Changes In System Research Articles

Transplacental Transfer of Oxytocin and Its Impact on Neonatal Cord Blood and In Vitro Retinal Cell Activity.

The development of fetal organs can be impacted by systemic changes in maternal circulation, with the placenta playing a pivotal role in maintaining pregnancy homeostasis and nutrient exchange. In clinical obstetrics, oxytocin (OXT) is commonly used to induce labor. To explore the potential role of OXT in the placental homeostasis of OXT, we compared OXT levels in neonatal cord blood among neonates (23-42 weeks gestation) whose mothers either received prenatal OXT or experienced spontaneous labor. Our previous research revealed that the oxytocin receptor (OXTR), essential in forming the blood-retina barrier, is expressed in the retinal pigment epithelium (RPE). We hypothesized that perinatal OXT administration might influence the development of the neural retina and its vasculature, offering therapeutic potential for retinal diseases such as retinopathy of prematurity (ROP). Plasma OXT levels were measured using a commercial OXT ELISA kit. Human fetal RPE (hfRPE) cells treated with OXT (10 µM) were assessed for gene expression via RNA sequencing, revealing 14 downregulated and 32 upregulated genes. To validate these differentially expressed genes (DEGs), hfRPE cells were exposed to OXT (0.01, 0.1, 1, or 10 µM) for 12 h, followed by RNA analysis via real-time PCR. Functional, enrichment, and network analyses (Gene Ontology term, FunRich, Cytoscape) were performed to predict the affected pathways. This translational study suggests that OXT likely crosses the placenta, altering fetal OXT concentrations. RNA sequencing identified 46 DEGs involved in vital metabolic and signaling pathways and critical cellular components. Our results indicate that the perinatal administration of OXT may affect neural retina and retinal vessel development, making OXT a potential therapeutic option for developmental eye diseases, including ROP.

Advancing flourishing as the north star of medical education: A call for personal and professional development as key to becoming physicians

Over the past 15 years, multiple calls to transform medical education, and by extension, health sciences education, have addressed issues pertaining to learners’ subjective experiences as well as the learning environment. By and large, these calls to transform share many of the same themes: greater engagement with the humanities, enhanced professional identity formation, leadership development, as well as systemic changes to enhance meaning, purpose, and belonging. However, the many initiatives and reforms underway in medical education have yet to fully reach their desired outcomes – particularly those focused on enhancing meaning, purpose, and belonging. We suggest that calls to transform medical education can be unified and guided by focusing on the promotion of human flourishing. Briefly, we define human flourishing as an aspirational objective enabling one to reach a state of ‘wholeness—of being and doing, of realizing one’s potential and helping others do the same.’ We share our implications of a flourishing guided medical education journey for medical students, residents, and faculty.

Justification of the effective sequence of group fitness classes with second mature women (45-55 years old)

This article deals with issues that are aimed at the organization of strength training. First of all, it is necessary to note significant differences between women and men in terms of strength. In women, they are 15-20% lower than in men. Women have a lower tendency to gain muscle mass. This is primarily related to the hormonal background, since the male hormone testosterone is responsible for the growth of muscle mass, and its amount in the body of women is many times smaller than that of men. At the same time, women's ability to display strength indicators of leg muscles is close to men's. Experts in age-related physiology note that at the age of 40-45, reverse processes begin in a woman's body. The main metabolism slows down, the productivity of various organs and systems decreases, the possibility of various pathological processes, chronic diseases, etc. increases. In connection with the decrease in the hormonal background, negative changes are observed in all organs and systems of the body. Blood pressure often rises, a tendency to osteoporosis appears, fat metabolism is disturbed, which often leads to an increase in body fat. There are significant changes in the respiratory system, the vital capacity of the lungs decreases, the mobility of the chest decreases. After 40 years, there is a significant decrease in muscle strength in women. The elasticity of muscles, tendons, and joint performance is lost. At the same time, muscle tone decreases, which leads to negative changes in posture.

Terrestrial land use signals on groundwater fauna beyond current protection buffers.

