Sustainable Safety Research Articles

Chronic Hepatitis B Finite Treatment: Similar and Different Concerns With New Drug Classes.

Chronic hepatitis B, a major cause of liver disease and cancer, affects >250 million people worldwide. Currently there is no cure, only suppressive therapies. Efforts to develop finite curative hepatitis B virus (HBV) therapies are underway, consisting of combinations of multiple novel agents with or without nucleos(t)ide reverse-transcriptase inhibitors. The HBV Forum convened a webinar in July 2021, along with subsequent working group discussions to address how and when to stop finite therapy for demonstration of sustained off-treatment efficacy and safety responses. Participants included leading experts in academia, clinical practice, pharmaceutical companies, patient representatives, and regulatory agencies. This Viewpoints article outlines areas of consensus within our multistakeholder group for stopping finite therapies in chronic hepatitis B investigational studies, including trial design, patient selection, outcomes, biomarkers, predefined stopping criteria, predefined retreatment criteria, duration of investigational therapies, and follow-up after stopping therapy. Future research of unmet needs are discussed.

A review of biocontrol agents in controlling late blight of potatoes and tomatoes caused by Phytophthora infestans and the underlying mechanisms.

Phytophthora infestans causes light blight on potatoes and tomatoes, which has a significant economic impact on agriculture. The management of late blight has been largely dependent on the application of synthetic fungicides, which is not ultimate solution for sustainable agriculture and environmental safety. Biocontrol strategies are expected to be alternative methods to the conventional chemicals in controlling plant diseases in the integrated pest management (IPM) programs. Well-studied biocontrol agents against P. infestans include fungi, oomycetes, bacteria, and compounds produced by these antagonists, in addition to certain bioactive metabolites produced by plants. Laboratory and greenhouse experiments suggest a potential for using biocontrol in practical late blight disease management. However, the transition of biocontrol to field applications is problematic for the moment, due to low and variable efficacies. In this review, we provide a comprehensive summary on these biocontrol strategies and the underlying corresponding mechanisms. To give a more intuitive understanding of the promising biocontrol agents against P. infestans in agricultural systems, we discuss the utilizations, modes of action and future potentials of these antagonists based on their taxonomic classifications. To achieve a goal of best possible results produced by biocontrol agents, it is suggested to work on field trials, strain modifications, formulations, regulations, and optimizations of application. Combined biocontrol agents having different modes of action or biological adaptation traits may be used to strengthen the biocontrol efficacy. More importantly, biological control agents should be applied in the coordination of other existing and forthcoming methods in the IPM programs. This article is protected by copyright. All rights reserved.

Potential of bacteriophage PCT27 to reduce the use of agrochemicals to control Pectobacterium carotovorum subsp. Carotovorum in Chinese cabbage (Brassica pekinensis)

As antimicrobial resistance (AMR) continues to spread among bacteria and poses a serious threat to global health, the indiscriminate use of antibiotics in various fields, including agriculture, should be avoided. Here, we isolated a novel bacteriophage (phage), PCT27, specific for Pectobacterium carotovorum subsp. carotovorum (Pcc), a phytopathogen responsible for soft rot of crops, and investigated its potential as an adjunct to reduce the use of agrochemicals in Pcc control. Phage PCT27, which belongs to the family Autographiviridae, inhibited in vitro growth of Pcc within 1 h of infection by recognizing colanic acid as a host receptor. More than 90% of the virions rapidly adsorbed to the host cells within 3 min, supporting the efficient control of Pcc by PCT27. PCT27 supplementation reduced the minimum inhibitory concentration of streptomycin by 50% for Pcc control in vitro. Accordingly, PCT27 successfully complemented an antibiotic-based agrochemical in preventing Pcc infection in Chinese cabbage leaves and seedlings by reducing the dose of the agrochemical by a quarter. As a biocontrol agent for Pcc that complements agrochemicals, PCT27 can not only prevent economic losses due to crop decay but would also contribute to addressing the AMR crisis for sustainable agriculture and environmental safety.

