Systematic Parameter Research Articles

Systematic Parameter Determination Aimed at a Catalyst-Controlled Asymmetric Rh(I)-Catalyzed Pauson–Khand Reaction

Systematic Parameter Determination Aimed at a Catalyst-Controlled Asymmetric Rh(I)-Catalyzed Pauson–Khand Reaction

Evaluating phasic transcutaneous vagus nerve stimulation (taVNS) with pupil dilation: the importance of stimulation intensity and sensory perception

The efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) as a non-invasive method to modulate physiological markers of noradrenergic activity of the Locus Coeruleus (LC), such as pupil dilation, is increasingly more discussed. However, taVNS studies show high heterogeneity of stimulation effects. Therefore, a taVNS setup was established here to test different frequencies (10 Hz and 25 Hz) and intensities (3 mA and 5 mA) during phasic stimulation (3 s) with time-synchronous recording of pupil dilation in younger adults. Specifically, phasic real taVNS and higher intensity led to increased pupil dilation, which is consistent with phasic invasive VNS studies in animals. The results also suggest that the influence of intensity on pupil dilation may be stronger than that of frequency. However, there was an attenuation of taVNS-induced pupil dilation when differences in perception of sensations were considered. Specifically, pupil dilation during phasic stimulation increased with perceived stimulation intensity. The extent to which the effect of taVNS induces pupil dilation and the involvement of sensory perception in the stimulation process are discussed here and require more extensive research. Additionally, it is crucial to strive for comparable stimulation sensations during systematic parameter testing in order to investigate possible effects of phasic taVNS on pupil dilation in more detail.

Design of ultralight multifunctional sandwich structure with n-h hybrid core for integrated sound absorption and load-bearing capacity

Multifunctionality has become an important evaluating index for structural design because engineering applications in complicated environment call for multifunctional and ultralight structures. With this in mind, this paper proposes a novel ultralight multifunctional micro-perforated sandwich structure with N-H type hybrid cores, which demonstrates superior sound absorption across a wide frequency range, while also achieving good load-bearing capacity. An analytical model is established to calculate the sound absorption coefficient, which is then validated through numerical simulation and experimental measurements. Furthermore, the underlying physical mechanisms for the satisfactory sound absorption are explored. The influences of specific parameters on the broadband sound absorption performance of the proposed structure are quantitatively demonstrated through systematic parameter studies. Additionally, in order to demonstrate the preeminent multifunctional attributes of the proposed structure, a numerical simulation method is employed to evaluate its out-of-plane compression properties. Compared to other micro-perforated sandwiches, the proposed structure exhibits an improvement in load bearing capacity. A radar chart is also created to display the advantages of the proposed micro-perforated sandwich structure over others. Overall, the proposed ultralight sandwich structure with N-H type hybrid cores shows great significance for engineering applications that demand high comprehensive performances owing to its multifunctionality.

Normative Profile of Retinal Nerve Fiber Layer Thickness and Lamina Cribrosa-Related Parameters in a Healthy Non-Glaucoma Cynomolgus Monkey Colony.

The purpose of this study was to investigate the normal range of ophthalmic parameters and the correlations between systematic and ocular parameters and retinal nerve fiber layer (RNFL) thickness among a healthy non-glaucoma cynomolgus monkey colony. All included monkeys were given detailed ophthalmic examinations, including anterior and posterior segments. Furthermore, univariate and multivariate linear regression models were conducted to estimate the relationship between systemic and ophthalmic parameters and global RNFL thickness. A total of 349 non-glaucoma monkeys (18.69 ± 2.88 years old) were collected. The global RNFL thickness was 94.61 ± 10.13 µm, and sex-specific differences existed in all sectors. The decreasing trend of RNFL is as follows: inferotemporal, superotemporal, inferonasal, superonasal, temporal, and nasal. For lamina cribrosa (LC)-related parameters, cup depth (P < 0.01), LC thickness (P = 0.014), and Bruch's membrane opening (BMO) - minimum rim width 2 (P = 0.002) were greater in the male group. However, LC depth (P = 0.02), anterior laminar insertion depth-1 (P = 0.009), and mean anterior laminar insertion depth (P = 0.029) of female monkeys were greater than those of male monkeys. In multivariate linear regression, only older age was significantly related to reduced global RNFL thickness (P < 0.001). Our findings suggest the differences in RNFL thickness distribution and sex between non-glaucoma cynomolgus monkeys and humans. Therefore, the impact of this difference on outcomes should be fully considered in laboratory animal studies. Our findings are also significant in terms of developing a normative optical coherence tomography (OCT) database in nonhuman primates (NHPs). We found that the differences in RNFL thickness distribution and sex between non-glaucoma cynomolgus monkey colonies and humans should be thoroughly taken into account in laboratory animal studies.