Terrestrial and aquatic ecosystems are tightly linked, with direct implications for applied resource management and conservation. It is well known that human land use change and intensification of terrestrial systems can have large impacts on surface freshwater ecosystems. Contrastingly, the study and understanding of such land use impacts on groundwater communities is lagging behind. Both the impact strength of land use on groundwater communities and the spatial extents at which such interlinkages are operating are largely unknown, despite our reliance on groundwater for drinking water extraction as a key ecosystem service. Here, we analyzed groundwater amphipod occurrence from several hundred shallow groundwater aquifers used for drinking water extraction across a region of varying agricultural intensity and human population density in Switzerland. Despite drinking water extraction sites being generally built at locations with expected minimal aboveground impacts on water quality, we found a direct correlation between land use type and intensity within the surrounding catchment area and the locally measured nitrate concentrations, which is a direct proxy for drinking water quality. Furthermore, groundwater amphipods were more likely to be found at sites with higher forest coverage than at sites with higher crop and intensive pasture coverages, clearly indicating a tight connection between aboveground land use and groundwater biodiversity. Our results indicate that land use type effects on groundwater communities are most relevant and pronounced to spatial scales of about 400-1000 m around the groundwater sampling site. Importantly, the here identified spatial scale is 1.2- to 3-fold exceeding the average extent of currently defined groundwater protection zones. We postulate that incorporating an ecosystem perspective into groundwater management strategies is needed for effective protection of groundwater quality and biodiversity.

Manifestation of polystyrene microplastic accumulation in brain with emphasis on morphometric and histopathological changes in limbic areas of Swiss albino mice

The widespread problem of microplastic (MP) contamination is becoming a major threat to the globe. Although most of the research to date has concentrated on the physiological impacts of MPs exposure, a relatively new field of study is beginning to examine its effects on the behaviour and limbic regions of the brain. In this study, exposure to polystyrene MPs (PS-MPs) for acute and sub-chronic durations negatively affected cognition and induced anxiety-like behaviour in mice. PS-MPs were detected in vital organs of mice, including the brain, which induced neurobehavioural and pathological changes in the limbic system. Furthermore, morphometric analysis revealed a significant decrease in the total cell count in the Dentate Gyrus (DG) and Cornu Ammonis (CA) regions of the hippocampus. Signs of neuronal injury and dystrophic changes were observed in the cortex, amygdala, and hypothalamus, potentially affecting anxiety and fear responses. Our study thus provides insight into the effect of PS-MPs on the neurobiology of the brain’s limbic system and related behavioural alterations.

Training for transformation: examining food systems courses at US land-grant universities

Higher education institutions can play an essential role in preparing students to participate in movements for just and sustainable food systems change. For the past two decades, many United States land-grant universities (LGUs) have developed food systems education (FSE) courses. This study examined the extent to which FSE courses employ four capacities deemed crucial by the FSE literature: multidimensional approaches, interdisciplinarity, centering equity, and training students to take action in food systems. The syllabi of 171 undergraduate courses at 20 LGUs were obtained by contacting instructors, and their course descriptions and learning outcomes were analyzed. This subset of LGUs were identified from the membership list of the Menus of Change University Research Collaborative (MCURC), a nationwide network of colleges using campus dining halls and classrooms as living laboratories for food systems change. Most course descriptions and learning outcomes exhibited multidimensional approaches and interdisciplinarity. However, many failed to incorporate teaching content and practices that help students critically examine equity and social justice issues in food systems, or engage in transformative change. LGUs have both the resources and urgent responsibility to empower students to be part of movements to transform unjust, unsustainable food systems. The findings of this study, and an accompanying open-access syllabus website, aim to accelerate the development of FSE curricula that prepare students to change food systems.

Bringing it all together: science priorities for improved understanding of Earth system change and to support international climate policy

