Synthetic Alternatives Research Articles

REVIEW ARTICLE ON THE EFFECTS OF AYURVEDIC VARNYA HERBS

In the contemporary landscape, the desire for a luminous complexion has grown remarkably, steering individuals towards an inclination for fair skin. This quest for radiance is witnessing a distinctive shift towards an increased preference for natural products over their synthetic alternatives. The unfolding narrative in the realm of skin enhancement delves into a burgeoning realm, constantly enriched by updated insights and discoveries. Intricately woven into this narrative is the timeless wisdom of Ayurveda, where terms like varṇya, raktaprasadana, and tvacya illuminate the path to skin luminosity. Ayurveda not only encapsulates a historical perspective on skin care but also aligns seamlessly with modern methodologies. Tyrosinase inhibition, a contemporary approach to skin lightening (whitening), finds resonance in Ayurvedic principles, forming a bridge between tradition and innovation. As societal beauty standards evolve, this nuanced interplay between tradition and modernity underscores a unique trajectory in the pursuit of radiant skin. The convergence of ancient wisdom and cutting-edge research epitomizes a distinctive approach to skincare, where the desire for light skin is not merely a trend but a harmonious blend of heritage and progress.

History of Horsehair Hair Sutures: Perspectives in Green Surgery.

Throughout history, animal hair and human hair have been used as suture materials in surgery and retain sporadic interest today. This systematic literature review examines 42 primary sources to uncover insights into the use of hair sutures. Several notable figures documented their experiences across specialties, highlighting horsehair's longevity and patient comfort. Despite waning popularity owing to synthetic alternatives, recent interest in autologous hair filaments for facial wounds signals a resurgence. The time-tested hair sutures offer a cost-effective, eco-friendly option, particularly in resource-limited settings.

Therapeutic potentials of Hibiscus trionum: Antioxidant, anti-lipid peroxidative, hypoglycemic, and hepatoprotective effects in type 1 diabetic rats

Recent advances in diabetes treatment have primarily focused on insulin and hypoglycemic agents; however, there is growing interest in exploring herbal and synthetic alternatives. Numerous studies have highlighted the preventive effectiveness of regular plant consumption in managing chronic conditions, particularly diabetes. Hibiscus, a medicinal plant recognized in various cultures, is known for its diverse health benefits. This study investigated the impact of Hibiscus trionum on glycemic control and assessed its influence on glucose and insulin levels in diabetes-induced rats. The concentrations of antioxidant enzymes, particularly superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), were scrutinized across multiple body tissues (plasma, heart, muscle, liver, and kidney). The malondialdehyde (MDA) concentration, an indicator of lipid peroxidation, was examined in both plasma and tissue samples. Serum total cholesterol (TC), triglyceride (TG), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels were evaluated. Diabetic Group (D) exhibited a significant decrease in body weight, increased fluid and food consumption, elevated blood glucose levels, and increased antioxidant enzyme activity. Moreover, the diabetic group also showed increased levels of MDA, TC, TG, AST, and ALT, along with reduced insulin levels, compared to the control group. A substantial improvement in all parameters impaired by diabetes was observed following the application of Hibiscus trionum (HTT) in the Diabetes+HTT group. The antioxidative stress-reducing, lipid peroxidation-improving, and hepatoprotective potential of Hibiscus trionum in mitigating diabetes-induced oxidative stress is noteworthy. These findings indicate that HTT supplementation has valuable beneficial effects in protecting against the harmful impacts of diabetes.

Fully synthetic, tunable poly(α-amino acids) as the base of bioinks curable by visible light

Bioinks play a crucial role in tissue engineering, influencing mechanical and chemical properties of the printed scaffold as well as the behavior of encapsulated cells. Recently, there has been a shift from animal origin materials to their synthetic alternatives. In this context, we present here bioinks based on fully synthetic and biodegradable poly(α,L-amino acids) (PolyAA) as an alternative to animal-based gelatin methacrylate (Gel-Ma) bioinks. Additionally, we first reported the possibility of the visible light photoinitiated incorporation of the bifunctional cell adhesive RGD peptide into the PolyAA hydrogel matrix. The obtained hydrogels are shown to be cytocompatible, and their mechanical properties closely resemble those of gelatin methacrylate-based scaffolds. Moreover, combining the unique properties of PolyAA-based bioinks, the photocrosslinking strategy, and the use of droplet-based printing allows the printing of constructs with high shape fidelity and structural integrity from low-viscosity bioinks without using any sacrificial components. Overall, presented PolyAA-based materials are a promising and versatile toolbox that extends the range of bioinks for droplet bioprinting.

