Reduction of turbulent drag force is one of important works in the design of airplanes and hypersonic aircrafts. The annular plasma synthetic jet (APSJ) has become an interesting and popular flow control method in reducing the drag of turbulent boundary layers. In this paper, a comprehensive experimental study is carried out on the turbulent drag reduction regulated by an array of annular plasma synthetic jet actuators. The effects of the operating parameters such as the actuation voltage, the pulse frequency and the incoming wind speed on the drag reduction rate are studied and discussed in detail. The performances of the plasma actuator array are evaluated and summarized at multiple working conditions. Finally, the coherent structures of turbulence and the hairpin-like vortices are depicted and discussed. The results show that the optimal drag reduction rate is achieved, as the actuation voltage, pulse frequency and incoming wind speed are Vpp = 7 kV, fp= 50 Hz, and U∞ = 7 m/s, respectively. A resonant coupling phenomenon is observed when the pulse frequency of the actuators approaches the characteristic frequency of the coherent structure. The upward sweep flow induced by APSJ actuators may lead to a reduction of the turbulent drag force, but the downward wash flow leads to an increase in the drag. Present study could provide solid experimental data and a helpful guidance for the drag reduction of an airplane.