Switchable Laser Research Articles

A Tunable and Switchable Multi-Wavelength Erbium-Doped Fiber Ring Laser Enabled by Adjusting the Spectral Fringe Visibility of a Mach-Zehnder Fiber Interferometer

This paper presents a tunable, switchable multi-wavelength emission from an erbium-doped fiber ring laser, enabled by adjusting the spectral fringe visibility of a fiber interferometer filter. The filter is formed with specially designed concatenated tapered fibers to configure a Mach-Zehnder fiber interferometer (MZFI). The laser emission is highly flexible and reconfigurable, allowing for tuning between single- and dual-wavelength operation. The laser can switch sequentially from one up to six wavelengths by fixing the curvature and adjusting the polarization state. The lasing emission is generated over a stable wavelength range between 1559.59 nm and 1563.54 nm, exhibiting an optical signal-to-noise ratio (OSNR) exceeding ~35 dB. The performance of amplitude and wavelength fluctuations were evaluated, indicating an appropriate stability of ~3 dB and a shift less than 0.1 nm within a 45 min period at room temperature. A detailed comparison with the literature is given.

Topological-charge-tunable and wavelength- switchable vortex laser enabled by a helically twisted high-absorption few-mode erbium-doped fiber.

Vortex beams carrying orbital angular momentum (OAM) offer a solution for enhancing spatial degrees of freedom, particularly in conjunction with wavelength division multiplexing, which can significantly boost data capacity for optical communication. Addressing the increasing demand for high information-carrying capacity, we present a dynamically tunable OAM laser source in this study. We demonstrate a ring-cavity vortex fiber laser employing intra-cavity mode conversion through a helically twisted high-absorption few-mode erbium-doped fiber (HA-FM-EDF). The constructed vortex fiber laser exhibits wavelength switchability via an integrated Sagnac loop, facilitated by a homemade ring-core fiber. Furthermore, topological-charge tunability is achieved through the utilization of twisted HA-FM-EDF with varying helical pitches. To our knowledge, this marks the first successful implementation of two-dimensional multiplexing of wavelength and OAM in a vortex fiber laser. The OAM laser serves as a versatile vortex source with high tunability and flexibility, holding significant potential for deployment in ultrahigh-speed/ultrahigh-capacity communications, ultrahigh-resolution imaging, and ultrahigh-sensitivity sensing applications.

Eight-wavelength-switchable single-frequency fiber laser with scattering-enhanced fiber-based wavelength self-adaptive linewidth compression

We demonstrate an eight-wavelength-switchable single-frequency (SF) ultra-narrow linewidth erbium-doped fiber laser (EDFL). A switchable polarization-dependent eight-channel filter (S-PDECF), fabricated using femtosecond laser direct-writing technology, determines the eight wavelengths of the laser output, with four channels concentrated near 1530 nm and the other four near 1550 nm. A dual-coupler ring-based compound-cavity filter is utilized to achieve single-longitudinal-mode selection for the EDFL. The introduction of a femtosecond laser direct-written scattering-enhanced fiber (SEF) effectively narrows the laser linewidth, enabling ultra-narrow linewidth outputs lasing at all eight wavelengths, and the wavelength self-adaptive linewidth compression of the SEF is verified for the first time. Furthermore, the incorporation of SEF significantly enhances the overall performance of the EDFL. The eight switchable single-wavelength laser outputs all exhibit exceptional characteristics, including spectral wavelength fluctuations of ≤0.011 nm, spectral peak power fluctuations of ≤0.54 dB, optical signal-to-noise ratios of ≥71 dB, linewidths of ≤248 Hz, output power fluctuations of ≤0.252 dB over a 10-min measurement period, and relative intensity noise of ≤−150.17 dB/Hz @≥ 3 MHz.

Exploring the ON/OFF nonlinear optical (NLO) response in tetracene-based chromophores: A DFT study on solvent and frequency-dependent NLO properties for switching applications

