Vein System Research Articles

Initiation and development of tectonic stylolite – Vein system in micritic limestone (Les Matelles, France)

In this study, we describe the characteristics of tectonic stylolites and related veins affecting a low-porosity micritic limestone (Jurassic carbonates, Les Matelles, South of France) in order to unravel the conditions of initiation and interaction between pressure-solution and fracturing in such rock. Field description, various petrographic and microstructural investigations (cathodoluminescence, SEM imaging, EBSD analysis), and petrophysical/geochemical analyses (Hg porosimetry, XRD, EPMA) are used. We document that pressure-solution initiates at micropores and propagates along calcite grain contacts, connecting surrounding stylolite micro-segments, and progressively concentrates insoluble material such as clays and siliceous particles. The dissolved material is evacuated to the veins where the newly-formed porous space is progressively filled by calcite cement. These deformation processes are strictly restricted to the stylolitic interface and veins, as no modification of porosity or grain deformation is detected in the neighboring host rock. This is due to the low-permeability of the surrounding host rock impeding the evacuation of dissolved material and fluids through interstitial porosity around the pressure-solution zone, leading to overpressure and veins formation. The water release and microporosity caused by diagenesis of the clay fraction (smectite-illite transformation) are discussed as key diagenetic processes instigating the conditions of pressure-solution initiation, then tectonic stylolite formation in low-porosity limestones.

Systematic trends in the substitution mechanisms of minor elements in cassiterite

A dataset of 4751 EPMA point analyses on cassiterite crystals from 18 localities spanning a range of different granite-related Sn-bearing mineral systems was investigated and compared with thermodynamic considerations from speciation and lattice strain models. The existence of previously inferred charge balanced coupled substitution mechanisms of Fe3+, Fe2+, Mn2+, Nb5+, Ta5+ and W6+ for Sn4+ are confirmed. The homo­valent substitution of Sn4+ by Ti4+ and Zr4+ is also confirmed, and the first evidence for homovalent substitution of Nb4+ and W4+ in natural cassiterite is presented. The preferred substitution mechanisms for Ti, Fe, Mn, Nb, Ta, W and Zr vary systematically as a function of the mineralising environment. Cassiterite precipitated from silicate liquid dominated systems (such as in pegmatites) primarily display a coupled Fe–(Nb,Ta) substitution mechanism with a 1:2 stoichiometry, whereas cassiterite precipitated in systems dominated by autometasomatic processes (such as greisens) more closely follow a 1:1 stoichiometry, as well as increased levels of Ti. Cassiterite precipitated solely from hydrothermal fluids (such as Sn–(W) quartz vein systems) exhibit the highest Ti concentrations, with lower contents of Fe–(Nb,Ta) coupled substitutions, instead displaying a switch to the incorporation of Fe3+ via FeO.OH stoichiometry. Hydrothermally precipitated cassiterite from skarn systems display the highest Fe3+ contents, and the lowest Nb, Ta and Ti contents. These systematic changes define a continuous trend in a Ti–(Fe + Mn)–(Nb,Ta) ternary diagram, allowing for classification of the primary source of alluvial cassiterite.

Parallel evolution of angiosperm-like venation in Peltaspermales: a reinvestigation of Furcula.

Leaf venation is a pivotal trait in the success of vascular plants. Whereas gymnosperms have single or sparsely branched parallel veins, angiosperms developed a hierarchical structure of veins that form a complex reticulum. Its physiological consequences are considered to have enabled angiosperms to dominate terrestrial ecosystems in the Late Cretaceous and Cenozoic. Although a hierarchical-reticulate venation also occurs in some groups of extinct seed plants, it is unclear whether these are stem relatives of angiosperms or have evolved these traits in parallel. Here, we re-examine the morphology of the enigmatic foliage taxon Furcula, a potential early Mesozoic angiosperm relative, and argue that its hierarchical vein network represents convergent evolution (in the Late Triassic) with flowering plants (which developed in the Early Cretaceous) based on details of vein architecture and the absence of angiosperm-like stomata and guard cells. We suggest that its nearest relatives are Peltaspermales similar to Scytophyllum and Vittaephyllum, the latter being a genus that originated during the Late Triassic (Carnian) and shares a hierarchical vein system with Furcula. We further suggest that the evolution of hierarchical venation systems in the early Permian, the Late Triassic, and the Early Cretaceous represent 'natural experiments' that might help resolve the selective pressures enabling this trait to evolve.