Safety and performance of the Vienna self-expandable transcatheter aortic valve system: 6-month results of the VIVA first-in-human feasibility study.

The novel Vienna TAVI system is repositionable and retrievable, already pre-mounted on the delivery system, eliminating the need for assembly and crimping of the device prior to valve implantation. The purpose of this first-in-human feasibility study was to determine the safety, feasibility, clinical and hemodynamic performance of the Vienna TAVI system at 6-month follow-up. (ClinicalTrials.gov identifier NCT04861805). This is a prospective, non-randomized, single-arm, single-center, first-stage FIH feasibility study, which is followed by a second-stage pivotal, multicenter, multinational study in symptomatic patients with severe aortic stenosis (SAS). The first-stage FIH study evaluated the safety and feasibility, clinical and hemodynamic performance of the device in 10 patients with SAS based on recommendations by the VARC-2. All patients were alive at 3-month follow-up. 1 non-cardiovascular mortality was reported 5 months after implantation. There were no new cerebrovascular events, life-threatening bleeding or conduction disturbances observed at 6-month follow-up. The mean AV gradient significantly decreased from 48.7 ± 10.8 to 7.32 ± 2.0 mmHg and mean AVA increased from 0.75 ± 0.18 to 2.16 ± 0.42 cm2 (p < 0.00001). There was no incidence of moderate or severe total AR observed. In the QoL questionnaires, the patients reported a significant improvement from the baseline 12-KCCQ mean score 58 ± 15 to 76 ± 20. NYHA functional class improved in two patients, remained unchanged in one patient. There was an increase in mean 6-min-walk distance from baseline 285 ± 97 to 347 ± 57 m. This study demonstrates that using Vienna TAVI system has favourable and sustained 6-month safety and performance outcomes in patients with symptomatic severe aortic stenosis.

A synergetic approach for quantification and analysis of coal fires in Jharia Coalfield, India

Temporal monitoring and understanding of the dynamics of coal fires in the Jharia Coalfield (JCF) are required to reduce its effect on sustainable industrial growth, environment & human safety. This research explores temporal dataset of Landsat 8 OLI Thermal Infrared Sensor (TIRS) from 2015 to 2019 to detect, map and quantify coal fire affected areas in JCF at the colliery level. The results indicated that the East Barora, Sijua, Katras, Kusunda, Kustore, Pootkee Balihari, Bastacolla, Jharia, and Lodna are intensely fire-affected collieries with a significant increase in risk area from 4.57 km2 in 2015 to 11.43 km2 in 2019. The central part of the area is highly affected. The extent of coal fire shows temporal fluctuation between 2015 and 2019, but overall exhibit a significant increase from 2.76 km2 to 7.52 km2. Sijua, Katras, Kusunda, Lodna, and Kustor occupying the central and southeastern parts of the JCF, respectively, constitute nearly ∼85% of the total fire. However, in comparison to the information inferred from the field-based knowledge, the results derived from satellite-based observations are slightly underestimated due to the reason that the coal fire-derived thermal anomalies are the function of depth, intensity and proportion of coal fire in a coarse resolution TIR pixel, structural attributes, interventions from the mining operation and regional land use planning. Further, the risk areas map out using the TIR-based approach have been integrated with the prevailing structural attributes and Landsat 8 OLI-derived surface thermal anomalies, which enabled an understanding of the dynamics of coal fire propagation in JCF.