Tetracene-based nonlinear optical (NLO) materials are an ambient field of interest in optoelectronic technology. Inspired by this material, we theoretically designed D-D-A framework molecules (ZO and ZO-1 to ZO-16) with auxiliary donor and acceptor screening of solo tetracene linear surface and investigated their reactivity, electrical properties, solvent-dependent optical and ON/OFF NLO properties utilizing DFT simulations. The CPCM and IEFPCM model is used to examine how entire spectrum of medium polarity, ranging from less polar to more polar solvents (chloroform (ε = 4.71) < tetrahydrofuran (ε = 7.43) < DMSO (ε = 46.83 < water (ε = 78.36)) affect the optical absorption and NLO characteristics (βtot, αtot, and μtot) of suggested compounds (ZO and ZO-1 to ZO-16). Furthermore, natural bond orbital analysis (NBO) and topological analysis (MEP, ELF, and LOL) were used to explain the NLO results. Regarding the charge transfer robustness, ZO-9, a promising tetracene derivative, is identified as an appealing second-order NLO candidate, with the lowest energy gap (1.642 eV) and largest λmax (546.692 nm) among all investigated derivatives. Moreover, the solvent-dependent optical absorption spectrum shows that polar solvent (THF) alleviates the λmax from 273.081 nm to 707.511 nm in ZO-11. Similarly, solvent also influences the NLO properties in all designed compounds, especially in ZO-9, which displayed giant βtotal = 7.244 × 105 in chloroform, 8.640 × 105 in THF, 1.153 × 106 in DMSO, and 1.180 × 106 in water as well as in gas (1.993 × 105). Additionally, the results of the second harmonic generation (SHG) β(−2ω, ω, ω) and the electro-optical Pockels effect (EOPE) β(−ω,ω,0) computed at the frequencies of ω = 1064 nm (0.0428 au) and ω = 532 nm (0.0856 au) validates that all tetracene based derivatives are excellent NLO candidates for laser working condition and switching applications.

High–Speed Laser Modulation for Low–Noise Micro–Cantilever Array Deflection Measurement

In this paper, an innovative approach is introduced to address the noise issues associated with micro–cantilever array deflection measurement systems employing multiple lasers. Conventional systems are affected by laser mode hopping during switching, resulting in wavelength instability and beam spot fluctuations that take several hundred milliseconds to stabilize. To mitigate these limitations, a high–speed laser modulation technique is utilized, leveraging the averaging effect over multiple modulation cycles within the sampling window. By driving the lasers with a high–frequency carrier signal, a low–noise and stable output suitable for micro–cantilever beam deflection measurement is achieved. The effectiveness of this approach is demonstrated by simultaneously modulating the lasers and rapidly observing the spectral and centroid variations during high–speed switching using a custom–built high–speed spectrometer. The centroid fluctuations are also analyzed under different modulation frequencies. The experimental results confirm that the high–speed modulation method can reduce the standard deviation of beam spot fluctuations by more than 90%, leading to significant improvements in noise reduction compared to traditional laser switching methods. The proposed high–speed laser modulation approach offers a promising solution for enhancing the precision and stability of multi–laser micro–cantilever array deflection measurement systems.

Refraction-Based Laser Scanning Microcantilever Array System

Microcantilever arrays are valuable tools for detecting minute physical and chemical changes. Traditional microcantilever array systems, including our previous work utilizing multiple laser arrays, frequently encounter high complexity, significant costs, and increased noise caused by laser switching. This study introduces a refraction-based laser scanning system that significantly mitigates these issues by employing a rotating glass optical block for multiplex scanning. This innovative approach not only simplifies the scanning process by eliminating the need to move the laser source or the microcantilever array but also enhances scanning speed and reduces noise, as demonstrated by our experiments. Overall, this research implements a new optical scanning strategy for microcantilever array systems, which is promising due to its direct application potential as it paves the way for more accurate, high-performing, and cost-effective sensing solutions.

Dynamic imaging of micro-vibrations with an ultra-wide bandwidth and a femtometer noise using switchable pulsed laser interferometry

Imaging the complex dynamics of micro-vibrations plays a fundamental role in the investigation of microelectromechanical systems (MEMS). However, it remains a challenge for achieving both a wide bandwidth and a low noise due to the high photodetector noise and electromagnetic interference at GHz frequencies. Here, we propose a pulsed laser interferometry system with an adaptable switch to image GHz vibrations based on stroboscopic mixing, while measuring lower-frequency vibrations based on the homodyne scheme. The noise power spectral density is shown in both regions from DC to 10 GHz with an average noise down to 30.8 fm/√Hz at GHz frequencies, which holds the highest resolution to the best of our knowledge. Vibrational amplitude and phase mappings of a kHz comb-drive resonator, a GHz piezoelectric transducer, and a GHz film bulk acoustic resonator are presented with animated visualizations and k-space analysis, paving a new paradigm for the first time to image and analyze various MEMS devices of a bandwidth spanning 10 orders of magnitude.

