Target Irradiation Research Articles

Encapsulation of Photothermal Nanoparticles in Stealth and pH-Responsive Micelles for Eradication of Infectious Biofilms In Vitro and In Vivo.

Photothermal nanoparticles can be used for non-antibiotic-based eradication of infectious biofilms, but this may cause collateral damage to tissue surrounding an infection site. In order to prevent collateral tissue damage, we encapsulated photothermal polydopamine-nanoparticles (PDA-NPs) in mixed shell polymeric micelles, composed of stealth polyethylene glycol (PEG) and pH-sensitive poly(β-amino ester) (PAE). To achieve encapsulation, PDA-NPs were made hydrophobic by electrostatic binding of indocyanine green (ICG). Coupling of ICG enhanced the photothermal conversion efficacy of PDA-NPs from 33% to 47%. Photothermal conversion was not affected by micellar encapsulation. No cytotoxicity or hemolytic effects of PEG-PAE encapsulated PDA-ICG-NPs were observed. PEG-PAE encapsulated PDA-ICG-NPs showed good penetration and accumulation in a Staphylococcus aureus biofilm. Penetration and accumulation were absent when nanoparticles were encapsulated in PEG-micelles without a pH-responsive moiety. PDA-ICG-NPs encapsulated in PEG-PAE-micelles found their way through the blood circulation to a sub-cutaneous infection site after tail-vein injection in mice, yielding faster eradication of infections upon near-infrared (NIR) irradiation than could be achieved after encapsulation in PEG-micelles. Moreover, staphylococcal counts in surrounding tissue were reduced facilitating faster wound healing. Thus, the combined effect of targeting and localized NIR irradiation prevented collateral tissue damage while eradicating an infectious biofilm.

Improved separation scheme for 44Sc produced by irradiation of natCa targets with 12.8 MeV protons

Introduction44Sc is of great interest as a positron emission tomography (PET) radionuclide due to its suitable nuclear characteristics: Eβ+max = 1.47 MeV, branching ratio 94.3% and convenient half-life of 3.97 h. Here, 44Sc was produced via the widely used reaction 44Ca (p,n)44Sc using natural calcium as a target. MethodsThe irradiation was performed at TRIUMF using the 13 MeV cyclotron. The separation consisted of a combination of DGA branched resin and Dowex 50Wx8 (200–400 mesh). The distribution coefficients of Sc3+ on Dowex 50Wx8 (NH4+ form, 200–400 mesh) with ammonium α-hydroxyisobutyrate (pH = 4.8) medium were determined in this study. Results and conclusionThe tested scheme allows both a reliable separation of 44Sc from the target material as well as from the other competitive metals and a final fraction with high specific activity. The achieved radiochemical yield was 95 ± 3%.

Features of ion generation by a picosecond laser in the range of 1011–1013 W cm−2 power densities

Picosecond lasers (ps-lasers) have significant advantages for the generation of low charge state ions compared to nanosecond lasers because the influence of heat conductivity on a solid target is almost negligible in the case of ps-laser ablation for laser pulse durations less than 10 ps. However, there is no comprehensive data on ion yields for different elements and target irradiation conditions for laser power densities at the target surface around and below 1013 W cm−2, which is of interest to our study of such plasmas as a source of low charge state ions for various applications, particularly for external injection of those ions into an Electron Beam Ion Source (EBIS). We investigated ion generation from Al, Ti, Cu, Nb and Ta target elements by a ps-laser with power densities in the range of 1011–1013 W cm−2 at the target surface. A ps-laser with 1.27 mJ maximum energy within an 8 ps pulse and repetition rate up to 400 Hz has been used to generate a laser-ablated plasma. Dependencies of ion current versus time, total charge of registered ions as well as ion kinetic energy distributions are characterized using a Faraday cup. Significant difference in ion current dynamics between first, second and following shots onto the same target spot was found for all five target elements. The total charge of ions registered by the Faraday cup increases linearly with increasing laser pulse energy and is almost independent of the target element and number of shots onto the same target spot for all five target elements studied. The results obtained give us a basis for specification and design of the source of low charge state ions for external injection into EBIS.

