Measurement of sustainable development is a separate area of research necessary for the formation and adoption of management decisions related to the development of the country's regions. The article presents a comparative analysis of various approaches and methodologies of domestic authors to assess sustainable development at the regional level. The study reveals the prevailing sources of information in the methodologies, the principles of selection of indicators and distribution by groups, methods and tools of assessment, interpretation of results, territorial coverage of approbation. Most authors adhere to the approach of deriving a consolidated aggregate index in combination with integral indicators for each component of sustainable development of the region, expanding the possibilities of interpreting the results. When forming the composition of indicators, choosing approaches and methods of measurement, researchers take into account the degree of severity of problems in achieving sustainable development goals in the region. At the same time, the principle of equal value of each component of sustainable development in accordance with the triune concept is not taken into account by all authors. In recent works, the wide inclusion of environmental indicators is recorded, which is due to the relevance of the implementation of the concepts of “low-carbon” and “green” economy. In general, the methodologies used to assess the sustainable development of regions have both advantages and disadvantages and are related to the objectives of researchers.