BIOTECH-KISAN Hub. Skilling the farmers involving KVKs for expansion of tasar through training of the KVK Scientists under ICAR & nurtured Community Resource Persons (CRPs) under aegis of Producer Institutions. Interpretation: With the new developments taking place in the field of sericulture, the training and development activity is considered as a necessity by all forward-looking organizations both national and international for updating the knowledge and skill, and hence training needs will continue to perpetuate at all levels of silk industry world wide. To achieve the potential productivity levels, strategies are suggested for a viable effective extension system in the country in general and orthwest region, in particular. Key words: Alternate extension organizations, Capacity building and training and silk production, Extension, Productivity potential, Tasar culture

Cross-Sectional 4D-Printing: Upscaling Self-Shaping Structures with Differentiated Material Properties Inspired by the Large-Flowered Butterwort (Pinguicula grandiflora).

Extrusion-based 4D-printing, which is an emerging field within additive manufacturing, has enabled the technical transfer of bioinspired self-shaping mechanisms by emulating the functional morphology of motile plant structures (e.g., leaves, petals, capsules). However, restricted by the layer-by-layer extrusion process, much of the resulting works are simplified abstractions of the pinecone scale's bilayer structure. This paper presents a new method of 4D-printing by rotating the printed axis of the bilayers, which enables the design and fabrication of self-shaping monomaterial systems in cross sections. This research introduces a computational workflow for programming, simulating, and 4D-printing differentiated cross sections with multilayered mechanical properties. Taking inspiration from the large-flowered butterwort (Pinguicula grandiflora), which shows the formation of depressions on its trap leaves upon contact with prey, we investigate the depression formation of bioinspired 4D-printed test structures by varying each depth layer. Cross-sectional 4D-printing expands the design space of bioinspired bilayer mechanisms beyond the XY plane, allows more control in tuning their self-shaping properties, and paves the way toward large-scale 4D-printed structures with high-resolution programmability.

Fluid flow analysis of the lattice-based ceramic filters in molten metal filter application

The ceramic lattice filters are ideal for various technical applications, including filtration, flow stability, and heat transfer, that could alter the transport characteristics like pressure, permeability, and velocity. The authors presented a computational study based on the fluid flow parameters for four struts-based lattice structures in this work. This study includes seven designs of four struts-based lattice structures systematically created with 30 pores per inch (PPI) and 80% porosity while varying the unit cell sizes and strut diameter. The present computational study has been carried out using the turbulent k-epsilon (k-ε) model with the chosen metal alloy, IN718. The efficacy of the lattice filters has been determined by visualizing the physical parameters like pressure drop and velocity distribution patterns inside the filters. This study concludes that the BCC and the Diamond lattice structures have outperformed the other designs. Moreover, the effects of the variation in the unit cell and strut size have been evaluated for different structures and discussed.

Technical transfer of a rapid microbial platform for vaccine production

Technical transfer of a rapid microbial platform for vaccine production

International tourism and business productivity: does eco-friendly technologies matter?

This research is aimed at determining whether eco-friendly technologies go beyond and above in providing business productivity in international tourism. For this, the study obtained data from different databases, and this data range consisted of 2010-2020. The study applied the co-integration analysis, random and static technique, regression analysis technique, split analysis technique, and mediating effect tests on Chinese data. This research shows that tourism business innovation contributed 12%, value proposition as 9%, internal marketing as 16%, customer relationship management as 19.3%, tourists motivation as 34.05%, tourists time as 18.94%, green technological adoption as 17.3%, tourists visit intention as 8.11%, and green technical transfer as 28.1% in study model. Thus, the findings confirmed that international tourism and business productivity have a dynamic empirical nexus with the mediating role of eco-friendly technology adoption. Furthermore, such findings are robust empirically and validate the empirical connections among the study variables. These results imply that Chinese tourism industry stakeholders may use eco-friendly technologies to good effect, significantly enhancing tourism business productivity, international tourists' satisfaction, and tourists' revisit intentions. Hence, the study also directs practical implications related to the study topicality and China's tourism industry for prudent growth acquisition.