Swelling Test Research Articles

Drug Release Study of Polyvinyl Alcohol-Gelatin-Montmorillonite Bionanocomposite Hydrogel Drug Delivery Systems Loaded with Clindamycin

One of the challenges facing medical science is the proper formulation of drug delivery systems for the correct transfer of active pharmaceutical ingredients to the body. Polymer and nanocomposite hydrogels have been considered ideal options in the preparation of drug delivery systems due to their proper properties, such as hydrophilicity and biocompatibility. In this, our research, described in this manuscript, the drug release from polyvinyl alcohol (PVA)-gelatin-montmorillonite (MMT) bionanocomposite hydrogel drug delivery systems loaded with clindamycin was studied. The structural and physical properties of prepared nanocomposite hydrogels were investigated using X-ray diffractometry (XRD), field emission scanning electron microscopy (FESEM), Fourier-transform infrared spectroscopy (FTIR), Brunauer-Emmette-Teller (BET) analysis, gel fraction and swelling tests. The results showed that by adding MMT clay to PVA-gelatin hydrogels, the amount of gel fraction increased, and due to the decrease in the size of the pores, the amount of swelling decreased. The results of the drug release tests showed that the release rate of clindamycin was inversely related to the percentage of MMT added to the nanocomposite hydrogel. The results also showed that the shape of the drug delivery system and its dimensions affected the release rate of clindamycin. The dominant mechanism of drug release in all samples was found to be Fickian transport. Considering the favorable in-vitro drug release performance of our PVA-gelatin-MMT nanocomposite hydrogels in the release of clindamycin, it was concluded that they are suitable options for preparing practical drug delivery systems with controlled drug release ability.

Изучение некоторых функциональных характеристик ферментативных гидролизатов пищевых белков

Food allergy is a matter of global concern, proteins being a popular allergen worldwide. Enzymatic protein hydrolysates serve as hypoallergenic components in functional foods. This article describes enzymatic hydrolysates of egg and soy proteins as potential antigens, sensitizers, and antioxidants. The research featured soy protein isolate and egg albumin. The protein hydrolysates were obtained in a two-step process with pepsin and trypsin to measure hydrolysis, total antioxidant activity, and residual antigenicity. The sensitizing ability of native proteins and their hydrolysates was studied using a delayed-type hypersensitivity (DTH) skin test of paw swelling in mice. The egg albumin and soy protein were hydrolyzed by sequentially adding the proteases, i.e., pepsin and trypsin. The degree of protein hydrolysis was calculated against total nitrogen and its contents in non-hydrolyzed raw materials and hydrolysate. It was 82.6% for the egg hydrolysate and 88.3% for the soy hydrolysate, the total antioxidant activity being 114.3 and 91.4 mg/100 mL, respectively. The residual antigenicity of the hydrolysates determined by ELISA in a sandwich version was 1.55×10–4 and 3.30×10–4 RU, respectively. The native egg and soy proteins demonstrated good allergenic properties, and the DTH response index increased fivefold. The hydrolysates reduced the DTH response indices by an average of 3.5 for egg hydrolysate and 2.6 times for soy hydrolysate. The resulting enzymatic hydrolysates of egg albumin and soy protein demonstrated a high degree of hydrolysis and antioxidant activity. They had low residual antigenicity (10–4) and low sensitizing ability. The resulting enzymatic hydrolysates could be used as hypoallergenic components and antioxidants in new functional foods.

Characteristics of Bachaur bull semen.

