High entropy silicide (Mo0.2Cr0.2Ta0.2Nb0.2W0.2)Si2 (named as MeSi2) coating was successfully prepared on Ta substrate by slurry sintering method. Firstly, precursor powders were initially obtained through mechanical alloying of silicide powders. Then powder slurry was coated on Ta substrate, and then the samples were sintered. For comparison, TaSi2 coating prepared by halide-activated pack cementation method was synthesized. Subsequently, the static oxidation resistance of both MeSi2 coating and TaSi2 coating was examined at 1200 °C, results revealing that the MeSi2 coating demonstrates an effective protection time of more than 60 h. The protective effect and duration of the MeSi2 coating on Ta substrate are significantly greater than that of TaSi2, indicating an improvement oxidation resistance due to the high entropy effect of the silicide coating. After oxidation, the coating evolved an outer SiO2 layer, followed by MeSi2, Me5Si3, TaSi2, and Ta5Si3 layers. As the oxidation progressed, MeSi2 gradually transformed into Me5Si3, leading to a loss of the coating's antioxidant capacity.