Hypervelocity impact against aluminium Whipple shields in the shatter regime with systematic parameter variation: An experimental and numerical study

Aluminium Whipple shields are commonly used to protect spacecraft against hypervelocity impacts (HVIs) from orbital debris and micrometeoroids. Since numerical models nowadays are vital in the design process of protective shields, experimental studies of HVI are important to ensure that the numerical methods are robust and capable of accurately describing a range of impact conditions and material responses. The shatter regime is the transition velocity range between ballistic impact and hypervelocity impact, typically defined from 3 to 7 km/s. In this region, the debris cloud generated by the impact transitions from a few large, solid fragments at the lower end of the velocity range, to a high number of smaller fragments and partial melting of the projectile at the higher velocities. In this study, an experimental campaign of 22 normal impacts of spherical AA1100 projectiles on AA6061-T6 Whipple shields is performed, where the impact velocity and bumper thickness are systematically varied to study the change in debris cloud characteristics and shield damage. Impact velocities from 2.6 to 5.0 km/s are investigated, combined with bumper thicknesses of 1.0, 1.5 and 2.0 mm. Analysis of the experimental results is conducted using high-speed camera footage of the debris clouds and post-impact analysis of bumpers and rear walls. A numerical model is then established using the Smoothed Particle Hydrodynamics (SPH) method in the IMPETUS Solver, and the numerical results are compared to the experimental data. The simulations are able to capture the main trends found in the experimental study, and show a similar level of damage as the experiments when varying the impact velocity and bumper thickness. The simulations have somewhat smaller fragments generated in the debris cloud than in the experiments, leading to slightly less damage inflicted on the rear wall.

Investigating the effect of limited spectral information on NIRS-derived changes in hemoglobin and cytochrome-c-oxidase concentration with a diffusion-based model.

This paper investigates the theoretical capability of near-infrared spectroscopy (NIRS) systems to accurately measure changes in the oxidation state of cerebral cytochrome-c-oxidase (CCO) alongside the hemoglobins, for a deeper understanding of NIRS limitations. Concentration changes of oxy and deoxyhemoglobin (HbO and HbR) indicate the oxygen status of blood vessels and correlate with several other physiological parameters across different pathologies. The oxidation state of CCO indicates cellular energy usage efficiency through oxidative metabolism, potentially serving as a biomarker for brain and other tissue disorders. This study employs an analytical model based on the diffusion equation and statistical analyses to explore the dependency of estimated concentration changes on various systematic parameters, such as choice of wavelengths, spectral bandwidth, and uncertainties in extinction coefficient (ε) and differential pathlength factor (DPF). When there is a 10% uncertainty in DPF and ε, errors were found to be highly dependent on the number of discrete wavelengths, but not on their bandwidth if appropriate considerations are taken to account for it.

A new hybrid fixed and adaptive gains control algorithm to reduce power losses on LLCL filter-based renewable energy conversion systems with systematic parametrization using Grey Wolf optimizer

