This article reviews, integrates, and expands upon research initiatives that explore the development and implementation of advanced artificial intelligence (AI)–driven tools and methodologies. In exploring collaborations with leading U.S. AI technology firms, including Nvidia, Dataiku, DataRobot, and C3.ai, this study is specifically aimed at identifying, preventing, and combating human trafficking. This collaborative effort seeks to create a synergistic framework that capitalizes on the unique capabilities and resources of each firm. The overarching goal is to enhance the effectiveness of AI technologies in detecting trafficking activities, analyzing diverse data sources, and providing vital support to law enforcement and NGOs in rescue and prevention efforts. The comprehensive review delves into the multifaceted applications of AI, emphasizing its role in prevention through machine learning, data analytics, and natural language processing. It navigates through collaborative initiatives, presenting partnerships with prominent U.S. tech firms, accompanied by case studies that showcase successful collaborative projects. Challenges inherent in collaborative AI efforts are addressed, and the paper proposes strategic solutions to overcome these obstacles. The ethical and legal considerations section scrutinizes the implications of deploying AI in human trafficking prevention, exploring the delicate balance between innovation and safeguarding privacy and civil liberties. Furthermore, the final section anticipates future directions and recommendations, providing insights into emerging technologies that could enhance anti-trafficking efforts. Specific recommendations are offered for fortifying collaborations between AI developers and tech firms, and the paper discusses broader implications for policy, suggesting avenues for future research in the dynamic field of AI-driven human trafficking prevention. In essence, this comprehensive review not only synthesizes existing knowledge but also integrates a forward-looking research initiative, contributing significantly to the ongoing discourse on leveraging technology to combat human trafficking on a global scale.