Sustainable occupational safety and health interventions: A study on the factors for an effective design

Effective interventions are a priority in continuously changing occupational environments, particularly in companies struggling to manage health and safety in the workplace. Practitioners may consider practical solutions for Occupational Safety and Health (OSH) improvement as a panacea for all major problems. However, they may overlook a range of other factors that affect the success of such solutions. The way in which a solution is developed, designed, implemented, and evaluated determines its impact. Participatory interventions are one way of ensuring better results. Consequently, this study proposes a way of establishing sustainable, effective, and efficient interventions by defining the required processes and actively involving responsible actors (i.e., who, when, and how).A national OSH intervention for introducing a near-miss management system, funded by the Italian National Institute for Insurance against Accidents at Work (INAIL), is used as a reference because its development process includes an accurate design stage. Based on this intervention, a multistep design process is built to answer how (how the intervention will persist by defining the context, processes, and scenarios), who (who will be the responsible actors actively participating), and when (when actors will be involved) questions.The design process established for the intervention, although within a specific context, provides clues to discriminant factors that would enable effectiveness in general interventions, and the proposed system for near-miss management generates insights that may be generalizable to other OSH interventions developed in different environments.

Safety accident analysis of power transmission and substation projects based on association rule mining.

To achieve the sustainable development goals (SDGs) of power transmission and substation project construction, statistical analysis was used to provide an outline of safety accidents, the 4M1E method was applied for sorting out and analyzing the risk factors, and the Apriori algorithm was carried out for exploring the intrinsic interaction among risk factors based on association rule mining. The results showed that the safety accidents that happen in the construction of power transmission and substation projects were not much frequent, but deadly; the process of foundation construction and high fall was the most accident-prone process and injury type respectively. In addition, human behaviors were the foremost factors leading to accidents, and there was a strong correlation among the risk factors of low project management level, lack of safety awareness, and poor risk identification ability. For improving the security situation, measures should be taken for controlling human factors, performing flexible management, and strengthening safety training. In further research, more detailed and diversified accident reports and case data should be analyzed, and more consideration should be put on the weighted risk factor analysis to obtain more comprehensive and objective safety accident analysis results for power transmission and substation projects. This study highlights the risks in power transmission and substation project construction and introduces a novel method for better analyzing the intrinsic interaction among risk factors, which provides theoretical support for related departments to conduct sustainable safety management.

BT18 Evaluation of a teledermatology service for lesion monitoring

Abstract Teledermatology (TD) is an established diagnostic and triage tool for the initial assessment of skin lesions and is increasingly being used for monitoring. A previous study conducted at our trust found that 5% of our 2-week wait (2WW) referrals required follow-up for lesion monitoring. We therefore established a TD follow-up pathway to accommodate these patients and increase capacity for face-to-face (F2F) appointments. We retrospectively reviewed the outcomes of all TD follow-up patients seen from 1 April 2022 to 22 December 2022. The TD follow-up is usually requested 4 months after an initial assessment. We evaluated the proportion of benign lesions and those requiring further follow-up or surgery. In total, 3796 patients were assessed via TD, with 319 (8.4%) comprising TD follow-up. Altogether, 292 (91.5%) patients were initially reviewed via TD 2WW referral and 27 (8.5%) were referred from the clinic. Forty-eight (15.0%) did not attend (DNA) their follow-up and were discharged. Of the remaining 271 patients, seven (2.6%) who failed to attend their TD follow-up were rebooked, 179 (66%) were discharged after one TD follow-up assessment, 16 (5.9%) were booked for further TD follow-up, 19 (7.0%) were booked for routine F2F follow-up and five (1.8%) were booked for an urgent 2WW F2F appointment. Patients were also referred directly for excision, with 21 (7.7%) referred routinely and 24 (8.8%) referred urgently. From the 24 lesions excised urgently, five (21%) were dysplastic naevi, one (4%) was a moderately differentiated squamous cell carcinoma, 11 (46%) were benign (naevi, seborrhoeic keratoses or dermatofibroma) and for seven (29%), histology was unavailable (DNA appointment, sought private treatment or excision pending) at the time of data collection. No lesions were confirmed histologically as melanoma. Of the five dysplastic lesions, dermoscopic changes noted at follow-up included new atypical amorphous streaks, new and darker globules, loss of pigment and erythema. Our data suggest that TD for lesion monitoring may offer a suitable and time-efficient approach to follow-up, helping to alleviate pressure on services. Three to six months of follow-up has previously been considered an appropriate time period for short-term lesion monitoring; however, the optimal duration remains debatable. The low numbers of malignant lesions detected suggest an encouraging safety profile. However, with 66% of patients being discharged after TD follow-up, we plan to pilot a collaborative team approach to initial decision-making through mega processing clinics with the aim of improving specificity and ‘getting it right first time’ for patients. Longer-term data and cost-effectiveness analyses are required to further evaluate the sustained safety and efficacy of this service.