Currently, there is a transition in the energy matrix around the world, where traditional sources of energy generation are continually being replaced by energy generation systems based on renewable sources to mitigate the climate crisis. In this bias, this work presents the mathematical modeling of an LLCL filter, used to connect power generation systems based on renewable energy sources to the electrical grid, and presents a novel hybrid fixed-and adaptive gains control strategy for current injection into the grid using this system. The developed hybrid controller is composed of a proportional–integral controller and a direct robust adaptive controller. The first term of the controller guarantees the reference current, while the second term of the controller is used for disturbance rejection. Furthermore, a systematic procedure for the controller’s parametrization based on Grey Wolf Optimizer is also provided. The control of the current injected into the grid is carried out considering the LLCL filter without passive damping resistors in the filter structure to avoid power losses due to the passive filter elements. Additionally, the LLCL filter model considers minimal parasitic resistances to evaluate the controller’s performance and optimize it for the application of interest, aiming to maximize the system performance by ensuring a short transient regime due to the fast closed-loop system response. Simulation results indicate high performance of this optimized control strategy with small tracking error even considering grid impedance variations.

Optimizing thermal performance in tube-in-tube heat exchangers with metal foam inserts: experimental and RSM analysis

ABSTRACT This study investigates tube-in-tube heat exchanger performance under steady-state conditions, examining co-current and counter-current flows. It explores various configurations, including metal foam enhancements, to optimize heat transfer efficiency and minimize pressure drop. Driven by the potential of metal foam to enhance heat transfer, the study aims to demonstrate significant improvements in thermal performance compared to conventional designs. Experimental methods involve testing four configurations with Nickel foam (10 PPI, 0.90 porosity) inserts, evaluating temperatures and pressure drops across flow rates of 25 to 50 LPH. Hot water at 65°C flows in the annulus, while normal water at 31°C flows in the outer annulus. Results show metal foam’s substantial enhancement in heat transfer, with counter-current metal foam configurations achieving up to 3.71 times greater efficiency than parallel flow setups. Moreover, comprehensive performance evaluation reveals that the counter-flow heat exchanger with metal foam is 2.03 times more efficient than the conventional co-current flow without metal foam. Conclusions highlight metal foam’s effectiveness in improving heat transfer performance and optimizing thermal systems through systematic parameter optimization using response surface methodology.

Evaluating phasic transcutaneous vagus nerve stimulation (taVNS) with pupil dilation: the importance of stimulation intensity and sensory perception.

The efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) as a non-invasive method to modulate physiological markers of noradrenergic activity of the Locus Coeruleus (LC), such as pupil dilation, is increasingly more discussed. However, taVNS studies show high heterogeneity of stimulation effects. Therefore, a taVNS setup was established here to test different frequencies (10 Hz and 25 Hz) and intensities (3 mA and 5 mA) during phasic stimulation (3 s) with time-synchronous recording of pupil dilation in younger adults. Specifically, phasic real taVNS and higher intensity led to increased pupil dilation, which is consistent with phasic invasive VNS studies in animals. The results also suggest that the influence of intensity on pupil dilation may be stronger than that of frequency. However, there was an attenuation of taVNS-induced pupil dilation when differences in perception of sensations were considered. Specifically, pupil dilation during phasic stimulation increased with perceived stimulation intensity. The extent to which the effect of taVNS induces pupil dilation and the involvement of sensory perception in the stimulation process are discussed here and require more extensive research. Additionally, it is crucial to strive for comparable stimulation sensations during systematic parameter testing in order to investigate possible effects of phasic taVNS on pupil dilation in more detail.

Effect of process parameters on the rheological properties of banana (Musa acuminata) fiber and optimization using response surface methodology

The labor-intensive, time-consuming, and uneconomical nature of manually extracting banana (Musa acuminata) fibers from pseudo-stem sheaths has prompted the exploration of automation as a solution. This study focuses on automating the feeding process of banana pseudostem sheaths using a quick return mechanism, which is more effective than other approaches. A comprehensive study was conducted to assess the impact of key process parameters, namely the decorticator (480–540 rpm), roller speed (50–80 rpm), and clearance between rollers (2–4 mm), on the mechanical properties of the extracted banana fiber. The Response Surface Methodology (RSM) was employed for the experimental design and analysis of data, and the mechanical properties under investigation included the tensile strength, Young's modulus, and strain percentage of the banana fiber. The results revealed that the decorticator speed, roller speed, and clearance between rollers are significantly influenced by their mechanical properties. Herein, the optimal process parameter values are identified as follows: a decorticator speed of 510 rpm, roller speed of 65 rpm, and clearance of 3 mm between rollers. The mechanical characterization of the optimized banana fiber exhibited impressive properties, with an ultimate tensile strength of 679.48 MPa, Young's modulus of 25.47 GPa, and strain of 3 %. This study demonstrates that automation coupled with systematic parameter optimization can enhance the mechanical attributes of banana fibers. This research not only addresses the challenges of manual extraction, but also advances the understanding of how process parameters affect banana fiber quality, thereby facilitating the utilization of this natural fiber in various industrial applications.