The Bachaur is a mediumized draft purpose breed which has been recognized by ICAR-National Bureau of Animal Genetic Resources (NBAGR) Karnal, India, and presently is on the verge of extinction. Since there are no data regarding the seminal parameters of this breed, this work was performed to evaluate seminal parameters of freshly ejaculated semen. A total of three healthy breeding Bachaur bulls aged 2.5-5 years were selected for the study which were maintained under identical managemental conditions. Semen parameters of these bulls were studied across 10 ejaculates. The average scrotal circumference and testicular weight of the three bulls were 27.78 ± 1.2 cm and 400.67 ± 26.6 g, respectively. The average overall volume (mL), pH, concentration (million/mL), liveability (%), abnormality (%), HOST (%) and acrosome integrity (%) were 2.20 ± 0.19, 6.86 ± 0.06, 1245.60 ± 23.49, 85.09 ± 0.91, 4.13 ± 0.06, 81.16 ± 1.18 and 83.54 ± 1.32, respectively. The average overall mass motility of three Bachaur bulls was 3.57 ± 0.06 in 0-5 scale and individual motility averaged 84.78 ± 1.70 per cent. The volume of ejaculates in Bachaur bull seemed to be lower as compared to other exotic and Indian breeds. However, the semen parameters with regard to mass motility, liveability, abnormalities, hypo-osmotic swelling test (HOST) and acrosomal integrity seemed similar to other exotic and Indian breeds.

A comparative study between curcumin and curcumin nanoparticles on reproductive performance and antioxidant system of aged roosters

Increased lipid peroxidation and decreased antioxidant status can result in reduced reproductive activity and fertility in aged male broiler breeders. This study was conducted to evaluate the effects of curcumin supplements (natural or nanoparticles) on the sperm characteristics, antioxidant system, fertility, and hatchability of aged roosters (54-64 wk), and to estimate the relative bioavailability value (RBV) of nano-curcumin on the measured parameters including the hypo-osmotic swelling test (HOST), motility, viability, sperm count, volume, the concentration of testosterone, glutathione peroxidase (GPx), and superoxide dismutase (SOD), diameter of the spermatogenic tube (DST), epithelium thickness (EpiTh), spermatogonia count (SPcount), fertility, hatchability, and relative weight of testis (RW-testis). A total of 30 roosters were individually caged and randomly assigned to 5 treatments comprising control (without curcumin as the basal diet), basal diet + 15 mg/kg curcumin (CUR15), basal diet + 30 mg/kg curcumin (CUR30), basal diet + 15 mg/kg nano-curcumin (Nano15), and basal diet + 30 mg/kg nano-curcumin (Nano30) for 10 wk. The slope ratio method was used to estimate the bioavailability of nano-curcumin by regressing each response on supplemental curcumin intake. Increasing dietary curcumin (P < 0.001) elicited a linear response to all studied traits. The RBV for volume, viability, motility, HOST, RW-testis, and GPx were estimated as 135 (CI: 115-156%), 143 (CI: 114-173%), 159 (CI: 122-196%), 132 (CI: 107-157%), 195 (CI: 126-264%), 176 (CI: 103-249%), and 178% (28-328%), respectively. Our findings revealed that curcumin nanoparticles enhance the reproductive efficiency of aged breeder roosters. In addition, the curcumin nanoparticles RBV exceeded that of natural curcumin, suggesting that lower concentrations of curcumin nanoparticles could have a significant effect on reproductive characteristics.

Evaluation of a novel paraffin wax microemulsion for improving wellbore stability in shale formations

High-performance shale stabilizers are urgently required to address the concerns of wellbore instability when drilling troublesome shale wells. Herein, a novel paraffin wax microemulsion (PM) containing cationic surfactant was prepared and evaluated for shale formations. The shale stability performance of PM was studied using shale pressure penetration test, shale swelling and dispersion test. The shale stabilization mechanism of PM was investigated by surface tension, contact angle, surface free energy, capillary tube rise and SEM tests. The experimental findings showed that the pressure penetration time in shale after treatment with PM was extended from 13 to 107 min. And PM could decrease the shale swelling rate by 41.5%, and increase the recovery rate to 89.4%. PM exhibited better sealing and inhibition properties than that of commonly used shale stabilizers. The mechanism research revealed that the nano-droplets in PM could freely penetrate into shale pores and cracks of different sizes to form an effective sealing membrane. The water contact angle reached 91.4° after treatment with PM and the surface energy was significantly reduced, effectively inhibiting surface hydration. Through decreasing the surface tension and changing the wettability, the capillary force experienced a noticeable decrease with further enhanced inhibition of shale hydration. Therefore, the application of PM for shale stabilization exhibited promising potential, suggesting its possible effective utilization in shale drilling.