Abstract. We review how the international modelling community, encompassing integrated assessment models, global and regional Earth system and climate models, and impact models, has worked together over the past few decades to advance understanding of Earth system change and its impacts on society and the environment and thereby support international climate policy. We go on to recommend a number of priority research areas for the coming decade, a timescale that encompasses a number of newly starting international modelling activities, as well as the IPCC Seventh Assessment Report (AR7) and the second UNFCCC Global Stocktake. Progress in these priority areas will significantly advance our understanding of Earth system change and its impacts, increasing the quality and utility of science support to climate policy. We emphasize the need for continued improvement in our understanding of, and ability to simulate, the coupled Earth system and the impacts of Earth system change. There is an urgent need to investigate plausible pathways and emission scenarios that realize the Paris climate targets – for example, pathways that overshoot 1.5 or 2 °C global warming, before returning to these levels at some later date. Earth system models need to be capable of thoroughly assessing such warming overshoots – in particular, the efficacy of mitigation measures, such as negative CO2 emissions, in reducing atmospheric CO2 and driving global cooling. An improved assessment of the long-term consequences of stabilizing climate at 1.5 or 2 °C above pre-industrial temperatures is also required. We recommend Earth system models run overshoot scenarios in CO2-emission mode to more fully represent coupled climate–carbon-cycle feedbacks and, wherever possible, interactively simulate other key Earth system phenomena at risk of rapid change during overshoot. Regional downscaling and impact models should use forcing data from these simulations, so impact and regional climate projections cover a more complete range of potential responses to a warming overshoot. An accurate simulation of the observed, historical record remains a fundamental requirement of models, as does accurate simulation of key metrics, such as the effective climate sensitivity and the transient climate response to cumulative carbon emissions. For adaptation, a key demand is improved guidance on potential changes in climate extremes and the modes of variability these extremes develop within. Such improvements will most likely be realized through a combination of increased model resolution, improvement of key model parameterizations, and enhanced representation of important Earth system processes, combined with targeted use of new artificial intelligence (AI) and machine learning (ML) techniques. We propose a deeper collaboration across such efforts over the coming decade. With respect to sampling future uncertainty, increased collaboration between approaches that emphasize large model ensembles and those focussed on statistical emulation is required. We recommend an increased focus on high-impact–low-likelihood (HILL) outcomes – in particular, the risk and consequences of exceeding critical tipping points during a warming overshoot and the potential impacts arising from this. For a comprehensive assessment of the impacts of Earth system change, including impacts arising directly as a result of climate mitigation actions, it is important that spatially detailed, disaggregated information used to generate future scenarios in integrated assessment models be available for use in impact models. Conversely, there is a need to develop methods that enable potential societal responses to projected Earth system change to be incorporated into scenario development. The new models, simulations, data, and scientific advances proposed in this article will not be possible without long-term development and maintenance of a robust, globally connected infrastructure ecosystem. This system must be easily accessible and useable by modelling communities across the world, allowing the global research community to be fully engaged in developing and delivering new scientific knowledge to support international climate policy.

To What Extent Is Public Demonstration Effective to Combat Environmental Injustice and Safeguard Community Rights in the United States?

Public demonstrations have emerged as an essential strategy for addressing environmental injustice and promoting systemic change. Other potential approaches such as legal actions face resistance due to resource limitations and urgent need for solutions in underprivileged regions. Through case studies, this research underscores the unique strength of public demonstration to mobilize comparatively immediate actions and exert political pressure. The substantial social influence made is crucial in driving reforms, given that environmental injustice issues typically pose continuous and serious health impacts on residents. The research points out that though community solidarity and governmental repression are two potential risks, public demonstration's effectiveness and accessibility still make it an optimal strategy. In addition, adopting micro protests across diverse locations is recommended to enhance the visibility of demonstrations further while reducing risks of injuries to participants. The study offers perspectives and operations for activists and community leaders on creating more resilient movements for equitable environmental governance.

Tissue oxidative stress and expression of chicken UCP and ANT mRNA in laying hens exposed to acute cold stress