Towards Sustainable Safe Driving: A Multimodal Fusion Method for Risk Level Recognition in Distracted Driving Status

Precise driving status recognition is a prerequisite for human–vehicle collaborative driving systems towards sustainable road safety. In this study, a simulated driving platform was built to capture multimodal information simultaneously, including vision-modal data representing driver behaviour and sensor-modal data representing vehicle motion. Multisource data are used to quantify the risk of distracted driving status from four levels, safe driving, slight risk, moderate risk, and severe risk, rather than detecting action categories. A multimodal fusion method called vision-sensor fusion transformer (V-SFT) was proposed to incorporate the vision-modal of driver behaviour and sensor-modal data of vehicle motion. Feature concatenation was employed to aggregate representations of different modalities. Then, successive internal interactions were performed to consider the spatiotemporal dependency. Finally, the representations were clipped and mapped into four risk level label spaces. The proposed approach was evaluated under different modality inputs on the collected datasets and compared with some baseline methods. The results showed that V-SFT achieved the best performance with an recognition accuracy of 92.0%. It also indicates that fusing multimodal information effectively improves driving status understanding, and V-SFT extensibility is conducive to integrating more modal data.

Internalization of the ‘Safety & Quality Assessment for Sustainability’ System Motivations and performance in Spanish road transport firms

The Safety & Quality Assessment for Sustainability (SQAS) system aims to measure sustainability levels – quality, safety, security and environmental requirements – of logistics providers in the distribution of European chemicals. In the context of SQAS adoption, the purpose of this work is twofold. First, it examines how the motivations of road transport companies carrying dangerous goods to evaluate through the SQAS system condition the real (not symbolic) internalization of the system. Secondly, it analyzes how the internalization of the SQAS system impacts sustainability performance. The study analyzes a sample of 78 Spanish companies assessed according to the SQAS Transport Service module. We use structural equations models applying partial least squares to test the research hypotheses. Results suggest that customer pressure is the main motivation for a company to undergo the assessment. In addition, in line with the literature on management standards, the results show that internal motivations impact to a greater extent than external ones in the internalization of SQAS, and that greater internalization contributes to better sustainability performance.

Assessing food safety risks based on a geospatial analysis: toward a cross-regional food safety management.

Food safety risks (FSRs) are increasingly characterized by geographical complexity along with rapid urbanization, changing dietary pattern, and the modernization of the food industry. These factors pose challenges for food risk control in developing economies, more so during the global COVID-19 pandemic. The accurate assessment of risk source and transfer path is a crucial step toward enhancing cross-regional food safety management. This study aims to examine the spatial distribution, transfer path and driving factors of FSRs in China, provided with a national food safety database collected from 8.63 million batches of food sampling inspections for 33 different types of foods across 30 provinces. The findings reveal significant regional disparities in FSRs, which is the highest in the west with small-scale sampling inspection and the lowest in the east with intensive sampling inspection. Catering and processed foods with higher daily consumption suffer more profound FSR than agricultural products. As evidenced by the shrinking low-low agglomeration areas, the local FSRs have been effectively controlled. The high-high agglomeration areas playing positive impacts on risk control are expanding while distributed discretely. The spatial transfer of FSRs is significantly driven by multiple drivers: regulatory capacity and intensity, information disclosure, food industry, regional economy, and food consumption. Assessing FSRs based on a geospatial analysis contributes to identifying risk sources, optimizing risk management, and constructing a sustainable food safety system. © 2023 Society of Chemical Industry.