Analysis of electromagnetic pulses generated from ultrashort laser irradiation of solid targets at CLAPA

Electromagnetic pulses (EMPs) produced by the interaction of a TW femtosecond laser with solid targets at the Compact Laser Plasma Accelerator (CLAPA) are measured and interpreted. The statistical results confirm that the intensities of the EMPs are closely related to both target material and thickness. The signal of the titanium target is more abundant than that of the copper target with the same thickness, and the intensity of EMP is positively correlated with the target thickness for aluminium foil. With the boosted EMP radiations, the energy of accelerated protons is also simultaneously enhanced. In addition, EMPs emitted from the front of the target exceed those from the rear, which are also pertinent to the specific target position. The resonant waveforms in the target chamber are analyzed using the fast Fourier transform, and the local resonance and the attenuation lead to changes of the frequency spectra of EMPs with variation of detecting positions, which is well supported by the modeling results. The findings are beneficial to gaining insight into the mechanism of EMP propagation in a typical target chamber and providing more information for EMP shielding design.

Comparative study of plume characteristics of polymeric propellants filled with different oxides for laser-electric hybrid thruster

Laser-electric hybrid thrusters have attracted increasing attention as a new concept for space propulsion systems because of their low weight, high propulsion performance, and controllable thrust. When the thruster works, the laser-ablation plasma induced by the laser irradiation of a solid target is additionally accelerated by electrical means in the discharge chamber, generating thrust. Therefore, a stable and continuous ablation plume is required to ensure the subsequent electromagnetic acceleration process. This study compared and analyzed the plume characteristics of polymeric propellants doped with different oxides under the same operating conditions. The plume images were examined using an ultrahigh-speed camera, and the plume length, expanding velocity, plume area, and normalized intensity distribution were collected from the plume images based on the image processing method. The results illustrated that the CuO dopant contributed to the rapid, stable, and massive formation of the ablation plume, and VO2 could make the plume have a certain distance from the ablation surface, and then reduce the particle reflux deposition effect to a certain extent. It was also found that the samples doped with CuO, NiO, and Fe2O3 generated a micro cluster with a duration of about 0.5 ms at the beginning of ablation, while the sample doped with VO2 did not generate such a cluster. There were two regions of high-intensity light in the plumes of the samples doped with CuO and VO2. Furthermore, the plume areas of the samples doped with NiO, VO2, and Fe2O3 experienced a quiescence of approximately 2 ms before rapid growth, while that of CuO continued to increase steadily.

Methods for extremely sparse-angle proton tomography.

Proton radiography is a widely fielded diagnostic used to measure magnetic structures in plasma. The deflection of protons with multi-MeV kinetic energy by the magnetic fields is used to infer their path-integrated field strength. Here the use of tomographic methods is proposed for the first time to lift the degeneracy inherent in these path-integrated measurements, allowing full reconstruction of spatially resolved magnetic field structures in three dimensions. Two techniques are proposed which improve the performance of tomographic reconstruction algorithms in cases with severely limited numbers of available probe beams, as is the case in laser-plasma interaction experiments where the probes are created by short, high-power laser pulse irradiation of secondary foil targets. A new configuration allowing production of more proton beams from a single short laser pulse is also presented and proposed for use in tandem with these analytical advancements.

Hydrodynamic simulation of laser-induced shock waves using the Turbulence Problem Solver software package

The problem of irradiation of a semi-infinite bulk metal target by a single laser pulse, being important for many lase technology applications, is considered. The model for simulating the propagation and attenuation of shock waves, occurring when metals are irradiated with single laser pulse, is presented. The paper describes the computational algorithm based on the model and features of its implementation in C++ in a software package Turbulence Problem Solver (TPS) for modeling a wide class of problems described by hyperbolic equations. The problem is modeled using different approaches and the results are compared. The object-oriented polymorphic architecture of the software complex accelerates and facilitates the process of model development and calibration, allowing for flexible configuration and combination of elements of numerical models: Riemann solvers, various types of and reconstructions, and equations of state of matter.

Markerless 3D tumor tracking during single-fraction free-breathing 10MV flattening-filter-free stereotactic lung radiotherapy