ABSTRACT 1. Exposure to stress alters normal homoeostasis and, hence, the antioxidant defence system. The aim of this study was to examine the effect of acute cold temperature on the antioxidant defence system in hens. 2. Hy-line grey commercial layers (80 40-week-old) were randomly assigned to one of eight groups. In groups 1 to 5, hens were exposed to low temperature at −8.68°C (cool stressed) for 2, 4, 6, 8 and 10 h, respectively. In groups 6 and 7, post 10 h cool stressed, hens were quickly transferred to room at 21°C to recovery for 2 h and 4h, respectively. In treatment groups 6 and 7, post 10 h cool stressed, hens were quickly transferred to room at 21°C for 2 h and 4 h, respectively. Group 8 was the control, where hens were housed under regular condition at 21°C as controls. 3. Antioxidant enzymes (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA), in skeletal muscle, the kidney, liver and pancreas were measured. The transcription of avUCP and ANT mRNA was tested by RT-PCR. 4. The T-AOC activity was increased in the skeletal muscle of hens cold stressed for 2, 4, 6, 8 and 10 h and the 2 h recovery groups compared with control hens (p < 0.05). The GPx activity was increased in the liver and skeletal muscle after cold stress 4 h and in the pancreas of cold stress 2 h compared with the control group (p < 0.05). Antioxidant SOD activity was increased in the kidney after cold stress 6 h and in the liver after cold stress 10 h compared to the control group (p < 0.05). Measured MDA activity was increased in the pancreas after 2 h cold stress (p < 0.05). 5. UCP mRNA expression level was increased in the pectoral muscle for 2 h and 4 h recovery groups compared with the control hens (p < 0.05) and avian uncoupling protein (UPC), adenine nucleotide translocator (ANT) expression level was increased in the leg muscle of hens cold stress for 2, 6, 8 h and recovery 2 and 4 h. 6. The observed changes in the antioxidant defence system were tissue specific. Increments in levels of ANT (leg muscle) and UCP (pectoral and leg muscle) mRNA expression may be involved in the regulation of thermogenesis in skeletal muscle.

Self-care practices during the gender transition of Costa Rican transgender men

Relatively little is known about the unique needs and issues faced by transgender men and their self-care practices during gender transition. This study aimed to analyse self-care practices during gender transition through the life histories of a group of Costa Rican transgender men. A qualitative study with a sociohistorical design employing a thematic life history approach was conducted with fourteen participants between April and September 2022. Data were analysed using Content Analysis. Three categories were developed concerning self-care: (i) the shaping of self-care practices throughout different life stages; (ii) self-care practices related to masculinising the body; and (iii) self-care practices on the margins of a cisheteronormative society. The identified self-care practices took place with the goal of materialising men’s gender identity socially, legally and medically. While self-care plays a key role in supporting individuals throughout the transition process, it is limited in its capacity to ensure comprehensive well-being. The social prejudice and violence encountered by transgender men poses a challenge to achieving full well-being. External pressures and adversities limit the effectiveness of self-care practices, highlighting the need for broader systemic change to enhance the overall health and wellness of transgender men in Costa Rica.

Frames of systems change in sustainability transformations: Lessons from sociotechnical systems and circular economy case studies

Tackling the world's most complex challenges requires transforming systems purposefully, which involves reflecting on the directionality of ongoing systems transformations and the design of policy mixes capable of steering systems in more desirable directions. It is argued that a framing lens helps to advance understanding of this challenge by surfacing situated and heterogeneous perspectives on systems change. Frames are knowledge structures and default assumptions that help to guide action. This paper examines the frames of ‘systems change’ in purposeful sustainability transformations. To this end, a meta-synthesis of 155 case studies of sociotechnical systems change for sustainability and circular economy was conducted. Inductively coding these cases and comparing the emergent themes, four frames of systems change for sustainability were identified, varying depending on what they deem feasible and desirable change, the mechanisms and processes of change-making, and the different actor roles in these pursuits. A process model is developed to explain how explicit attention to frames can support opening up the directionality of purposeful systems transformations in ways that inform the design and implementation of more plural policy mixes. This contributes to the literature on directionality by providing insights on the boundaries of frames for systems change and the policy mix literature by identifying ways to engage directly with key assumptions guiding change-making efforts.

Stigma and fear of schizophrenia and severe mental illness: the positive effect of peer support