Interface Interaction of Waste Rubber–Asphalt System

Asphalt pavement construction is a large-volume project, with the ability to recycle the industrial waste and reduce carbon emissions. Rubber-modified asphalt is a carbon-neutralized asphalt-based material, facilitating the recycling of waste rubber materials and improving the road performance of the asphalt mixture. To evaluate the interface interaction of the rubber–asphalt system and its effect on the viscosity characteristics of rubber-modified asphalt, the contact properties of rubber particles in asphalt were analyzed on a microscopic level. Rubber swelling tests and solvent elution tests were conducted on the rubber–asphalt system under different preparation conditions. The swelling ratio, degradation ratio, and swelling–degradation ratio were proposed to evaluate the interface interaction. The results show that the interface interaction of the rubber–asphalt system can be divided into the following three stages: swelling, effective degradation, and over-degradation. The degree of swelling is mainly affected by the content and size of the rubber particles and it is physically condensed, while the degradation is mainly affected by the preparation temperature and preparation time. The effective interface interaction greatly affects the viscosity with the building of the stable three-dimensional network structure. The stronger the interface interaction, the greater the viscosity of the rubber-modified asphalt, except for the 25% content of rubber particles. The gel film will be generated on the surface of the rubber particles throughout the swelling and effective degradation, increasing the viscosity of the rubber-modified asphalt.

Combined Effect of the Microstructure and Mechanical Behavior of Lateritic Soils in the Instability of a Road Cut Slope in Rwanda

A very common hazard in Rwanda is represented by the instability of steep road cut slopes in lateritic soil. In its natural state, this material appears as a fine-grained weak and altered rock, generally in unsaturated conditions. Steep cut slopes made by this material could remain stable for a long time unless weathering weakens its mechanical behavior and heavy rainfall provokes a rapid landslide. This paper presents the results of an experimental investigation on the microstructural, petrophysical, and geotechnical properties of lateritic soil from a road cut slope located in Kabaya (Ngororero District—Rwanda), which was recently subjected to a landslide. The mechanical properties of the material are strictly related to the geological origin and history of the deposits, their formation environment, and weathering processes. These characteristics were revealed by peculiar microstructural features (micro-texture, porosity, and degree of alteration of original mineral paragenesis). The experimental investigations included identification and classification tests, direct shear tests on saturated samples, and swelling tests. This multidisciplinary approach provided insights into the relationship between geotechnical properties and the microstructural, petrophysical, and chemical characteristics of the altered rocks. This study showed how different levels of chemical alteration operated by weathering processes, in conjunction with brittle deformation related to the tectonic history, formed in the same site two shallow rock layers with similar macro-scale features and mechanical behaviors but markedly different microstructural and chemical properties. The innovative aspect of this research suggests an integrated multidisciplinary approach to considering microstructural aspects in addition to mechanical behavior in the slope stability analyses in lateritic soil. In particular, this study demonstrates the importance of such an approach since the failure mechanism is better explained if it is based on microstructural observations instead of considering the soil shear strength parameters only. This research helped to explain the formation of the landslide failure mechanism in a specific road cut slope, which could be assumed as representative of many other similar slopes subjected to landslides in Rwanda.

