Promoting the organic integration of innovation and entrepreneurship education and professional education is not only the objective requirement for the cultivation of innovative talents in Colleges and Universities, but also the realistic challenge for the reform and development of colleges and universities. On the basis of elaborating the necessity of the integration of the innovation and entrepreneurship education and professional education, this thesis analyzes the main problems which separate from professional education in the process of implementing the innovation and entrepreneurship education in Colleges and Universities, and puts forward some measures for realizing the close integration of the innovation and entrepreneurship education and professional education.