Purpose The purpose of this service user narrative is to highlight the stigma and prejudice that is often targeted at people with schizophrenia and severe mental illness, which causes fear and isolation. The therapeutic effect of peer support is further explored as offering hope, connection, aspirations, advocacy, autonomy and openness for service users as well as the possibility of recovery and a reduction in feelings of stigma, prejudice and exclusion. Design/methodology/approach Ben was diagnosed with paranoid schizophrenia in 2003, so this paper draws on over 20 years of experience of the harmful label of schizophrenia. In the last 15 months, he has been working as a peer worker on a men’s mental health ward in the East of England. He has kept a reflective journal and conducted participant observation on the ward, which informs this paper and its findings. Findings There are observations based on peer support on the ward in the last 15 months and over 20 years as a schizophrenic. People with schizophrenia and severe mental illness are stigmatised and experience discrimination and prejudice. This paper introduces the new idea and neologisms of schizophobia and insanophobia that people with severe mental illness will experience in their daily lives, in health and social care settings (such as the men’s ward), in education and in employment. People with mental illness are also often discriminated against as being a danger or a risk to themselves and others. They are often considered as aggressive or violent. Their diagnosis can stop them from getting a job, a mortgage or even from travelling to some places in the world. But this paper details the violent assault by a nurse on a patient while Ben was working on a long stay ward in a large psychiatric asylum in 1990. It is pertinent to note that things have progressed since the 1990's but there continues to be the stigmatisation of people with a severe mental illness, which requires societal and systemic change. In Ben’s experience, people with mental illness seem far more likely to experience violence upon their person rather than being violent towards other people, such as staff, members of the public, family or carers. Originality/value This service user narrative is a first person account, so it is original. It is of further value because it outlines the ways in which peer support can help with feelings of stigma and exclusion as well openness about hearing voices/ seeing things (hallucinations) and strange thought or beliefs (delusions).

Racial and Ethnic Discrimination and Medical Students’ Identity Formation

Investigating racial and ethnic discrimination in medical education is crucial for addressing disparities and fostering an inclusive environment. To assess how racial and ethnic discrimination in medical school is associated with personal and professional identity formation (PPIF) by race and ethnicity. This retrospective cross-sectional study used deidentified data on 37 610 medical students who matriculated in 2014 or 2015 and took the Association of American Medical Colleges Graduation Questionnaire (GQ) between 2016 and 2020. Statistical analysis was performed from September 1 to November 20, 2023. Experiences of racial and ethnic discrimination were assessed through responses to 3 GQ questions about denial of opportunities, offensive remarks or names, and lower evaluations or grades due to race or ethnicity. Personal and professional development were measured as 2 separate outcomes using 2 GQ statements rated on a 5-point Likert scale (where 1 indicated strongly disagree and 5 indicated strongly agree): "My medical school has done a good job fostering and nurturing my development as a person" and "My medical school has done a good job fostering and nurturing my development as a physician." Variables of personal and professional development were both dichotomized. Of 37 610 medical students, 18 200 (48.4%) were female, and 19 410 (51.6%) were male; 2458 (6.5%) were African American or Black, 7801 (20.7%) were Asian, 2430 (6.5%) were Hispanic, 21 380 (56.9%) were White, 2404 (6.4%) were multiracial, and 1137 (3%) were other race or ethnicity. Most respondents attested that their medical school fostered their personal (27 272 [72.5%]) and professional (34 560 [91.9%]) development. African American or Black students reported the lowest rates of personal (1603 of 2458 [65.2%]) and professional (2182 of 2458 [88.8%]) development, and experienced lower likelihoods of personal (adjusted risk ratio [ARR], 0.89 [95% CI, 0.86-0.93]) and professional (ARR, 0.95 [95% CI, 0.94-0.97]) development than White students. Racial discrimination was inversely associated with development, with the highest PPIF rates among those never experiencing discrimination (personal, 25 089 of 33 508 [74.9%]; and professional, 31 257 of 33 508 [93.3%]). Those experiencing isolated discrimination (personal: ARR, 0.83 [95% CI, 0.80-0.87]; professional: ARR, 0.92 [95% CI, 0.91-0.95]) and recurrent discrimination (personal: ARR, 0.63 [95% CI, 0.60-0.66]; professional: ARR, 0.82 [95% CI, 0.80-0.84]) had relatively lower likelihoods of PPIF. African American or Black students experienced the highest rate of recurrent discrimination (543 of 2458 [22.1%]). No significant PPIF risk differences were found for other racial and ethnic groups underrepresented in medicine without discrimination compared with White students without discrimination, but all groups with recurrent discrimination had relatively lower PPIF risk. In this cross-sectional study of US medical students, racial and ethnic discrimination was associated with lower PPIF across all racial and ethnic groups compared with White students without such experiences. African American or Black students disproportionately faced this discrimination. Systemic changes in medical education are needed to combat discrimination and ensure equity in holistic student development.

