Tablets Research Articles

The Role of Tablets in the Development of a Bilingual Case in a Monolingual Society

The Role of Tablets in the Development of a Bilingual Case in a Monolingual Society

A Randomized, Open, Single-Centre, Crossed Study of the Effect of Food on the Pharmacokinetics of One Oral Dose of Alflutinib Mesylate Tablets (AST2818) in Healthy Male Subjects.

The aim of the study was to study the PK of AST2818 tablets after one oral dose in healthy male subjects on an empty stomach and in a postprandial state and to evaluate the effect of food on AST2818 bioavailability. Sixteen healthy Chinese male subjects were randomly divided into two groups: a fasting-postprandial group and a postprandial-fasting group. The drug was administered once per evaluation at a dose of 80 mg, with an interval of 22 days between the two treatments. The LC-MS/MS method was used to determine the concentrations of AST2818 and its metabolite AST5902. Plasma pharmacokinetic parameters were calculated by noncompartmental analysis (NCA). WinNonlin® version 7.0 was used to analyse PK parameters, and SAS version 9.4 was used for statistical analyses. After a meal, the peak concentration of alflutinib increased by approximately 53%, and the AUC increased by approximately 32%; The peak concentration of its metabolite AST5902 decreased by approximately 20%, and the AUC decreased by approximately 8%. There was no significant change in peak time. The peak AST5902 concentration and AUC0-∞ were 27.4% and 71.4%, respectively, of that of alflutinib. None of the subjects experienced serious AEs, and both fasting and high-fat meal administration were safe. There was no statistically significant difference between groups in AEs (P = 0.102, RR = 1.40) or adverse reactions (P = 0.180, RR = 1.30). The effects of food may not need to be considered for the clinical use of alflutinib. No serious AEs occurred, and drug administration was safe and tolerable after fasting or a high-fat meal.

A new therapeutic approach for the Dry Eye Syndrome in patients with laryngopharyngeal reflux: first data.

Laryngopharyngeal reflux (LPR) is a common disorder. Pepsin has been detected also at eye level, this was a starting point for newest theories about LPR impact on Dry Eye Syndrome. The current preliminary study compared two treatments in patients with Dry Eye Syndrome and LPR. Patients were treated with Gastroftal eye drops and Gastroftal tablets or hyaluronic acid eye drops for 3 months. The following parameters were evaluated: Ocular Surface Disease Index (OSDI), OSDI categories, Reflux Symptom Index (RSI), Reflux Finding Score (RFS), Fluorescein Tear Breakup Time (B-TUT), and Schirmer test before and after treatment. On the whole, 21 patients were enrolled: 10 were treated with hyaluronic acid Atlantis (Group A) and 11 with Gastroftal eye drops and tablets (Group B). After treatment, in Group A only OSDI significantly diminished (p=0.029); in Group B there were significant reductions concerning OSDI (p=0.0277), OSDI categories (p=0.0211), RSI (p=0.0172), Schirmer test (p=0.0172), T-BUT (p=0.0265), and RFS (p=0.0205). The current preliminary demonstrated that the combined ocular and systemic therapy with hyaluronic acid, Magnesium alginate, Simethicone, and Camelia sinensis may be considered a promising treatment in patients with Dry Eye Syndrome due to LPR. (www.actabiomedica.it)

Formulation and Evaluation of Levocetirizine Gastro-Retentive Floating Tablets

Formulation and Evaluation of Levocetirizine Gastro-Retentive Floating Tablets

Studies on the development of Orally Disintegrating Tablets of Irbesartan

Studies on the development of Orally Disintegrating Tablets of Irbesartan

Honeyed Words and Waxen Tablets: Aldhelm’s Bees and the Materiality of Anglo-Saxon Literacy

Honeyed Words and Waxen Tablets: Aldhelm’s Bees and the Materiality of Anglo-Saxon Literacy