The Effect of Type of Reinforcement, Type of Glue and Reinforcement Place on Mechanical and Physical Properties of LVL

This study investigated the effect of the reinforcement type, glue type, and reinforcement placement on the mechanical and physical properties of LVL. In the study, the glues used were phenol- formaldehyde (FF), epoxy (EX), and polyurethane (PU), while reinforcement materials used were glass fiber, basalt, jute, and cotton fabric. The following three reinforcement combinations were applied: the first was on the bottom surface, the second was on the first adhesive line at the bottom, and the third was on both the bottom and the first adhesive line at the bottom. As part of the study, researchers manufactured 9-layer laminated veneer lumber (LVL) using alder veneers for the surface, and poplar veneers for the middle layers. They produced a total of 39 different combinations of LVL. The mechanical and physical properties of the produced samples were determined. According to the test results, bending strength (BS), modulus of elasticity (MOE), oven-dry specific gravity, and equilibrium moisture content of samples were higher with FF than with other glues. While the samples with EX glue provided the lowest values in water absorption and thickness swelling tests, glass fiber-reinforced samples provided the highest mechanical values. In addition, the samples having reinforcement on the bottom surface provided higher BS and MOE values.

A novel strategy and characteristics of PVA/citric acid cross-linked hydrophilic elastic sponge of cellulose based on medicinal herb residue

A new ultra-hydrophilic elastic sponge composite has been proposed. Medicinal herbs, commonly used in herbal medicine and subsequently discarded, are rich in natural polymer substances, making them promising candidates for various material industries. TEMPO-oxidized cellulose was extracted from medicinal herb residue, and the physicochemical properties of an ultra-hydrophilic elastic sponge, prepared through a PVA and CA impregnate cross-linking process, were investigated. The fabricated composite sponge exhibited an increase in compressive stress-strain proportional to the PVA cross-linking concentration, and its water retention capability was assessed through retention tests. Swelling tests for various solvents were conducted to evaluate the potential use of the sponge in diverse industries, revealing the highest swelling ratio in water. Pressure distribution measurements using prescale film indicated that the sponge's shock absorption capacity was enhanced by PVA cross-linking, leading to improved pressure dispersion.

Preparation and Characterization of Chitosan/Hydroxypropyl Methylcellulose Temperature-Sensitive Hydrogel Containing Inorganic Salts for Forest Fire Suppression.

Effective forest fire suppression remains a critical challenge, necessitating innovative solutions. Temperature-sensitive hydrogels represent a promising avenue in this endeavor. Traditional firefighting methods often struggle to address forest fires efficiently while mitigating ecological harm and optimizing resource utilization. In this study, a novel intelligent temperature-sensitive hydrogel was prepared specially for forest fire extinguishment. Utilizing a one-pot synthesis approach, this material demonstrates exceptional fluidity at ambient temperatures, facilitating convenient application and transport. Upon exposure to elevated temperatures, it undergoes a phase transition to form a solid, barrier-like structure essential for containing forest fires. The incorporation of environmentally friendly phosphorus salts into the chitosan/hydroxypropyl methylcellulose gel system enhances the formation of temperature-sensitive hydrogels, thereby enhancing their structural integrity and firefighting efficacy. Morphological and thermal stability analyses elucidate the outstanding performance, with the hydrogel forming a dense carbonized layer that acts as a robust barrier against the spread of forest fires. Additionally, comprehensive evaluations employing rheological tests, cone calorimeter tests, a swelling test, and infrared thermography reveal the multifaceted roles of temperature-sensitive hydrogels in forest fire prevention and suppression strategies.

Novel insights into necrozoospermia from a single-center study: reference ranges, possible etiology, and impact on male fertility.