A comprehensive framework for circular product-service systems in infrastructure: Enhancing customer-contractor collaboration

Product-service systems (PSS) represent a business model that increases material decoupling and decreases environmental risks while providing customer value. PSS can help realize a more sustainable construction industry, which remains among the largest polluting and waste-generating sectors. Systemic change in the infrastructure sector requires client involvement, which is represented by the government. However, establishing circular PSS is challenging due to the complexities, which need to combine the lifecycle approach, customer-client aspects, new contracting, knowledge transfer, technology, and PSS-specific aspects. It requires ex-ante evaluation of real case studies to increase knowledge and understanding. This article presents a first-of-its-kind framework for infrastructure based on the current literature and analysis of five infrastructure pilots in the Netherlands (bridge deck, digital road lights, guide rails, roads). The final multistakeholder integrated circular PSS framework includes i) lifecycle perspective and circularity, a) materials and b) management, ii) customer-contractor relationship including a) customer-perspective b) co-creation aspects, c) client-customer hierarchy, iii) technology perspective (functions and resources) iv) business aspects such as a) network and b) value creation and retention. The framework allows customer-contractor communication and can serve as decision support. It is applicable to circular PSS where the customer has more involvement in the formulation of PSS.

How Public Libraries Build Sustainable Communities in the 21st Century

This panel presents research and scholarship, case studies, and reflective narratives that exemplify how public libraries use social capital to build communities and affect social change (Wojciechowska, 2021). Session participants will hear from the book editors and chapter authors of a book entitled How Public Libraries Build Sustainable Communities in the 21st Century published by Emerald in 2023. Panelists will share both national and international case studies. This panel, led by the book editors: Kaurri C. Williams-Cockfield, a Ph.D. student at the University of Alabama, and Dr. Bharat Mehra, Professor &amp; EBSCO Endowed Chair in Social Justice in the School of Information Sciences at the University of Alabama, features speakers, discussing their chapter case studies including Dr. Lynn Connaway, Executive Director for Research at OCLC who discusses library programs designed to close the legal justice gap; Christine D’Arpa, Assistant Professor in the School of Information Sciences at Wayne State University who proposes a sustainable communities model based on four separate research projects focusing on the role library staff play in building sustainable communities; Amber Matthews, Ph.D. candidate at Western University who discusses the development of a black community public library in Canada; Dr. Yong Ju Jung, Assistant Professor in the School of Library and Information Science at the University of Oklahoma who discusses a picturebook library designed to address book culture and empower children’s ecological sensitivity in South Korea; and Dr. Sarah Ryan, Associate Professor of Information Science and Director of the Law Librarianship Program at the University of North Texas who discusses the role of public libraries in the knowledge economy. These case studies situate public libraries as a backbone organization within the community and illustrate how public libraries support the implementation of the U.N. Sustainable Development Goals (SDGs). In 2021, Kania et al. researched the implementations of collective impact since 2011 assessing the effectiveness and ways different groups have adapted the model. The key finding from this analysis is that successful collective impact efforts must make equity the focus of their work (p. 38). Kania et. al (p. 41) identified five strategies for centering equity: Ground the work in data and context and target solutions Focus on systems change, in addition to programs and services Shift power within the collaborative Listen to and act with the community Build equity leadership and accountability The correlation between public libraries and the UN SDGs is clear given that “information is a central component of sustainable development goals'' (Kosciejew, 2020, p. 330). The International Federation of Library Associations and Institutions (IFLA) direct involvement in the data gathering and planning processes for the SDGs ensured that information access was part of every SDG and was identified as the common connector between the goals (Kosciejew, 2020, p.332). In Access and Opportunity for All: How Libraries Contribute to the United Nations 2030 Agenda, the IFLA (2019) outlines how libraries support all the SDGs by promoting literacy, providing access to information, serving as a network hub, supporting digital inclusion, encouraging research and academics, and by preserving culture and heritage. As public awareness and advocacy for the SDGs increase, the work of public libraries in community building is receiving greater attention given that public libraries expand social capital through their program and service connections. These connections are best illustrated by correlating the voices, programs, and research of the IS community to the SDGs, and by examining the collective strategic actions needed to achieve “collective impact” (Albright et al., 2022; Collective Impact Forum, 2016; Kania et al., 2021; Library of the Future, n.d.; Lynn et. al, 2018; Paschalville Partnership, n.d.; Veccharelli, J. 2018; Williams-Cockfield, K., 2022; Wojceichowska, M. D., 2021). Table 1 provides an outline of the program agenda. Program Agenda Activity Duration Introduction to the Project and the Panelists: Williams-Cockfield, Mehra 5 Minutes Discussion of Selected Chapters ● Lynn Silipigni Connaway – “The Library Serves as an Amplifier and Connector to the Community it Serves: Building Bridges to Legal Assistance” ● Christine D’Arpa – “Sustaining Ourselves, Sustaining Relationships, Sustaining Communities” ● Amber Matthews – Anti-racism in Practice: The Development of a Black Community Public Library in Canada” ● Yong Ju Jung – “A Small Library Making Big Changes: A Case Study of the Baramsup Library” ● Sarah Ryan – “Public Libraries as Key Knowledge Infrastructure Need to Empower Communities, Promote Economic Development, and Foster Social Justice” 40 Minutes Chapter Q&amp;A 10 Minutes Breakout, Small Group Sessions - How Does Your Work Relate to the SDGs? 20 Minutes Debrief of Breakout Sessions and Conclusion: Williams-Cockfield, Mehra 15 Minutes Table 1: Williams, K. (2024) By the conclusion of this panel, participants should understand how public libraries impact social change in communities and ideas for public library programming that supports the SDGs. Educators will have concrete examples that can be used as case studies in the classroom.