HELIOTECTURE: ARCTIC OASES AND NORTHERN TABLETS

HELIOTECTURE: ARCTIC OASES AND NORTHERN TABLETS

Development and Evaluation of Gastroretentive Floating Tablets of Nizatidine based on Effervescent Technology

Development and Evaluation of Gastroretentive Floating Tablets of Nizatidine based on Effervescent Technology

Formulation and Evaluation of Fast Disintegrating Tenoxicam Tablets and The Comparison with Marketed Product

Formulation and Evaluation of Fast Disintegrating Tenoxicam Tablets and The Comparison with Marketed Product

Critical Quality Attributes and Pharmaceutical Equivalence Assessment of Allopurinol Tablets in Argentina

Fil: Varillas, Maria Alejandra. Universidad Nacional del Sur. Departamento de Biologia, Bioquimica y Farmacia; Argentina

Cafergot tablets will be prohibited in NZ from May 2020

Cafergot tablets will be prohibited in NZ from May 2020

Development of film coated orally disintegrating tablets “REMITCH<sup>®</sup> OD TABLETS 2.5µg

Development of film coated orally disintegrating tablets “REMITCH<sup>®</sup> OD TABLETS 2.5µg

Patented Technologies in Fast Dissolving Tablets: A Review

Patented Technologies in Fast Dissolving Tablets: A Review

Touchscreen tablets and people with dementia: interest, intentions and modalities of use

Touchscreen tablets are increasingly used to support people with dementia. An inventory of the literature is proposed to specify the nature and intentions of use, the modalities of use and technical characteristics. Tablets are used for psychosocial interventions, life support, social living and leisure activities. Autonomously use is possible and group uses promote interpersonal relationships. The equipment must take into account the physical, sensory, cognitive and interests of people with dementia. Use of tablets should promote social inclusion in a non-stigmatizing approach.

Levothyroxine ‐ not all tablets are the same

Most patients with hypothyroidism tolerate levothyroxine therapy well, but a significant minority are dissatisfied with treatment. Here, the authors examine whether this could be a result of intolerance to the excipients in the specific levothyroxine product prescribed or dispensed.

Losartan-containing tablets recalled due to NMBA impurity

Losartan-containing tablets recalled due to NMBA impurity

함안 성산산성 출토 부찰목간의 지명 및 인명 기재방식과 서식

함안 성산산성 출토 부찰목간의 지명 및 인명 기재방식과 서식

Evaluation of the nimesulide content in splitting tablets

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) that inhibits the action of the enzyme cyclooxygenase-2 and is widely used in many countries for the treatment of pain and inflammation. It is often given on a dosage adjustment basis mainly in the elderly and children. In the present work the nimesulide tablet splitting process from three different suppliers was studied using a tablet cutter in order to verify the influence of the breakdown of the same on the content of each obtained fragment. The tests of average weight, hardness, friability, disintegration, dosage and uniformity of unit doses were performed following the official methodology established by the Brazilian Pharmacopoeia. The samples studied met the official specifications before being submitted to the partition procedure; however, after dividing the tablets, the drug content in the halves presented excessive variation, showing that this procedure should not be performed for the drug Nimesulide. In cases of need for varying administration doses of Nimesulide, it is recommended that the drug be manipulated or that another pharmaceutical form is used in order to ensure dosage in each unit of the dosage form.

FERRAMENTAS DIGITAIS E ESCOLA: Estudo de uma proposta pedagógica

The Digital Information and Communication Technologies have been offering new features and possibilities for Education, especially mobile devices, which also allow access to digital learning resources and environments. The Digital Information and Communication Technologies have been used and recommended as a tool and support to the teaching-learning process. The article presents exploratory research data from a case study of a private school located in Cuiaba, capital of the state of Mato Grosso, whose pedagogical proposal includes the use of tablets among other digital tools for teachers and students.

Phase Ib/IIa Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of D-0120 Tablets

Phase Ib/IIa Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of D-0120 Tablets