Background and purposePositional verification during single fraction lung SBRT could increase confidence and reduce the chance of geographic miss. As planar 2DkV imaging during VMAT irradiation is already available on current linear accelerators, markerless tracking based on these images could offer widely available and low-cost verification. We evaluated treatment delivery data and template matching and triangulation for 3D-positional verification during free-breathing, single fraction (34 Gy), 10 MV flattening-filter-free VMAT lung SBRT. Methods and materialsTumor tracking based on kV imaging at 7 frames/second was performed during irradiation in 6 consecutive patients (7 lesions). Tumor characteristics, tracking ability, comparison of tracking displacements with CBCT-based shifts, tumor position relative to the PTV margin, and treatment times are reported. ResultsFor all 7 lesions combined, 3D tumor position could be determined for, on average, 71% (51–84%) of the total irradiation time. Visually estimated tracked and automated match +/− manually-corrected CBCT-derived displacements generally agreed within 1 mm. During the tracked period, the longitudinal, lateral and vertical position of the tumor was within a 5 mm/3 mm PTV margin 95.5/85.3% of the time. The PTV was derived from the ITV including all tumor motion. The total time from first set-up imaging to end of the last arc was 18.3–31.4 min (mean = 23.4, SD = 4.1). Conclusion3D positional verification during irradiation of small lung targets with limited motion, was feasible. However, tumor position could not be determined for on average 29% of the time. Improvements are needed. Margin reduction may be feasible. Imaging and delivery of a single 34 Gy fraction was fast.

Production and measurement of fission product noble gases

Gaseous fission products have been produced via thermal neutron irradiation of a highly-enriched uranium target and extracted using a custom gas processing system for measurement on a prototype, high-resolution β − γ coincidence detection system. The gas was extracted and measured in two stages in order to measure the prompt and β−–delayed fission products. This paper presents an overview of the system used to produce gaseous fission products, and the results of the advanced coincidence spectrometry techniques used to identify and quantify decays from the radionuclides produced, including the noble gases 85Kr, 85mKr, 88Kr, 133Xe, 135Xe, 133mXe and 135mXe, as well as 133I and 88Rb. The measurements were validated by determination of the nuclear decay half-lives, specifically for the ground state decay of 135Xe, which was found to be 9.15(49) hours and consistent with the literature value. This work demonstrates the UK capability to produce gaseous radionuclides for quality assurance and calibration purposes in Radionuclide Laboratories supporting the Comprehensive Nuclear-Test-Ban Treaty (CTBT).

Duration and distance of a laser-driven shock wave formation in a plasma with subcritical density

Theory and computational results are presented through the generation and propagation of a plane laser-driven shock wave in a substance with a density less than the critical plasma density. A model of the phenomenon is developed, the essence of which consists in the formation of pressure behind the front of the laser-driven ionization wave, which provides hydrodynamic motion with the speed exceeding the speed of the ionization wave front and the sound speed in unperturbed matter ahead of it. The dependences of the duration and distance of shock wave formation on the intensity and radiation wavelength of the impacting laser pulse, as well as on the density of the target substance, are established. The results are discussed for the conditions of irradiation of targets with a density up to 0.1 mg cm−3 by a pulse of short-wavelength radiation of the first–third harmonics of the Nd laser with an intensity of 1012−1015 W cm−2.

Freeform beam splitting system design for generating an array of identical sub-beams.

Laser beam splitting by freeform optics is promising but less studied. Instead of directly forming a target spot array, we propose to first convert the input beam into a closely connected Gaussian sub-beam array. All the Gaussian sub-beams have the same optical field distributions which thus can produce identical discrete spots on the target plane. Such a design concept is very beneficial to ensure the consistency for laser processing. Importantly, the introduction of an intermediate Gaussian sub-beam array can reduce diffraction effects when the size of each Gaussian sub-beam is sufficiently larger than that of the corresponding sub-area within the input beam. The desired transformation can be achieved by two typical systems. The first system consists of two plano-freeform lenses. The second system is composed of a plano-freeform lens and a lens with an entrance freeform surface and an exit surface of freeform lens array. The two freeform beam splitting systems can be determined based on appropriate ray mappings among the input, intermediate and target irradiance distributions and a subsequent double-surface construction. Geometrical and physical simulations verify the effectivenesses of the two beam splitting systems.

Manufacturing LEU-foil annular target in Brazil

Molybdenum-99 is the most important isotope because its daughter isotope, technetium-99m, has been the most used medical radioisotope. The primary method used to produce Mo-99 derives from the fission of U-235 incorporated in so-called irradiation targets. Two routes are being developed to make Mo-99 by fissioning with low enriched uranium (LEU) fuel. The first adopts UAlx-Al dispersion plate targets. The second uses uranium metal foil annular targets. The significant advantage of uranium foil targets over UAlx-Al dispersion targets is the high density of uranium metal. This work presents the experience obtained in the development of the uranium metal annular target manufacturing steps. An innovative method to improve the procedure for assembling the uranium foil on the tubular target was presented. The experience attained will help the future production of Mo-99 in Brazil through the target irradiation in the Brazilian Multipurpose Reactor (RMB).