Exploration of optimal disinfection model based on groundwater risk assessment in disinfection process

Under the influence of different types of disinfectants and disinfection environments, the removal level of pathogens and the formation potential of disinfection by-products (DBPs) will have a dual impact on the groundwater environment. The key points for sustainable groundwater safety management are how to balance the positive and negative relationship and formulate a scientific disinfection model in combination with risk assessment. In this study, the effects of sodium hypochlorite (NaClO) and peracetic acid (PAA) concentrations on pathogenic E. coli and DBPs were investigated using static-batch and dynamic-column experiments, as well as the optimal disinfection model for groundwater risk assessment was explored using quantitative microbial risk assessment and disability-adjusted life years (DALYs) models. Compared to static disinfection, deposition and adsorption were the dominant factors causing E. coli migration at lower NaClO levels of 0–0.25 mg/L under dynamic state, while disinfection was its migration factor at higher NaClO levels of 0.5–6.5 mg/L. In contrast, E. coli removed by PAA was the result of the combined action of deposition, adsorption, and disinfection. The disinfection effects of NaClO and PAA on E. coli differed under dynamic and static conditions. At the same NaClO level, the health risk associated with E. coli in groundwater was higher, whereas, under the same PAA conditions, the health risk was lower. Under dynamic conditions, the optimal disinfectant dosage required for NaClO and PAA to reach the same acceptable risk level was 2 and 0.85 times (irrigation) or 0.92 times (drinking) of static disinfection, respectively. The results may help prevent the misuse of disinfectants and provide theoretical support for managing twin health risks posed by pathogens and DBPs in water treatment.

Land Resources in Organic Agriculture: Trends and Challenges in the Twenty-First Century from Global to Croatian Contexts

Organic agriculture (OA) is a continuously growing global concept that emphasizes the use of sustainable and environmentally-friendly practices. By adopting OA, it is possible to improve ecosystems services, increase biodiversity, decrease environmental pollution, reduce carbon footprints and mitigate greenhouse gas emissions, generating food that is free from harmful residues of agrochemicals, thereby enhancing food safety and security. This study provides a comprehensive review of the latest insights on the global utilization of land resources in OA, focusing particularly on some EU countries that experienced a notable and rapid progress in organic farming during the past two decades. With negligible 1.6% (75 Mha) of global cropland is currently dedicated to OA, there is ample opportunity to expand the adoption of OA and realize its multi-beneficial potential for farmers (by premium prices), and consumers (by healthier and nutritious food). The importance of OA has been recognized by the most recent EU agro-environmental policies and green strategies, with an ambitious goal to have at least 25% of agroecosystems under organic management by 2030. Despite numerous financial supports and a multifold increase in OA land area, many member states are unlikely to achieve this goal, including Croatia, which currently has a share of only 8% (~109,000 ha) of lands in OA. Furthermore, converting conventional land to organic farming has not always led to an increase in value-added final OA products. EU policies related to OA have been focused on the area of land cultivated organically, rather than overall production performance, and financial subsidies have been essential to achieve this policy. Therefore, some of critical obstacles and challenges for OA under rising pressures due to global climate change, public health and geopolitical crises need to be managed by specifically designed policies and regulations, which would contribute to more sustainable OA, i.e., food safety and security.

A Review of Surrogate Safety Measures Uses in Historical Crash Investigations

Historical road crash data are the main indicator for measuring road safety outcomes. Over the past few decades, significant efforts have been made in obtaining and exploiting Surrogate Safety Measures (SSMs). SSMs have the potential to provide excellent sustainable road safety indicators and proxy measurements which can complement traditional historical crash analyses or even substitute them. By using SSMs, crash data collection demands can be bypassed and areas can be investigated before crashes occur. Due to such advantages, the objective of the present research is to provide a review of the scientific literature regarding studies exploiting SSMs for historical crash record investigations. Specifically, 34 studies were examined, providing insights on the different types of SSMs collected under real road environment conditions, the way they are collected, their connection with specific road crash types, and the type of the developed statistical models are examined and discussed. Particular focus is also placed on the temporal dimension of the collection period of both SSMs and road crashes. Finally, the overall trends deriving from the reviewed studies are summarized and future research directions are provided.

