Drug Release Study of Polyvinyl Alcohol-Gelatin-Montmorillonite Bionanocomposite Hydrogel Drug Delivery Systems Loaded with Clindamycin

Abstract

One of the challenges facing medical science is the proper formulation of drug delivery systems for the correct transfer of active pharmaceutical ingredients to the body. Polymer and nanocomposite hydrogels have been considered ideal options in the preparation of drug delivery systems due to their proper properties, such as hydrophilicity and biocompatibility. In this, our research, described in this manuscript, the drug release from polyvinyl alcohol (PVA)-gelatin-montmorillonite (MMT) bionanocomposite hydrogel drug delivery systems loaded with clindamycin was studied. The structural and physical properties of prepared nanocomposite hydrogels were investigated using X-ray diffractometry (XRD), field emission scanning electron microscopy (FESEM), Fourier-transform infrared spectroscopy (FTIR), Brunauer-Emmette-Teller (BET) analysis, gel fraction and swelling tests. The results showed that by adding MMT clay to PVA-gelatin hydrogels, the amount of gel fraction increased, and due to the decrease in the size of the pores, the amount of swelling decreased. The results of the drug release tests showed that the release rate of clindamycin was inversely related to the percentage of MMT added to the nanocomposite hydrogel. The results also showed that the shape of the drug delivery system and its dimensions affected the release rate of clindamycin. The dominant mechanism of drug release in all samples was found to be Fickian transport. Considering the favorable in-vitro drug release performance of our PVA-gelatin-MMT nanocomposite hydrogels in the release of clindamycin, it was concluded that they are suitable options for preparing practical drug delivery systems with controlled drug release ability.