TSC-1 Offner Spectrometer Prototype Characterization

The Thai Space Consortium (TSC) has undertaken the development of an Offner spectrometer prototype for the TSC-1 satellite mission, aiming to enhance Earth observation capabilities. Through systematic parameter selection and radiometric analyses, optimal performance of the hyperspectral imager within established specifications was achieved in the previous study. The design phase involved selecting a two-mirror off-axis telescope coupled with the Offner spectrometer for its diffraction-limited performance. Rigorous testing validated the prototype’s alignment with simulated performance, affirming its ability to meet demanding Earth observation requirements. The experimental results demonstrate that the Offner spectrometer prototype has been successfully developed. The spatial resolution ranges between 21.0 and 24.1 µm, and the spectral resolution ranges between 7.3 and 8.7 nm, with no significant distortion. Furthermore, the signal-to-noise ratio at 550 nm is 100. This achievement positions the TSC at the forefront of innovative Earth observation instrumentation in Thailand, with implications for future space missions requiring precise and efficient hyperspectral imaging.

CS12192, a novel JAK3/JAK1/TBK1 inhibitor, attenuates autoimmune dermatoses in murine models

Objective Autoimmune dermatosis (AID) occurs when the body’s immune system attacks skin or tissue, leading to various types of skin disorders or injuries. Recent studies show that Janus kinases (JAKs) play critical roles in autoimmune diseases including AID by regulating multiple cytokine signaling pathways. CS12192, a novel JAK3/JAK1/TBK1 inhibitor, has been reported to exert ameliorative effects in rheumatoid arthritis. However, the efficacy of CS12192 on AID is undetermined. This study aims to investigate the therapeutic efficacy of CS12192 on psoriasis (PSO), systemic lupus erythematosus (SLE) and atopic dermatitis (AD) in mouse models. Methods Interleukin-23 (IL-23)-induced PSO model, spontaneous SLE model of MRL/MpJ-Faslpr/J (MRL/lpr) mice, and oxazolone (OXA) and dinitrochlorobenzene (DNCB)-induced murine AD models were used for the evaluation of curative effects of CS12192, respectively. The skin lesion, biochemical parameters, ear thickness, ear weight and histopathology were assessed accordingly. Results In PSO model, mice treated with CS12192 show reduced ear thickness and ear weight as compared with vehicle. In SLE model, CS12192 ameliorates cutaneous parameters such as lymphadenectasis and skin lesion but not systematic parameters such as proteinuria concentration and score, serum dsDNA and BUN concentration. In AD models, CS12192 dose-dependently improves ear swelling and reduces histological scores, exerting equivalent efficacy with baricitinib, a marketed JAK1/JAK2 inhibitor. Conclusion Our findings suggest that the novel JAK3/JAK1/TBK1 inhibitor CS12192 is potentially to alleviate autoimmune dermatosis.

Power spectra and circular polarization of primordial gravitational waves with parity and Lorentz violations

The violations of parity and Lorentz symmetries in gravity can change the propagating properties of gravitational waves (GWs) in the cosmological background, which can arise from a large number of parity- and Lorentz-violating theories. In this paper, through a systematic parametrization for characterizing possible derivations from the standard GW propagation in general relativity, we study both the parity- and Lorentz-violating effects on the power spectra and the polarization of the primordial gravitational waves (PGWs) during the slow-roll inflation. To this end, we calculate explicitly the power spectrum and the corresponding circular polarization of the PGWs analytically by using the uniform asymptotic approximation. It is shown that the new contributions to power spectra contain two parts, one from the parity-violating terms and the other from the Lorentz-violating terms. While the Lorentz-violating terms can only affect the overall amplitudes of PGWs, the parity-violating terms induce nonzero circular polarization of PGWs, i.e., the left-hand and right-hand polarization modes of GWs have different amplitudes.