Features of Hemodynamics of Retinal Vessels in Hypermetropic and Myopic Defoci during Treatment with Orthokeratological Lenses

Conduct a study of the hemodynamics of retinal vessels in eyes with myopia with hypermetropic and myopic defocuses: 60 eyes (30 patients) with mild myopia and 100 eyes (50 patients) with moderate myopia were examined. The average age of the patients was 12.0±0.38 years. The average degree of myopia was — (−) 2.2±0.25 D with a mild degree; (−) 4.7±0.22 D at average; The control group consisted of 40 eyes (20 patients) with emmetropia, average age -13.0±0.27 years. Along with generally accepted research methods, the following were carried out: autorefractometry, ophthalmometry, biometry, keratotopography, binocular ophthalmoscopy, OST of the optic disc and macula, OST-A with calimetry, ultrasound of the vessels of the central nervous system and central veins. All patients were fitted with orthokeratological lenses of reverse geometry Moonlens from Sky Optix, with repeated examinations after 1-3-6-12-24 months. With a weak degree of myopia, a narrowing of the caliber of the vessels of the central nervous system was revealed to 71.0±0.60 µm in 14.8% with hypermetropic defocus, with the absence of narrowing of these vessels with myopic defocus. With an average degree of myopia, narrowing of the vessels of the central nervous system to 66.1±0.60 μm was detected in 55% (55 eyes) with hypermetropic defocus, versus 35.8% (36 eyes) with the caliber of the vessels of the central nervous system — 68.6±0.57 μm (P <0.05). Along with this, in patients with an average degree of myopia, a narrowing of the vessels of the central vein with hypermetropic defocus was found to 93.1±0.59 μm in 72.7% (73 eyes), versus 56.4% (56 eyes) with myopic defocus. In both groups, normalization of LBF in the central vascular system to 5.8±0.59 cm/sec and 5.3±0.63 cm/sec with myopic defocus was revealed, and LBF in the central vein to 15.3±0.64 cm/sec. sec with average degree of myopia (P <0.05). In both groups, an increase in the resistivity coefficient (RI) was found to 0.85±0.54 (P <0.01). Conducted studies of OCT-A with calimetry of the vessels of the central nervous system and central nervous system in moderate myopia revealed a significant decrease in the frequency of vasoconstriction in myopic defocus. When examining vessels using ultrasound, a significant normalization of LBF in the central nervous system and central veins was revealed, with myopic defocus with mild and moderate myopia during treatment with orthokeratological lenses. Accordingly, the state of eye hemodynamics may be one of the factors in the effectiveness of treating myopia with orthokeratological lenses.

Resection and reconstruction of the largest abdominal vein system (the inferior vena cava, hepatic, and portal vein): a narrative review.

As tumors invade major abdominal veins, surgical procedures are transformed from simple and basic to complicated and challenging. In this narrative review, we focus on what is currently known and not known regarding the technical aspects of major abdominal venous resection and its reconstruction, patency, and oncologic benefit in a cross-cutting perspective. A systematic literature search was performed in PubMed and Semantic Scholar from inception up to October 18, 2023. We reviewed 106 papers by title, abstract, and full text regarding resection or reconstruction of the inferior vena cava, hepatic vein confluence, portal vein (PV), and middle hepatic vein (MHV) tributaries in living donor liver transplantation (LDLT) in a cross-cutting perspective. The oncologic benefit of aggressive hepatic vein resection with suitable reconstruction against adenocarcinoma remains unclear, and further studies are required to clarify this point. A superior mesenteric/PV resection is now a universal, indispensable, and effective procedure for pancreatic ductal adenocarcinoma. Although many case series using tailor-made autologous venous grafts have been reported, not only size mismatch but also additional surgical incisions and a longer operation time remain obstacles for venous reconstruction. The use of autologous alternative tissue remains only an alternative procedure because the patency rate of customized tubular conduit type to interpose or replace the resected vein is not known. Unlike arterial replacement, venous replacement using synthetic vascular grafts is still rarely reported and there are several inherent limitations except for reconstruction of tributaries of MHV in LDLT. Various approaches to abdominal vein resection and replacement or reconstruction are technically feasible with satisfactory results. Synthetic vascular grafts may be appropriate but have a certain rate of complications.