Necrozoospermia is a poorly documented condition with a low incidence, and its definition and clinical significance are unclear. Herein, we provide a reference range for necrozoospermia and discuss its possible etiology and impact on male fertility and assisted reproductive outcomes. We extracted relevant information from 650 Chinese male partners of infertile couples and statistically analyzed sperm vitality. Necrozoospermia was present in 3.4% (22/650) of our study population, and the lower cut-off value for sperm vitality was 75.3%. We compared two methods for assessing sperm vitality (eosin-nigrosin head staining and hypo-osmotic swelling test [HOST]), for which the percentage in the eosin-nigrosin group (mean ± standard deviation [s.d.]: 77.5% ± 10.5%) was significantly higher than that in the HOST group (mean ± s.d.: 58.1% ± 6.7% [5-10 min after incubation] and 55.6% ± 8.2% [25-30 min after incubation]; both P < 0.001). The incidence of necrozoospermia increased with age (odds ratio [OR] = 1.116, 95% confidence interval [CI]: 1.048-1.189, P = 0.001), while the percentage of normal sperm morphology and DNA fragmentation index (DFI) were significantly associated with necrozoospermia, with ORs of 0.691 (95% CI: 0.511-0.935, P = 0.017) and 1.281 (95% CI: 1.180-1.390, P < 0.001), respectively. In the following 6 months, we recruited 166 patients in the nonnecrozoospermia group and 87 patients in the necrozoospermia group to compare intracytoplasmic sperm injection (ICSI) and pregnancy outcomes between the two groups. The necrozoospermia group had a significantly lower normal fertilization rate (74.7% vs 78.2%, P = 0.041; OR = 0.822; 95% CI: 0.682-0.992) than that in the nonnecrozoospermia group. This study presents substantial information on necrozoospermia to establish comprehensive and applicable reference values for sperm vitality for spontaneous conception and artificially assisted reproductive management.

Long-term and accelerated swelling of steel slag-glass powder and steel slag-fly ash mixtures as sustainable geo-materials

The volumetric instability of steel slag hinders its use in pavement layers and embankments. Accordingly, evaluating the swelling potential of steel slag and designing volumetrically stable steel slag mixtures is required to promote its sustainable utilization. This paper focuses on the comparison of the swelling response of basic-oxygen-furnace steel slag (BOFS), electric-arc-furnace steel slag (EAFS), BOFS-fly ash and BOFS-glass powder mixtures based on the results of three different types of tests: (i) long-term California bearing ratio (CBR) swelling, (ii) heated water bath swelling and (iii) autoclave tests. BOFS mixtures were prepared using glass powder or class F fly ash with 5%, 10%, and 20% replacement ratios. The compaction characteristics, permeability, and California bearing ratio (CBR) of steel slag and steel slag mixtures were also assessed within the framework of a detailed discussion of their swelling response. At the end of swelling tests, the measured maximum 1D strains of EAFS were all at negligible levels. Based on the test results, BOFS and BOFS-glass powder mixtures had ∼5.0–5.5% swelling strains after 20.5 months without signs of stabilization. 20% class F fly ash replacement stabilized the swelling strains of the mixture at about 0.75% after ∼3 months of monitoring in long-term tests. 1D swelling rates measured for all BOFS-class F fly ash mixtures decreased with increasing fly ash content. CBR and swelling response of BOFS-class F fly ash mixtures were more favorable compared to those of BOFS. The heated water bath tests provided higher estimates of the swelling strains compared to those obtained from autoclave tests for the steel slag mixtures that contain 15% or more fines. The results of this study showed that glass powder replacement is not effective in alleviating the swelling of BOFS. The volumetrically stable BOFS-class F fly ash mixtures indicated favorable mechanical properties for their use in pavement layers.

The preparation of edible water-soluble films comprising κ-carrageenan/carboxymethyl starch/gum ghatti and their application in instant coffee powder packaging

This study successfully prepared an edible packaging film that rapidly dissolves in water by utilizing a combination of κ-carrageenan, carboxymethyl starch, and gum ghatti. We investigated the influence of these three materials on the microstructure and physical properties of the film, as well as the impact of the film's dissolution on the stability of beverages. SEM, FTIR, and XRD analyses revealed that the κ-carrageenan, carboxymethyl starch, and gum ghatti primarily interacted through hydrogen bonding, resulting in a more uniform and dense film structure. Surface hydrophilicity and swelling tests indicated an increased presence of hydrophilic groups in the composite film. The inclusion of carboxymethyl starch and gum ghatti significantly improves the film's physical properties, resulting in a notable reduction in water solubility time, an increase in elongation at break from 19.5 % to 26.0 %, a rise in the contact angle from 49.1° to 67.0°, and a decrease in water vapor permeability from 7.5 × 10–10 to 6.2 × 10–10 g/m·s·Pa. Furthermore, coffee packaging bags made from this composite film dissolved entirely in hot water in just 40 s. Dissolving these bags significantly improved the stability of instant coffee, reducing centrifugal sedimentation from 3.8 % to 1.7 %. This study highlights the substantial potential of the κ-carrageenan/carboxymethyl starch/gum ghatti composite film as a packaging material for solid beverages.