Dynamic exploration of laser linewidth compression in resonant feedback external-cavity laser

An external-cavity laser with resonant optical feedback is a common and mature method to achieve narrow linewidth lasers. Since the proposal of optical feedback in 1964, a series of studies on resonant optical feedback have been reported. Although longer feedback length leads to narrower linewidth, it also introduces coupling of environmental noise and causes instability in the laser cavity, which is detrimental to high-speed tuning of the laser wavelength. With such a challenge, current research on resonant optical feedback primarily focuses on the static results of laser linewidth compression. In order to obtain narrow linewidth high-speed tuned external-cavity lasers, further research on the laser dynamics is required to obtain dynamic tuning of narrow linewidth external-cavity lasers. In this work, we construct an external-cavity laser based on resonant optical feedback, and utilize a coherent detection method to measure the dynamic process of laser linewidth compression and wavelength tuning. Based on resonant optical feedback from the external cavity, the linewidth of the main-cavity laser can be compressed from near 100 kHz to the 100 Hz level, with the frequency noise compressed from the order of 104 to the 102 Hz2/Hz level. Since the wavelength switching process includes frequency shift process, linewidth compression process, and frequency stabilization process, etc., we first conduct a research on laser linewidth compression dynamics. In the results of linewidth compression dynamics, we discover that using a shorter fiber ring results in shorter linewidth compression time, which is advantageous for laser dynamic tuning. We subsequently carry out the laser wavelength switching process with a main-cavity switching time in milliseconds. In the wavelength switching process, while undergoing the frequency shift process of fast tuning transient laser frequency, the laser first undergoes the linewidth broadening process, then enters the main-cavity laser frequency stabilization process and undergoes the linewidth compression process at the same time. The experimental results show that the 100 m feedback fiber ring will not significantly increase the external-cavity laser wavelength switching time under the condition that linewidth compression is faster than main-cavity laser switching, while a longer fiber ring will introduce a strong noise. Our work experimentally demonstrates that shorter feedback ring lengths lead to faster compression, which provides valuable insights for the development of high-speed and high-precision tunable narrow linewidth external-cavity lasers.

Switchable Faraday laser with frequencies of 85Rb and 87Rb 780 nm transitions using a single isotope 87Rb Faraday atomic filter

In the development of atomic physics, laser sources with Frequencies corresponding to atomic transition and high stability are essential. The Faraday laser is a special diode laser using the Faraday anomalous dispersion optical filter (FADOF) to realize frequency selection, so the output laser frequency is automatically limited to the atomic Doppler broadening. However, the frequency of a Faraday laser corresponds to the range around only one atomic hyperfine transition. Here, we realize a switchable Faraday laser with two isotopes laser frequencies corresponding to 85Rb 52S1/2 (F=3)→52P3/2 and 87Rb 52S1/2 (F=2)→52P3/2 transitions based on a single isotope 87Rb-FADOF. The laser has good robustness against the fluctuation of diode current and temperature, with wavelength fluctuating within 0.8 pm from 16 to 30 °C of diode temperature, and has a free-running linewidth of 18 kHz. We also lock the laser frequency to the two cycling transitions of 85Rb 52S1/2 (F=3)→52P3/2 (F′=4) and 87Rb 52S1/2 (F=2)→52P3/2 (F′=3) by the modulation transfer spectroscopy technique. The Allan deviation of the residual error signal is 3×10−14/τ, and the frequency stability of the beat detection reaches 2.8×10−12 at 1 s integration time. This 780 nm switchable Faraday laser expands the application scenarios of Faraday lasers, which can be used in laser cooling atoms, optical frequency standards, and other quantum precision measurement fields.

Optical nanoimaging of laser-switched phase-change plasmonic infrared antennas.

We investigate the plasmonic properties of laser-printed chalcogenide phase-change material In3SeTb2 (IST) antennas through near-field nanoimaging. Antennas of varying lengths were fabricated by laser switching an amorphous IST film into its crystalline metallic state. Near-field imaging elucidates the pronounced field confinement and enhancement at the antenna extremities along with the emergence of different ordered plasmonic modes with increasing length. Compared to gold antennas, the PCM antennas exhibit slightly lower but still substantial near-field enhancement with greater compactness. The interplay between antenna length, illumination angle, and excitation frequency enables versatile control over the resonant near-field distribution. Our work provides deeper understanding and tunable functionalities of laser-printed PCM nanoantennas for potential applications in compact, dynamically reconfigurable nanophotonic devices.