Discriminating Superimposed Alteration Associated with Epigenetic Base and Precious Metal Vein Systems in the Rouyn-Noranda Mining District, Quebec; Implications for Exploration in Ancient Volcanic Districts

Abstract The Rouyn-Noranda mining district of Quebec contains 20 Cu-Zn (±Au ±Ag) volcanogenic massive sulfide (VMS) deposits, including the giant and gold-rich Quemont and Horne deposits. Mineralized epigenetic veins are also present, but their origin and relative timing remain enigmatic. The nature and extent of their alteration signatures and the effect of their superposition on district-scale alteration patterns is unknown. The VMS-related quartz-sulfide Cu-Zn-Ag veins have δ18Oquartz values of 8.5 ± 0.8‰, reflecting δ18Ofluid compositions of –0.4 to 3.1‰ (250°–350°C) that are typical of Archean seawater. They are associated with a proximal Fe-rich chlorite alteration and marginal spotted sericite-chlorite alteration with whole-rock δ18O values of 2.9 to 5.9‰ and are interpreted to have formed within the structurally controlled discordant upflow zones of a VMS hydrothermal system. Younger gold-bearing quartz-carbonate veins were emplaced along mechanical anisotropies created by mafic dikes during north-south compression and the formation of regional E-trending faults, folds, and cleavage. They are characterized by δ18Oquartz values of 11.3 ± 0.8‰, reflecting δ18Ofluid compositions of 2.4 to 5.9‰ (250°–350°C), typical of a metamorphic fluid, possibly mixed with a lower δ18O upper crustal fluid. They are associated with ankerite, calcite, muscovite, chlorite, albite, and quartz ± hematite alteration with whole-rock δ18O values of 5.8 to 10.3‰. Chemical abrasion-isotope dilution-thermal ionization mass spectrometry (CA-ID-TIMS) U-Pb zircon ages for two tonalite intrusions constrain the maximum age of the Cu-Zn-Ag veins to 2697.6 ± 0.7 Ma and the minimum age to 2695.3 ± 1.0 Ma, which is also the maximum age of the gold quartz-carbonate veins. Superposition of alteration related to the gold quartz-carbonate veins on previously chlorite- and sericite-altered rocks has resulted in mixed alteration signals with whole-rock δ18O values of ~6 to 8‰ that have perturbed and masked regional alteration patterns related to older VMS mineralization, such as those found in the Quemont and Horne deposits. These results indicate that defining alteration vectors in camps that have superimposed hydrothermal systems requires full consideration of the hydrothermal history of the camp, and if such constraints are lacking, whole-rock δ18O values should not be used as a stand-alone exploration method.

DIFFERENTIAL APPROACH IN THE COMBINED SURGICAL TREATMENT OF VARICOSE VEINS OF THE LOWER EXTREMITIES ACCORDING TO THE RESULTS OF ULTRASOUND DOPPLER ULTRASOUND