System of fibre-optic smoothing of laser radiation on the Luch laser facility

A front end system with spatiotemporal smoothing based on the use of multimode optical fibre has been developed on the Luch laser. The system consists of a broadband master oscillator, a smoothing fibre, preamplifiers, and subsystems for the formation of temporal and spatial radiation profile. The processes of generation of partially coherent radiation, its amplification and conversion into the second harmonic are experimentally investigated. At the amplifying channel output, the pulse energy of the first harmonic reaches up to 1200 J with a pulse duration of 4 ns; the technical coefficient of radiation conversion to the second harmonic is up to 44%, and the beam divergence is 0.2 – 0.25 mrad. When using smoothed radiation, the speckled structure in the far field is almost completely eliminated: the small-scale inhomogeneity of the target irradiation, integrated over the pulse time, is reduced by 1 – 2 orders of magnitude compared to unsmoothed radiation.

Integrable solution for light shaping based on a Fourier-pair mapping

In far-field light shaping, one of the design methods is based on a one-to-one map between the irradiance of the source and target. However, an integrability issue may occur in this kind of algorithms, either in the ray mapping method for designing a freeform surface or in those geometric-optics-based methods for achieving a required output phase. We introduce another mapping-type algorithm to tackle the integrability problem, which instead of establishing a mapping between both the source and target irradiance in the space domain, the mapping is assumed on electric fields of a Fourier pair between the space domain and the spatial-frequency domain. By solving the mapping from the Fourier pair, the gradient of the output phase is achieved, that the gradient is equivalent to the obtained mapping function. Moreover, the existence and the characterization of the mapping guarantees the integrability of the gradient so that a smooth output phase can be directly integrated. Based on the obtained smooth output phase, a freeform surface can then be designed for the light-shaping task. Numerical examples are demonstrated for the comparison of the approaches with different mapping assumptions.

Radioisotope research and development at the Linear Accelerator of the Institute for Nuclear Research of RAS

Radioisotope research at the linear accelerator of INR RAS has been developing since 1989. In 1992, a facility for the irradiation of isotope targets and radioisotope production was built, operating on a diverted proton beam with an energy of 160 MeV and a current of more than 120 μA, which was the most productive facility in the world at that time. The facility is used for both fundamental and applied research. The main focus is the study of the processes of the generation and recovery of medical radioisotopes, as well as the development of technology for their production. The main radionuclides produced now are strontium-82 and actinium-225. A Russian 82 Sr/82 Rb generator for PET-diagnostics has been developed by INR RAS and is being introduced for medicine. New types of 225Ac/213Bi generators are also being developed for the treatment of oncological diseases. In addition, the study of the process for the production and chemical recovery of medical radionuclides 117mSn, 68 Ge, 72Se, 64, 67Cu, 223Ra, 230 Pa, and 230U is being carried out, as is the study of some generators with some of these isotopes. The technology developed at INR is used in Russia and abroad. Physical processes of proton interaction with different nuclei are also investigated in the laboratory of the radioisotope complex of INR RAS. The produced 22Na, 83Rb, 109Cd, and radioactive sources with these radionuclides are used in physical research and technology.

Characterization of angularly resolved EUV emission from 2-µm-wavelength laser-driven Sn plasmas using preformed liquid disk targets

The emission properties of tin plasmas, produced by the irradiation of preformed liquid tin targets by several-ns-long 2 µm-wavelength laser pulses, are studied in the extreme ultraviolet (EUV) regime. In a two-pulse scheme, a pre-pulse laser is first used to deform tin microdroplets into thin, extended disks before the main (2 µm) pulse creates the EUV-emitting plasma. Irradiating 30- to 300 µm-diameter targets with 2 µm laser pulses, we find that the efficiency in creating EUV light around 13.5 nm follows the fraction of laser light that overlaps with the target. Next, the effects of a change in 2 µm drive laser intensity (0.6–1.8 × 1011 W cm−2) and pulse duration (3.7–7.4 ns) are studied. It is found that the angular dependence of the emission of light within a 2% bandwidth around 13.5 nm and within the backward 2π hemisphere around the incoming laser beam is almost independent of intensity and duration of the 2 µm drive laser. With increasing target diameter, the emission in this 2% bandwidth becomes increasingly anisotropic, with a greater fraction of light being emitted into the hemisphere of the incoming laser beam. For direct comparison, a similar set of experiments is performed with a 1 µm-wavelength drive laser. Emission spectra, recorded in a 5.5–25.5 nm wavelength range, show significant self-absorption of light around 13.5 nm in the 1 µm case, while in the 2 µm case only an opacity-related broadening of the spectral feature at 13.5 nm is observed. This work demonstrates the enhanced capabilities and performance of 2 µm-driven plasmas produced from disk targets when compared to 1 µm-driven plasmas, providing strong motivation for the use of 2 µm lasers as drive lasers in future high-power sources of EUV light.