The Backscatter Gating method for time, energy, and position resolution characterization of long form factor organic scintillators

This work details a Compton-scattering-based methodology, referred to as Backscatter Gating (BSG), for characterizing the time, energy, and position resolutions of long form factor organic scintillators using a single, fairly minimal measurement setup. Such a method can ease the experimental burden in scenarios where many such scintillator elements may need to be individually characterized before assembly into a larger detector system. A thorough theoretical exploration of the systematic parameters is provided, and the BSG method is then demonstrated by a series of experimental measurements. This “complete” characterization via the BSG method is novel, having previously been used primarily for energy resolution characterization. The method also allows for determination of the assembled scintillator's technical attenuation length and provides a means of verifying the presence or absence of flaws within the scintillator or its optical coupling.

Modeling of double-row cylindrical roller bearing under combined loads and angular misalignment

Abstract To enhance the reliability of the double-row cylindrical roller bearing (DCRB), a new quasi-static model, which is capable of considering inner ring misalignment and combined loads, has been established. This model was used to calculate the distribution of internal loads and contact pressure. First, the model was verified with published data. Secondly, systematic parameter analyses are conducted to investigate how axial load, inner ring misalignment and roller profile influence the contact performance. The results indicate that when the bearing is subjected to a combined load, the difference between the radial loads borne by the two rows increases with the increase of axial load. The combined load and misalignment of the inner ring would cause significant changes in the numerical value and distribution of contact load and pressure between the rollers and raceways. The roller profile optimization can reduce contact pressure and alleviate the edge effect.

Two-dimensional Eclipse Mapping of the Hot-Jupiter WASP-43b with JWST MIRI/LRS

We present eclipse maps of the two-dimensional thermal emission from the dayside of the hot-Jupiter WASP-43b, derived from an observation of a phase curve with the JWST MIRI/LRS instrument. The observed eclipse shapes deviate significantly from those expected for a planet emitting uniformly over its surface. We fit a map to this deviation, constructed from spherical harmonics up to order ℓmax=2 , alongside the planetary, orbital, stellar, and systematic parameters. This yields a map with a meridionally averaged eastward hot-spot shift of (7.75 ± 0.36)°, with no significant degeneracy between the map and the additional parameters. We show the latitudinal and longitudinal contributions of the dayside emission structure to the eclipse shape, finding a latitudinal signal of ∼200 ppm and a longitudinal signal of ∼250 ppm. To investigate the sensitivity of the map to the method, we fix the parameters not used for mapping and derive an “eigenmap” fitted with an optimized number of orthogonal phase curves, which yields a similar map to the ℓmax=2 map. We also fit a map up to ℓmax=3 , which shows a smaller hot-spot shift, with a larger uncertainty. These maps are similar to those produced by atmospheric simulations. We conclude that there is a significant mapping signal which constrains the spherical harmonic components of our model up to ℓmax=2 . Alternative mapping models may derive different structures with smaller-scale features; we suggest that further observations of WASP-43b and other planets will drive the development of more robust methods and more accurate maps.

Continuous-time Lyapunov stability analysis and systematic parametrization of robust adaptive sliding mode controller for systems with matched and unmatched dynamics

Continuous-time Lyapunov stability analysis and systematic parametrization of robust adaptive sliding mode controller for systems with matched and unmatched dynamics

Numerical simulation of shelter effect assessment for single-row windbreaks on the periphery of oasis farmland