The most common pathology of the lower extremity veins is varicose veins, which is an urgent medical and social problem. The number of patients with trophic disorders is not decreasing, despite the improvement of treatment methods, which leads to a deterioration in the quality of life. Therefore, the topic of introducing new and improving existing minimally invasive treatment methods is relevant and requires further research. According to international studies, the combined laser method of treatment is superior in terms of therapeutic and cosmetic results to all known methods of surgical treatment of varicose veins and can be used in most cases.Aim. To demonstrate the eff ectiveness of individual diff erentiated combined surgical techniques for the treatment of varicose veins of the lower extremities, taking into account the data of ultrasound preoperative and intraoperative navigation.Material and methods. The study included 246 patients with varicose veins of the lower extremities of class C2-C5, who had various variants of varicose veins of the lower extremities – saphenous varicose veins in the system of small and/or large saphenous veins, which in some patients was combined with varicose veins in the basin of non-saphenous veins and reticular varicose veins. Patients were divided into clinical groups due to the diff erence in surgical and tactical treatment approach. All patients underwent preoperative ultrasound Doppler ultrasonography (USG) of the lower extremity veins in horizontal and vertical positions. The patency of deep and saphenous veins, the presence of unable varicose dilated saphenous venous tributaries with an assessment of the aff ected basin (saphenous, non-saphenous varicose veins and combined forms) were assessed. Horizontal and vertical pathological venous refl uxes were detected. All patients underwent combined surgical intervention – EVLC and miniphlebectomy under ultrasound Doppler monitoring, and sclerotherapy as indicated. The observation period lasted 1.5 years for each patient.Research results and discussion. The assessment of the treatment results was based on the presence of patient complaints, analysis of the clinical picture, the presence or absence of complications during the observation period, recurrence of the disease during the observation period, and analysis of the ultrasound assessment of the veins by an ultrasound diagnostician during a dynamic examination. USG was mandatorily performed in patients of all groups before surgical treatment, during surgical correction and as a control within 1-3 days after surgery. Dynamic follow-up was performed in all patients at 1, 3, 6 and 12-18 months after surgical treatment.Conclusions. Most patients have a complete recovery after surgical treatment. Careful history taking in patients of this group and performance of ultrasound Doppler ultrasonography of the veins of the lower extremities allowed to choose an eff ective individual surgical treatment. Specialists’ understanding of the capabilities of ultrasound Doppler ultrasound of the veins of the lower extremities, as well as compliance with the full examination protocol for ultrasound Doppler veins, allows us to provide detailed information to determine the most eff ective treatment tactics and prevent complications of the disease.

DIAGNOSIS OF COMBINED STRUCTURAL VARIANTS OF THE LEFT RENAL VEIN (LITERATURE REVIEW WITH A CLINICAL EXAMPLE)

Tributaries of the inferior vena cava, in particular the renal veins, are characterized by structural variability and variants of collaterals, which causes difficulties in interpreting diagnostic images. The purpose of the review is to demonstrate the importance of detailed visualization of structural variants of the renal and adrenal veins using the example of a literature review. Materials and methods. A literature search was conducted in the PubMed database, as well as illustrative clinical data are provided. The methods of analysis and generalization are used as scientific methods. Results. A review of the literature on a combined venous anomaly – dystopia with a retroaortic location of the left renal vein and an independent left adrenal vein trunk with schematic images of structural variants of the renal and adrenal veins is presented, a clinical example of a patient with a corresponding anomaly is given, as well as a possible explanation for compensation of venous outflow violations through the retroaortic renal vein – drainage mainly into the portal vein system. Conclusions. Awareness on the structural features of the inferior vena cava tributaries makes it possible to explain the symptoms and clinical manifestations in these patients in order to determine further therapeutic tactics.

Live to Move and Move to Live: The Health of the Lymphatic System Relies on Mobility and the Foot and Calf Pump Connection

The foot and calf muscle pump, collectively known as the venous muscle pump, plays a crucial role in the circulatory system (veins, arteries, and lymphatics), particularly in the return of blood from the lower extremities to the heart. Further, the venous muscle pump is crucial to lymphatic health and essential in chronic edema/lymphedema management. This article will highlight the significance of the venous pump and review the functional anatomy and physiology of the foot and calf, integrating the connection to venous and lymphatic health. The complementary importance of mobility, exercise, and breathing will also be explored.

