Abstract
Abstract A male patient, born in 1920, presented a history with bronchial asthma and lupus erythematosus with haemolytic anaemia and rheumatoid arthritis. In 1957 the patient acquired hypersensitivity to porcine ACTH with signs of anaphylaxis. Positive intracutaneous tests and/or Prausnitz‐Küstner's test were observed for the following preparations: 1. Native preparations of porcine and human ACTH of various purity. 2. Synthetic ACTH peptides with human amino acid sequences (αh1–39, αh1–28) without addition of any prolongating agent. 3. Synthetic peptide, comprising the N‐terminal part of ACTH and common to all species known so far, possessing full steroidogenic property (α1–24). Intracutaneous tests were negative for a peptide comprising only the first 14 N‐terminal amino acids in the molecule. The results show that allergic reactions, induced by porcine ACTH, are also obtained with natural and synthetic human ACTH and synthetic shorter chain ACTH peptides.
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