Abstract Background Syncope is a transient loss of consciousness secondary to cerebral hypoperfusion and is characterized by a sudden onset, short duration and spontaneous recovery. The prevalence of syncope is between 30 to 50% in children and adolescents, 75% of them could corresponding to neuromediated reflex syncope (NRS) and to postural orthostatic tachycardic syndrome (POTS). The efficacy of education and lifestyle measures to prevent syncope prodromes in schoolchildren is still little known. Objective The aim of this study was to assess the education and lifestyle measures (syncope prodromes recognition, frequent water intake, counter-pressure maneuvers and physical activity) for preventing syncope prodromes in schoolchildren over 12 months. Methods We included 123 children and, at baseline, we assessed clinical parameters such as heart rate (HR), and systolic and diastolic blood pressure (SBP and DBP, respectively), and oriented how to recognize syncope prodromes and triggers as well as to take lifestyle and other measures (frequent water intake, counter-pressure maneuvers and physical activity). We performed statistical analysis using ANOVA for continuous variables and Qui-Square Test or Fisher Exact Test for categorical variables, when appropriate. Results Children were divided in three groups: no NRS-POTS (noNRS-POTS; n=103, mean age: 10.0 years, 49 male, height: ∼1.42 m, weight: ∼60.9 kg, HR: ∼63 bpm, SBP: ∼100,1 mmHg and DBP: ∼65.8 mmHg), NRS (n=5, mean age: 10.4 years, 2 male, height: ∼1.39 m, weight: ∼63.9 kg, HR: ∼68 bpm, SBP: ∼107,2 mmHg and DBP: ∼69.8 mmHg), and POTS (n=15, mean age: 10.47 years, 6 male, height: ∼1.39 m, weight: ∼69.0 kg, HR: ∼53 bpm, SBP: ∼100,7 mmHg and DBP: ∼63.6 mmHg). From 123 children, 95% (n=117) had history of syncope prodromes and 13.8% (n=17) had syncope history. Over the 12-month, only 10.6% of them (n=13) continued to have syncope prodromes and, most interesting, none of them had a new syncope event. Conclusion Education and lifestyle measures were effective to significantly reduce syncope prodromes and to prevent any new syncope event. Funding Acknowledgement Type of funding sources: Public Institution(s). Main funding source(s): University of Sao Paulo