San Albino, Nicaragua: A Low-Angle, Thrust-Controlled Orogenic Gold Deposit

Abstract The San Albino deposit is an orogenic gold occurrence hosted by a low-angle thrust that is the site of a new open-pit mine in northern Nicaragua. The deposit is hosted in greenschist facies rocks of the Jurassic metasedimentary Neuvo Segovia Formation. The schist was uplifted and exposed during arc accretion and Cretaceous thin-skin deformation, forming the NE-striking Colon fold-and-thrust belt. Deformation included emplacement of the 119 to 113 Ma NE-trending Dipilto batholith into the regionally metamorphosed clastic rocks about 5 km northwest of the San Albino deposit. Mineralization is dominated by three laminated quartz vein systems (i.e., San Albino, Naranjo, Arras) that broadly follow shallowly dipping (approx. 30°) carbonaceous shears roughly concordant to schistosity along the limbs of a doubly plunging antiform. The three main parallel shears are each separated by about 90 m and individually reach a maximum thickness of about 8 m. Maximum thickness of ore zones is where post-ore local folding and reverse motion along the shallow shears has duplicated the laminated low-angle gold-bearing veins (D2 and early D3). Additional gold was added to the veins, with abundant sulfides, during a subsequent brecciation event of the early formed quartz veins that accompanied progressive thrusting (late D3). This predated boudinage of the veins during continued compression and thrust loading (D4); high gold grades are particularly notable along pyrite- and arsenopyrite-bearing stylolites formed during D4 pressure solution. The D2 to D3 gold event is likely coeval with Albian uplift of the Dipilto batholith and with back thrusting in the schist aided by the stress inhomogeneities provided by the igneous complex. Low-angle thrust-controlled orogenic gold deposits may represent world-class exploration targets because of their large linear footprints, although they are traditionally looked at as less favorable exploration targets relative to gold systems developed more commonly along high-angle reverse faults. Our case study of the San Albino deposit shows that although low-angle deposits are not inherently misoriented for failure like the more common subvertical reverse fault-related deposits, they may be sites of significant pressure buildup due to hydrothermal mineral precipitation during initial water-rock interaction or slight temperature decreases along the low-angle flow path. Resulting fluid cycling may lead to thick laminated vein development, such as seen at San Albino, where especially high-grade zones may be associated with local steepening and/or dilational zones within the broader, low-angle vein-hosting shear system.

Sub-gluteal ligation of the internal pudendal vein for management of veno-occlusive erectile dysfunction (Shaeer's Vein Ligation-I): the cadaveric study.

Vein ligation for veno-occlusive erectile dysfunction is being abandoned due to the recurrence rate. Among the reasons for failure is inability to ligate the deep system of veins; the internal pudendal vein. The vein exits the pelvis in the gluteal region, from the lesser sciatic foramen to the greater sciatic foramen, coursing over the ischial spine and sacro-spinous ligament, under the gluteus maximus. This work aims to verify feasibility of the first surgical procedure to ligate the internal pudendal vein through the gluteal approach. This cadaveric study involved five formalin-fixed cadavers. A surface anatomical landmark was designed to identify the ischial spine, at the intersection of two lines: a vertical line from posterior superior iliac spine to ischial tuberosity, and a horizontal line extending from sacro-coccygeal joint, laterally. An incision is cut encompassing the target point. Subcutaneous fat is dissected down to the gluteus maximus, which is split along the direction of its fibers. The vein can be found crossing over the ischial spine. "Shaeer's Vein Ligation - I" appears to be surgically feasible. A protocol for a surgical study is registered at clinicaltrials.gov, and is open for participation.

Prognostic value of instrumental research methods in the diagnosis of complicated forms of liver malignant tumors

Objective: To determine prognostic value of instrumental methods in the diagnosis of complicated forms of malignant forms of focal liver lesion.Material and methods: The experience of treating 112 patients with primary and secondary tumor lesions of the liver was analyzed. Life-threatening complications, such as spontaneous rupture of the tumor node leading to massive intraperitoneal bleeding and cancerous peritonitis, were noted in 32 (28.5%) cases. Clinical and echographic signs of the threat of this complication developing were observed in 26 (23.2%) patient. Ultrasound (US) and CT semiotics of the tumor node rupture included signs of hemoperitoneum, focal heterogeneous formation with the presence of perilesional hematoma, active extravasation of contrast medium, and focal discontinuity of the liver contour at the site of the focal formation.Results and discussion: Most often, the size of the tumor node exceeded 8.0 cm (in 65% of patients). Protrusion of the tumor through the liver surface was noted in 23 (39.6%) cases. Invasion of the tumor into adjacent organs and tissues was observed in 16 (27.5%) patients. Sites of phlebothrombosis, predominantly in the system of hepatic veins, detected by echo-Dopplerography of liver vessels, were present in 12 (20.6%) patients.Conclusion: Predictors of spontaneous rupture of the tumor node may include: size of the formation more than 5 cm; protrusion of the tumor through the liver surface; phlebothrombosis by tumor masses, leading to increased intramural pressure; extraliver invasion of the tumor into adjacent organs and tissues.