When “symbolic” policy is anything but: Policy design and feedbacks from California's human right to water law

AbstractDespite the reality that advocates frequently expend significant resources to pass symbolic policies, this policy design has often been neglected by policy studies scholarship. We combine policy design and policy feedback theory to examine this oft overlooked policy design in practice using the case of California's human right to water law (Assembly Bill 685, or AB 685). Through semi‐structured interviews, archival research, and document analysis, we reveal how grassroots advocates deliberately and effectively pursued AB 685 to build power across the water justice movement and catalyze narrative change about drinking water access, while also building state responsiveness on the topic. These interpretive policy feedback effects then accelerated the policy's resource effects through formal policy changes in funding allocations, administrative structures, and regulatory systems. Collectively, feedbacks from AB 685 have transformed the sociopolitics of drinking water access. Contrary to prevailing wisdom, the policy's ambiguity proved key to building the broad coalition necessary to accomplish these changes, and it facilitated work across policy venues and governance scales through time, which is critical to enacting transformational change. Based on these findings, we argue that symbolic policies merit attention as a potentially advantageous policy design for social movements seeking social change and transformation.

Patient and family aftercare enhance interactions between Helicopter Emergency Medicine Services and former patients and families

BackgroundHelicopter Emergency Medical Services (HEMS) in the United Kingdom (UK) deliver enhanced care to high-acuity, critically ill and injured patients. To enable patients to meet the HEMS team who treated them, many services within the UK have developed or are in the process of developing a Patient and Family Aftercare Service (PFAS). This study aims to evaluate whether the introduction of PFAS mitigates anxiety associated with patient aftercare visits.MethodsA service evaluation of anxiety in HEMS team members before and after patient aftercare visits were conducted. The study was carried out between 1 September 2023, and 31 October 2023, and patient visits were undertaken between March 2022 and July 2023. An electronic survey was distributed to the respondents who provided informed consent for participation. The survey comprised the validated generalised anxiety disorder anxiety scale (GAD-7) and five additional contextualised statements developed through the wider PFAS. Anonymised data were collected using REDCap, a secure electronic database and was analysed in R programming. Free-text comments were reported by content analysis, placed into themes, and discussed with a narrative to complement the quantitative analysis.ResultsOf the 33 recipients, 25 completed the questionnaire. Between the pre- and post-aftercare visits, a statistically significant difference was found between scores for GAD-7 (0.004, p < 0.05) and contextualised statements (0.001, p < 0.05). In addition, six broad themes were identified through content analysis. These include the emotional impact of patient interaction, coping strategies and structural changes in the aftercare system, challenges in patient and family expectations, anxieties relating to operational commitments, memory and recall of the incident, and a positive impact on personal growth.ConclusionAnxiety related to patient aftercare visits was reduced when measured before and after the patient visits. Following this service evaluation, we can hypothesise that within pre-hospital care, PFAS plays an important structural role. Future research should focus on affirming the correct tool to measure anxiety in multi-disciplinary teams and prospectively evaluating these methods collaboratively across multiple pre-hospital services.

