Purpose This paper aims to present a comprehensive analysis of conjugate heat transfer phenomena occurring within the developing region of square ducts under both isothermal and isoflux boundary conditions. The study involves a rigorous numerical investigation, using advanced computational methods to simulate the complex heat exchange interactions between solid structures and surrounding fluid flows. The results of this analysis provide valuable insights into the heat transfer characteristics of such systems and contribute to a deeper understanding of fluid–thermal interactions in duct flows. Design/methodology/approach The manuscript outlines a detailed numerical methodology, combining computational fluid dynamics and finite element analysis, to accurately model the conjugate heat transfer process. This approach ensures both the thermal behaviour of the solid walls and the fluid flow dynamics are well captured. Findings The results presented in the manuscript reveal significant variations in heat transfer characteristics for isothermal and isoflux boundary conditions. These findings have implications for optimizing heat exchangers and enhancing thermal performance in various engineering applications. Practical implications The insights gained from this study have the potential to influence the design and optimization of heat exchange systems, contributing to advancements in energy efficiency and engineering practices. Originality/value The research introduces a novel approach to study conjugate heat transfer in square ducts, particularly focusing on the developing region. This unique perspective offers fresh insights into heat transfer mechanisms that were previously not thoroughly explored.