Levoatrial Cardinal Vein: A Rare Differential

Levoatrial cardinal vein is a rare congenital anomaly characterised by an anomalous connection between left atrium or pulmonary veins and systemic veins. This abnormal connection is usually found in cases of left sided obstructive lesions. In this report we present a case of ventricular septal defect and severe pulmonary hypertension. The suspicion of a levocardinal atrial vein was raised was on echocardiography and confirmed on computed tomography. A mulitimodality diagnostic approach is mandatory for the correct diagnosis and surgical repair of this anomaly as this can also be a contributing factor for causing severe pulmonary hypertension.

A Novel Exploration of the Choroidal Vortex Vein System: Incidence and Characteristics of Posterior Vortex Veins in Healthy Eyes.

The purpose of this study was to investigate the incidence and characteristics of posterior vortex veins (PVVs) in healthy eyes and explore their relationship with age and refractive status. This retrospective cross-sectional analysis encompassed 510 eyes from 255 consecutive healthy participants. Wide-field optical coherence tomography angiography (WF-OCTA) imaging was used to assess the presence of PVVs. Eyes were classified according to refractive status (emmetropia, low and moderate myopia, and high myopia) and age (minors and adults). The incidence and characteristics of eyes with PVVs were analyzed. Participants (mean age = 30.60 ± 21.12 years, 47.4% men) showed a mean refractive error of -2.83 ± 3.10 diopters (D; range = -12.00 to +0.75). PVVs were observed in 16.1% (82/510) of eyes. Of these, 39% (32/82) had PVVs in one eye and 61% (50/82) in both eyes. The mean number of PVVs per eye was 1.65 ± 1.05 (range = 1-6). PVVs are mainly around the optic disc (78%, 64/82) of eyes with PVVs and less in the macular area (6.1%, 5/82) or elsewhere (15.9%, 13/82). PVV incidence correlated with refractive status: 10.3% (22/213) in emmetropia, 16.6% (31/187) in low and moderate myopia, and 26.4% (29/110) in high myopia (P = 0.001), but not with age. Refractive status was the key predictor of PVV occurrence (odds ratio [OR] = 1.45, 95% confidence interval [CI] = 1.02-2.06, P = 0.038). This study confirms PVVs' presence in healthy eyes, highlighting their inherent existence and susceptibility to alterations due to refractive conditions. These findings enhance our understanding of the vortex vein system and its distribution within the eyes.

Cold deep subduction of Indian continental crust and release of ultrahigh‐pressure fluid during initial exhumation: Insights from coesite‐bearing eclogite‐vein systems in Kaghan Valley, Pakistan