Efficacy of Two Laser Treatment Strategies for Breast Cancer Survivors With Genitourinary Syndrome of Menopause.

Background A typical symptom of patients with genitourinary syndrome of menopause (GSM) is dyspareunia. Dyspareunia has been thought to be caused by vaginal dryness. In recent years, a survey of breast cancer survivors (BCS) with GSM has shown that para-hymen is the most painful. Dyspareunia and superficial vulvar pain (vulvodynia) may be closely linked. A recent study showed that vulvodynia is very common in BCS. Therefore, we believe treatment targeting the vagina and the vulva is necessary for pain in BCS with GSM. We hypothesized that treating both the vagina and the vulva would solve the problem of BCS with GSM. We compared the vaginal erbium SMOOTH mode laser (VEL) and neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser (VEL+Nd:YAG) combination treatment over time. This study explores therapeutic targets for pain in BCS with GSM. Methodology This retrospective, case-control study targeted sexually active BCS who reported GSM with vulvodynia and dyspareunia. After all women enrolled in the VEL treatment group had completed treatment, we treated women enrolled in the VEL+Nd:YAG treatment group. A total of 256 women who received either VEL+Nd:YAG or VEL were enrolled. Propensity score (PS)-matching analysis was used to compare two-year postoperative data retrospectively. The PS-matching results registered 102 patients in the VEL+Nd:YAG group and 102 patients in the VEL group. Symptoms were assessed using the visual analog scale (VAS) for vulvodynia before and after laser treatment for one, three, six, 12, and 24 months after completion. As a preliminary study, the vulvodynia swab test confirmed the causative location of dyspareunia. Moreover, the Female Sexual Function Index (FSFI) and Vaginal Health Index Score (VHIS) were assessed. FSFI and VHIS were treated as supplement research because the conditions were unmet. Results In the vulvodynia swab test, dyspareunia, and para-hymen (especially at 4 o'clock and 9 o'clock), all felt pain, and only a few felt pain in the vagina and labia. FSFI improved significantly in the VEL+Nd:YAG group and persisted for two years. VHIS improved equally in both groups and was not significantly different. After the first laser application, the VEL+Nd:YAG and the VEL groups showed sustained efficacy and safety in vulvodynia. Baseline VAS scores (8.74 ± 0.72 vs. 8.79 ± 0.74; p = 0.564) were similar in both groups. Both groups had a significant (p < 0.001) decrease in the VAS score. The VAS values in the VEL+Nd:YAG group and the VEL group decreased from the pretreatment to 3.79 ± 0.63 (p < 0.001 vs. baseline) and 5.56 ± 0.89 (p < 0.001 vs. baseline) after the third treatments, respectively. After 24 months, the VAS value in the VEL+Nd:YAG group and the VEL group was at 4.43 ± 1.38 (p < 0.001 vs. baseline) and 5.56 ± 0.89 (p < 0.001 vs. baseline), respectively. The side effects in both groups were short-term and minor. Conclusions Both VEL+NdYAG and VEL effectively and safely treat GSM dyspareunia and vulvodynia in BCS. Comparing the two groups, we confirmed that VEL+Nd:YAG treatment of the vaginal vestibule and vaginal opening reduced superficial vulvar pain more effectively, extensively, and over a longer period than VEL. The results of the vulvodynia swab test, FSFI, and VHIS suggest that the vulva and the vagina are important therapeutic targets for pain in BCS with GSM. The importance of treating the vulvar area for superficial pain and dyspareunia in GSM has been emphasized.