(Invited) Facile Formation of Luminescent Colloidal Silicon Quantum Dots from Porous Silicon

Silicon quantum dot is nanometer sized single crystalline silicon particles. It shows exotic luminescence properties such as size tuneablilty of luminescence band and quasi-direct electron-hole recombination resulting in efficient visible luminescence at room temperature, due to quantum confinement effects. Because of its environmental friendliness and low cost, the silicon quantum dot is a promising material for future light-emitting applications. Recently, a free-standing form of silicon quantum dot dispersed in solution, i.e., colloidal silicon quantum dots are intensively investigated due to their potential usefulness in solution based light emitting technology. The luminescence properties and solution dispersibility in silicon quantum dots are known to depend on the surface properties such as the coverage of surface termination and the kinds of surface terminated species.Various formation techniques for colloidal silicon quantum dot have been proposed, such as wet-chemical synthesis, plasma synthesis and high-temperature thermal processing. Pulsed-laser irradiation in liquid is one of the simplest top-down method for the formation of colloidal silicon quantum dots. By irradiating bulk crystalline silicon target with a high power pulsed-laser beam in liquid, silicon quantum dots are easily formed due to the ablation of silicon crystal and resultant condensation effect of ablated silicon at the liquid interface. An additional merit of this process is the easiness of surface termination control; because the nanocrystal surface formed by laser ablation actively reacts with molecules consisting of solution, one can control the surface termination by changing the kinds of solution. However, the control of the formed quantum dot size is still a challenging work and the size distribution of the quantum dots prepared by this process is usually wide.To overcome these issues, we developed a novel top-down pulsed laser irradiation technique for the formation of colloidal silicon quantum dots. We used an interconnected wire-nanostructure assembly, i.e., porous silicon (PSi), as a target material for the laser irradiation process, on behalf of bulk crystalline silicon target. PSi has beneficial properties for laser irradiation target such as low thermal conductivity and large surface areas. Because of these properties, the pulsed-laser irradiation of PSi target in organic solution allows us to generate the silicon quantum dots with relatively high preparation yields, and with various emission bands by changing irradiation conditions and the porosity of PSi. Furthermore, in our developed process, the formed dots are brighter than the original PSi target due to the stable organic terminations.Recently, we further improved our developed facile formation process of luminescent colloidal silicon quantum dots via porous silicon target. In the improved process, we employed electrochemically prepared PSi flakes, which purely consists of porous layer. The PSi flakes show extremely low thermal conductivity and heat capacity due to their intrinsic geometrical feature. Thus, even a low temperature thermal treatment as well as pulsed laser irradiation to PSi flakes in organic solution are efficiently converted porous silicon layer to colloidal silicon quantum dots. Furthermore, we succeeded in preparing silicon quantum dots dispersed in a polar and non-polar solvent depending on the ligands terminated on the dot surface by using different solutions. The present facile formation process of silicon quantum dots from PSi allows us to develop future top-down and low-cost mass production of luminescent colloidal silicon quantum dots.

Commissioning of a clinical pencil beam scanning proton therapy unit for ultra‐high dose rates (FLASH)