Antibacterial Herbal Mouthwash Formulation and Evaluation Against Oral Disorders

The goal of the present study is to create and assess a herbal mouthwash and determine how well it works to lower oral cavity bacterial counts. Following their collection, the plant materials' water-soluble components were removed. We also assessed the mouthwash's physicochemical characteristics and antibacterial efficacy. The mouthwash that is now available on the market has strong antimicrobial qualities. The stability investigation's findings attest to the preparation's efficacy. These days, mouthwash is marketed as a liquid and usually includes antiseptic and antibacterial ingredients. These solutions have the potential to serve several purposes, including inhibiting the growth of germs in the oral cavity and acting as an analgesic, anti-inflammatory, or anti-fungal agent. The oral cavity is home to a variety of microbes. While certain types of oral bacteria are harmless, others can lead to mouth illnesses, plaque buildup in the mouth, and bad breath. Therefore, keeping good oral hygiene is essential for both physical and mental well-being. The effectiveness of herbs is thought to be relatively high when compared to chemical products. Medicinal plants are crucial in treating a variety of illnesses due to their potent antibacterial and antifungal effects against human infections. Herbal remedies aid in tooth cleaning, reduce dental plaque, inhibit the growth of bacteria, and freshen breath. Herbal mouthwashes can be used in addition to your normal dental hygiene routine, which includes brushing and flossing. They are helpful in supportive periodontal treatment because of their potent antiinflammatory and anti-plaque characteristics. Many herbal remedies and their extracts, including those made from peppermint, cloves, neem, and turmeric, have demonstrated notable benefits over synthetic alternatives. Due to their long-lasting anti-bacterial, antimicrobial, and anti-fungal actions on human pathogens, medicinal herbs are essential for the treatment of illness. Using natural mouthwash in place of conventional ones may have several advantages. If a formulation like this could be invented that folks could safely and simply prepare at home using natural ingredients. As a result, the general oral health of the community could get better. Because they function on oral infections, quickly relieve pain, have few or no side effects, and target oral pathogens, herbal mouthwashes are quite popular. Among the most common infectious diseases that many individuals encounter at different times in their life are dental caries and periodontal disease. The purpose of this article is to give a general review of natural substances that can be effective mouthwashes. The objective of this study was to use polyherbal components to make mouthwash that has antibacterial properties.

Finite element modelling and analysis of jute fibre reinforced PLA matrix composite

A number of environmental issues, including the production of waste, buildup in disposal systems, and recyclability, are major factors in the usage of numerous biodegradable materials. Every day, more and more plastic consumers are requesting and using biopolymers, which is driving up their use. One of the most promising biopolymers that has been thoroughly studied is polylactic acid (PLA), which is now starting to replace plastic materials in several applications. In the same way, natural fibers are beginning to replace synthetic fibers in reinforced composites for a wide range of products due to their technological advantages, economic advantages, and environmental benefits. This research paper delves into the comprehensive exploration of jute fibre reinforced PLA matrix bio-composite, focusing on their load carrying capacity and strength. Through empirical analysis, the research showcases the specific case of Jute Fibre-PLA composite, which serves as a representative example to highlight the exceptional compatibility and potential advantages of bio-composites over traditional synthetic alternatives. In this work, PLA matrix and Jute fibres have been used to prepare the composite material. By using Finite element method (FEM), Jute fibre lengths of 140 mm (long fibres) and 9 mm length (short fibres) were analyzed. Results revealed that short fibres have the effective strengthening property as compared to long fibre lengths.

АЛКАЛОИДТАРДЫ ТАЗАЛАУ ЖӘНЕ БӨЛІП АЛУ

Natural products and their derivatives have been used for medical purposes for many years. Plants are the main source of new medicinal compounds, since herbal medicines are widely used to maintain and improve human health. The main advantages of using herbal medicines are that they are relatively safe compared to synthetic alternatives, providing profound therapeutic benefits and accessibility. Over the past 30 years, the process of finding and developing medicines, especially natural products, has increasingly been carried out in template ways. According to the data, alkaloid plants began to be used since 2000 BC throughout Asia, Europe and Africa. In the nineteenth century, Friedrich Serturner isolated morphine. This led to the successful isolation and discovery of individual compounds by several European scientists, including the secretion of xanthine, strychnine, atropine, quinine and caffeine [1].Alkaloids were initially identified as alkaline substances secreted by a plant with biological activity. This definition has been repeatedly refined to define compounds that do not belong to the plant kingdom, and compounds that have a biosynthetic origin in common with alkaloids, but do not contain basic nitrogen.