Preliminary study on food-based dust explosion: Effect of physicochemical properties & thermal behaviour

Severe dust explosions occur frequently in the food processing industry, and explosion damage increases with the rate of flame propagation in pipes or plants. It is important for the food industry to recognize the potential hazards associated with food-based dust explosions. Appropriate investments are required to achieve sustainable industrial development and operational safety. In this study, the effect of the physicochemical properties of brown rice and tea powder on the severity of dust explosions was investigated over a size range of 1–138 µm. Thermogravimetric analysis (TGA) was applied to determine the physicochemical properties of the samples. Results showed that volatility, moisture content, and fixed carbon had a significant effect on the combustion. Brown rice, with a lower moisture content (6.52 wt%) and higher volatile matter (71.7 wt%) compared to tea powder, exhibited a higher explosion pressure (16.50 bar) and rate of pressure rise (95.0 bar/s). The lower moisture and fixed carbon content, combined with a higher volatile matter content, make it highly reactive in combustion. Its dryness also meant less agglomeration which contributed to its higher explosion pressure. It was observed that the physicochemical properties of the dust had a significant effect on the severity of the ensuing dust explosions. While there is a general understanding of the factors that contribute to dust explosions, there may be specific types of dust or mixtures of dust that require further study. Understanding the specific characteristics and behavior of these types of dust can inform safety guidelines and best practices for handling and processing them.

ENSURING FOOD SECURITY AT THE HOUSEHOLD LEVEL: SOCIO-ECONOMIC DIAGNOSTICS

The purpose of this scientific article is to research the important issues of food supply in Ukraine at the regional level by diagnosing the current state of food ensuring based on a survey of relevant respondents with the purpose to improve the level of socio-economic development of the country in the long run.In research have been interviewed households from Kyiv of Ukraine according to the following main criteria: physical and economic conditions, food availability, supply and access to food consumption to evaluate household food security status by calculating the sample size, a few details about the target population, its size, variance, margin of error and desired level of confidence in empirical estimates of important variables.In this research, the Minimum Dietary Energy Requirement (MDER) and a threshold that shows the minimum amount of energy needed by a hypothetical average person in the population to be healthy and engage in socially acceptable levels of activity have been examined. The state of nutritional food security in terms of protein, carbohydrate, and fat consumption has been investigated.The main aspect of the results approved that almost half of the respondents are showing conditions of life for them as “just adequate and few people seem not to be satisfied showing «less than adequate». These results are important from the viewpoint of food security as adequate food intake; availability and sustainability are the main components of food security and show the quality-of-life status.It is proved that at the present stage of national economic status human development plays an important role in achieving long-term food security goals. It has been established that in order to attain sustainable food safety at the national level, it is important to improve the population's health condition and to change the existing food consumption models in the country, in households in particular the food basket containing imported foodstuff. This can be achieved through promoting safe and healthy eating habits, education improving in the field of food systems and technologies, and facilitating access to information for consumers and producers.

Long-term efficacy and safety of ravulizumab in adults with anti-acetylcholine receptor antibody-positive generalized myasthenia gravis: results from the phase 3 CHAMPION MG open-label extension