The purpose of this work was to provide a flexible platform for FLASH research with protons by adapting a former clinical pencil beam scanning gantry to irradiations with ultra-high dose rates. PSI Gantry 1 treated patients until December 2018. We optimized the beamline parameters to transport the 250MeV beam extracted from the PSI COMET accelerator to the treatment room, maximizing the transmission of beam intensity to the sample. We characterized a dose monitor on the gantry to ensure good control of the dose, delivered in spot-scanning mode. We characterized the beam for different dose rates and field sizes for transmission irradiations. We explored scanning possibilities in order to enable conformal irradiations or transmission irradiations of large targets (with transverse scanning). We achieved a transmission of 86% from the cyclotron to the treatment room. We reached a peak dose rate of 9000Gy/s at 3mm water equivalent depth, along the central axis of a single pencil beam. Field sizes of up to 5×5mm2 were achieved for single-spot FLASH irradiations. Fast transverse scanning allowed to cover a field of 16×1.2cm2 . With the use of a nozzle-mounted range shifter, we are able to span depths in water ranging from 19.6 to 37.9cm. Various dose levels were delivered with precision within less than 1%. We have realized a proton FLASH irradiation setup able to investigate continuously a wide dose rate spectrum, from 1 to 9000Gy/s in single-spot irradiation as well as in the pencil beam scanning mode. As such, we have developed a versatile test bench for FLASH research.

Characteristics of very high-energy electron beams for the irradiation of deep-seated targets.

Driven by advances in accelerator technology and the potential of exploiting the FLASH effect for the treatment of deep-seated targets (>5cm), there is an active interest in the construction of devices to deliver very high-energy electron (VHEE) beams for radiation therapy. The application of novel VHEE devices, however, requires an assessment of the tradeoffs between the different beam parameter choices including beam energies, beam divergences, and maximal field sizes. This study systematically examines the dosimetric beam properties of VHEE beams, determining their clinical usefulness while marking their limits of applications for different beam configurations. We performed Monte Carlo simulations of the dose distributions of electron beams for different energies (25-250MeV), source-to-surface distances (SSD) (50cm, 100cm, parallel), and field sizes (2cm2 ×2cm2 to 15cm2 ×15cm2 ) in water using a research version of the RayStation treatment planning system (RaySearch Labs 9A IONPG). The beam was simulated using a monoenergetic point source and perfect collimation. Central axis percentage depth dose (PDD) and transverse dose profiles at multiple depths were evaluated and compared to those of MV photon beams. Profile characteristics including therapeutic range (TR) at 90%, proximal fall-off (PFO) at 90%, lateral penumbra (LP) at 90%-10%, and field width (FW) at 90% were obtained. Very high-energy electrons beams with SSD 100cm and parallel beams (infinite SSD) exhibit a linear to near-linear increase of TR as a function of energy in the simulated energy range and reach values well beyond the typical depths of lesions encountered in clinics (<20cm). Their TR show a marked field size dependence only for field sizes <10cm2 ×10cm2 . For VHEE beams with SSD 50cm, TR are largely reduced (4-8cm). For beam energies >150MeV with large SSD (>100cm), for many configurations, there is no substantial difference in PDD when adding an opposed beam. This may potentially reduce the number of VHEE beams needed for treatment by a factor of two compared to a treatment using lower energies and lower SSD. In order to cover deep-seated targets homogeneously, VHEE devices with a parallel beam must provide a maximum field size up to several centimeters larger than the tumor size. For the investigated diverging beams, there is not such a significant field width reduction with depth for larger fields as it is compensated by divergence. Penumbrae of VHEE beams are smaller than those of clinical MV photon beams for lower depths (<5cm) but increase quickly for larger depths. There is only a relatively small dependence of penumbra on the SSD of the beam. The findings presented in this study assess the performance of VHEE beams and offer a first estimate of treatment indications and tradeoffs for a given design of a VHEE device. SSD >100cm results in clinically more favorable PDD. Beam energies of 100MeV and above are needed to cover common tumors (5-15cm in-depth) conformally. Higher energies provide an additional benefit specifically for small and deep-seated lesions due to their reduced lateral penumbrae.

UV-C LED를 이용한 유수살균장치의 자외선 조사량 및 균일도 개선을 위한 광학계 설계 연구

This paper carried out the study of optical system design which can increase the irradiation volume and uniformity of UV LED lamp used in oil-water sterilization device. Sterilizing devices that use LEDs have lower output than UV lamps, making it difficult to sterilize running water as they require a long time to reach the target amount of irradiation. In addition, Cytop, a material used in optical design, has a high transmittance at 275 nm, but the high price range requires minimum volume in optical design. To solve these problems, the volume of the optical system was minimized. In addition, optical system design of sterilizing device was carried out to satisfy target irradiation quantity and have high illumination intensity uniformity. Finally, the design was verified by applying the optical system designed to the actual sterilization environment to carry out the simulation and analyzing the amount of irradiation and uniformity accordingly.