Effect of West Indian Bay Leaf (Pimenta racemosa) and Turmeric (Curcuma longa) Essential Oils on Preserving Raw Chicken Breasts.

While the use of chemical preservatives in meat may appear to be tremendously advantageous, they have long been purported to increase the risk of incidence of certain types of cancers. Consequently, many people have opted for minimally processed alternatives. This consumer shift has placed substantial pressure on the food industry to implement more natural alternatives to these synthetic preservatives in the meat industry. Research on plant extracts as potential agents for food additives is increasing. The bioactive components present in West Indian bay leaf and turmeric essential oils have a promising potential for use as novel, green preservatives in the meat industry. Raw chicken breast samples (28 g) were each treated with different volumes (0.5, 1 and 1.5 mL) of the essential oil of West Indian bay leaf or turmeric or their mixture (1:1 to make up a final volume of 0.5, 1 and 1.5 mL). Physicochemical, microbiological and sensory evaluations were performed on the fresh and treated samples stored for 14 days at 4 °C. The West Indian bay leaf oil had a higher extraction yield and total phenolic content, while the turmeric oil had a higher total flavonoid content. The most effective treatments, compared to the control, significantly (p<0.05) minimized the pH increase by 13.9 % (1.5 mL bay leaf oil), reduced texture loss by 44.8 % (1.5 mL oil mixture) and reduced protein loss by 98.9 % (1 mL bay leaf oil). Most treated samples had reduced microbial loads, with the turmeric oil showing the highest efficacy against lactic acid bacteria, yeasts and moulds. Treated samples had significantly higher (p<0.05) sensory scores than the control on the final day of storage, with the 1.5 mL oil mixture proving to be the most effective, as the storage life of the chicken breast sample was extended by 6 days. This study has shown for the first time that the essential oil from turmeric and West Indian bay leaf can extend the shelf life of raw chicken breast and highlights the potential of the oil as natural preservative agents in lieu of synthetic alternatives.

Aptamer-Targeted Dendrimersomes Assembled from Azido-Modified Janus Dendrimers "Clicked" to DNA.

Amphiphilic Janus dendrimers (JDs), synthetic alternatives to lipids, have the potential to expand the scope of nanocarrier delivery systems. JDs self-assemble into vesicles called dendrimersomes, encapsulate both hydrophobic cargo and nucleic acids, and demonstrate enhanced stability in comparison to lipid nanoparticles (LNPs). Here, we report the ability to enhance the cellular uptake of Janus dendrimersomes using DNA aptamers. Azido-modified JDs were synthesized and conjugated to alkyne-modified DNAs using copper-catalyzed azide alkyne cycloaddition. DNA-functionalized JDs form nanometer-sized dendrimersomes in aqueous solution via thin film hydration. These vesicles, now displaying short DNAs, are then hybridized to transferrin receptor binding DNA aptamers. Aptamer-targeted dendrimersomes show improved cellular uptake as compared to control vesicles via fluorescence microscopy and flow cytometry. This work demonstrates the versatility of using click chemistry to conjugate functionalized JDs with biologically relevant molecules and the feasibility of targeting DNA-modified dendrimersomes for drug delivery applications.

Exploring FDA-Approved Frontiers: Insights into Natural and Engineered Peptide Analogues in the GLP-1, GIP, GHRH, CCK, ACTH, and α-MSH Realms.

Peptides continue to gain significance in the pharmaceutical arena. Since the unveiling of insulin in 1921, the Food and Drug Administration (FDA) has authorised around 100 peptides for various applications. Peptides, although initially derived from endogenous sources, have evolved beyond their natural origins, exhibiting favourable therapeutic effectiveness. Medicinal chemistry has played a pivotal role in synthesising valuable natural peptide analogues, providing synthetic alternatives with therapeutic potential. Furthermore, key chemical modifications have enhanced the stability of peptides and strengthened their interactions with therapeutic targets. For instance, selective modifications have extended their half-life and lessened the frequency of their administration while maintaining the desired therapeutic action. In this review, I analyse the FDA approval of natural peptides, as well as engineered peptides for diabetes treatment, growth-hormone-releasing hormone (GHRH), cholecystokinin (CCK), adrenocorticotropic hormone (ACTH), and α-melanocyte stimulating hormone (α-MSH) peptide analogues. Attention will be paid to the structure, mode of action, developmental journey, FDA authorisation, and the adverse effects of these peptides.