Development of a Controlled Released System Based on IPN Types Hydrogel for Cartilage Repair

The purpose of this study is to develop a controlled Fluconazole and Naproxen releasing system for cartilage repair. Interpenetrating polymer network (IPN) type of hydrogels were prepared by using different ratios of 2-Hydroxyethyl methacrylate (HEMA) and gelatin. The hydrogels were synthesized by using ammonium persulfate (APS) and sodium metabisulfite (SBS) as initiator pair and ethylene glycol dimethacrylate (EGDMA) and glutaraldehyde (GA) as cross linkers. The prepared hydrogels were characterized via hydrogel formation and swelling/degradation measurements, Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscope (SEM) analysis. From swelling tests, it is observed that semi-IPN hydrogels swell much more than full-IPNs which crosslinked by two agents, EGDMA and GA. The higher ratios of HEMA/gelatin negatively affect swelling values. In general, the IPN hydrogel discs were not affected by the variation of temperature. The release studies of Fluconazole and Naproxen were performed at 37 ⁰C and it is found that the swelling and releasing profiles were similar to each other. The releases of drugs increase rapidly at first and then complies nearly 36 h-48 h. Because of the looser and porous structure, semi-IPN hydrogels have higher release values than full-IPNs.

Synthesis and physicochemical characterization of sago starch-porang glucomannan hydrogels crosslinked fumaric acid as a new material for drug delivery system

Abstract Sago starch and porang glucomannan are natural polymers commonly used as pharmaceutical excipients. The nature of starch, which is easily damaged and has low stability, is an obstacle to its use as a drug-delivery polymer. Chemical modification with crosslinked fumaric acid produces hydrogels with controlled hydrophilicity. This research aimed to synthesize and evaluate the physicochemical characteristics of hydrogels from sago starch-porang glucomannan crosslinked with fumaric acid. Starch synthesis was carried out using the phase inversion method. Tests on the hydrogels formed from sago starch-porang glucomannan included solubility tests, swelling tests, FT-IR, SEM, and XRD analyses used to explore the hydrogels. The results of the swelling tests at 22 and 60 show an increase in the amount of water the hydrogels can absorb. Crosslinked through the development of esters is revealed by the ATR-FTIR spectrum in the fingerprint region. The results of the SEM test of hydrogels, sago starch, and porang glucomannan show a spherical to polyhedral shape with varying powder sizes. XRD analysis shows that the hydrogels from sago starch-porang glucomannan crosslinked with fumaric acid are semi-crystalline, and some formulas are amorphous. In conclusion, the synthesis of hydrogels from sago starch-porang glucomannan crosslinked with fumaric acid has characteristics that can be developed as a new material for drug delivery systems.

Assessment of the Swelling Behavior of NaOH-Contaminated Red Earth in the Visakhapatnam Region of India Using X-ray Diffraction Analysis

