Momentous advancement in nanotechnology has greatly participated in bringing transformations in various challenges of society like energy production, information technology, health and environment. Out of all the challenges society is currently facing, health is the major issue. Cancer, Bacterial, Fungal and other numerous diseases are there which we need to encounter with the best possible methods. Nanoparticles owing to their better size to area ratio act as good drug delivery agents. Synthesis of nanoparticles (NPs) has already travelled a long pathway and researchers are looking for green synthesis of NPs which is non-toxic and non-hazardous pathway of NPs synthesis. Green synthesis of NPs can be performed using bacteria, fungi, algae, virus, plant extracts etc. Green synthesis is preferable because of its cost-effectiveness, energy-efficient nature, bio-compatibility and being therapeutically significant. Biological media tend to have antioxidant properties preferably plant resources which when incorporated with metal, transport same property to such nanoparticles synthesized. Since ancient times, it has been read and well-researched that silver accounts various health benefits. Therefore, silver NPs (AgNPs) are looked upon for their novel use in therapies and treatment against numerous diseases as anticancer, anti-fungal, antibacterial. This review commentates on therapeutic activity of green synthesized AgNPs, their mode of action, and potential medicinal use against many diseases as well as their antioxidant potential.