AbstractThe ultrahigh‐pressure (UHP) eclogites from the Kaghan Valley in Pakistan, which formed by the deep subduction of the Indian plate beneath the Asian plate in the Eocene, contain complex metamorphic vein systems (including both isolated veins and vein networks), with mineral assemblages of epidote + quartz + kyanite + phengite ± omphacite ± garnet. The investigations on the Kaghan UHP eclogite‐vein systems provide important insights into the mechanism and timing of metamorphic dehydration, fluid flow, and fluid–rock interaction in the deeply subducted Indian continental slab as well as the chemical characteristics of slab‐derived, aqueous fluids. Abundant lawsonite pseudomorphs, characterized by prismatic aggregates of epidote, kyanite, and quartz porphyroblasts, are first recognized in the Kaghan eclogites. This observation, in combination with the occurrence of coesite pseudomorphs in epidote porphyroblasts as well as the coexistence of epidote and coesite in the eclogite zircon, indicates the previous existence of UHP lawsonite in these eclogites. Petrological studies and phase equilibrium modelling reveal clockwise P–T trajectories for the Kaghan eclogites that are featured by prograde vectors in lawsonite‐stability regions with peak conditions of 3.0–3.4 GPa/650–690°C, followed by isothermal decompression and lawsonite breakdown under UHP conditions during the initial exhumation stage. The results of metamorphic evolution, together with in situ epidote and bulk Sr isotopic analyses, indicate that the fluids responsible for vein systems are most likely derived from the breakdown of UHP lawsonite in the eclogites. SIMS U–Pb dating of metamorphic zircons from the eclogites, integrated with the Raman analysis of inclusions in zircons, indicates that the UHP dehydration of eclogites occurred at 46.4 ± 1.2 and 46.8 ± 0.9 Ma. Analyses of hydrothermal zircons from the veins yielded slightly younger ages of 44.7 ± 1.0 and 44.9 ± 1.4 Ma, which represent the timing of fluid flow and/or vein crystallization during exhumation of the UHP rocks. Mass‐balance calculation results, in combination with the vein compositions, show that the fluid flow and fluid‐eclogite interaction led to the transfer of Si, Al, Ca, K, and incompatible trace elements from the eclogites into the fluids, from which the vein systems crystallized. This study indicates cold deep subduction of Indian continental crust along low geothermal gradients (6–7°C/km). The UHP fluid liberation and channelized fluid flow occurred during the initial exhumation of the cold Indian slab and are expected to induce the transfer of H2O and incompatible trace elements from the Indian slab to the Asian lithosphere, which potentially contributes to the formation of post‐collisional magmas. Moreover, we suggest that metamorphic vein systems in UHP lawsonite eclogites offer important constraints on the occurrence and timing of fast slab exhumation in continental subduction‐collision zones.

Pneumoascariasis: Ascaris Worm Infestation in the Lungs

Pneumoascariasis is an infestation from one of the most common worms or helminths found on earth in the respiratory system. The worm is called Ascaris lumbricoides, which penetrates and infests the human body through the fecal-oral process. The fertilized Ascaris ova, or simply egg, would develop into larvae, which then move to the liver and lungs through the portal vein system. These larvae will soon develop into mature worms in the human respiratory system, inside the lungs, particularly in the bronchioles. These Ascaris larvae trigger common symptoms such as persistent cough, shortness of breath, and wheezing. To diagnose this condition, supplementary examinations are necessary since it is difficult to diagnose only by history taking and some physical exams. Additional exams include chest X-rays that, at one point, display lung infiltration. The chest computed tomography (CT) scan shows ground-glass opacity and a classic inflammation marker called Charcot-Leyden crystals that are most likely present. Pneumoascariasis is often misinterpreted and misdiagnosed. Therefore, this literature review was made to further understand about pneumoascariasis.

The base metal sulfide and Ni–Co arsenide-bearing veins of Valsassina, Lombardy, Italy: a preliminary study

Abstract Valsassina (Lombardy, Northern Italy) is located in the Lombard Southern Alps and is characterised by the presence of a metamorphic basement, by a major late Variscan intrusive complex and by Carboniferous–Permian volcano-sedimentary cover units. These rocks host a pervasive system of inadequately studied mineralised veins. These veins are characterised by base metal (Pb, Zn, Cu and Fe) and complex polymetallic assemblages. In this study, we have investigated the ore textures, mineral compositions of sulfides and sulfosalts (by EMPA–WDS and LA–ICP–MS analyses), and stable isotopes (C and O) in carbonate gangue minerals of various mineralised veins to determine the conditions of deposition of these ore deposits. Two different vein families can be recognised in Valsassina: NNW–SSE veins characterised by a complex polymetallic sulfide–sulfosalt assemblage, also with Ni–Co–Fe arsenides and other Ag–Bi-bearing minerals; and NE–SW veins with a simpler, base metal sulfide assemblage. The Ni–Co-bearing NNW–SSE veins have some distinctive features of the ‘five-element vein’ type deposits, with the Ni–Co–Fe arsenide ore stage pre-dating a sulfide-tetrahedrite-dominated ore stage. LA–ICP–MS data for pyrite and sphalerite, and stable isotopic compositions (C and O) of the carbonate gangue minerals, show no clear differences between the two families of veins, which are probably linked genetically. The isotopic compositions of the Valsassina vein carbonates are closely comparable with the signature of several major five-element ore districts. Preliminary temperature estimates for the Valsassina vein systems were based on the sphalerite composition, applying the GGIMFis geothermometer. The estimated temperatures for the sulfide-dominated ore stage post-dating the Ni–Co minerals precipitation range between 100 and 250°C. The crosscutting relationships, observed for all the veins with the host rocks, suggest a possible late to post Variscan (late Permian) age, making these vein systems comparable with other late–post Variscan polyphase hydrothermal events affecting large sectors of the Southern Alpine domain.