Research on the impact of alkali contamination on the swelling behavior of red earth in the Visakhapatnam region has been notably limited. Therefore, this study aims to investigate the effects of alkali (NaOH) contamination on the swelling characteristics of the region’s red earth. The red earth of this region was found to be a well-graded sandy soil with 81% sand and 18% fines. X-ray diffraction studies showed that this region’s red earth mainly consists of quartz, kaolinite, and hematite. The soil is inherently non-swelling. However, the free swell tests showed considerable swell under contamination of NaOH solutions of various normalities (0.05, 0.1, 1, 2, and 4N). One-dimensional consolidation tests have shown that the swell increased with the concentration of the NaOH solution and with the duration of the interaction. Red earth exhibited 'an equilibrium swelling' of 5.6, 10, 15, 17, and 20% when contaminated with 0.05, 0.1, 1, 2, and 4N NaOH solutions, respectively. XRD studies revealed that the red earth sample contaminated with even 0.05N NaOH solution and cured for 56 days exhibited the formation of zeolites analcime and natrolite. Silicate minerals like paragonite and ussingite were also formed along with the zeolites. N-A-S-H compounds, hydrosodalites, and zeolites like super hydrated natrolite, zeolite SSZ16, and zeolite ZK-14 were formed at higher normalities of NaOH after a curing period of 56 days, which caused increased swell. The research demonstrated that the formation of zeolites resulting from the alkali contamination led to swelling in the red earth.

Blends of Carboxymethyl Cellulose and Cottonseed Protein as Biodegradable Films.

With the increasing awareness of plastic pollution in the environment and the accumulation of microplastics in water, a significant amount of research and development is ongoing to replace the synthetic plastics in packaging and coatings. In this work, we explored the blends of carboxymethyl cellulose (CMC) and washed cottonseed meal (CSM, consisting mostly of cottonseed protein) as agro-based, biodegradable, and sustainable alternatives to plastics. Glycerol was found to be a suitable plasticizer for these blends. The blends of CMC/CSM were produced as single-layer films from 50 to 90 μm in thickness, consisting of different proportions of the components and plasticizer. The evaluated properties included opacity, water vapor permeability, mechanical properties, thermogravimetric analysis, moisture sorption analysis, and water swelling test. Higher percentages of CSM in the blend resulted in higher opacity and lower water vapor permeation rates. The mechanical strength waned with lower levels of CMC. Possible applications for these blends include their use as water-soluble food packaging and coatings and as dissolvable bags and pouches for detergents and agrochemicals.

Improving Water-Based Drilling Mud Performance Using Biopolymer Gum: Integrating Experimental and Machine Learning Techniques.

Drilling through shale formations can be expensive and time-consuming due to the instability of the wellbore. Further, there is a need to develop inhibitors that are environmentally friendly. Our study discovered a cost-effective solution to this problem using Gum Arabic (ArG). We evaluated the inhibition potential of an ArG clay swelling inhibitor and fluid loss controller in water-based mud (WBM) by conducting a linear swelling test, capillary suction timer test, and zeta potential, fluid loss, and rheology tests. Our results displayed a significant reduction in linear swelling of bentonite clay (Na-Ben) by up to 36.1% at a concentration of 1.0 wt. % ArG. The capillary suction timer (CST) showed that capillary suction time also increased with the increase in the concentration of ArG, which indicates the fluid-loss-controlling potential of ArG. Adding ArG to the drilling mud prominently decreased fluid loss by up to 50%. Further, ArG reduced the shear stresses of the base mud, showing its inhibition and friction-reducing effect. These findings suggest that ArG is a strong candidate for an alternate green swelling inhibitor and fluid loss controller in WBM. Introducing this new green additive could significantly reduce non-productive time and costs associated with wellbore instability while drilling. Further, a dynamic linear swelling model, based on machine learning (ML), was created to forecast the linear swelling capacity of clay samples treated with ArG. The ML model proposed demonstrates exceptional accuracy (R2 score = 0.998 on testing) in predicting the swelling properties of ArG in drilling mud.

Predictive models for treated clayey soils using waste powdered glass and expanded polystyrene beads using regression analysis and artificial neural network