Tunable Three-Wavelength Fiber Laser and Transient Switching between Three-Wavelength Soliton and Q-Switched Mode-Locked States

We report a passive mode-locked fiber laser that can realize single-wavelength tuning and multi-wavelength spacing tuning simultaneously. The tuning range is from 1528 nm–1560 nm, and up to three bands of soliton states can be output at the same time. These results are confirmed by a nonlinear Schrödinger equation model based on the split-step Fourier method. In addition, we reveal a way to transform the multi-wavelength soliton state into the Q-switched mode-locked state, which is period doubling. These results will promote the development of optical communication, optical sensing and multi-signal pulse emission.

A Single NIR-II Laser-Triggered Self-Enhancing Photo/Enzyme-coupled Three-in-One Nanosystems for Breast Cancer Phototheranostics.

Multifunctional phototheranostics, employing precise and non-invasive techniques, is widely developed to enhance theranostic efficiency of breast cancer (BC), reduce side-effects, and improve quality of life. Integrating all phototheranostic modalities into a single photosensitizer for highly effective BC treatment is particularly challenging due to the potential inefficiency and time consumption associated with repeated switching of multiple-wavelength lasers. Herein, a novel single NIR-II laser-triggered three-in-one nanosystem(PdCu NY) is rationally designed, which enables dual-modal (NIR-II FL/NIR-II PA) imaging-guided self-enhancing photothermal-photodynamic therapy (PTT-PDT) in NIR-II window. The PdCu NY based on optimal Pd/Cu molar-ratio(1:11) can be easily fabricated and large-scale production for simultaneous PTT-PDT against BC under a single 1064nm laser irradiation. Significantly, the PdCu NY acted as a promising photocatalyst for decomposition of H2O into O2 upon the same laser irradiation. In addition, the inherent catalase (CAT)-like activity of PdCu NYs enables photo-enzyme dual-catalytic O2 supply to effectively alleviate hypoxia, achieving self-enhanced PDT efficiency. These PTT-PDT self-enhanced nanosystems demonstrate precise lesion localization and complete tumor ablation using a single 1064nm laser source by "one-laser, multi-functions" strategy. More importantly, this study not only reports a three-in-one PdCu-based phototheranostic agent, but also sheds light on the exploration of versatile biosafety nanosystems for clinical applications.

Multi‐Level Optical Switching by Amorphization in Single‐ and Multi‐Phase Change Material Structures

AbstractThe optical properties of phase‐change materials (PCMs) can be tuned to multiple levels by controlling the transition between their amorphous and crystalline phases. In multi‐material PCM structures, the number of discrete reflectance levels can be increased according to the number of PCM layers. However, the effect of increasing the number of layers on quenching and reversibility has not been thoroughly studied. In this work, the phase‐change physics and thermal conditions required for reversible switching of single and multi‐material PCM switches are discussed based on thermo‐optical phase‐change models and laser switching experiments. By using nanosecond laser pulses, 16 different reflectance levels in Ge2Sb2Te5 are demonstrated via amorphization. Furthermore, a multi‐material switch based on Ge2Sb2Te5 and GeTe with four discrete reflectance levels is experimentally proven with a reversible multi‐level response. The results and design principles presented herein will impact active photonics applications that rely on dynamic multi‐level operation, such as optical computing, beam steering, and next‐generation display technologies.

Two wavelength band emission WGM lasers via photo-isomerization

Abstract Wavelength switchable microcavity is indispensable component for various integrated photonic devices. However, achieving two wavelength band emission of the whispering gallery mode (WGM) laser is challenging. Here, we propose a strategy to realize two wavelength band emission WGM lasers activated by photo-isomerization based on excited-state intramolecular proton transfer (ESIPT) process in isolated/coupled polymer microfiber cavities. The WGM microcavity is built by highly polarized organic intramolecular charge-transfer (ICT) dye molecules. The two cooperative gain states of ICT dye molecules can be controlled by optimizing energy levels. Thereby, the lasing wavelength can be reversibly switched under photo-isomerization activated in the ESIPT energy-level progress. The photonic bar code can be generated by following the strategy of proposed design. This work provides a promising route to achieve switchable WGM laser in on-chip photonic integration.