Comparative assessment of neurotrophic proteins in vibration disease

Introduction. The problem of health impairment due to the impact of physical factors, including vibration disease (VD), retains medical and social relevance due to the significant specific gravity in the structure of occupational morbidity and high prevalence. Under vibration exposure, the acid-base equilibrium, immune status are disturbed, rheological properties and properties of the neurohumoral system, as well as functional indices of the central and peripheral nervous system change. Neurotrophins are known to play an important role in regulating the development and functioning of the central and peripheral nervous systems. In this regard, research is needed to determine in VD patients the levels of neurospecific proteins, which may serve as one of the markers for tracing changes in the nervous system in workers. The aim of the study was to identify the peculiarities of changes in neurospecific proteins (BDNF, S100β, and MBP) in the serum of patients with VD of different genesis. Materials and methods. Serum concentrations of neurotrophic proteins: brain neurotrophic factor – BDNF, S100β protein and myelin basic protein (MBP) were studied by solid-phase enzyme-linked immunoassay. Results. There was an increase in serum BDNF, S100β protein, and MBP concentrations in persons with VD due to combined exposure to local and general vibration, and an increase in MBP was observed in patients with VD due to exposure to local vibration. Limitations. The limitations of this work are small groups of employees. Conclusion. As a result of studies, it can be assumed that in VD due to exposure to combined vibration, changes are observed in the peripheral and central parts of the nervous system, and in VD due to local vibration, disorders seem to be mainly associated with the peripheral nervous system. The general pattern of the revealed disorders in the content of MBP lies in the neurodestructive processes occurring in the nerve fibers in patients with VD, regardless of genesis. Summarizing the above mentioned, the validity of studying the concentration of neurospecific proteins in vibration disease occurring with damaging processes in the nervous tissue should be recognized.

Advanced Methods for Verifying Memory Controllers in Modern Computing Systems

The primary component of the computer system that requires enhancement is the memory's performance. A memory controller helps in the management of control between the memory as well as the processor. This study gives a general outline of how controller performance in systems based on power converters may be improved using AI approaches. Among the many uses for power converters in today's electrical and energy systems are the effective control and conversion of energy in electric cars, renewable energy sources, and industrial automation, among others. Complementary control strategies used in classical approaches, although work well, may experience difficulties when it comes to system complication, change, and unpredictability. To overcome these restrictions, artificial intelligence methods appear rather prospective. Among the AI types one can distinguish neural networks, fuzzy logic, machine learning that may help to control the converters with enhanced efficiency by using adaptive and intelligent control. These approaches enhance control precision, succession, and reaction time to enhance system effectiveness and dependability. Moreover, this integration of AI enhances the most power converters by making it easier to predict maintenance, detect faults, and optimise for energy hence enhancing the systems. The paper presents new trends in the advanced smart control of the power converters, total control techniques, advantages as well as the challenges posed by AI control strategies. It also describes future trends and research areas for achieving enhanced performance in power converter-based systems through AI and Control techniques

Impact of COVID-19 on women leadership in Saudi higher education institutions

The COVID-19 epidemic caused unexpected complications, complexities and challenges in higher educational institutions (HEIs). In order to promote and strengthen the role of women leadership, this study aimed to clarify the unique challenges faced by female leaders at Saudi HEIs during the epidemic, find possible solutions to these challenges, and provide policy as well as management implications. A systematic literature review (SLR) was conducted, examining 27 records (i.e., research papers, articles and conference studies). The data were qualitatively analysed and categorized based on themes like challenges faced, opportunities recognized, and solutions proposed. Findings highlighted women leaders in Saudi HEIs grappled with multiple challenges, including technological barriers, cultural constraints, and increased workloads. Merging challenges with solvable strategies offers a forward-looking perspective, advocating for systemic changes that can shape a resilient and inclusive future for HEIs in Saudi Arabia.