This study aims to test the feasibility level of HOTS-Based Communication and Business Negotiation teaching materials in learning. The method used in this research is the R&D method using a 4D model with 4 stages, namely define, design, develop and disseminate. The population in this study was the fourth semester students of the Unimed FE Business Education Study Program. Data collection techniques used observations and questionnaires with research instruments in the form of validation sheets for expert assessments and student response questionnaires. This research activity begins with a preliminary study by conducting interviews with the Head of the Study Program and the course lecturers. Then the design and development is carried out by analyzing the RPS and learning outcomes of graduates, collecting reference sources and compiling drafts of teaching materials. The next stage is to evaluate the product by conducting a limited trial, revising the product and then carrying out data processing and evaluation. Based on the practicality test, it can be seen that the HOTS-Based Communication and Business Negotiation Textbook is very practical to use, it can be seen from 92% of respondents stating that the HOTS-Based Communication and Business Negotiation Textbook is very practical to use, 8% said it was practical and there were no respondents who say that the book is impractical or impractical. There is an effect of using HOTS-Based Communication and Business Negotiation teaching materials on student learning outcomes in the Business Education study program, Faculty of Economics, State University of Medan. Increasing and the correlation value between the pre-test and post-test was 0.947 at a significance level of 0.000<0.005.