“A Review of Nanofiber: Current Progress in Application of Polymeric Nanofibers to Tissue Engineering”

Numerous types of polymer nanofibers have been developed to serve as synthetic alternatives to extracellular matrix (ECM). Among these, electrospinning is a widely used technique for the production of nanofibrous scaffolds. This method creates nanofibers having a porous structure and a large specific surface area. Both organic and artificial Electrospun polymers have been used to create a fibrous framework that mimics the ECM and promotes cell activity. Tissue engineering is a technology that uses biomaterials, chemistry, and cell biology to create tissues in three dimensions (3D) that closely resemble the matrix extracellular in structure. The ECM is formed by braiding nanofibrous structures together. Electrospinning is widely used in the creation of nanofibrous scaffolds. It produces porous nanofibers with a highly particular surface area. The electrospinning technique and the parameters of the solution strongly influence the nanofibers' structural shape and assembly. By combining natural or synthetic polymers used in electrospun nanofibers, their function can be modified. Furthermore, electrospun nanofibers can be functionalized using a range of surface modification methods. This work presents the latest advancements in electrospun nanofiber synthesis and describes various methods for surface modification of the scaffolds to increase their activity. There is also discussion of the use of cutting-edge polymeric nanofibrous scaffolds in human vascular tissue regeneration, ligaments, and tendons.

Design and Evaluation of Hair Growth - Hair Fall Oil Formulation from Botanicals

Hair loss in adult men albeit common, can cause emotional distress. Many people with hair fall issues try chemical-based treatments that may lead to health complications and allergic reactions. Cosmetics using natural ingredients derived from plants have fewer side effects compared to synthetic alternatives. The study aimed to formulate herbal hair oil using various ingredients like castor oil, sunflower oil, jojoba oil, olive oil, pumpkin oil, etc. and evaluate its effectiveness in promoting hair growth and prevention of hair fall (HG-HF). Besides, the oil was supposed to provide a range of benefits for hair health, including preventing dandruff, improving scalp health, providing antioxidant properties, and thereby protecting against oxidative damage. The DPPH radical scavenging test was done to evaluate the antioxidant activity of the oils. Varying IC50 values were found such as olive oil and sunflower oil showed IC50 values of 3.79 μg/ml and 4.44 μg/ml respectively. Hence, these oils have significant antioxidant activity with a strong ability to scavenge or neutralize free radicals. A study was conducted on sixteen volunteers with hair loss, dandruff, and other hair problems to check the performance of the oil. 56.25% of the participants experienced increased hair growth and 50% reported a decrease in hair fall after using the oil for 3 months, with no remarkable side effects. Data demonstrated effectiveness and overall acceptable perception of the HG-HF oil by the participants. Bangladesh Pharmaceutical Journal 27(1): 9-18, 2024 (January)

Metal-free production of natural blue colorants through anthocyanin–protein interactions

IntroductionThe scarcity of naturally available sources for blue colorants has driven reliance on synthetic alternatives. Nevertheless, growing health concerns have prompted the development of naturally derived blue colorants, which remains challenging with limited success thus far. Anthocyanins (ACNs) are known for providing blue colors in plants, and metal complexation with acylated ACNs remains the primary strategy to generate stable blue hues. However, this approach can be costly and raise concerns regarding potential metal consumption risks. ObjectivesOur study aims to introduce a metal-free approach to achieve blue coloration in commonly distributed non-acylated 3-glucoside ACNs by exploring their interactions with proteins and unveiling the underlying mechanisms. MethodsUsing human serum albumin (HSA) as a model protein, we investigated the structural influences of ACNs on their blue color generation using visible absorption spectroscopy, fluorescence quenching, and molecular simulations. Additionally, we examined the bluing effects of six proteins derived from milk and egg and identified the remarkable roles of bovine serum albumin (BSA) and lysozyme (LYS). ResultsOur findings highlighted the importance of two or more hydroxyl or methoxyl substituents in the B-ring of ACNs for generating blue colors. Cyanidin-, delphinidin- and petunidin-3-glucoside, featuring two neighboring hydroxyl groups in the B-ring, exhibited blue coloration when interacting with HSA or LYS, driven primarily by favorable enthalpy changes. In contrast, malvidin-3-glucoside, with two methoxyl substituents, achieved blue coloration through interactions with HSA or BSA, where entropy change played significant roles. ConclusionOur work, for the first time, demonstrates the remarkable capability of widely distributed 3-glucoside ACNs to generate diverse blue shades through interactions with certain proteins. This offers a promising and straightforward strategy for the production of ACN-based blue colorants, stimulating further research in this field.