IntroductionRavulizumab demonstrated efficacy and an acceptable safety profile versus placebo in the randomized controlled period (RCP) of the phase 3 CHAMPION MG trial in patients with anti-acetylcholine receptor antibody-positive generalized myasthenia gravis. We report an interim analysis of the ongoing open-label extension (OLE) designed to evaluate long-term treatment effects.MethodsFollowing completion of the 26-week RCP, patients could enter the OLE; patients who received ravulizumab in the RCP continued the drug; patients who previously received placebo switched to ravulizumab. Patients receive body-weight-based maintenance dosing of ravulizumab every 8 weeks. Efficacy endpoints up to 60 weeks included Myasthenia Gravis–Activities of Daily Living (MG-ADL) and Quantitative Myasthenia Gravis (QMG) scores, with least-squares (LS) mean change and 95% confidence intervals (95% CI) reported.ResultsLong-term efficacy and safety in the OLE were analyzed in 161 and 169 patients, respectively. Improvements in all scores were maintained through 60 weeks in patients who received ravulizumab during the RCP; LS mean change from RCP baseline in MG-ADL score was − 4.0 (95% CI: − 4.8, − 3.1; p < 0.0001). Rapid (within 2 weeks) and sustained improvements occurred in patients previously receiving placebo; LS mean change in MG-ADL score from OLE baseline to Week 60 was − 1.7 (95% CI: − 2.7, − 0.8; p = 0.0007). Similar trends were seen in QMG scores. Ravulizumab treatment was associated with a decreased rate of clinical deterioration events compared with placebo. Ravulizumab was well tolerated; no meningococcal infections were reported.ConclusionFindings support the sustained efficacy and long-term safety of ravulizumab, administered every 8 weeks, in adults with anti-acetylcholine receptor antibody-positive generalized myasthenia gravis.ClinicalTrials.gov identifier: NCT03920293; EudraCT: 2018-003243-39.

Radiographers' perception of patient safety culture in radiology

IntroductionRadiographers play a central role in patient safety because of their knowledge of and responsibilities in relation to the imaging process. To maintain safe care, the workplace must create a safety culture that enables sustainable safety work. AimThis study aims to describe radiographers' perceptions of the patient safety culture in radiology units in Sweden. MethodsThe Swedish Hospital Survey of Patients' Safety Culture (S-HSOPSC) was used to gather descriptive data from 171 Swedish registered radiographers working in five radiology clinics distributed across 15 units. Fifty-one questionnaire items and one open-ended question were analysed, comprising perceptions of the overall safety grade, the frequency of number of reported risks and events, and 14 composites regarding patient safety dimensions. ResultsThe radiographers' concerns surrounding the patient safety culture in their workplaces related to weaknesses regarding the safety dimensions “Staffing”, “Frequency of error reporting”, “Organizational learning – continuous improvement” and “Executive management support for patient safety”. They perceived “Teamwork within the unit” to be a strength. ConclusionDespite some weaknesses in the patient safety culture, the radiographers perceived that the overall patient safety level was good, in part because of their ability to spot risks in time. The executive management, however, needed to improve their feedback on safety measures; and another reason for some weaknesses in the patient safety culture could be staffing issues such as lack of time for meetings for continuous improvement. Managers and leaders have a great responsibility to establish a patient safety culture through support and good leadership. Implications for practiceAn understanding of what creates a safety culture is important to prevent patient safety incidents.

Efficient detoxification of textile wastewater by applying Chenopodium album nanoparticles and its application in simulated metal-bearing effluents removal.

Large-scale pollution of water and soils bodies is associated with the discharge of the untreated textile industry effluents. Halophytes grows on saline lands and accumulate secondary metabolites and other stress protective compounds. Utilization of Chenopodium album (halophytes) to synthesize zinc oxide (ZnO) and their efficiency to treat different concentrations of textile industry waste water is proposed in this study. Potential of nanoparticles textile industry waste water effluents was also analyzed by exposing different concentrations of nanoparticles (0 (control), 0.2, 0.5, 1mg) and time intervals of 5, 10, and 15days. The absorption peaks by UV region, FTIR and SEM analysis were used characterized on ZnO NPs for the first time. FTIR analysis showed the preens of various functional groups and vital phytochemicals that can play its role in the formation of nanoparticles that can be used for trace elements removal and bioremediation. SEM analysis indicated that the pure ZnO NPs synthesis ranged from 30 to 57nm. Results shows that the green synthesis of halophytic nanoparticles presents maximum removal capacity after 15days exposure to 1mg of ZnO NPs. Hence, the prepared ZnO Nps from halophytes can be a viable solution for treating the textile industry effluents before they are discharged into water bodies for sustainable environmental growth and environmental safety.