Structural, electronic, linear, and nonlinear optical properties of undoped and Mo (I, II)-doped LiNbO3 crystal

In this paper, density functional theory (DFT) calculations used to investigate the structural, electronic, linear and nonlinear optical properties of pure lithium niobate crystal (LiNbO3) and doped LiNbO3 by Mo (I) and Mo (I). The lattice constants were calculated by analysing the optimised unit cell, and the results were found to be in good agreement with both the experimental and theoretical values that were reported. The results indicate a clear distinction in the electronic characteristics of LiNbO3 and doped LiNbO3 (Mo-Nb), the band structures that have been computed indicate that the band gap of LiNbO3 can be narrowed by adding Mo (I) and Mo (II) dopants to 2.068 eV and 0.476 eV, respectively. Interesting results were obtained by this doping process, as these results showed that the effect of doping led to an improvement in some optical properties, such as the absorption spectrum of the material, and also led to an increase in the effect of second harmonic generation (SHG), which is considered a basic requirement for developing optical devices in many photonic applications such as laser, electro-optic applications and optical switches.

Tunable and switchable multi-wavelength pulsed fiber laser based on a nonlinear optical loop mirror and an improved Sagnac filter.

We propose and experimentally demonstrate a tunable and switchable multi-wavelength erbium-doped fiber ring pulsed laser based on a nonlinear optical loop mirror (NOLM) and an improved Sagnac filter. To achieve multi-wavelength pulsed laser output, we adopt a NOLM as a quasi-saturable absorber and an improved Sagnac loop as a wavelength selected filter. The constructed laser has a maximum output wavelength number of five with a pulse repetition frequency of 40.45kHz and pulse duration of 108ns. The laser can output single-wavelength and dual-wavelength pulsed lasers within a certain wavelength tuning range and a five-wavelength pulsed laser with a constant wavelength interval of 3nm by adjusting the polarization controller. Dual-wavelength, three-wavelength, and four-wavelength pulsed lasers with various wavelength intervals are also obtained. The output performance of the constructed laser is tested with a maximum average output power of 127.45µW and minimum pulse duration of 52ns, and the stability of the laser output is also tested with a maximum power fluctuation of 0.62dB and minimum wavelength drift of 0.51nm with pump power of 350mW.

Wavelength tunable double-ring cavity erbium-doped random fiber laser based on a Mach–Zehnder interferometer

A wavelength-tunable double-ring cavity erbium-doped random fiber laser (RFL) based on a Mach–Zehnder interferometer (MZI) was proposed in this study. The MZI structure, which was based on two 2 × 2 optical fiber couplers, exhibits a comb-filtering effect. Rayleigh scattering (RS) was generated by a 10-km-long single-mode fiber (SMF) to provide randomly distributed feedback. A double-ring cavity structure based on forward and backward RS was built using two 2 × 2 fiber couplers. The threshold of the laser was 104 mW, and the slope efficiency of the total power output to the pump power was approximately 1.2%. When the pump power was 158 mW, a laser beam with a wavelength of 1555.3 nm was formed. By adjusting the polarization controller (PC), a single-wavelength switched RFL at 1547.9 nm and 1559.6 nm was obtained. The maximum peak power difference was less than 0.67 dB, the signal-to-noise ratio (SNR) was greater than 17.27 dB, and the peak power fluctuation was less than 0.92 dB during a scan time of 30 min at 25 °C. Regarding dual-wavelength switchable laser emission, two groups of different wavelengths with an SNR greater than 16.88 dB, power fluctuation less than 0.81 dB, and wavelength fluctuation less than 0.26 nm could be achieved under the same monitoring conditions. By further adjusting the PC, three- and four-wavelength RFLs were achieved, and the SNRs exceeded 16.31 dB and 14.64 dB, respectively. The proposed RFL has promising application prospects for distributed sensing systems and speckle imaging.

Femtosecond laser-inscribed polarization-maintaining fiber Bragg grating using line-by-line technique for generating wavelength-switchable erbium-doped fiber lasers

In this study, a polarization-maintaining fiber Bragg grating (PM-FBG) was inscribed by a femtosecond laser using a line-by-line method through fiber coating and used as a wavelength selector for a wavelength-switchable erbium-doped fiber laser (EDFL). The PM-FBG period was 1.075 μm, and the grating length was 3200 μm. For the proposed EDFL, the lasing threshold was 64 mW, and switchable lasing emissions with stable single and dual wavelengths were realized by adjusting a polarization controller. For the experiments, different single-wavelength switchable lasers with scope values of 1563.34–1564.02 nm were generated, six dual-wavelength lasers were obtained, and a triple-wavelength laser output was realized. The power fluctuations of the single- and dual-wavelength lasers were lower than 0.331 and 0.682 dB, respectively, over a 25 min monitoring time.