Waste materials contribute to a wide range of environmental and economic problems. To minimize their effects, a safe strategy for reducing such negative impact is required. Recycling and reusing waste materials have proved to be effective measures in this respect. In this study, an eco-friendly treatment is investigated based on using waste powdered glass (WGP) and EPS beads (EPSb) as mechanical and chemical admixers in soils. For this purpose, Atterberg limit, standard proctor, free swell, and unconfined compression tests are performed on soil samples with different ratios of waste materials at their optimum moisture contents. The obtained test results indicate that adding WGP to cohesive soils increases the unconfined compressive strength (UCS) and reduces free swell (FS). In contrast, using EPSb reduces both FS and UCS of the treated soil samples. An optimum combination of both waste materials is determined for the improvement of the properties of high plasticity clay used in this study. Furthermore, multiple linear regression (MLR) and artificial neural network (ANN) methods are used to predict the FS and UCS of the clayey soils based on the data obtained here and the experimental test results reported in the literature. Once the FS and UCS values of untreated soil and additive percentages are defined as independent variables, both methods are shown to predict the FS and UCS values of the treated soil samples on a satisfactory level with the coefficient of correlation (R2\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${R}^{2}$$\\end{document}) values greater than 0.926. Additionally, when only the index properties (liquid limit, plastic limit, and plasticity index) of the soil samples with waste materials are used as dependent variables, the R2\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${R}^{2}$$\\end{document} values obtained by the ANN method are 0.968 and 0.974 for FS and UCS, respectively. The results of the untreated soil samples' FS and UCS tests are known, and the linear regression and ANN techniques yield similar results. Lastly, the ANN method is used to predict the FS and UCS of the treated samples in accordance to the limited predictors (e.g., only the Atterberg limits of the soil sample).

Dynamic Mechanical Performance of Sulfate-Bearing Soils Stabilized by Magnesia-Ground Granulated Blast Furnace Slag

Sulfate soils often caused foundation settlement, uneven deformation, and ground cracking. The distribution of sulfate-bearing soil is extensive, and effective stabilization of sulfate-bearing soil could potentially exert a profound influence on environmental protection. Ground granulated blast furnace slag (GGBS)–magnesia (MgO) can be an effective solution to stabilize sulfate soils. Dynamic cyclic loading can be used to simulate moving vehicles applied on subgrade soils, but studies on the dynamic mechanical properties of sulfate-bearing soil under cyclic loading are limited. In this study, GGBS-MgO was used to treat Ca-sulfate soil and Mg-sulfate soil. The swelling of the specimens was analyzed by a three-dimensional swelling test, and the change in compressive strength of the specimens after immersion was analyzed by an unconfined test. The dynamic elastic properties and energy dissipation of GGBS-MgO-stabilized sulfate soils were evaluated using a fatigue test, and the mineralogy and microstructure of the stabilized soils were investigated by X-ray diffraction and scanning electron microscopy. The results showed that the maximum swelling percentage of stabilized Ca-sulfate soil was achieved when the GGBS:MgO ratio was 6:4, resulting in an expansion rate of 14.211%. In contrast, stabilized Mg-sulfate soil exhibited maximum swelling at GGBS:MgO = 9:1, with a swelling percentage of 5.127%. As the GGBS:MgO ratio decreased, the dynamic elastic modulus of stabilized Ca-sulfate soil diminished from 2.8 MPa to 2.69 MPa, and energy dissipation reduced from 0.02 MJ/m3 to 0.019 MJ/m3. Conversely, the dynamic elastic modulus of stabilized Mg-sulfate soil escalated from 2.16 MPa to 6.12 MPa, while energy dissipation decreased from 0.023 MJ/m3 to 0.004 MJ/m3. After soaking, the dynamic elastic modulus of Ca-sulfate soil peaked (4.01 MPa) and energy dissipation was at its lowest (0.012 MJ/m3) at GGBS:MgO = 9:1. However, stabilized Mg-sulfate soil exhibited superior performance at GGBS:MgO = 6:4, with a dynamic elastic modulus of 0.74 MPa and energy dissipation of 0.05 MJ/m3. CSH increased significantly in the Ca-sulfate soil treated with GGBS-MgO. The generation of ettringite increased with the decrease in the GGBS-MgO ratio after immersion. MSH and less CSH were formed in GGBS-MgO-stabilized Mg-sulfate soil compared to Ca-sulfate soils. In summary, the results of this study provide some references for the improvement and application of sulfate soil in the field of road subgrade.