Dust storms, resulting from aeolian erosion, pose significant environmental hazards, while farmland is one of the main sources of dust storm release. An effective strategy to mitigate surface wind speed and curb dust emissions involves the establishment of windbreaks on the periphery of oasis farmland. This study conducts a series of numerical simulations using computational fluid dynamics (CFD) to explore the airflow fields around windbreaks with diverse systematic structural parameters, encompassing porosity, planting spacing, and fence effects. The main findings are as follows: (1) When the vegetation porosity is consistent (e.g., porosity α = 0.7, 0.8, and 0.9), exact geometry results can effectively reflect the distribution of wall shear stress, while the porous medium model overlooks these details. (2) The “Venturi effect” contributes to the acceleration of surface erosion and improper planting spacing results in an elevation of near-surface velocity. Planting spacing of 0.5 m demonstrates superior wind speed reduction performance, mitigating aeolian erosion and accumulation. (3) When the fence is positioned at l = 5h (h represents the height of the windbreaks), the flow field around the windbreaks is minimally influenced. The optimal placement distance for fences should be close to the windbreaks, featuring minimal porosity (l = 0 h, α = 0.1), extending the shelter distance from 3 to 4 h to 5–6 h. The research results can provide a theoretical basis for optimizing the plant configuration of biological desertification control and soil erosion control measures.

Sol-gel derived silicate-phosphate glass SiO2–P2O5–CaO–TiO2: The effect of titanium isopropoxide on porosity and thermomechanical stability

Despite of several decades lasting extensive research of bioactive and bioresorbable glasses the systematic parametrization and determination of the key factors affecting porosity and thermomechanical characteristics still remains challenging. Here, we present silica-phosphate glasses, with the composition 70SiO2–20P2O5–(10-x)CaO–xTiO2 (mol%; x = 0, 2.5, 5, and 7.5), prepared by sol-gel method and reinforced by titanium dioxide via titanium isopropoxide (TTIP) incorporation which demonstrated tunable variation of porosity from micro-to macro-region and superb mechanical integrity during the calcination process. The presence of 7.5 mol% TiO2 promotes dimensional stability up to 1000 °C as investigated by thermomechanical analysis. The XRD showed the dominant presence of silicon phosphate [Si(P2O7)], titanium phosphate [Ti(P2O7)] and calcium phosphates [β-Ca(P2O6) and γ- Ca2(P2O7)]. The effect of TiO2 doping on the multiscale morphology and porosity was investigated by means of SEM, MIP, μCT, N2 adsorption and USAXS/SAXS. Increasing TiO2 content leads to the formation of open porosity up to 70 vol% and drives the formation of a refined interconnected macroporosity of 2–30 μm. In contrast, mesoporosity with a dominance of 3–6 nm pores decreases in all samples with increasing TiO2 content. USAXS/SAXS revealed an increase in primary particle size with increasing TiO2 content which is in good agreement with the nitrogen physisorption analysis showing that microporosity decreases with increasing TiO2 content.

State-of-the-Art Low-Cost Air Quality Sensors, Assemblies, Calibration and Evaluation for Respiration-Associated Diseases: A Systematic Review

Indoor air quality and respiratory health have always been an area of prime interest across the globe. The significance of low-cost air quality sensing and indoor public health practices spiked during the pandemic when indoor air pollution became a threat to living beings, especially human beings. Problem Definition: Indoor respiration-associated diseases are hard to diagnose if they are due to indoor environmental conditions. A major challenge was observed in establishing a baseline between indoor air quality sensors and associated respiratory diseases. Methods: In this work, 10,000+ articles from top literature databases were reviewed using six bibliometric analysis methods (Lorenz Curve of Citations, Hirch’s H-Index, Kosmulski’s H2-Index, Harzing’s Hl-Norm-Index, Sidoropolous’s HC-Index, and Schrieber’s HM-index) to formulate indoor air quality sensor and disease correlation publication rubrics to critically review 482 articles. Results: A set of 152 articles was found based on systematic review parameters in six bibliometric indices for publications that used WHO, NIH, US EPA, CDC, and FDA-defined principles. Five major respiratory diseases were found to be causing major death toll (up to 32%) due to five key pollutants, measured by 30+ low-cost sensors and further optimized by seven calibration systems for seven practical parameters tailored to respiratory disease baselines evaluated through 10 cost parameters. Impact: This review was conducted to assist end-users, public health facilities, state agencies, researchers, scientists, and air quality protection agencies.