Authentication of Fennel, Star Anise, and Anise Essential Oils by Gas Chromatography (GC/MS) and Stable Isotope Ratio (GC/IRMS) Analyses.

The aromatic compound (E)-anethol is widely used in the flavor, fragrance, and medicinal industries. This compound is commonly produced through steam distillation of fennel, star anise, and anise seed. Given the cost of production, these natural and authentic essential oils are commonly adulterated with lower-cost natural materials or synthetic alternatives. The current study investigates essential oil profiles (gas chromatography/mass spectrometry) and stable isotope ratios (gas chromatography/isotope ratio mass spectrometry) of the abundant compound (E)-anethol in both authentic reference standards (n = 15) and commercially available samples (n = 30). This multifaceted analytical approach establishes techniques for ensuring the authenticity of essential oil sources of (E)-anethol and was then used to evaluate the current essential oil market sources of (E)-anethol. These findings report that adulteration of (E)-anethol-containing natural products takes various forms, and a multifaceted analytical approach is recommended for authentication. Of the commercial samples analyzed for this report, 27% were adulterated.

Preparation and evaluation of bioactive cellulose acetate films from Musa acuminata

Natural biodegradable polymers serve as a more sustainable and cost effective solution for food packaging compared to synthetic alternatives.

Electrochemical sensors based on molecularly imprinted polymers for the detection of chlorophenols as emergent distributing chemicals (EDCs): a review.

Environmental pollutants like chlorophenol chemicals and their derivatives are commonplace. These compounds serve as building blocks in the production of medicines, biocides, dyes, and agricultural chemicals. Chlorophenols enter the environment through several different pathways, including the breakdown of complex chlorinated hydrocarbons, industrial waste, herbicides, and insecticides. Chlorophenols are destroyed thermally and chemically, creating dangerous chemicals that pose a threat to public health. Water in particular is affected, and thorough monitoring is required to find this source of pollution because it can pose a major hazard to both human and environmental health. For the detection of chlorophenols, molecularly imprinted polymers (MIPs) have been incorporated into a variety of electrochemical sensing systems and assay formats. Due to their long-term chemical and physical stability as well as their simple and affordable synthesis process, MIPs have become intriguing synthetic alternatives over the past few decades. In this review, we concentrate on the commercial potential of the MIP technology. Additionally, we want to outline the most recent advancements in their incorporation into electrochemical sensors with a high commercial potential for detecting chlorophenols.

A noble metal-enhanced Au@CuO heterostructure with multienzyme-mimicking activities for colorimetric detection of tannic acid.

Nanozymes, serving as synthetic alternatives to natural enzymes, offer several benefits including cost-effectiveness, enzyme-like catalytic abilities, enhanced stability, adjustable catalytic activity, easy recyclability, mild reaction conditions, and environmental friendliness. Nonetheless, the ongoing quest to develop nanozymes with enhanced activity and to delve into the catalytic mechanism remains a challenge. In our research, we effectively developed Au@CuO nanocomposites (Au@CuO Nc), replicating the functions of four enzymes found in nature: peroxidase (POD), catalase (CAT), glutathione peroxidase (GPx), and oxidase (OXD). The catalytic efficiency of Au@CuO Nc for TMB oxidation (oxTMB) was approximately 4.8 times greater than that of plain Cu2O cubes, attributed to the synergistic catalytic impact between the Au element and Cu2O within Au@CuO Nc. Mechanistic studies revealed that the novel Au@CuO Nc nanozyme greatly enhances the decomposition of H2O2 to reactive oxygen species (ROS) intermediates (˙OH, ˙O2- and 1O2), resulting in increased POD-like activity of the single-component Cu2O cubes. When an antioxidant like TA was added to the chromogenic system, it converted oxTMB into a colorless form of TMB, enabling further evaluation of TA. Hence, a colorimetric sensor was developed for the rapid and precise quantitative measurement of TA, demonstrating strong linearity between 0.3 and 2.4 μM and featuring a low detection threshold of 0.25 μM. Moreover, this sensor was effectively utilized for the assessment of TA in actual tea samples. This work innovatively proposes a simplified and reliable strategy for the advanced design of highly effective Cu-based nanozymes, enhancing enzyme-like reactions for simultaneous, on-site colorimetric probing of antioxidants.

