Synthetic Human ACTH Research Articles

Hypersensitivity to different ACTH peptides.

Abstract A male patient, born in 1920, presented a history with bronchial asthma and lupus erythematosus with haemolytic anaemia and rheumatoid arthritis. In 1957 the patient acquired hypersensitivity to porcine ACTH with signs of anaphylaxis. Positive intracutaneous tests and/or Prausnitz‐Küstner's test were observed for the following preparations: 1. Native preparations of porcine and human ACTH of various purity. 2. Synthetic ACTH peptides with human amino acid sequences (αh1–39, αh1–28) without addition of any prolongating agent. 3. Synthetic peptide, comprising the N‐terminal part of ACTH and common to all species known so far, possessing full steroidogenic property (α1–24). Intracutaneous tests were negative for a peptide comprising only the first 14 N‐terminal amino acids in the molecule. The results show that allergic reactions, induced by porcine ACTH, are also obtained with natural and synthetic human ACTH and synthetic shorter chain ACTH peptides.

Imitation of the adreno-cortical response to surgery by intravenous infusion of synthetic human ACTH.

ABSTRACT The concentration of plasma corticosteroids was followed during major surgery and during the infusion of synthetic human ACTH at dose rates varying from 2400 ng to 15 000 ng per hour. The results showed that the time course of plasma corticosteroids during major surgery was intermediate between that obtained during the infusion of 7500 and 15 000 ng synthetic human ACTH per hour. This gives an estimated ACTH secretion rate during major surgery of between 7500 ng and 15 000 ng per hour.

THE DURATION OF ACTION OF TWO SYNTHETIC HUMAN ACTH PEPTIDES IN DIFFERENT VEHICLES

THE DURATION OF ACTION OF TWO SYNTHETIC HUMAN ACTH PEPTIDES IN DIFFERENT VEHICLES