Specification and formation process of enriched portions in Au veins in an epithermal deposit via clustering and geostatistical approaches

Even though epithermal vein-type deposits are the main sources of Au and Ag worldwide, accurate three-dimensional modeling of vein structures and the extraction of high-grade zones are still difficult because of geologic structure heterogeneities and the scarcity of available data, mostly obtained via drilling. Accordingly, by selecting a low-sulfidation epithermal Au–Ag deposit in the Philippine archipelago, we develop an efficient and reliable workflow for determining the spatial distribution of Au-rich veins in detail and the transport of hydrothermal fluids. The studied deposit is mostly hosted in open fractures and breccias with a relatively large tonnage of low Au+Ag grades and/or a small tonnage of high Au+Ag grades. The whole-rock geochemical data (1877 core samples) and lithological data (56 drilling sites) are processed using hierarchical clustering analysis (HCA) and two geostatistical simulations: turning bands simulation for the Au grade distribution and interpretation of mineralization process and truncated Gaussian simulation for the spatial distribution of clusters with similar Au–Ag grade features as classified by HCA. The general correlation between the Au and Ag grades, with a linear correlation coefficient of ≈ 0.69, is based on the HCA application, and the clusters were likely formed by three-stage mineralization processes. A plausible three-dimensional geologic model is then constructed, delineating in detail hydrothermally mineralized and altered zones with Au enrichment and vein system structures in the study area.

An Analysis of Various Electrical Activity in Heart Cavities for Ischemia-Related Issue

The heart is the hub of the circulatory system, a system of blood veins that distributes blood throughout the body. When arterial blood flow to a tissue, organ, or extremity is interrupted, it is known as ischemia. If left untreated, ischemia can cause tissue death. Since the heart's structure may be represented and simulated for cardiac contraction and relaxation, it is significant in COMSOL Multiphysics. The Fitzhugh-Nagumo (FN) and Ginzburg-Landau (GL) equations are used to implement the electrical activity in presumably different cardiac cavities with the ultimate goal of addressing ischemia-related problems. The heart model is divided into four distinct models to illustrate blood flow. Both the observed plots and the dependent variables' waves have a spiral shape.

TAPVR: Molecular Pathways and Animal Models.

The venous pole of the heart where the pulmonary veins will develop encompasses the sinus venosus and the atrium. In the fourth week of development, the sinus venosus consists of a left and a right part receiving blood from the common cardinal vein, the omphalomesenteric and umbilical veins. Asymmetrical expansion of the common atrium corresponds with a rightward shift of the connection of the sinus to the atrium. The right-sided part of the sinus venosus including its tributing cardinal veins enlarges to form the right superior and inferior vena cava that will incorporate into the right atrium. The left-sided part in human development largely obliterates and remodels to form the coronary sinus in adults. In approximately the same time window (4th-fifth weeks), a splanchnic vascular plexus surrounds the developing lung buds (putative lungs) with a twofold connection. Of note, during early developmental stages, the primary route of drainage from the pulmonary plexus is toward the systemic veins and not to the heart. After lumenization of the so-called mid-pharyngeal endothelial strand (MPES), the first anlage of the pulmonary vein, the common pulmonary vein can be observed in the dorsal mesocardium, and the primary route of drainage will gradually change toward a cardiac drainage. The splanchnic pulmonary venous connections with the systemic cardinal veins will gradually disappear during normal development. In case of absence or atresia of the MPES, the pulmonary-to-systemic connections will persist, clinically resulting in total anomalous pulmonary venous return (TAPVR). This chapter describes the developmental processes and molecular pathways underlying anomalous pulmonary venous connections.