Silk-based intelligent fibers and textiles: structures, properties, and applications.

Multifunctional fibers represent a cornerstone of human civilization, playing a pivotal role in numerous aspects of societal development. Natural biomaterials, in contrast to synthetic alternatives, offer environmental sustainability, biocompatibility, and biodegradability. Among these biomaterials, natural silk is favored in biomedical applications and smart fiber technology due to its accessibility, superior mechanical properties, diverse functional groups, controllable structure, and exceptional biocompatibility. This review delves into the intricate structure and properties of natural silk fibers and their extensive applications in biomedicine and smart fiber technology. It highlights the critical significance of silk fibers in the development of multifunctional materials, emphasizing their mechanical strength, biocompatibility, and biodegradability. A detailed analysis of the hierarchical structure of silk fibers elucidates how these structural features contribute to their unique properties. The review also encompasses the biomedical applications of silk fibers, including surgical sutures, tissue engineering, and drug delivery systems, along with recent advancements in smart fiber applications such as sensing, optical technologies, and energy storage. The enhancement of functional properties of silk fibers through chemical or physical modifications is discussed, suggesting broader high-end applications. Additionally, the review addresses current challenges and future directions in the application of silk fibers in biomedicine and smart fiber technologies, underscoring silk's potential in driving contemporary technological innovations. The versatility and sustainability of silk fibers position them as pivotal elements in contemporary materials science and technology, fostering the development of next-generation smart materials.

Prospect of waste banana fiber use in industry: A narrative review

In recent years, there has been significant research and investigation into the utilization of natural plant fibers. These fibers are increasingly recognized for their superiority over synthetic alternatives due to their biodegradable nature, renewable source, lightweight composition, and enhanced biochemical and tensile characteristics. Banana fiber holds significant importance due to the widespread use of bananas globally. Different components of the banana plant, including the fruit, fruit skin, flower buds, leaves, and pseudo-stem (banana trunk), are employed for diverse industrial applications. The pseudo-stem constitutes a significant proportion of the biomass derived from banana waste and possesses high-quality fiber that exhibits promising potential for various industrial applications. These applications include the production of sanitary pads, textiles, pulp and paper, food products, reinforced composite materials for automobiles, construction materials, aerospace components, and other composite materials. Additionally, the residual waste generated from its production can be effectively employed for the development of bio-based products, thereby making a direct contribution to a country's economy. In summary, this review study provides valuable insights for many stakeholders, including farmers, businesspeople, planners, scientists, and the government, to facilitate informed decision-making and promote socioeconomic advancement within the country.

The Effect of Parent Cell Type on Small Extracellular Vesicle-Derived Vehicle Functionality.

Cell therapies involving c-kit+ progenitor cells (CPCs) and mesenchymal stem cells (MSCs) have been actively studied for cardiac repair. The benefits of such therapies have more recently been attributed to the release of small extracellular vesicles (sEVs) from the parent cells. These sEVs are 30-180nm vesicles containing protein/nucleic acid cargo encapsulated within an amphiphilic bilayer membrane. Despite their pro-reparative effects, sEV composition and cargo loading is highly variable, making it challenging to develop robust therapies with sEVs. Synthetic alternatives have been developed to allow cargo modulation, including prior work from the laboratory, to design sEV-like vehicles (ELVs). ELVs are synthesized from the sEV membrane but allow controlled cargo loading. It is previously shown that loading pro-angiogenic miR-126 into CPC-derived ELVs significantly increases endothelial cell angiogenesis compared to CPC-sEVs alone. Here, they expand on this work to design MSC-derived ELVs and study the role of the parent cell type on ELV composition and function. It is found that ELV origin does affect the ELV potency and that ELV membrane composition can affect outcomes. This study showcases the versatility of ELVs to be synthesized from different parent cells and highlights the importance of selecting ELV source cells based on the desired functional outcomes.