In the context of the transition of the Russian Federation to innovation-oriented economic growth, the importance of the innovation and investment potential of meso-level socio-economic systems is increasing. The inconsistency of the activities of economic agents in the context of the transformation of the economic model leads to the fact that regional policy faces a number of challenges that cause a decrease in the effectiveness of strategic development. It is assumed that determining the priorities of the spatial and sectoral structure in the development of socio-economic development Strategies allows regions to effectively adapt to environmental conditions and form a competitive innovation infra-structure under the influence of a favorable investment climate. The purpose of this work is to study the regularity of the region's position in the ratings from the presence of priorities of the spatial and sectoral structure in the implementa-tion of the Strategy of socio-economic development and strengthening of innovation and investment potential. The paper analyzed the regional distribution according to Russian ratings with further research of socio-economic develop-ment Strategies and a general assessment of the factors studied, which made it possible to identify the importance of the interdependence of priority areas of the spatial and sectoral structure of the region with the Strategy of socio-economic development and innovation and investment potential. The author's model of the regional innovation system is proposed, which allows to gradually determine the subsystems of the implementation of regional investment and innovation policy, as well as to assess the possibilities of their dynamic interaction, ensuring the continuous circulation of knowledge, investment flows and human capital. The innovation and investment potential as a result of the coordi-nation of the elements of the regional innovation system represents a triad of interaction between the system of creation, dissemination and application of knowledge. The communicative interaction between science, education and business leads to the formation of regional innovation clusters, which are the highest manifestation of the level of development of the innovation and investment potential of the socio-economic system (region/subject of the Russian Federation).
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