Intraoperative Fluorescein Angiography Can Efficiently Identify Biomarkers and Guide Surgical Decision-Making.

We sought to develop an efficient method for fluorescein angiography (FA) during digitally assisted vitreoretinal surgery (DAVS). A 485-nm bandpass filter was placed into the filter holder of the accessory light sources of the Constellation Vision System with steel modified washers to produce an exciter source. A barrier filter was placed into the blank slot of a switchable laser filter with a 535-nm bandpass filter and another washer or created digitally with a specific color channel using NGENUITY software version 1.4. Fluorescein, 250 to 500 mg, was then injected intravenously during retinal surgery. These fluorescence patterns accurately detect many fluorescein angiography biomarkers, such as determination of vascular filling times, ischemia, neovascularization, shunt vessels, microaneurysms, and leakage into the vitreous. This enhanced surgical visualization permitted intervention in real time such as laser or diathermy to residual microvascular abnormalities after delamination of retinal neovascularization as well as heavier panretinal laser placement in areas of retinal capillary dropout to relatively preserve areas of more intact retinal microcirculation. The authors of this study are the first to report an efficient method that permits high-resolution detection of many classic FA biomarkers such as during DAVS to enhance surgical visualization and intervention in real time.

Abstract 820: Photo-activatable ON-OFF microparticles for on-demand pulsatile drug delivery in a breast cancer model

Abstract The ability to treat tumors with high efficacy in a local microenvironment, while mitigating the side effects of systemic toxicity is an area of active investigation. Towards this goal, designing a minimally-invasive local therapeutic modality, with a controlled, pulsatile drug release mechanism is an attractive proposition. In this study, a near-infrared (NIR) photo-activatable microparticle was developed for localized, pulsatile delivery of encapsulated anticancer drugs into the tumor with simultaneous thermal ablation, with controlled ON-OFF thermal cycles using NIR laser irradiation. The microparticles were fabricated using a poly(caprolactone) (PCL) matrix, containing 2D molybdenum disulfide (MoS2) nanosheets as the NIR-responsive photothermal agent, and doxorubicin or violacein, as hydrophilic and hydrophobic model anticancer drugs, respectively. Cubic microparticles of 200 µm size were fabricated by casting a polymer-MoS2-drug film on PDMS mold with loading efficiency of 2 μg MoS2 per particle, and 0.2-8 μg of drug per particle. A cytotoxicity assay was performed to test the efficacy of the loaded microparticles in reducing the viability of 4T1 murine-derived cell culture, using the ON-OFF laser switch mechanism. In order to select a suitable laser power and duration of treatment for in vivo studies, a Machine Learning algorithm based on a Random Forest classifier was trained, to arrive at the optimal treatment conditions: 0.4-0.5 W/cm2 of laser power at 808 nm, for 3 cumulative minutes of laser irradiation, to reach the target temperature of 50 °C, which activates PCL melting and subsequent drug release. The effect of pulsatile treatment was studied in vivo in a murine-derived 4T1 subcutaneous mouse model of breast cancer, using this photo-activatable ON-OFF switch mechanism, for up to 3 cycles of laser irradiation. As control groups, tumor only (no treatment), laser only (no drug or microparticle), drug only (no laser or microparticle), microparticles only (no drug or laser), and microparticles with laser (no drug) were studied. The cohorts receiving the photo-activated 3-cyclic treatment for both drugs showed increased median survival up to 40 days post tumor induction, compared to a median survival of 16 days for the control groups. Although one laser cycle was enough to trigger drug release, there was a significant shrinkage in the tumor volume noticed with 3 cycles, with eventual scarring and shedding of the tissue with no evidence of residual tumor at the primary site. While this cyclic drug release modality is very effective at treating the primary site, subsequent histopathology revealed that the aggressive tumor in some animals had metastasized to the liver and other organs. More work is ongoing to design better targeted approaches to deliver the drug-loaded microparticles to the site of metastatic tumors, to increase the survival prospects of this disease. Citation Format: Maria Kanelli, Neelkanth M. Bardhan, Morteza Sarmadi, Shahad Alsaiari, William Rothwell, Apurva Pardeshi, Angela M. Belcher, Ana Jaklenec, Robert S. Langer. Photo-activatable ON-OFF microparticles for on-demand pulsatile drug delivery in a breast cancer model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 820.